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Entry version 121 (02 Jun 2021)
Sequence version 1 (05 Jul 2005)
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Protein

Cyclic nucleotide ras GEF

Gene

PDZGEF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationARBA annotation, Guanine-nucleotide releasing factorPROSITE-ProRule annotationARBA annotation
Biological processDifferentiationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclic nucleotide ras GEFARBA annotation
Alternative name(s):
Neural RAP guanine nucleotide exchange proteinARBA annotation
PDZ domain-containing guanine nucleotide exchange factor 1ARBA annotation
RA-GEF-1ARBA annotation
Rap guanine nucleotide exchange factor 2ARBA annotation
Ras/Rap1-associating GEF-1ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDZGEF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junctionARBA annotation, MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Ubl conjugationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini115 – 215Cyclic nucleotide-bindingInterPro annotationAdd BLAST101
Domaini247 – 360N-terminal Ras-GEFInterPro annotationAdd BLAST114
Domaini365 – 435PDZInterPro annotationAdd BLAST71
Domaini586 – 672Ras-associatingInterPro annotationAdd BLAST87
Domaini697 – 924Ras-GEFInterPro annotationAdd BLAST228

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 79DisorderedSequence analysisAdd BLAST62
Regioni982 – 1030DisorderedSequence analysisAdd BLAST49
Regioni1075 – 1140DisorderedSequence analysisAdd BLAST66
Regioni1204 – 1236DisorderedSequence analysisAdd BLAST33
Regioni1285 – 1479DisorderedSequence analysisAdd BLAST195

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili208 – 228Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 45Polar residuesSequence analysisAdd BLAST28
Compositional biasi61 – 76Acidic residuesSequence analysisAdd BLAST16
Compositional biasi1004 – 1018Polar residuesSequence analysisAdd BLAST15
Compositional biasi1086 – 1140Polar residuesSequence analysisAdd BLAST55
Compositional biasi1285 – 1316Polar residuesSequence analysisAdd BLAST32
Compositional biasi1319 – 1333Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1335 – 1349Polar residuesSequence analysisAdd BLAST15
Compositional biasi1415 – 1447Polar residuesSequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RAPGEF2 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPEGHAH

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00038, CAP_ED, 1 hit
cd00155, RasGEF, 1 hit
cd06224, REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit
2.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR030739, RapGEF2
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR014710, RmlC-like_jellyroll
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR23113, PTHR23113, 1 hit
PTHR23113:SF217, PTHR23113:SF217, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 1 hit
PF00788, RA, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00100, cNMP, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48366, SSF48366, 1 hit
SSF50156, SSF50156, 1 hit
SSF51206, SSF51206, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50042, CNMP_BINDING_3, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q4W5Q4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LPADFTKLHL TDSLHPQVTH VSSSHSGCSI TSDSGSSSLS DIYQATESEA
60 70 80 90 100
GDMDLSGLPE TAVDSEDDDD EEDIERASDP LMSRDIVRDC LEKDPIDRTD
110 120 130 140 150
DDIEQLLEFM HQLPAFANMT MSVRRELCAV MVFAVVERAG TIVLNDGEEL
160 170 180 190 200
DSWSVILNGS VEVTYPDGKA EILCMGNSFG VSPTMDKEYM KGVMRTKVDD
210 220 230 240 250
CQFVCIAQQD YCRILNQVEK NMQKVEEEGE IVMVKEHREL DRTGTRKGHI
260 270 280 290 300
VIKGTSERLT MHLVEEHSVV DPTFIEDFLL TYRTFLSSPM EVGKKLLEWF
310 320 330 340 350
NDPSLRDKVT RVVLLWVNNH FNDFEGDPAM TRFLEEFENN LEREKMGGHL
360 370 380 390 400
RLLNIACAAK AKRRLMTLTK PSREAPLPFI LLGGSEKGFG IFVDSVDSGS
410 420 430 440 450
KATEAGLKRG DQILEVNGQN FENIQLSKAM EILRNNTHLS ITVKTNLFVF
460 470 480 490 500
KELLTRLSEE KRNGAPHLPK IGDIKKASRY SIPDLAVDVE QVIGLEKVNK
510 520 530 540 550
KSKANTVGGR NKLKKILDKT RISILPQKPY NDIGIGQSQD DSIVGLRQTK
560 570 580 590 600
HIPTALPVSG TLSSSNPDLL QSHHRILDFS ATPDLPDQVL RVFKADQQSR
610 620 630 640 650
YIMISKDTTA KEVVIQAIRE FAVTATPDQY SLCEVSVTPE GVIKQRRLPD
660 670 680 690 700
QLSKLADRIQ LSGRYYLKNN METETLCSDE DAQELLRESQ ISLLQLSTVE
710 720 730 740 750
VATQLSMRNF ELFRNIEPTE YIDDLFKLRS KTSCANLKRF EEVINQETFW
760 770 780 790 800
VASEILRETN QLKRMKIIKH FIKIALHCRE CKNFNSMFAI ISGLNLAPVA
810 820 830 840 850
RLRTTWEKLP NKYEKLFQDL QDLFDPSRNM AKYRNVLNSQ NLQPPIIPLF
860 870 880 890 900
PVIKKDLTFL HEGNDSKVDG LVNFEKLRMI AKEIRHVGRM ASVNMDPALM
910 920 930 940 950
FRTRKKKWRS LGSLSQGSTN ATVLDVAQTG GHKKRVRRSS FLNAKKLYED
960 970 980 990 1000
AQMARKVKQY LSNLELEMDE ESLQTLSLQC EPATNTLPKN PGDKKPVKSE
1010 1020 1030 1040 1050
TSPVAPRAGS QQKAQSLPQP QQQPPPAHKI NQGLQVPAVS LYPSRKKVPV
1060 1070 1080 1090 1100
KDLPPFGINS PQALKKILSL SEEGSLERHK KQAEDTISNA SSQLSSPPTS
1110 1120 1130 1140 1150
PQSSPRKGYT LAPSGTVDNF SDSGHSEISS RSSIVSNSSF DSVPVSLHDE
1160 1170 1180 1190 1200
RRQRHSVSIV ETNLGMGRME RRTMIEPDQY SLGSYAPMSE GRGLYATATV
1210 1220 1230 1240 1250
ISSPSTEELS QDQGDRASLD AADSGRGSWT SCSSGSHDNI QTIQHQRSWE
1260 1270 1280 1290 1300
TLPFGHTHFD YSGDPAGLWA SSSHMDQIMF SDHSTKYNRQ NQSRESLEQA
1310 1320 1330 1340 1350
QSRASWASST GYWGEDSEGD TGTIKRRGGK DVSIEAESSS LTSVTTEETK
1360 1370 1380 1390 1400
PVPMPAHIAV ASSTTKGLIA RKEGRYREPP PTPPGYIGIP ITDFPEGHSH
1410 1420 1430 1440 1450
PARKPPDYNV ALQRSRMVAR SSDTAGPSSV QQPHGHPTSS RPVNKPQWHK
1460 1470
PNESDPRLAP YQSQGFSTEE DEDEQVSAV
Length:1,479
Mass (Da):165,261
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9084E05EFEA7C99
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC074344 Genomic DNA Translation: AAY40909.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC074344 Genomic DNA Translation: AAY40909.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

OMAiFPEGHAH

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RAPGEF2, human

Family and domain databases

CDDicd00038, CAP_ED, 1 hit
cd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
Gene3Di2.30.42.10, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR030739, RapGEF2
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR014710, RmlC-like_jellyroll
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR23113, PTHR23113, 1 hit
PTHR23113:SF217, PTHR23113:SF217, 1 hit
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
PF00788, RA, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00100, cNMP, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit
SUPFAMiSSF48366, SSF48366, 1 hit
SSF50156, SSF50156, 1 hit
SSF51206, SSF51206, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50042, CNMP_BINDING_3, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4W5Q4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4W5Q4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 2, 2021
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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