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Protein

Polyadenylate-binding protein 1-like

Gene

PABPC1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein 1-like
Gene namesi
Name:PABPC1L
Synonyms:C20orf119
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101104.12
HGNCiHGNC:15797 PABPC1L
neXtProtiNX_Q4VXU2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101104
PharmGKBiPA162398552

Polymorphism and mutation databases

BioMutaiPABPC1L
DMDMi74754038

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002778791 – 614Polyadenylate-binding protein 1-likeAdd BLAST614

Proteomic databases

EPDiQ4VXU2
MaxQBiQ4VXU2
PaxDbiQ4VXU2
PeptideAtlasiQ4VXU2
PRIDEiQ4VXU2
ProteomicsDBi62357

PTM databases

iPTMnetiQ4VXU2
PhosphoSitePlusiQ4VXU2
SwissPalmiQ4VXU2

Expressioni

Gene expression databases

BgeeiENSG00000101104 Expressed in 161 organ(s), highest expression level in right lobe of thyroid gland
CleanExiHS_PABPC1L
ExpressionAtlasiQ4VXU2 baseline and differential
GenevisibleiQ4VXU2 HS

Organism-specific databases

HPAiHPA066650

Interactioni

Protein-protein interaction databases

BioGridi123246, 6 interactors
IntActiQ4VXU2, 4 interactors
STRINGi9606.ENSP00000217073

Structurei

3D structure databases

ProteinModelPortaliQ4VXU2
SMRiQ4VXU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 89RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini99 – 175RRM 2PROSITE-ProRule annotationAdd BLAST77
Domaini191 – 268RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini294 – 370RRM 4PROSITE-ProRule annotationAdd BLAST77
Domaini528 – 605PABCPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi409 – 458Pro-richAdd BLAST50

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
InParanoidiQ4VXU2
KOiK13126
OMAiPIMSIRV
OrthoDBiEOG091G03ZE
PhylomeDBiQ4VXU2
TreeFamiTF300458

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4VXU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNASGSGYPL ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDVATRR
60 70 80 90 100
SLGYAYINFQ QPADAERALD TMNFEMLKGQ PIRIMWSQRD PGLRKSGVGN
110 120 130 140 150
IFIKNLEDSI DNKALYDTFS TFGNILSCKV ACDEHGSRGF GFVHFETHEA
160 170 180 190 200
AQQAINTMNG MLLNDRKVFV GHFKSRRERE AELGARALEF TNIYVKNLPV
210 220 230 240 250
DVDEQGLQDL FSQFGKMLSV KVMRDNSGHS RCFGFVNFEK HEEAQKAVVH
260 270 280 290 300
MNGKEVSGRL LYAGRAQKRV ERQNELKRRF EQMKQDRLRR YQGVNLYVKN
310 320 330 340 350
LDDSIDDDKL RKEFSPYGVI TSAKVMTEGG HSKGFGFVCF SSPEEATKAV
360 370 380 390 400
TEMNGRIVGT KPLYVALAQR KEERKAILTN QYMQRLSTMR TLSNPLLGSF
410 420 430 440 450
QQPSSYFLPA MPQPPAQAAY YGCGPVTPTQ PAPRWTSQPP RPSCASMVRP
460 470 480 490 500
PVVPRRPPAH ISSVRQASTQ VPRTVPHTQR VANIGTQTTG PSGVGCCTPG
510 520 530 540 550
RPLLPCKCSS AAHSTYRVQE PAVHIPGQEP LTASMLAAAP LHEQKQMIGE
560 570 580 590 600
RLYPLIHDVH TQLAGKITGM LLEIDNSELL LMLESPESLH AKIDEAVAVL
610
QAHQAMEQPK AYMH
Length:614
Mass (Da):68,392
Last modified:July 5, 2005 - v1
Checksum:i3A809F527CE688FF
GO
Isoform 2 (identifier: Q4VXU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-330: VMTEGG → KRRQRP
     331-614: Missing.

Note: No experimental confirmation available.
Show »
Length:330
Mass (Da):37,737
Checksum:iF32E4B65B9890FB5
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q4VXT6Q4VXT6_HUMAN
Polyadenylate-binding protein 1-lik...
PABPC1L
149Annotation score:
Q4VXT5Q4VXT5_HUMAN
Polyadenylate-binding protein 1-lik...
PABPC1L
171Annotation score:
Q4VXT4Q4VXT4_HUMAN
HCG2019100, isoform CRA_b
PABPC1L hCG_2019100
168Annotation score:
H0Y386H0Y386_HUMAN
Polyadenylate-binding protein 1-lik...
PABPC1L
152Annotation score:
Q4VXT8Q4VXT8_HUMAN
Polyadenylate-binding protein 1-lik...
PABPC1L
134Annotation score:
F2Z2Z0F2Z2Z0_HUMAN
Polyadenylate-binding protein 1-lik...
PABPC1L
174Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054047212S → A. Corresponds to variant dbSNP:rs2075960Ensembl.1
Natural variantiVAR_060184492S → G. Corresponds to variant dbSNP:rs6513956Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057071325 – 330VMTEGG → KRRQRP in isoform 2. 1 Publication6
Alternative sequenceiVSP_057072331 – 614Missing in isoform 2. 1 PublicationAdd BLAST284

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU190483 mRNA Translation: ABY64766.1
AL109839 Genomic DNA No translation available.
AL008725 Genomic DNA No translation available.
CCDSiCCDS42878.1 [Q4VXU2-1]
RefSeqiNP_001118228.1, NM_001124756.2 [Q4VXU2-1]
UniGeneiHs.641481

Genome annotation databases

EnsembliENST00000217073; ENSP00000217073; ENSG00000101104 [Q4VXU2-1]
ENST00000217074; ENSP00000217074; ENSG00000101104 [Q4VXU2-2]
ENST00000255136; ENSP00000255136; ENSG00000101104 [Q4VXU2-1]
ENST00000537323; ENSP00000445661; ENSG00000101104 [Q4VXU2-2]
GeneIDi80336
KEGGihsa:80336
UCSCiuc010ggv.1 human [Q4VXU2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU190483 mRNA Translation: ABY64766.1
AL109839 Genomic DNA No translation available.
AL008725 Genomic DNA No translation available.
CCDSiCCDS42878.1 [Q4VXU2-1]
RefSeqiNP_001118228.1, NM_001124756.2 [Q4VXU2-1]
UniGeneiHs.641481

3D structure databases

ProteinModelPortaliQ4VXU2
SMRiQ4VXU2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123246, 6 interactors
IntActiQ4VXU2, 4 interactors
STRINGi9606.ENSP00000217073

PTM databases

iPTMnetiQ4VXU2
PhosphoSitePlusiQ4VXU2
SwissPalmiQ4VXU2

Polymorphism and mutation databases

BioMutaiPABPC1L
DMDMi74754038

Proteomic databases

EPDiQ4VXU2
MaxQBiQ4VXU2
PaxDbiQ4VXU2
PeptideAtlasiQ4VXU2
PRIDEiQ4VXU2
ProteomicsDBi62357

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217073; ENSP00000217073; ENSG00000101104 [Q4VXU2-1]
ENST00000217074; ENSP00000217074; ENSG00000101104 [Q4VXU2-2]
ENST00000255136; ENSP00000255136; ENSG00000101104 [Q4VXU2-1]
ENST00000537323; ENSP00000445661; ENSG00000101104 [Q4VXU2-2]
GeneIDi80336
KEGGihsa:80336
UCSCiuc010ggv.1 human [Q4VXU2-1]

Organism-specific databases

CTDi80336
EuPathDBiHostDB:ENSG00000101104.12
GeneCardsiPABPC1L
HGNCiHGNC:15797 PABPC1L
HPAiHPA066650
neXtProtiNX_Q4VXU2
OpenTargetsiENSG00000101104
PharmGKBiPA162398552
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0123 Eukaryota
ENOG410XR5X LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000217922
HOVERGENiHBG002295
InParanoidiQ4VXU2
KOiK13126
OMAiPIMSIRV
OrthoDBiEOG091G03ZE
PhylomeDBiQ4VXU2
TreeFamiTF300458

Miscellaneous databases

ChiTaRSiPABPC1L human
GenomeRNAii80336
PROiPR:Q4VXU2

Gene expression databases

BgeeiENSG00000101104 Expressed in 161 organ(s), highest expression level in right lobe of thyroid gland
CleanExiHS_PABPC1L
ExpressionAtlasiQ4VXU2 baseline and differential
GenevisibleiQ4VXU2 HS

Family and domain databases

Gene3Di3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR036053 PABP-dom
IPR006515 PABP_1234
IPR002004 PABP_HYD
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
PfamiView protein in Pfam
PF00658 PABP, 1 hit
PF00076 RRM_1, 4 hits
SMARTiView protein in SMART
SM00517 PolyA, 1 hit
SM00360 RRM, 4 hits
SM00361 RRM_1, 3 hits
SUPFAMiSSF54928 SSF54928, 2 hits
SSF63570 SSF63570, 1 hit
TIGRFAMsiTIGR01628 PABP-1234, 1 hit
PROSITEiView protein in PROSITE
PS51309 PABC, 1 hit
PS50102 RRM, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPAP1L_HUMAN
AccessioniPrimary (citable) accession number: Q4VXU2
Secondary accession number(s): Q4VY17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2005
Last modified: October 10, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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