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UniProtKB - Q4VNC0 (AT135_HUMAN)
Protein
Probable cation-transporting ATPase 13A5
Gene
ATP13A5
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 486 | 4-aspartylphosphate intermediateBy similarity | 1 | |
Metal bindingi | 850 | MagnesiumBy similarity | 1 | |
Metal bindingi | 854 | MagnesiumBy similarity | 1 |
GO - Molecular functioni
- ATPase-coupled cation transmembrane transporter activity Source: Reactome
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cellular calcium ion homeostasis Source: GO_Central
- ion transmembrane transport Source: Reactome
Keywordsi
Molecular function | Translocase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q4VNC0 |
Reactomei | R-HSA-936837, Ion transport by P-type ATPases |
Names & Taxonomyi
Protein namesi | Recommended name: Probable cation-transporting ATPase 13A5 (EC:7.2.2.-)Alternative name(s): P5-ATPase isoform 5 |
Gene namesi | Name:ATP13A5 ORF Names:UNQ488/PRO1004 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31789, ATP13A5 |
MIMi | 619119, gene |
neXtProti | NX_Q4VNC0 |
VEuPathDBi | HostDB:ENSG00000187527 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 33 – 53 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 222 – 242 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 401 – 421 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 433 – 453 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 903 – 923 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 940 – 956 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 973 – 993 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1042 – 1062 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1077 – 1097 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1115 – 1135 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 344905 |
OpenTargetsi | ENSG00000187527 |
PharmGKBi | PA134952038 |
Miscellaneous databases
Pharosi | Q4VNC0, Tdark |
Genetic variation databases
BioMutai | ATP13A5 |
DMDMi | 74753861 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000337122 | 1 – 1218 | Probable cation-transporting ATPase 13A5Add BLAST | 1218 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 540 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 669 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 819 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q4VNC0 |
PaxDbi | Q4VNC0 |
PeptideAtlasi | Q4VNC0 |
PRIDEi | Q4VNC0 |
ProteomicsDBi | 62310 |
PTM databases
GlyGeni | Q4VNC0, 3 sites |
iPTMneti | Q4VNC0 |
PhosphoSitePlusi | Q4VNC0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187527, Expressed in epithelium of mammary gland and 104 other tissues |
ExpressionAtlasi | Q4VNC0, baseline and differential |
Genevisiblei | Q4VNC0, HS |
Organism-specific databases
HPAi | ENSG00000187527, Group enriched (breast, choroid plexus, salivary gland) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000341942 |
Miscellaneous databases
RNActi | Q4VNC0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0208, Eukaryota |
GeneTreei | ENSGT00940000160327 |
HOGENOMi | CLU_001828_0_0_1 |
InParanoidi | Q4VNC0 |
OMAi | KMEDCNV |
OrthoDBi | 172453at2759 |
PhylomeDBi | Q4VNC0 |
TreeFami | TF300331 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006544, P-type_TPase_V IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00690, Cation_ATPase_N, 1 hit PF12409, P5-ATPase, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 1 hit TIGR01657, P-ATPase-V, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q4VNC0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEENSKKDHR ALLNQGEEDE LEVFGYRDHN VRKAFCLVAS VLTCGGLLLV
60 70 80 90 100
FYWRPQWRVW ANCIPCPLQE ADTVLLRTTD EFQRYMRKKV FCLYLSTLKF
110 120 130 140 150
PVSKKWEESL VADRHSVINQ ALIKPELKLR CMEVQKIRYV WNDLEKRFQK
160 170 180 190 200
VGLLEDSNSC SDIHQTFGLG LTSEEQEVRR LVCGPNAIEV EIQPIWKLLV
210 220 230 240 250
KQVLNPFYVF QAFTLTLWLS QGYIEYSVAI IILTVISIVL SVYDLRQQSV
260 270 280 290 300
KLHNLVEDHN KVQVTIIVKD KGLEELESRL LVPGDILILP GKFSLPCDAV
310 320 330 340 350
LIDGSCVVNE GMLTGESIPV TKTPLPQMEN TMPWKCHSLE DYRKHVLFCG
360 370 380 390 400
TEVIQVKPSG QGPVRAVVLQ TGYNTAKGDL VRSILYPRPL NFKLYSDAFK
410 420 430 440 450
FIVFLACLGV MGFFYALGVY MYHGVPPKDT VTMALILLTV TVPPVLPAAL
460 470 480 490 500
TIGNVYAQKR LKKKKIFCIS PQRINMCGQI NLVCFDKTGT LTEDGLDLWG
510 520 530 540 550
TVPTADNCFQ EAHSFASGQA VPWSPLCAAM ASCHSLILLN GTIQGDPLDL
560 570 580 590 600
KMFEGTAWKM EDCIVDSCKF GTSVSNIIKP GPKASKSPVE AIITLCQFPF
610 620 630 640 650
SSSLQRMSVI AQLAGENHFH VYMKGAPEMV ARFCRSETVP KNFPQELRSY
660 670 680 690 700
TVQGFRVIAL AHKTLKMGNL SEVEHLAREK VESELTFLGL LIMENRLKKE
710 720 730 740 750
TKLVLKELSE ARIRTVMITG DNLQTAITVA KNSEMIPPGS QVIIVEADEP
760 770 780 790 800
EEFVPASVTW QLVENQETGP GKKEIYMHTG NSSTPRGEGG SCYHFAMSGK
810 820 830 840 850
SYQVIFQHFN SLLPKILVNG TVFARMSPGQ KSSLIEEFQK LNYYVGMCGD
860 870 880 890 900
GANDCGALKA AHAGISLSEQ EASVASPFTS KTTNIQCVPH LIREGRAALV
910 920 930 940 950
SSFGVFKYLT MYGIIQFISA LLLYWQLQLF GNYQYLMQDV AITLMVCLTM
960 970 980 990 1000
SSTHAYPKLA PYRPAGQLLS PPLLLSIFLN SCFSCIVQIS AFLYVKQQPW
1010 1020 1030 1040 1050
YCEVYQYSEC FLANQSNFST NVSLERNWTG NATLIPGSIL SFETTTLWPI
1060 1070 1080 1090 1100
TTINYITVAF IFSKGKPFRK PIYTNYIFSF LLLAALGLTI FILFSDFQVI
1110 1120 1130 1140 1150
YRGMELIPTI TSWRVLILVV ALTQFCVAFF VEDSILQNHE LWLLIKREFG
1160 1170 1180 1190 1200
FYSKSQYRTW QKKLAEDSTW PPINRTDYSG DGKNGFYING GYESHEQIPK
1210
RKLKLGGQPT EQHFWARL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JPQ4 | C9JPQ4_HUMAN | Cation-transporting ATPase | ATP13A5 | 158 | Annotation score: |
Sequence cautioni
The sequence AAQ89030 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ89030 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 357 | K → E in BAC85490 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061039 | 96 | S → Y1 PublicationCorresponds to variant dbSNP:rs12637558Ensembl. | 1 | |
Natural variantiVAR_043614 | 133 | E → Q. Corresponds to variant dbSNP:rs6797429Ensembl. | 1 | |
Natural variantiVAR_043615 | 739 | G → S. Corresponds to variant dbSNP:rs2280268Ensembl. | 1 | |
Natural variantiVAR_043616 | 1053 | I → V. Corresponds to variant dbSNP:rs6787746Ensembl. | 1 | |
Natural variantiVAR_043617 | 1131 | V → A1 PublicationCorresponds to variant dbSNP:rs2271791Ensembl. | 1 | |
Natural variantiVAR_043618 | 1204 | K → Q. Corresponds to variant dbSNP:rs7428010Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY823163 mRNA Translation: AAX24103.1 AK122613 mRNA Translation: BAC85490.1 Sequence problems. AY358667 mRNA Translation: AAQ89030.1 Sequence problems. |
CCDSi | CCDS33914.1 |
RefSeqi | NP_940907.2, NM_198505.2 |
Genome annotation databases
Ensembli | ENST00000342358.9; ENSP00000341942.4; ENSG00000187527.12 |
GeneIDi | 344905 |
KEGGi | hsa:344905 |
MANE-Selecti | ENST00000342358.9; ENSP00000341942.4; NM_198505.4; NP_940907.2 |
UCSCi | uc011bsq.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY823163 mRNA Translation: AAX24103.1 AK122613 mRNA Translation: BAC85490.1 Sequence problems. AY358667 mRNA Translation: AAQ89030.1 Sequence problems. |
CCDSi | CCDS33914.1 |
RefSeqi | NP_940907.2, NM_198505.2 |
3D structure databases
AlphaFoldDBi | Q4VNC0 |
SMRi | Q4VNC0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000341942 |
PTM databases
GlyGeni | Q4VNC0, 3 sites |
iPTMneti | Q4VNC0 |
PhosphoSitePlusi | Q4VNC0 |
Genetic variation databases
BioMutai | ATP13A5 |
DMDMi | 74753861 |
Proteomic databases
MassIVEi | Q4VNC0 |
PaxDbi | Q4VNC0 |
PeptideAtlasi | Q4VNC0 |
PRIDEi | Q4VNC0 |
ProteomicsDBi | 62310 |
Protocols and materials databases
Antibodypediai | 65947, 10 antibodies from 6 providers |
DNASUi | 344905 |
Genome annotation databases
Ensembli | ENST00000342358.9; ENSP00000341942.4; ENSG00000187527.12 |
GeneIDi | 344905 |
KEGGi | hsa:344905 |
MANE-Selecti | ENST00000342358.9; ENSP00000341942.4; NM_198505.4; NP_940907.2 |
UCSCi | uc011bsq.3, human |
Organism-specific databases
CTDi | 344905 |
DisGeNETi | 344905 |
GeneCardsi | ATP13A5 |
HGNCi | HGNC:31789, ATP13A5 |
HPAi | ENSG00000187527, Group enriched (breast, choroid plexus, salivary gland) |
MIMi | 619119, gene |
neXtProti | NX_Q4VNC0 |
OpenTargetsi | ENSG00000187527 |
PharmGKBi | PA134952038 |
VEuPathDBi | HostDB:ENSG00000187527 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0208, Eukaryota |
GeneTreei | ENSGT00940000160327 |
HOGENOMi | CLU_001828_0_0_1 |
InParanoidi | Q4VNC0 |
OMAi | KMEDCNV |
OrthoDBi | 172453at2759 |
PhylomeDBi | Q4VNC0 |
TreeFami | TF300331 |
Enzyme and pathway databases
PathwayCommonsi | Q4VNC0 |
Reactomei | R-HSA-936837, Ion transport by P-type ATPases |
Miscellaneous databases
BioGRID-ORCSi | 344905, 10 hits in 1061 CRISPR screens |
GenomeRNAii | 344905 |
Pharosi | Q4VNC0, Tdark |
PROi | PR:Q4VNC0 |
RNActi | Q4VNC0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187527, Expressed in epithelium of mammary gland and 104 other tissues |
ExpressionAtlasi | Q4VNC0, baseline and differential |
Genevisiblei | Q4VNC0, HS |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006544, P-type_TPase_V IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00690, Cation_ATPase_N, 1 hit PF12409, P5-ATPase, 1 hit |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 1 hit TIGR01657, P-ATPase-V, 1 hit |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT135_HUMAN | |
Accessioni | Q4VNC0Primary (citable) accession number: Q4VNC0 Secondary accession number(s): Q6UWS4, Q6ZWL0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | July 5, 2005 | |
Last modified: | May 25, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families