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Protein

Helicase swr1

Gene

swr1

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi855 – 862ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: UniProtKB-KW
  • helicase activity Source: UniProtKB-KW
  • histone binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase swr1 (EC:3.6.4.12)
Gene namesi
Name:swr1
ORF Names:AFUA_7G02370
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componentsi: Chromosome 7, Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:Afu7g02370

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743631 – 1695Helicase swr1Add BLAST1695

Proteomic databases

PRIDEiQ4WAS9

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00008646

Structurei

3D structure databases

ProteinModelPortaliQ4WAS9
SMRiQ4WAS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini334 – 408HSAPROSITE-ProRule annotationAdd BLAST75
Domaini842 – 1007Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1382 – 1532Helicase C-terminalPROSITE-ProRule annotationAdd BLAST151

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi958 – 961DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi468 – 677Asp-richAdd BLAST210

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000186095
InParanoidiQ4WAS9
KOiK11681
OMAiRQGWNND
OrthoDBiEOG092C1YH4

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WAS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQDGSLNGLS HHNDERVNHE NEDKSLNTSA LGDSPDSANR ELIPSESKEN
60 70 80 90 100
GVPTDSIEGP PSKRRKLAGP DNSRRSTPRP PSPPWKKAGV DGPTSFLQDG
110 120 130 140 150
KRRSSRVNAI PLELQPPSDK RKTRAAQRST VNKNLSGNGK VVASSPLSMS
160 170 180 190 200
VSQSGINGKH TGGNLTTGSP RTATPRGASA RRRRISRSPP RQTPSRTRSQ
210 220 230 240 250
SSATSAPNDP TSHNARSKRS HSNVTSTPTI GIDELWNDIG GETDLGDEQG
260 270 280 290 300
QRVPRLRIKV KKPVIGFQHP SHVIPPRKYN SFREWLESGE GRIEDGAVLT
310 320 330 340 350
PEAALVEARK RCRVLEATEP GGLLSPEVCS AYLPEQQEEP PQQYSHQDHL
360 370 380 390 400
VAHALYFKKL LDQEHRRHRN TARLLAQWCA DAWRKRNKRP EDILREQQEE
410 420 430 440 450
VRVKRKQLAR DLQKMFDLAR AEVDRMRLAR WEEERKVEDQ RALDRAIKQS
460 470 480 490 500
TMLFEKRRLE ILGETGSDFL DSTDAEESGT DATTSDAEED ESNMSSTDSE
510 520 530 540 550
TEDEDEVDDD EGLTAEELRQ KYADLPQSSL VSDRESVASD TSESSDGTRT
560 570 580 590 600
SHILQNIEDI NDSQGETPLE QIELDEVDPM LLDDSEDEST DMDDDMGDSD
610 620 630 640 650
EDGDADGTDS DDESDDGPGL LGFFSSKDRV LNDAHRFDDE GDDPLAVSNH
660 670 680 690 700
EGGSGFDDDG QSVSVDEDGD EELEDADEVS LVPNGPSNSV SISQSTAEVS
710 720 730 740 750
PVTETPDEEP DEQAEVVDTD MAAAAPSEGP APLEASAPLE DLVAIDKRGD
760 770 780 790 800
AMGECHRQQC SPLVNNLDEQ ELRQNGGASS EASPGTLATK PSEPESISSF
810 820 830 840 850
EAPGEKPPQP SESPAPGLKT PIPHLLRGTL REYQHYGLDW LAGLYNNHIN
860 870 880 890 900
GILADEMGLG KTIQTIALLA HLAVEHEVWG PHLVVVPTSV ILNWEMEFKK
910 920 930 940 950
WCPGFKIMTY YGSIEERRQK RKGWTDDTSW NVLITSYQLV LQDQQVLKRR
960 970 980 990 1000
NWHYMVLDEA HNIKNFRSQK WQTLLTFRTR ARLLLTGTPL QNNLTELWSL
1010 1020 1030 1040 1050
LFFLMPSDGD GTGIEGFADL RNFSEWFRRP VEQILEHGRE TMDDETKRVV
1060 1070 1080 1090 1100
TKLHTILRPY ILRRLKADVE KQMPAKYEHV VYCRLSKRQR FLYDGFMSMA
1110 1120 1130 1140 1150
QTKETLASGN YLSIINCLMQ LRKVCNHPDL FETRQISTSF VMHHSVATEY
1160 1170 1180 1190 1200
ASKEQLVRRR LLYEHPLTKL DLDFLNLVPI SREDISRRLA DDSTRLMAYG
1210 1220 1230 1240 1250
PFNILRERQY KRTNWQMMFD GSTVQSTLEA LENDARKRRM AELERCLYFE
1260 1270 1280 1290 1300
SKRHGRRPVY GTSLVEFLTA DSKQKPTLGG RPQTQSLAEW LSNRSSILAS
1310 1320 1330 1340 1350
MILSIEERSQ AMDGYVRRFA CVTPAAVASG ITEAALTPIE TRYLTEKERF
1360 1370 1380 1390 1400
PPYDPFHEAQ MRLSIAFPDK RLLQYDCGKL QRLDKLLRDL KAGGHRALIF
1410 1420 1430 1440 1450
TQMTKMLDIL EQFLNIHGHR YLRLDGTTKV EQRQILTDRF NNDDRILVFI
1460 1470 1480 1490 1500
LSSRSGGLGI NLTGADTVIF YDLDWNPAMD KQCQDRCHRI GQTRDVHIYR
1510 1520 1530 1540 1550
FVSEHTIESN ILRKANQKRM LDDVVIQEGE FTTDYFTKLD VRDMIGEEAE
1560 1570 1580 1590 1600
AQDEASAAMD RVLSSRVATG GSRVFEQAED KEDIDAAKNA QKEMEQADND
1610 1620 1630 1640 1650
DFGDRSISHT PGQVGTPLAT GPQEGETPGA QLITTPQIHG VDETVDVEPQ
1660 1670 1680 1690
PGHIDDYLLR FMEWNMKDEP LVLPPDKTKK KSKKGKEHRL SKRRR
Length:1,695
Mass (Da):191,097
Last modified:July 5, 2005 - v1
Checksum:iA83AF4D41401F81E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000015 Genomic DNA Translation: EAL84657.1
RefSeqiXP_746695.1, XM_741602.1

Genome annotation databases

EnsemblFungiiEAL84657; EAL84657; AFUA_7G02370
GeneIDi3504252
KEGGiafm:AFUA_7G02370

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000015 Genomic DNA Translation: EAL84657.1
RefSeqiXP_746695.1, XM_741602.1

3D structure databases

ProteinModelPortaliQ4WAS9
SMRiQ4WAS9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5085.CADAFUBP00008646

Proteomic databases

PRIDEiQ4WAS9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL84657; EAL84657; AFUA_7G02370
GeneIDi3504252
KEGGiafm:AFUA_7G02370

Organism-specific databases

EuPathDBiFungiDB:Afu7g02370

Phylogenomic databases

HOGENOMiHOG000186095
InParanoidiQ4WAS9
KOiK11681
OMAiRQGWNND
OrthoDBiEOG092C1YH4

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSWR1_ASPFU
AccessioniPrimary (citable) accession number: Q4WAS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2005
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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