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Protein
Submitted name:

F-box/WD repeat-containing protein 2

Gene

FBXW2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ4VXH1

Names & Taxonomyi

Protein namesi
Submitted name:
F-box/WD repeat-containing protein 2Imported
Gene namesi
Name:FBXW2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000119402.16
HGNCiHGNC:13608 FBXW2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119402

PTM / Processingi

Proteomic databases

MaxQBiQ4VXH1
PeptideAtlasiQ4VXH1
PRIDEiQ4VXH1

Expressioni

Gene expression databases

BgeeiENSG00000119402 Expressed in 232 organ(s), highest expression level in female gonad
ExpressionAtlasiQ4VXH1 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ4VXH1, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ4VXH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 185WD_REPEATS_REGIONInterPro annotationAdd BLAST171
Repeati15 – 54WDPROSITE-ProRule annotationAdd BLAST40
Repeati93 – 134WDPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQD2 Eukaryota
ENOG410XP3H LUCA
GeneTreeiENSGT00930000151016
HOGENOMiHOG000231971
HOVERGENiHBG051593

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q4VXH1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQLEDHEAF ETSSLIGHSA RVYALYYKDG LLCTGSDDLS AKLWDVSTGQ
60 70 80 90 100
CVYGIQTHTC AAVKFDEQKL VTGSFDNTVA CWEWSSGART QHFRGHTGAV
110 120 130 140 150
FSVDYNDELD ILVSGSADFT VKVWALSAGT CLNTLTGHTE WVTKVVLQKC
160 170 180 190 200
KVKSLLHSPG DYILLSADKY EIKIWPIGRE INCKCLKTLS VSEDRSICLQ

PRLHFDGK
Length:208
Mass (Da):23,132
Last modified:July 5, 2005 - v1
Checksum:i5D4C78B53DAFA164
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UKT8FBXW2_HUMAN
F-box/WD repeat-containing protein ...
FBXW2 FBW2, FWD2
454Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei208Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138836 Genomic DNA No translation available.
AL161911 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000453291; ENSP00000398662; ENSG00000119402
UCSCiuc064viy.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138836 Genomic DNA No translation available.
AL161911 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliQ4VXH1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4VXH1, 1 interactor

Proteomic databases

MaxQBiQ4VXH1
PeptideAtlasiQ4VXH1
PRIDEiQ4VXH1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000453291; ENSP00000398662; ENSG00000119402
UCSCiuc064viy.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000119402.16
HGNCiHGNC:13608 FBXW2
OpenTargetsiENSG00000119402
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQD2 Eukaryota
ENOG410XP3H LUCA
GeneTreeiENSGT00930000151016
HOGENOMiHOG000231971
HOVERGENiHBG051593

Enzyme and pathway databases

SignaLinkiQ4VXH1

Miscellaneous databases

ChiTaRSiFBXW2 human

Gene expression databases

BgeeiENSG00000119402 Expressed in 232 organ(s), highest expression level in female gonad
ExpressionAtlasiQ4VXH1 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ4VXH1_HUMAN
AccessioniPrimary (citable) accession number: Q4VXH1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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