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Entry version 129 (07 Apr 2021)
Sequence version 3 (18 May 2010)
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Protein

Probable cation-transporting ATPase 13A4

Gene

ATP13A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4864-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi848MagnesiumBy similarity1
Metal bindingi852MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q4VNC1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-936837, Ion transport by P-type ATPases

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.3.10.20, the p-type atpase (p-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A4 (EC:7.2.2.-)
Alternative name(s):
P5-ATPase isoform 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP13A4
ORF Names:UNQ3052/PRO9871
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25422, ATP13A4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609556, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q4VNC1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000127249.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 31CytoplasmicSequence analysisAdd BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Topological domaini53 – 197ExtracellularSequence analysisAdd BLAST145
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 223CytoplasmicSequence analysis5
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Topological domaini245 – 400ExtracellularSequence analysisAdd BLAST156
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 436CytoplasmicSequence analysisAdd BLAST15
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Topological domaini458 – 900ExtracellularSequence analysisAdd BLAST443
Transmembranei901 – 921HelicalSequence analysisAdd BLAST21
Topological domaini922 – 932CytoplasmicSequence analysisAdd BLAST11
Transmembranei933 – 953HelicalSequence analysisAdd BLAST21
Topological domaini954 – 972ExtracellularSequence analysisAdd BLAST19
Transmembranei973 – 993HelicalSequence analysisAdd BLAST21
Topological domaini994 – 1035CytoplasmicSequence analysisAdd BLAST42
Transmembranei1036 – 1056HelicalSequence analysisAdd BLAST21
Topological domaini1057 – 1070ExtracellularSequence analysisAdd BLAST14
Transmembranei1071 – 1091HelicalSequence analysisAdd BLAST21
Topological domaini1092 – 1109CytoplasmicSequence analysisAdd BLAST18
Transmembranei1110 – 1130HelicalSequence analysisAdd BLAST21
Topological domaini1131 – 1196ExtracellularSequence analysisAdd BLAST66

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ATP13A4 is found in 2 patients with specific language impairment (SLI) disorders. Paracentric inversion inv(3)(q25;q29). The inversion produces a disruption of the protein.1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
84239

Open Targets

More...
OpenTargetsi
ENSG00000127249

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134979581

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q4VNC1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP13A4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439435

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003186751 – 1196Probable cation-transporting ATPase 13A4Add BLAST1196

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q4VNC1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q4VNC1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4VNC1

PeptideAtlas

More...
PeptideAtlasi
Q4VNC1

PRoteomics IDEntifications database

More...
PRIDEi
Q4VNC1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62311 [Q4VNC1-1]
62312 [Q4VNC1-2]
62313 [Q4VNC1-3]
62314 [Q4VNC1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4VNC1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4VNC1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, placenta, liver, skeletal muscles, and pancreas. Lower levels of expression are also detected in brain, lung and kidney. Weakly expressed in the adult brain. Expression in fetal brain is higher than in adult brain, with levels similar to several other fetal tissues including spleen and skeletal muscle. In adult brain expressed at low levels in all tissues examined, including the temporal lobe and putamen.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Decreased by half in the SLI patient lymphoblasts.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127249, Expressed in left lobe of thyroid gland and 178 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4VNC1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4VNC1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000127249, Tissue enhanced (epididymis, parathyroid gland, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q4VNC1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339182

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4VNC1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0208, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159448

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1299363_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4VNC1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSWPPIN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4VNC1

TreeFam database of animal gene trees

More...
TreeFami
TF300331

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 2 hits
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00690, Cation_ATPase_N, 1 hit
PF12409, P5-ATPase, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDF00027, p-type_atpase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00831, Cation_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01494, ATPase_P-type, 3 hits
TIGR01657, P-ATPase-V, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4VNC1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGHFEKGQHA LLNEGEENEM EIFGYRTQGC RKSLCLAGSI FSFGILPLVF
60 70 80 90 100
YWRPAWHVWA HCVPCSLQEA DTVLLRTTDE FQIYSWKKVI WIYLSALNSA
110 120 130 140 150
FGLTPDHPLM TDEEYIINRA IRKPDLKVRC IKVQKIRYVW NYLEGQFQKI
160 170 180 190 200
GSLEDWLSSA KIHQKFGSGL TREEQEIRRL ICGPNTIDVE VTPIWKLLIK
210 220 230 240 250
EVLNPFYIFQ LFSVCLWFSE DYKEYAFAII IMSIISISLT VYDLREQSVK
260 270 280 290 300
LHHLVESHNS ITVSVCGRKA GVQELESRVL VPGDLLILTG NKVLMPCDAV
310 320 330 340 350
LIEGSCVVDE GMLTGESIPV TKTPLPKMDS SVPWKTQSEA DYKRHVLFCG
360 370 380 390 400
TEVIQAKAAC SGTVRAVVLQ TGFNTAKGDL VRSILYPKPV NFQLYRDAIR
410 420 430 440 450
FLLCLVGTAT IGMIYTLCVY VLSGEPPEEV VRKALDVITI AVPPALPAAL
460 470 480 490 500
TTGIIYAQRR LKKRGIFCIS PQRINVCGQL NLVCFDKTGT LTRDGLDLWG
510 520 530 540 550
VVSCDRNGFQ EVHSFASGQA LPWGPLCAAM ASCHSLILLD GTIQGDPLDL
560 570 580 590 600
KMFEATTWEM AFSGDDFHIK GVPAHAMVVK PCRTASQVPV EGIAILHQFP
610 620 630 640 650
FSSALQRMTV IVQEMGGDRL AFMKGAPERV ASFCQPETVP TSFVSELQIY
660 670 680 690 700
TTQGFRVIAL AYKKLENDHH ATTLTRETVE SDLIFLGLLI LENRLKEETK
710 720 730 740 750
PVLEELISAR IRTVMITGDN LQTAITVARK SGMVSESQKV ILIEANETTG
760 770 780 790 800
SSSASISWTL VEEKKHIMYG NQDNYINIRD EVSDKGREGS YHFALTGKSF
810 820 830 840 850
HVISQHFSSL LPKILINGTI FARMSPGQKS SLVEEFQKLD YFVGMCGDGA
860 870 880 890 900
NDCGALKMAH VGISLSEQEA SVASPFTSKT PNIECVPHLI KEGRAALVTS
910 920 930 940 950
FCMFKYMALY SMIQYVGVLL LYWETNSLSN YQFLFQDLAI TTLIGVTMNL
960 970 980 990 1000
NGAYPKLVPF RPAGRLISPP LLLSVIFNIL LSLAMHIAGF ILVQRQPWYS
1010 1020 1030 1040 1050
VEIHSACTVQ NESISELTMS PTAPEKMESN STFTSFENTT VWFLGTINCI
1060 1070 1080 1090 1100
TVALVFSKGK PFRQPTYTNY IFVLVLIIQL GVCLFILFAD IPELYRRLDL
1110 1120 1130 1140 1150
LCTPVLWRAS IVIMLSLNFI VSLVAEEAVI ENRALWMMIK RCFGYQSKSQ
1160 1170 1180 1190
YRIWQRDLAN DPSWPPLNQT SHSDMPECGR GVSYSNPVFE SNEEQL
Length:1,196
Mass (Da):133,987
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1D7F81F2BC266663
GO
Isoform 2 (identifier: Q4VNC1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     841-1196: Missing.

Note: Dubious isoform lacking mature mRNA evidence.Curated
Show »
Length:840
Mass (Da):93,942
Checksum:iDD58938371710B93
GO
Isoform 3 (identifier: Q4VNC1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     559-576: EMAFSGDDFHIKGVPAHA → VSLCSSENLRSFFNARAT
     577-1196: Missing.

Show »
Length:576
Mass (Da):64,597
Checksum:iA878E82DBC38293A
GO
Isoform 4 (identifier: Q4VNC1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-984: Missing.

Show »
Length:212
Mass (Da):24,332
Checksum:i05E159C0B52CB7A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7WPN9B7WPN9_HUMAN
Cation-transporting ATPase
ATP13A4
1,177Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9W3F8W9W3_HUMAN
Cation-transporting ATPase
ATP13A4
83Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4Z2H0Y4Z2_HUMAN
Probable cation-transporting ATPase...
ATP13A4
576Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1P5H7C1P5_HUMAN
Probable cation-transporting ATPase...
ATP13A4
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAC21667 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti840D → E in BAC04520 (PubMed:14702039).Curated1
Sequence conflicti840D → E in AAI01497 (PubMed:15489334).Curated1
Sequence conflicti975V → A in AAX24102 (PubMed:15925480).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038849181I → M1 PublicationCorresponds to variant dbSNP:rs6788448Ensembl.1
Natural variantiVAR_038850353V → A1 Publication1
Natural variantiVAR_038851646E → D1 PublicationCorresponds to variant dbSNP:rs35424709Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0312581 – 984Missing in isoform 4. 1 PublicationAdd BLAST984
Alternative sequenceiVSP_031259559 – 576EMAFS…VPAHA → VSLCSSENLRSFFNARAT in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_031260577 – 1196Missing in isoform 3. 1 PublicationAdd BLAST620
Alternative sequenceiVSP_031261841 – 1196Missing in isoform 2. 2 PublicationsAdd BLAST356

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY823162 mRNA Translation: AAX24102.1
AY358110 mRNA Translation: AAQ88477.1
AK095277 mRNA Translation: BAC04520.1
AC048351 Genomic DNA No translation available.
AC092942 Genomic DNA No translation available.
AC105057 Genomic DNA No translation available.
BC101496 mRNA Translation: AAI01497.1
AL512736 mRNA Translation: CAC21667.2 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3304.2 [Q4VNC1-1]

NCBI Reference Sequences

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RefSeqi
NP_115655.2, NM_032279.3 [Q4VNC1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000295548; ENSP00000295548; ENSG00000127249 [Q4VNC1-3]
ENST00000342695; ENSP00000339182; ENSG00000127249 [Q4VNC1-1]
ENST00000400270; ENSP00000383129; ENSG00000127249 [Q4VNC1-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84239

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84239

UCSC genome browser

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UCSCi
uc003ftd.4, human [Q4VNC1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823162 mRNA Translation: AAX24102.1
AY358110 mRNA Translation: AAQ88477.1
AK095277 mRNA Translation: BAC04520.1
AC048351 Genomic DNA No translation available.
AC092942 Genomic DNA No translation available.
AC105057 Genomic DNA No translation available.
BC101496 mRNA Translation: AAI01497.1
AL512736 mRNA Translation: CAC21667.2 Sequence problems.
CCDSiCCDS3304.2 [Q4VNC1-1]
RefSeqiNP_115655.2, NM_032279.3 [Q4VNC1-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ4VNC1, 1 interactor
STRINGi9606.ENSP00000339182

Protein family/group databases

TCDBi3.A.3.10.20, the p-type atpase (p-atpase) superfamily

PTM databases

iPTMnetiQ4VNC1
PhosphoSitePlusiQ4VNC1

Genetic variation databases

BioMutaiATP13A4
DMDMi296439435

Proteomic databases

jPOSTiQ4VNC1
MassIVEiQ4VNC1
PaxDbiQ4VNC1
PeptideAtlasiQ4VNC1
PRIDEiQ4VNC1
ProteomicsDBi62311 [Q4VNC1-1]
62312 [Q4VNC1-2]
62313 [Q4VNC1-3]
62314 [Q4VNC1-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56173, 3 antibodies

Genome annotation databases

EnsembliENST00000295548; ENSP00000295548; ENSG00000127249 [Q4VNC1-3]
ENST00000342695; ENSP00000339182; ENSG00000127249 [Q4VNC1-1]
ENST00000400270; ENSP00000383129; ENSG00000127249 [Q4VNC1-4]
GeneIDi84239
KEGGihsa:84239
UCSCiuc003ftd.4, human [Q4VNC1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84239
DisGeNETi84239

GeneCards: human genes, protein and diseases

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GeneCardsi
ATP13A4
HGNCiHGNC:25422, ATP13A4
HPAiENSG00000127249, Tissue enhanced (epididymis, parathyroid gland, thyroid gland)
MIMi609556, gene
neXtProtiNX_Q4VNC1
OpenTargetsiENSG00000127249
PharmGKBiPA134979581
VEuPathDBiHostDB:ENSG00000127249.14

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0208, Eukaryota
GeneTreeiENSGT00940000159448
HOGENOMiCLU_1299363_0_0_1
InParanoidiQ4VNC1
OMAiPSWPPIN
PhylomeDBiQ4VNC1
TreeFamiTF300331

Enzyme and pathway databases

PathwayCommonsiQ4VNC1
ReactomeiR-HSA-936837, Ion transport by P-type ATPases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84239, 6 hits in 980 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ATP13A4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84239
PharosiQ4VNC1, Tdark

Protein Ontology

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PROi
PR:Q4VNC1
RNActiQ4VNC1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127249, Expressed in left lobe of thyroid gland and 178 other tissues
ExpressionAtlasiQ4VNC1, baseline and differential
GenevisibleiQ4VNC1, HS

Family and domain databases

Gene3Di3.40.1110.10, 2 hits
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom
PfamiView protein in Pfam
PF00690, Cation_ATPase_N, 1 hit
PF12409, P5-ATPase, 1 hit
SFLDiSFLDF00027, p-type_atpase, 1 hit
SMARTiView protein in SMART
SM00831, Cation_ATPase_N, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01494, ATPase_P-type, 3 hits
TIGR01657, P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT134_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4VNC1
Secondary accession number(s): B7WPC7
, Q6UY23, Q8N1Q9, Q9H043
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 129 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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