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Protein

Tigger transposable element-derived protein 2

Gene

TIGD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 48H-T-H motifBy similarityAdd BLAST21
DNA bindingi100 – 132H-T-H motifBy similarityAdd BLAST33

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 2
Gene namesi
Name:TIGD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000180346.3
HGNCiHGNC:18333 TIGD2
MIMi612973 gene
neXtProtiNX_Q4W5G0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180346
PharmGKBiPA38526

Polymorphism and mutation databases

BioMutaiTIGD2
DMDMi74754171

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002710881 – 525Tigger transposable element-derived protein 2Add BLAST525

Proteomic databases

EPDiQ4W5G0
PaxDbiQ4W5G0
PeptideAtlasiQ4W5G0
PRIDEiQ4W5G0
ProteomicsDBi62372

PTM databases

iPTMnetiQ4W5G0
PhosphoSitePlusiQ4W5G0

Expressioni

Gene expression databases

BgeeiENSG00000180346 Expressed in 178 organ(s), highest expression level in placenta
CleanExiHS_TIGD2
ExpressionAtlasiQ4W5G0 baseline and differential
GenevisibleiQ4W5G0 HS

Organism-specific databases

HPAiHPA054844
HPA071168

Interactioni

Protein-protein interaction databases

BioGridi127935, 1 interactor
IntActiQ4W5G0, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ4W5G0
SMRiQ4W5G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 52HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini67 – 139HTH CENPB-typePROSITE-ProRule annotationAdd BLAST73
Domaini168 – 385DDE-1Sequence analysisAdd BLAST218

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3105 Eukaryota
ENOG4110CDI LUCA
GeneTreeiENSGT00760000119149
HOGENOMiHOG000130798
HOVERGENiHBG101551
InParanoidiQ4W5G0
OMAiEFCGNFQ
OrthoDBiEOG091G05QK
PhylomeDBiQ4W5G0
TreeFamiTF101131

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q4W5G0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE
60 70 80 90 100
RIINYANSSD PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT
110 120 130 140 150
ICAKQAKFFF DALGMEGDFN ASSGWLTRFK QRHGIPKAAG KGTKLKGDET
160 170 180 190 200
AAREFCGSFQ EFVEKENLQP EQIYGADQTG LFWKCLPSRT LTLETDQSTS
210 220 230 240 250
GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT DLSNLPVTYY
260 270 280 290 300
SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE
310 320 330 340 350
EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG
360 370 380 390 400
NDPKIFWKNL TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI
410 420 430 440 450
DEGAILAANL ATVLQNTEEC EHVDIENIDQ WFDSRSSDSS CQVLTDSESA
460 470 480 490 500
EDQTKAAEQK PSSKSRKTEL NPEKHISHKA ALEWTENLLD YLEQQDDMLL
510 520
SDKLVLRRLR TIIRKKQKIQ NNKNH
Length:525
Mass (Da):59,623
Last modified:July 5, 2005 - v1
Checksum:i5FD2A8B1765D1001
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053036475H → R. Corresponds to variant dbSNP:rs2280099Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104785 Genomic DNA Translation: AAY40951.1
CCDSiCCDS3633.1
RefSeqiNP_663761.1, NM_145715.2
UniGeneiHs.58924

Genome annotation databases

EnsembliENST00000317005; ENSP00000317170; ENSG00000180346
ENST00000603357; ENSP00000486687; ENSG00000180346
GeneIDi166815
KEGGihsa:166815

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104785 Genomic DNA Translation: AAY40951.1
CCDSiCCDS3633.1
RefSeqiNP_663761.1, NM_145715.2
UniGeneiHs.58924

3D structure databases

ProteinModelPortaliQ4W5G0
SMRiQ4W5G0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127935, 1 interactor
IntActiQ4W5G0, 1 interactor

PTM databases

iPTMnetiQ4W5G0
PhosphoSitePlusiQ4W5G0

Polymorphism and mutation databases

BioMutaiTIGD2
DMDMi74754171

Proteomic databases

EPDiQ4W5G0
PaxDbiQ4W5G0
PeptideAtlasiQ4W5G0
PRIDEiQ4W5G0
ProteomicsDBi62372

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317005; ENSP00000317170; ENSG00000180346
ENST00000603357; ENSP00000486687; ENSG00000180346
GeneIDi166815
KEGGihsa:166815

Organism-specific databases

CTDi166815
EuPathDBiHostDB:ENSG00000180346.3
GeneCardsiTIGD2
HGNCiHGNC:18333 TIGD2
HPAiHPA054844
HPA071168
MIMi612973 gene
neXtProtiNX_Q4W5G0
OpenTargetsiENSG00000180346
PharmGKBiPA38526
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3105 Eukaryota
ENOG4110CDI LUCA
GeneTreeiENSGT00760000119149
HOGENOMiHOG000130798
HOVERGENiHBG101551
InParanoidiQ4W5G0
OMAiEFCGNFQ
OrthoDBiEOG091G05QK
PhylomeDBiQ4W5G0
TreeFamiTF101131

Miscellaneous databases

GenomeRNAii166815
PROiPR:Q4W5G0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180346 Expressed in 178 organ(s), highest expression level in placenta
CleanExiHS_TIGD2
ExpressionAtlasiQ4W5G0 baseline and differential
GenevisibleiQ4W5G0 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR004875 DDE_SF_endonuclease_dom
IPR009057 Homeobox-like_sf
IPR006600 HTH_CenpB_DNA-bd_dom
IPR007889 HTH_Psq
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF04218 CENP-B_N, 1 hit
PF03184 DDE_1, 1 hit
PF03221 HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674 CENPB, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51253 HTH_CENPB, 1 hit
PS50960 HTH_PSQ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTIGD2_HUMAN
AccessioniPrimary (citable) accession number: Q4W5G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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