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Entry version 85 (07 Apr 2021)
Sequence version 2 (16 Oct 2013)
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Protein

Tryprostatin B synthase

Gene

ftmPT1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the prenylation of brevianamide F. Can also prenylate other tryptophan-containing cyclic dipeptides. Prenylation occurs mainly at C-2, but also at C-3.2 Publications

Caution

In contrast to other A.fumigatus strains, strain ATCC MYA-4609 does not produce indole alkaloids such as fumitremorgins and verruculogen. While the biosynthetic pathway is complete, a variation in the O-methyltransferase FtmD (AC Q4WAW6) abolishes production of the tryprostatin A intermediate (PubMed:23649274).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=55 µM for brevianamide F1 Publication
  2. KM=74 µM for dimethylallyl diphosphate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei94Brevianamide F1 Publication1
    Binding sitei102Brevianamide F1 Publication1
    Binding sitei113Dimethylallyl diphosphate1 Publication1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei115Required for regioselectivity1 Publication1
    Binding sitei201Dimethylallyl diphosphate1 Publication1
    Binding sitei203Dimethylallyl diphosphate1 Publication1
    Binding sitei205Brevianamide F1 Publication1
    Binding sitei294Dimethylallyl diphosphate1 Publication1
    Binding sitei296Dimethylallyl diphosphate1 Publication1
    Binding sitei380Dimethylallyl diphosphate1 Publication1
    Binding sitei382Dimethylallyl diphosphate1 Publication1
    Binding sitei446Dimethylallyl diphosphate1 Publication1
    Binding sitei450Dimethylallyl diphosphate1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionPrenyltransferase, Transferase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:MONOMER-18762

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.5.1.106, 508

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M77.004

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Tryprostatin B synthase (EC:2.5.1.1061 Publication)
    Alternative name(s):
    Brevianamide F prenyltransferase
    Fumitremorgin biosynthesis protein B
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ftmPT1
    Synonyms:ftmB
    ORF Names:AFUA_8G00210
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Fumigati
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 8, Unassembled WGS sequence

    Organism-specific databases

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    FungiDB:Afu8g00210

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi102E → Q: Abolishes tryprostatin B synthase activity. 1 Publication1
    Mutagenesisi115G → T: Retains ability to consume brevianamide F but mediates formation of a different product that carries a reverse prenyl moiety at the C-3 of the indole nucleus. 1 Publication1
    Mutagenesisi279H → F: Slightly affects tryprostatin B synthase activity. 1 Publication1

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL5635

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004241111 – 464Tryprostatin B synthaseAdd BLAST464

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    746128.CADAFUBP00008411

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1464
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q4WAW7

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG502S2XP, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_037431_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q4WAW7

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    FYASERH

    Database of Orthologous Groups

    More...
    OrthoDBi
    1531660at2759

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd13929, PT-DMATS_CymD, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR033964, Aro_prenylTrfase
    IPR017795, Aro_prenylTrfase_DMATS
    IPR012148, DMATS-type_fun

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR40627, PTHR40627, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF11991, Trp_DMAT, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000509, Trp_DMAT, 1 hit

    Structure-Function Linkage Database

    More...
    SFLDi
    SFLDS00036, Aromatic_Prenyltransferase, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR03429, arom_pren_DMATS, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q4WAW7-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MPPAPPDQKP CHQLQPAPYR ALSESILFGS VDEERWWHST APILSRLLIS
    60 70 80 90 100
    SNYDVDVQYK YLSLYRHLVL PALGPYPQRD PETGIIATQW RSGMVLTGLP
    110 120 130 140 150
    IEFSNNVARA LIRIGVDPVT ADSGTAQDPF NTTRPKVYLE TAARLLPGVD
    160 170 180 190 200
    LTRFYEFETE LVITKAEEAV LQANPDLFRS PWKSQILTAM DLQKSGTVLV
    210 220 230 240 250
    KAYFYPQPKS AVTGRSTEDL LVNAIRKVDR EGRFETQLAN LQRYIERRRR
    260 270 280 290 300
    GLHVPGVTAD KPPATAADKA FDACSFFPHF LSTDLVEPGK SRVKFYASER
    310 320 330 340 350
    HVNLQMVEDI WTFGGLRRDP DALRGLELLR HFWADIQMRE GYYTMPRGFC
    360 370 380 390 400
    ELGKSSAGFE APMMFHFHLD GSQSPFPDPQ MYVCVFGMNS RKLVEGLTTF
    410 420 430 440 450
    YRRVGWEEMA SHYQGNFLAN YPDEDFEKAA HLCAYVSFAY KNGGAYVTLY
    460
    NHSFNPVGDV SFPN
    Length:464
    Mass (Da):52,607
    Last modified:October 16, 2013 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75B775A0420B6D5B
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence EAL85145 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti415G → A in AAX56314 (PubMed:16000710).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY861687 mRNA Translation: AAX56314.1
    AAHF01000014 Genomic DNA Translation: EAL85145.1 Different initiation.

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_747183.1, XM_742090.1

    Genome annotation databases

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    3504530

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    afm:AFUA_8G00210

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY861687 mRNA Translation: AAX56314.1
    AAHF01000014 Genomic DNA Translation: EAL85145.1 Different initiation.
    RefSeqiXP_747183.1, XM_742090.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3O24X-ray2.50A1-464[»]
    3O2KX-ray2.40A1-464[»]
    SMRiQ4WAW7
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    STRINGi746128.CADAFUBP00008411

    Chemistry databases

    ChEMBLiCHEMBL5635

    Protein family/group databases

    MEROPSiM77.004

    Genome annotation databases

    GeneIDi3504530
    KEGGiafm:AFUA_8G00210

    Organism-specific databases

    VEuPathDBiFungiDB:Afu8g00210

    Phylogenomic databases

    eggNOGiENOG502S2XP, Eukaryota
    HOGENOMiCLU_037431_0_0_1
    InParanoidiQ4WAW7
    OMAiFYASERH
    OrthoDBi1531660at2759

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-18762
    BRENDAi2.5.1.106, 508

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q4WAW7

    Family and domain databases

    CDDicd13929, PT-DMATS_CymD, 1 hit
    InterProiView protein in InterPro
    IPR033964, Aro_prenylTrfase
    IPR017795, Aro_prenylTrfase_DMATS
    IPR012148, DMATS-type_fun
    PANTHERiPTHR40627, PTHR40627, 1 hit
    PfamiView protein in Pfam
    PF11991, Trp_DMAT, 1 hit
    PIRSFiPIRSF000509, Trp_DMAT, 1 hit
    SFLDiSFLDS00036, Aromatic_Prenyltransferase, 1 hit
    TIGRFAMsiTIGR03429, arom_pren_DMATS, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFTMB_ASPFU
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WAW7
    Secondary accession number(s): Q4G2I1
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
    Last sequence update: October 16, 2013
    Last modified: April 7, 2021
    This is version 85 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
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