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UniProtKB - Q4WAW9 (FTMF_ASPFU)
Protein
Verruculogen synthase
Gene
ftmOx1
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Functioni
Catalyzes the conversion of fumitremorgin B to verruculogen.
1 PublicationCaution
Despite the presence of this enzyme, this enzyme may not be involved in verruculogen synthesis in vivo. In contrast to other A.fumigatus strains, strain ATCC MYA-4609 does not produce indole alkaloids such as fumitremorgins and verruculogen. While the biosynthetic pathway is complete, a variation in the O-methyltransferase FtmD (AC Q4WAW6) abolishes production of the tryprostatin A intermediate (PubMed:23649274).1 Publication
Catalytic activityi
- 2-oxoglutarate + AH2 + fumitremorgin B + 2 O2 = A + CO2 + H2O + succinate + verruculogen1 PublicationEC:1.14.11.381 Publication
Cofactori
Fe cation1 Publication
GO - Molecular functioni
- dioxygenase activity Source: AspGD
GO - Biological processi
- verruculogen biosynthetic process Source: AspGD
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Ligand | Iron |
Names & Taxonomyi
Protein namesi | Recommended name: Verruculogen synthase (EC:1.14.11.38)Alternative name(s): Fumitremorgin biosynthesis protein F |
Gene namesi | Name:ftmOx1 Synonyms:ftmF ORF Names:AFUA_8G00230 |
Organismi | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
Taxonomic identifieri | 330879 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Fumigati › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:Afu8g00230 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000424133 | 1 – 291 | Verruculogen synthaseAdd BLAST | 291 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationBinary interactionsi
Q4WAW9
With | #Exp. | IntAct |
---|---|---|
itself | 3 | EBI-16183015,EBI-16183015 |
Protein-protein interaction databases
DIPi | DIP-61797N |
STRINGi | 746128.CADAFUBP00008409 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q4WAW9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the PhyH family.Curated
Phylogenomic databases
eggNOGi | ENOG502S7ZW, Eukaryota |
HOGENOMi | CLU_047725_1_0_1 |
InParanoidi | Q4WAW9 |
OMAi | VIHAICE |
OrthoDBi | 623398at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR008775, Phytyl_CoA_dOase |
Pfami | View protein in Pfam PF05721, PhyH, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4WAW9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVDSKPQLQ RLAADADVDR MCRLLEEDGA FILKGLLPFD VVESFNRELD
60 70 80 90 100
VQMAIPPPKG ERLLADKYPP HFKYVPNVAT TCPTFRNTVL INPVIHAICE
110 120 130 140 150
AYFQRTGDYW LSAAFLREIE SGMPAQPFHR DDATHPLMHY QPLEAPPVSL
160 170 180 190 200
SVIFPLTEFT EENGATEVIL GSHRWTEVGT PERDQAVLAT MDPGDVLIVR
210 220 230 240 250
QRVVHAGGGN RTTAGKPRRV VLAYFNSVQL TPFETYRTMP REMVESMTVL
260 270 280 290
GQRMLGWRTM KPSDPNIVGI NLIDDKRLEN VLQLKAADSP A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAHF01000014 Genomic DNA Translation: EAL85143.1 |
RefSeqi | XP_747181.1, XM_742088.1 |
Genome annotation databases
EnsemblFungii | EAL85143; EAL85143; AFUA_8G00230 |
GeneIDi | 3504528 |
KEGGi | afm:AFUA_8G00230 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAHF01000014 Genomic DNA Translation: EAL85143.1 |
RefSeqi | XP_747181.1, XM_742088.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4Y5S | X-ray | 2.54 | A/B | 2-291 | [»] | |
4Y5T | X-ray | 1.95 | A/B | 2-291 | [»] | |
6OXH | X-ray | 1.92 | A/B | 1-291 | [»] | |
6OXJ | X-ray | 1.55 | A/B | 1-291 | [»] | |
SMRi | Q4WAW9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-61797N |
STRINGi | 746128.CADAFUBP00008409 |
Genome annotation databases
EnsemblFungii | EAL85143; EAL85143; AFUA_8G00230 |
GeneIDi | 3504528 |
KEGGi | afm:AFUA_8G00230 |
Organism-specific databases
VEuPathDBi | FungiDB:Afu8g00230 |
Phylogenomic databases
eggNOGi | ENOG502S7ZW, Eukaryota |
HOGENOMi | CLU_047725_1_0_1 |
InParanoidi | Q4WAW9 |
OMAi | VIHAICE |
OrthoDBi | 623398at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR008775, Phytyl_CoA_dOase |
Pfami | View protein in Pfam PF05721, PhyH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FTMF_ASPFU | |
Accessioni | Q4WAW9Primary (citable) accession number: Q4WAW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 16, 2013 |
Last sequence update: | July 5, 2005 | |
Last modified: | February 23, 2022 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families