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UniProtKB - Q4W5G0 (TIGD2_HUMAN)
Protein
Tigger transposable element-derived protein 2
Gene
TIGD2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 28 – 48 | H-T-H motifBy similarityAdd BLAST | 21 | |
DNA bindingi | 100 – 132 | H-T-H motifBy similarityAdd BLAST | 33 |
GO - Molecular functioni
- DNA binding Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | Q4W5G0 |
SignaLinki | Q4W5G0 |
Names & Taxonomyi
Protein namesi | Recommended name: Tigger transposable element-derived protein 2 |
Gene namesi | Name:TIGD2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18333, TIGD2 |
MIMi | 612973, gene |
neXtProti | NX_Q4W5G0 |
VEuPathDBi | HostDB:ENSG00000180346 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000180346 |
PharmGKBi | PA38526 |
Miscellaneous databases
Pharosi | Q4W5G0, Tdark |
Genetic variation databases
BioMutai | TIGD2 |
DMDMi | 74754171 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271088 | 1 – 525 | Tigger transposable element-derived protein 2Add BLAST | 525 |
Proteomic databases
EPDi | Q4W5G0 |
jPOSTi | Q4W5G0 |
MassIVEi | Q4W5G0 |
PaxDbi | Q4W5G0 |
PeptideAtlasi | Q4W5G0 |
PRIDEi | Q4W5G0 |
ProteomicsDBi | 62372 |
PTM databases
iPTMneti | Q4W5G0 |
PhosphoSitePlusi | Q4W5G0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180346, Expressed in placenta and 195 other tissues |
ExpressionAtlasi | Q4W5G0, baseline and differential |
Genevisiblei | Q4W5G0, HS |
Organism-specific databases
HPAi | ENSG00000180346, Tissue enhanced (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127935, 3 interactors |
IntActi | Q4W5G0, 1 interactor |
STRINGi | 9606.ENSP00000317170 |
Miscellaneous databases
RNActi | Q4W5G0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 52 | HTH psq-typePROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 67 – 139 | HTH CENPB-typePROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 168 – 385 | DDE-1Sequence analysisAdd BLAST | 218 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 442 – 474 | DisorderedSequence analysisAdd BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 451 – 474 | Basic and acidic residuesSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the tigger transposable element derived protein family.Curated
Phylogenomic databases
eggNOGi | KOG3105, Eukaryota |
GeneTreei | ENSGT00940000162273 |
InParanoidi | Q4W5G0 |
OMAi | QWFDSQS |
OrthoDBi | 1343623at2759 |
PhylomeDBi | Q4W5G0 |
TreeFami | TF101131 |
Family and domain databases
InterProi | View protein in InterPro IPR004875, DDE_SF_endonuclease_dom IPR009057, Homeobox-like_sf IPR006600, HTH_CenpB_DNA-bd_dom IPR007889, HTH_Psq |
Pfami | View protein in Pfam PF04218, CENP-B_N, 1 hit PF03184, DDE_1, 1 hit PF03221, HTH_Tnp_Tc5, 1 hit |
SMARTi | View protein in SMART SM00674, CENPB, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51253, HTH_CENPB, 1 hit PS50960, HTH_PSQ, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4W5G0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE
60 70 80 90 100
RIINYANSSD PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT
110 120 130 140 150
ICAKQAKFFF DALGMEGDFN ASSGWLTRFK QRHGIPKAAG KGTKLKGDET
160 170 180 190 200
AAREFCGSFQ EFVEKENLQP EQIYGADQTG LFWKCLPSRT LTLETDQSTS
210 220 230 240 250
GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT DLSNLPVTYY
260 270 280 290 300
SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE
310 320 330 340 350
EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG
360 370 380 390 400
NDPKIFWKNL TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI
410 420 430 440 450
DEGAILAANL ATVLQNTEEC EHVDIENIDQ WFDSRSSDSS CQVLTDSESA
460 470 480 490 500
EDQTKAAEQK PSSKSRKTEL NPEKHISHKA ALEWTENLLD YLEQQDDMLL
510 520
SDKLVLRRLR TIIRKKQKIQ NNKNH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053036 | 475 | H → R. Corresponds to variant dbSNP:rs2280099Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104785 Genomic DNA Translation: AAY40951.1 |
CCDSi | CCDS3633.1 |
RefSeqi | NP_663761.1, NM_145715.2 |
Genome annotation databases
Ensembli | ENST00000603357.3; ENSP00000486687.1; ENSG00000180346.5 |
GeneIDi | 166815 |
KEGGi | hsa:166815 |
MANE-Selecti | ENST00000603357.3; ENSP00000486687.1; NM_145715.3; NP_663761.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC104785 Genomic DNA Translation: AAY40951.1 |
CCDSi | CCDS3633.1 |
RefSeqi | NP_663761.1, NM_145715.2 |
3D structure databases
AlphaFoldDBi | Q4W5G0 |
SMRi | Q4W5G0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127935, 3 interactors |
IntActi | Q4W5G0, 1 interactor |
STRINGi | 9606.ENSP00000317170 |
PTM databases
iPTMneti | Q4W5G0 |
PhosphoSitePlusi | Q4W5G0 |
Genetic variation databases
BioMutai | TIGD2 |
DMDMi | 74754171 |
Proteomic databases
EPDi | Q4W5G0 |
jPOSTi | Q4W5G0 |
MassIVEi | Q4W5G0 |
PaxDbi | Q4W5G0 |
PeptideAtlasi | Q4W5G0 |
PRIDEi | Q4W5G0 |
ProteomicsDBi | 62372 |
Protocols and materials databases
Antibodypediai | 65566, 19 antibodies from 10 providers |
DNASUi | 166815 |
Genome annotation databases
Ensembli | ENST00000603357.3; ENSP00000486687.1; ENSG00000180346.5 |
GeneIDi | 166815 |
KEGGi | hsa:166815 |
MANE-Selecti | ENST00000603357.3; ENSP00000486687.1; NM_145715.3; NP_663761.1 |
Organism-specific databases
CTDi | 166815 |
GeneCardsi | TIGD2 |
HGNCi | HGNC:18333, TIGD2 |
HPAi | ENSG00000180346, Tissue enhanced (liver) |
MIMi | 612973, gene |
neXtProti | NX_Q4W5G0 |
OpenTargetsi | ENSG00000180346 |
PharmGKBi | PA38526 |
VEuPathDBi | HostDB:ENSG00000180346 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3105, Eukaryota |
GeneTreei | ENSGT00940000162273 |
InParanoidi | Q4W5G0 |
OMAi | QWFDSQS |
OrthoDBi | 1343623at2759 |
PhylomeDBi | Q4W5G0 |
TreeFami | TF101131 |
Enzyme and pathway databases
PathwayCommonsi | Q4W5G0 |
SignaLinki | Q4W5G0 |
Miscellaneous databases
BioGRID-ORCSi | 166815, 13 hits in 1075 CRISPR screens |
GenomeRNAii | 166815 |
Pharosi | Q4W5G0, Tdark |
PROi | PR:Q4W5G0 |
RNActi | Q4W5G0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180346, Expressed in placenta and 195 other tissues |
ExpressionAtlasi | Q4W5G0, baseline and differential |
Genevisiblei | Q4W5G0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004875, DDE_SF_endonuclease_dom IPR009057, Homeobox-like_sf IPR006600, HTH_CenpB_DNA-bd_dom IPR007889, HTH_Psq |
Pfami | View protein in Pfam PF04218, CENP-B_N, 1 hit PF03184, DDE_1, 1 hit PF03221, HTH_Tnp_Tc5, 1 hit |
SMARTi | View protein in SMART SM00674, CENPB, 1 hit |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51253, HTH_CENPB, 1 hit PS50960, HTH_PSQ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TIGD2_HUMAN | |
Accessioni | Q4W5G0Primary (citable) accession number: Q4W5G0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | July 5, 2005 | |
Last modified: | May 25, 2022 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families