TIGD2

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	28 – 48	H-T-H motifBy similarityAdd BLAST		21
DNA bindingⁱ	100 – 132	H-T-H motifBy similarityAdd BLAST		33

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tigger transposable element-derived protein 2
Gene namesⁱ	Name:TIGD2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180346.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18333 TIGD2
MIMⁱ	612973 gene
neXtProtⁱ	NX_Q4W5G0

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000180346
PharmGKBⁱ	PA38526

Polymorphism and mutation databases

BioMutaⁱ	TIGD2
DMDMⁱ	74754171

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000271088	1 – 525	Tigger transposable element-derived protein 2Add BLAST		525

Proteomic databases

EPDⁱ	Q4W5G0
PaxDbⁱ	Q4W5G0
PeptideAtlas More...PeptideAtlasⁱ	Q4W5G0
PRIDEⁱ	Q4W5G0
ProteomicsDBⁱ	62372

PTM databases

iPTMnetⁱ	Q4W5G0
PhosphoSitePlusⁱ	Q4W5G0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000180346 Expressed in 178 organ(s), highest expression level in placenta
CleanExⁱ	HS_TIGD2
ExpressionAtlasⁱ	Q4W5G0 baseline and differential
Genevisibleⁱ	Q4W5G0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054844 HPA071168

HPAⁱ

HPA054844
HPA071168

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127935, 1 interactor
IntActⁱ	Q4W5G0, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q4W5G0
SMRⁱ	Q4W5G0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 52	HTH psq-typePROSITE-ProRule annotationAdd BLAST	52
Domainⁱ	67 – 139	HTH CENPB-typePROSITE-ProRule annotationAdd BLAST	73
Domainⁱ	168 – 385	DDE-1Sequence analysisAdd BLAST	218

Sequence similaritiesⁱ

Belongs to the tigger transposable element derived protein family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3105 Eukaryota ENOG4110CDI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119149
HOGENOMⁱ	HOG000130798
HOVERGENⁱ	HBG101551
InParanoidⁱ	Q4W5G0
OMAⁱ	EFCGNFQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05QK
PhylomeDBⁱ	Q4W5G0
TreeFamⁱ	TF101131

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR004875 DDE_SF_endonuclease_dom IPR009057 Homeobox-like_sf IPR006600 HTH_CenpB_DNA-bd_dom IPR007889 HTH_Psq IPR036388 WH-like_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04218 CENP-B_N, 1 hit PF03184 DDE_1, 1 hit PF03221 HTH_Tnp_Tc5, 1 hit
SMARTⁱ	View protein in SMART SM00674 CENPB, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS51253 HTH_CENPB, 1 hit PS50960 HTH_PSQ, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q4W5G0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLGKRKRVVL TIKDKLDIIK KLEEGISFKK LSVVYGIGES TVRDIKKNKE 
        60         70         80         90        100
RIINYANSSD PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT 
       110        120        130        140        150
ICAKQAKFFF DALGMEGDFN ASSGWLTRFK QRHGIPKAAG KGTKLKGDET 
       160        170        180        190        200
AAREFCGSFQ EFVEKENLQP EQIYGADQTG LFWKCLPSRT LTLETDQSTS 
       210        220        230        240        250
GCRSSRERII IMCCANATGL HKLNLCVVGK AKKPRAFKGT DLSNLPVTYY 
       260        270        280        290        300
SQKGAWIEQS VFRQWFEKYF VPQVQKHLKS KGLLEKAVLL LDFPPARPNE 
       310        320        330        340        350
EMLSSDDGRI IVKYLPPNVT SLIQPMSQGV LATVKRYYRA GLLQKYMDEG 
       360        370        380        390        400
NDPKIFWKNL TVLDAIYEVS RAWNMVKSST ITKAWKKLFP GNEENSGMNI 
       410        420        430        440        450
DEGAILAANL ATVLQNTEEC EHVDIENIDQ WFDSRSSDSS CQVLTDSESA 
       460        470        480        490        500
EDQTKAAEQK PSSKSRKTEL NPEKHISHKA ALEWTENLLD YLEQQDDMLL 
       510        520 
SDKLVLRRLR TIIRKKQKIQ NNKNH

Length:525

Mass (Da):59,623

Last modified:July 5, 2005 - v1

Checksum:ⁱ5FD2A8B1765D1001

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_053036	475	H → R. Corresponds to variant dbSNP:rs2280099Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC104785 Genomic DNA Translation: AAY40951.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3633.1
NCBI Reference Sequences More...RefSeqⁱ	NP_663761.1, NM_145715.2
UniGeneⁱ	Hs.58924

Genome annotation databases

Ensemblⁱ	ENST00000317005; ENSP00000317170; ENSG00000180346 ENST00000603357; ENSP00000486687; ENSG00000180346
GeneIDⁱ	166815
KEGGⁱ	hsa:166815

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q4W5G0	Epididymis luminal protein 106		HUMAN		525	UniRef100_Q4W5G0

Protein	Similar proteins		Species	Score	Length	Source
Q4W5G0	Epididymis luminal protein 106		HUMAN		525	UniRef90_Q4W5G0
Uncharacterized protein		NOMLE		554
Tigger transposable element derived 2		PANPA		539
Uncharacterized protein		ICTTR		526
Tigger transposable element derived 2		MACFA		525
+98

Protein	Similar proteins		Species	Score	Length	Source
Q4W5G0	Epididymis luminal protein 106		HUMAN		525	UniRef50_Q4W5G0
Uncharacterized protein		NOMLE		554
Tigger transposable element derived 2		PANPA		539
Uncharacterized protein		ICTTR		526
Tigger transposable element derived 2		MACFA		525
+103

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC104785 Genomic DNA Translation: AAY40951.1
CCDSⁱ	CCDS3633.1
RefSeqⁱ	NP_663761.1, NM_145715.2
UniGeneⁱ	Hs.58924

3D structure databases

ProteinModelPortalⁱ	Q4W5G0
SMRⁱ	Q4W5G0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127935, 1 interactor
IntActⁱ	Q4W5G0, 1 interactor

PTM databases

iPTMnetⁱ	Q4W5G0
PhosphoSitePlusⁱ	Q4W5G0

Polymorphism and mutation databases

BioMutaⁱ	TIGD2
DMDMⁱ	74754171

Proteomic databases

EPDⁱ	Q4W5G0
PaxDbⁱ	Q4W5G0
PeptideAtlasⁱ	Q4W5G0
PRIDEⁱ	Q4W5G0
ProteomicsDBⁱ	62372

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000317005; ENSP00000317170; ENSG00000180346 ENST00000603357; ENSP00000486687; ENSG00000180346
GeneIDⁱ	166815
KEGGⁱ	hsa:166815

Organism-specific databases

CTDⁱ	166815
EuPathDBⁱ	HostDB:ENSG00000180346.3
GeneCardsⁱ	TIGD2
HGNCⁱ	HGNC:18333 TIGD2
HPAⁱ	HPA054844 HPA071168
MIMⁱ	612973 gene
neXtProtⁱ	NX_Q4W5G0
OpenTargetsⁱ	ENSG00000180346
PharmGKBⁱ	PA38526
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3105 Eukaryota ENOG4110CDI LUCA
GeneTreeⁱ	ENSGT00760000119149
HOGENOMⁱ	HOG000130798
HOVERGENⁱ	HBG101551
InParanoidⁱ	Q4W5G0
OMAⁱ	EFCGNFQ
OrthoDBⁱ	EOG091G05QK
PhylomeDBⁱ	Q4W5G0
TreeFamⁱ	TF101131

Miscellaneous databases

GenomeRNAiⁱ	166815
Protein Ontology More...PROⁱ	PR:Q4W5G0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000180346 Expressed in 178 organ(s), highest expression level in placenta
CleanExⁱ	HS_TIGD2
ExpressionAtlasⁱ	Q4W5G0 baseline and differential
Genevisibleⁱ	Q4W5G0 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR004875 DDE_SF_endonuclease_dom IPR009057 Homeobox-like_sf IPR006600 HTH_CenpB_DNA-bd_dom IPR007889 HTH_Psq IPR036388 WH-like_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF04218 CENP-B_N, 1 hit PF03184 DDE_1, 1 hit PF03221 HTH_Tnp_Tc5, 1 hit
SMARTⁱ	View protein in SMART SM00674 CENPB, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 2 hits
PROSITEⁱ	View protein in PROSITE PS51253 HTH_CENPB, 1 hit PS50960 HTH_PSQ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TIGD2_HUMAN
Accessionⁱ	Q4W5G0Primary (citable) accession number: Q4W5G0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
	Last sequence update:	July 5, 2005
	Last modified:	November 7, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q4W5G0 (TIGD2_HUMAN)

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Tigger transposable element-derived protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ