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Protein

RNA polymerase II transcription factor B subunit 2

Gene

AFUA_4G04360

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:AFUA_4G04360Imported
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiFungiDB:Afu4g04360

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00009586

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000170529
InParanoidiQ4W9N0
KOiK03144
OMAiYLEQYAH
OrthoDBiEOG092C3703

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4W9N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPPRPFD YLESLPGTVF NKLYQQPSTA LAIFRRMLPD LAKCFVMALL
60 70 80 90 100
YLKDPLPAAD LEAWVRPGSL KERDNALSIL GRLHIMTSTT TSDNIKAYTV
110 120 130 140 150
TDPFASSLRQ ALTGAEQTQS FGVLSQISDK EAVSIADLDE YSRRQWEGVL
160 170 180 190 200
GYMVGTSGLG MQRDVSLSKG VKELLQAGHL VEIRDRRVEI TQDGFAFALQ
210 220 230 240 250
DVGTQVWHIL VLYVESAAAI GMDSVEVLSF VFFLSSLELG KSYEKKQLTS
260 270 280 290 300
NQLRTLTDLA DFGIVYQETP DATHFYPTRL ATTLTSDSST LSNPLAGSLS
310 320 330 340 350
GPTGTSSSKA GSGFIIIETN YRLYAYTSSP LQISLIALFT TLKYRFPNLI
360 370 380 390 400
TGKITRQSVR RAVEMGITAD QIISYLSTHA HPQMRKHNVS RSTSNQAGMP
410 420 430 440 450
VSVLPPTVVD QIRLWQLERD RVKATHGFLF RDFNTLAEYE APCRYAEEIG
460 470
VLVWKSDRKR MFFVTRHHQV AAFLKSRRK
Length:479
Mass (Da):53,416
Last modified:July 5, 2005 - v1
Checksum:iE35140A3B66E2A5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000016 Genomic DNA Translation: EAL84583.1
RefSeqiXP_746621.1, XM_741528.1

Genome annotation databases

EnsemblFungiiEAL84583; EAL84583; AFUA_4G04360
GeneIDi3503993
KEGGiafm:AFUA_4G04360

Entry informationi

Entry nameiQ4W9N0_ASPFU
AccessioniPrimary (citable) accession number: Q4W9N0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 20, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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