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UniProtKB - Q4VNC0 (AT135_HUMAN)

Entry version 130 (25 May 2022)
Sequence version 1 (05 Jul 2005)
Previous versions | rss
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Protein

Probable cation-transporting ATPase 13A5

Gene

ATP13A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4864-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi850MagnesiumBy similarity1
Metal bindingi854MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q4VNC0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-936837, Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A5 (EC:7.2.2.-)
Alternative name(s):
P5-ATPase isoform 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP13A5
ORF Names:UNQ488/PRO1004
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:31789, ATP13A5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		619119, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q4VNC0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000187527

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Transmembranei903 – 923HelicalSequence analysisAdd BLAST21
Transmembranei940 – 956HelicalSequence analysisAdd BLAST17
Transmembranei973 – 993HelicalSequence analysisAdd BLAST21
Transmembranei1042 – 1062HelicalSequence analysisAdd BLAST21
Transmembranei1077 – 1097HelicalSequence analysisAdd BLAST21
Transmembranei1115 – 1135HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		344905

Open Targets

More...OpenTargetsi		ENSG00000187527

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134952038

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q4VNC0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP13A5

Domain mapping of disease mutations (DMDM)

More...DMDMi		74753861

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371221 – 1218Probable cation-transporting ATPase 13A5Add BLAST1218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi669N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi819N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q4VNC0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q4VNC0

PeptideAtlas

More...PeptideAtlasi		Q4VNC0

PRoteomics IDEntifications database

More...PRIDEi		Q4VNC0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62310

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q4VNC0, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q4VNC0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q4VNC0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000187527, Expressed in epithelium of mammary gland and 104 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q4VNC0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q4VNC0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000187527, Group enriched (breast, choroid plexus, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000341942

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q4VNC0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q4VNC0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4VNC0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0208, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160327

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001828_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4VNC0

Identification of Orthologs from Complete Genome Data

More...OMAi		KMEDCNV

Database of Orthologous Groups

More...OrthoDBi		172453at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q4VNC0

TreeFam database of animal gene trees

More...TreeFami		TF300331

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00690, Cation_ATPase_N, 1 hit
PF12409, P5-ATPase, 1 hit

Structure-Function Linkage Database

More...SFLDi		SFLDF00027, p-type_atpase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01494, ATPase_P-type, 1 hit
TIGR01657, P-ATPase-V, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q4VNC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEENSKKDHR ALLNQGEEDE LEVFGYRDHN VRKAFCLVAS VLTCGGLLLV 
        60         70         80         90        100
FYWRPQWRVW ANCIPCPLQE ADTVLLRTTD EFQRYMRKKV FCLYLSTLKF 
       110        120        130        140        150
PVSKKWEESL VADRHSVINQ ALIKPELKLR CMEVQKIRYV WNDLEKRFQK 
       160        170        180        190        200
VGLLEDSNSC SDIHQTFGLG LTSEEQEVRR LVCGPNAIEV EIQPIWKLLV 
       210        220        230        240        250
KQVLNPFYVF QAFTLTLWLS QGYIEYSVAI IILTVISIVL SVYDLRQQSV 
       260        270        280        290        300
KLHNLVEDHN KVQVTIIVKD KGLEELESRL LVPGDILILP GKFSLPCDAV 
       310        320        330        340        350
LIDGSCVVNE GMLTGESIPV TKTPLPQMEN TMPWKCHSLE DYRKHVLFCG 
       360        370        380        390        400
TEVIQVKPSG QGPVRAVVLQ TGYNTAKGDL VRSILYPRPL NFKLYSDAFK 
       410        420        430        440        450
FIVFLACLGV MGFFYALGVY MYHGVPPKDT VTMALILLTV TVPPVLPAAL 
       460        470        480        490        500
TIGNVYAQKR LKKKKIFCIS PQRINMCGQI NLVCFDKTGT LTEDGLDLWG 
       510        520        530        540        550
TVPTADNCFQ EAHSFASGQA VPWSPLCAAM ASCHSLILLN GTIQGDPLDL 
       560        570        580        590        600
KMFEGTAWKM EDCIVDSCKF GTSVSNIIKP GPKASKSPVE AIITLCQFPF 
       610        620        630        640        650
SSSLQRMSVI AQLAGENHFH VYMKGAPEMV ARFCRSETVP KNFPQELRSY 
       660        670        680        690        700
TVQGFRVIAL AHKTLKMGNL SEVEHLAREK VESELTFLGL LIMENRLKKE 
       710        720        730        740        750
TKLVLKELSE ARIRTVMITG DNLQTAITVA KNSEMIPPGS QVIIVEADEP 
       760        770        780        790        800
EEFVPASVTW QLVENQETGP GKKEIYMHTG NSSTPRGEGG SCYHFAMSGK 
       810        820        830        840        850
SYQVIFQHFN SLLPKILVNG TVFARMSPGQ KSSLIEEFQK LNYYVGMCGD 
       860        870        880        890        900
GANDCGALKA AHAGISLSEQ EASVASPFTS KTTNIQCVPH LIREGRAALV 
       910        920        930        940        950
SSFGVFKYLT MYGIIQFISA LLLYWQLQLF GNYQYLMQDV AITLMVCLTM 
       960        970        980        990       1000
SSTHAYPKLA PYRPAGQLLS PPLLLSIFLN SCFSCIVQIS AFLYVKQQPW 
      1010       1020       1030       1040       1050
YCEVYQYSEC FLANQSNFST NVSLERNWTG NATLIPGSIL SFETTTLWPI 
      1060       1070       1080       1090       1100
TTINYITVAF IFSKGKPFRK PIYTNYIFSF LLLAALGLTI FILFSDFQVI 
      1110       1120       1130       1140       1150
YRGMELIPTI TSWRVLILVV ALTQFCVAFF VEDSILQNHE LWLLIKREFG 
      1160       1170       1180       1190       1200
FYSKSQYRTW QKKLAEDSTW PPINRTDYSG DGKNGFYING GYESHEQIPK 
      1210 
RKLKLGGQPT EQHFWARL
Length:1,218
Mass (Da):137,327
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70A58A83549DEE31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JPQ4C9JPQ4_HUMAN
Cation-transporting ATPase
ATP13A5
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ89030 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ89030 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85490 differs from that shown. Unlikely isoform. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti357K → E in BAC85490 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06103996S → Y1 PublicationCorresponds to variant dbSNP:rs12637558Ensembl.1
Natural variantiVAR_043614133E → Q. Corresponds to variant dbSNP:rs6797429Ensembl.1
Natural variantiVAR_043615739G → S. Corresponds to variant dbSNP:rs2280268Ensembl.1
Natural variantiVAR_0436161053I → V. Corresponds to variant dbSNP:rs6787746Ensembl.1
Natural variantiVAR_0436171131V → A1 PublicationCorresponds to variant dbSNP:rs2271791Ensembl.1
Natural variantiVAR_0436181204K → Q. Corresponds to variant dbSNP:rs7428010Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY823163 mRNA Translation: AAX24103.1
AK122613 mRNA Translation: BAC85490.1 Sequence problems.
AY358667 mRNA Translation: AAQ89030.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33914.1

NCBI Reference Sequences

More...RefSeqi		NP_940907.2, NM_198505.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342358.9; ENSP00000341942.4; ENSG00000187527.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		344905

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:344905

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000342358.9; ENSP00000341942.4; NM_198505.4; NP_940907.2

UCSC genome browser

More...UCSCi		uc011bsq.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823163 mRNA Translation: AAX24103.1
AK122613 mRNA Translation: BAC85490.1 Sequence problems.
AY358667 mRNA Translation: AAQ89030.1 Sequence problems.
CCDSiCCDS33914.1
RefSeqiNP_940907.2, NM_198505.2

3D structure databases

AlphaFoldDBiQ4VNC0
SMRiQ4VNC0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341942

PTM databases

GlyGeniQ4VNC0, 3 sites
iPTMnetiQ4VNC0
PhosphoSitePlusiQ4VNC0

Genetic variation databases

BioMutaiATP13A5
DMDMi74753861

Proteomic databases

MassIVEiQ4VNC0
PaxDbiQ4VNC0
PeptideAtlasiQ4VNC0
PRIDEiQ4VNC0
ProteomicsDBi62310

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		65947, 10 antibodies from 6 providers

The DNASU plasmid repository

More...DNASUi		344905

Genome annotation databases

EnsembliENST00000342358.9; ENSP00000341942.4; ENSG00000187527.12
GeneIDi344905
KEGGihsa:344905
MANE-SelectiENST00000342358.9; ENSP00000341942.4; NM_198505.4; NP_940907.2
UCSCiuc011bsq.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		344905
DisGeNETi344905

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATP13A5
HGNCiHGNC:31789, ATP13A5
HPAiENSG00000187527, Group enriched (breast, choroid plexus, salivary gland)
MIMi619119, gene
neXtProtiNX_Q4VNC0
OpenTargetsiENSG00000187527
PharmGKBiPA134952038
VEuPathDBiHostDB:ENSG00000187527

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0208, Eukaryota
GeneTreeiENSGT00940000160327
HOGENOMiCLU_001828_0_0_1
InParanoidiQ4VNC0
OMAiKMEDCNV
OrthoDBi172453at2759
PhylomeDBiQ4VNC0
TreeFamiTF300331

Enzyme and pathway databases

PathwayCommonsiQ4VNC0
ReactomeiR-HSA-936837, Ion transport by P-type ATPases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		344905, 10 hits in 1061 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		344905
PharosiQ4VNC0, Tdark

Protein Ontology

More...PROi		PR:Q4VNC0
RNActiQ4VNC0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000187527, Expressed in epithelium of mammary gland and 104 other tissues
ExpressionAtlasiQ4VNC0, baseline and differential
GenevisibleiQ4VNC0, HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom
PfamiView protein in Pfam
PF00690, Cation_ATPase_N, 1 hit
PF12409, P5-ATPase, 1 hit
SFLDiSFLDF00027, p-type_atpase, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01494, ATPase_P-type, 1 hit
TIGR01657, P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT135_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4VNC0
Secondary accession number(s): Q6UWS4, Q6ZWL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2005
Last modified: May 25, 2022
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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