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UniProtKB - Q4W5G0 (TIGD2_HUMAN)

Entry version 132 (12 Aug 2020)
Sequence version 1 (05 Jul 2005)
Previous versions | rss
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Protein

Tigger transposable element-derived protein 2

Gene

TIGD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi28 – 48H-T-H motifBy similarityAdd BLAST21
DNA bindingi100 – 132H-T-H motifBy similarityAdd BLAST33

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q4W5G0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tigger transposable element-derived protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TIGD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000180346.3

Human Gene Nomenclature Database

More...HGNCi		HGNC:18333, TIGD2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612973, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q4W5G0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000180346

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38526

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q4W5G0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TIGD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74754171

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002710881 – 525Tigger transposable element-derived protein 2Add BLAST525

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q4W5G0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q4W5G0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q4W5G0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q4W5G0

PeptideAtlas

More...PeptideAtlasi		Q4W5G0

PRoteomics IDEntifications database

More...PRIDEi		Q4W5G0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62372

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q4W5G0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q4W5G0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000180346, Expressed in placenta and 194 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q4W5G0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q4W5G0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000180346, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127935, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q4W5G0, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000317170

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q4W5G0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4W5G0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 52HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini67 – 139HTH CENPB-typePROSITE-ProRule annotationAdd BLAST73
Domaini168 – 385DDE-1Sequence analysisAdd BLAST218

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tigger transposable element derived protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3105, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162273

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4W5G0

Identification of Orthologs from Complete Genome Data

More...OMAi		QWFDSQS

Database of Orthologous Groups

More...OrthoDBi		1343623at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q4W5G0

TreeFam database of animal gene trees

More...TreeFami		TF101131

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004875, DDE_SF_endonuclease_dom
IPR009057, Homeobox-like_sf
IPR006600, HTH_CenpB_DNA-bd_dom
IPR007889, HTH_Psq
IPR036388, WH-like_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04218, CENP-B_N, 1 hit
PF03184, DDE_1, 1 hit
PF03221, HTH_Tnp_Tc5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00674, CENPB, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51253, HTH_CENPB, 1 hit
PS50960, HTH_PSQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4W5G0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE 
        60         70         80         90        100
RIINYANSSD PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT 
       110        120        130        140        150
ICAKQAKFFF DALGMEGDFN ASSGWLTRFK QRHGIPKAAG KGTKLKGDET 
       160        170        180        190        200
AAREFCGSFQ EFVEKENLQP EQIYGADQTG LFWKCLPSRT LTLETDQSTS 
       210        220        230        240        250
GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT DLSNLPVTYY 
       260        270        280        290        300
SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE 
       310        320        330        340        350
EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG 
       360        370        380        390        400
NDPKIFWKNL TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI 
       410        420        430        440        450
DEGAILAANL ATVLQNTEEC EHVDIENIDQ WFDSRSSDSS CQVLTDSESA 
       460        470        480        490        500
EDQTKAAEQK PSSKSRKTEL NPEKHISHKA ALEWTENLLD YLEQQDDMLL 
       510        520 
SDKLVLRRLR TIIRKKQKIQ NNKNH
Length:525
Mass (Da):59,623
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FD2A8B1765D1001
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053036475H → R. Corresponds to variant dbSNP:rs2280099Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC104785 Genomic DNA Translation: AAY40951.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3633.1

NCBI Reference Sequences

More...RefSeqi		NP_663761.1, NM_145715.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000317005; ENSP00000317170; ENSG00000180346
ENST00000603357; ENSP00000486687; ENSG00000180346

Database of genes from NCBI RefSeq genomes

More...GeneIDi		166815

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:166815

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC104785 Genomic DNA Translation: AAY40951.1
CCDSiCCDS3633.1
RefSeqiNP_663761.1, NM_145715.2

3D structure databases

SMRiQ4W5G0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127935, 3 interactors
IntActiQ4W5G0, 1 interactor
STRINGi9606.ENSP00000317170

PTM databases

iPTMnetiQ4W5G0
PhosphoSitePlusiQ4W5G0

Polymorphism and mutation databases

BioMutaiTIGD2
DMDMi74754171

Proteomic databases

EPDiQ4W5G0
jPOSTiQ4W5G0
MassIVEiQ4W5G0
PaxDbiQ4W5G0
PeptideAtlasiQ4W5G0
PRIDEiQ4W5G0
ProteomicsDBi62372

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		65566, 15 antibodies

Genome annotation databases

EnsembliENST00000317005; ENSP00000317170; ENSG00000180346
ENST00000603357; ENSP00000486687; ENSG00000180346
GeneIDi166815
KEGGihsa:166815

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		166815
EuPathDBiHostDB:ENSG00000180346.3

GeneCards: human genes, protein and diseases

More...GeneCardsi		TIGD2
HGNCiHGNC:18333, TIGD2
HPAiENSG00000180346, Tissue enhanced (liver)
MIMi612973, gene
neXtProtiNX_Q4W5G0
OpenTargetsiENSG00000180346
PharmGKBiPA38526

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3105, Eukaryota
GeneTreeiENSGT00940000162273
InParanoidiQ4W5G0
OMAiQWFDSQS
OrthoDBi1343623at2759
PhylomeDBiQ4W5G0
TreeFamiTF101131

Enzyme and pathway databases

PathwayCommonsiQ4W5G0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		166815, 3 hits in 867 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		166815
PharosiQ4W5G0, Tdark

Protein Ontology

More...PROi		PR:Q4W5G0
RNActiQ4W5G0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000180346, Expressed in placenta and 194 other tissues
ExpressionAtlasiQ4W5G0, baseline and differential
GenevisibleiQ4W5G0, HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR004875, DDE_SF_endonuclease_dom
IPR009057, Homeobox-like_sf
IPR006600, HTH_CenpB_DNA-bd_dom
IPR007889, HTH_Psq
IPR036388, WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF04218, CENP-B_N, 1 hit
PF03184, DDE_1, 1 hit
PF03221, HTH_Tnp_Tc5, 1 hit
SMARTiView protein in SMART
SM00674, CENPB, 1 hit
SUPFAMiSSF46689, SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51253, HTH_CENPB, 1 hit
PS50960, HTH_PSQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTIGD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4W5G0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2005
Last modified: August 12, 2020
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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