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Entry version 126 (07 Apr 2021)
Sequence version 1 (05 Jul 2005)
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Protein

Probable cation-transporting ATPase 13A5

Gene

ATP13A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4864-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi850MagnesiumBy similarity1
Metal bindingi854MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q4VNC0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-936837, Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A5 (EC:7.2.2.-)
Alternative name(s):
P5-ATPase isoform 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP13A5
ORF Names:UNQ488/PRO1004
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:31789, ATP13A5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
619119, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q4VNC0

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000187527.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Transmembranei903 – 923HelicalSequence analysisAdd BLAST21
Transmembranei940 – 956HelicalSequence analysisAdd BLAST17
Transmembranei973 – 993HelicalSequence analysisAdd BLAST21
Transmembranei1042 – 1062HelicalSequence analysisAdd BLAST21
Transmembranei1077 – 1097HelicalSequence analysisAdd BLAST21
Transmembranei1115 – 1135HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
344905

Open Targets

More...
OpenTargetsi
ENSG00000187527

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134952038

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q4VNC0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP13A5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74753861

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371221 – 1218Probable cation-transporting ATPase 13A5Add BLAST1218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi669N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi819N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q4VNC0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4VNC0

PeptideAtlas

More...
PeptideAtlasi
Q4VNC0

PRoteomics IDEntifications database

More...
PRIDEi
Q4VNC0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62310

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q4VNC0, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4VNC0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4VNC0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187527, Expressed in epithelium of mammary gland and 103 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4VNC0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4VNC0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000187527, Group enriched (brain, breast, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341942

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4VNC0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi462 – 465Poly-Lys4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0208, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160327

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001828_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4VNC0

Identification of Orthologs from Complete Genome Data

More...
OMAi
KMEDCNV

Database of Orthologous Groups

More...
OrthoDBi
172453at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4VNC0

TreeFam database of animal gene trees

More...
TreeFami
TF300331

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00690, Cation_ATPase_N, 1 hit
PF12409, P5-ATPase, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDF00027, p-type_atpase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01494, ATPase_P-type, 1 hit
TIGR01657, P-ATPase-V, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q4VNC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEENSKKDHR ALLNQGEEDE LEVFGYRDHN VRKAFCLVAS VLTCGGLLLV
60 70 80 90 100
FYWRPQWRVW ANCIPCPLQE ADTVLLRTTD EFQRYMRKKV FCLYLSTLKF
110 120 130 140 150
PVSKKWEESL VADRHSVINQ ALIKPELKLR CMEVQKIRYV WNDLEKRFQK
160 170 180 190 200
VGLLEDSNSC SDIHQTFGLG LTSEEQEVRR LVCGPNAIEV EIQPIWKLLV
210 220 230 240 250
KQVLNPFYVF QAFTLTLWLS QGYIEYSVAI IILTVISIVL SVYDLRQQSV
260 270 280 290 300
KLHNLVEDHN KVQVTIIVKD KGLEELESRL LVPGDILILP GKFSLPCDAV
310 320 330 340 350
LIDGSCVVNE GMLTGESIPV TKTPLPQMEN TMPWKCHSLE DYRKHVLFCG
360 370 380 390 400
TEVIQVKPSG QGPVRAVVLQ TGYNTAKGDL VRSILYPRPL NFKLYSDAFK
410 420 430 440 450
FIVFLACLGV MGFFYALGVY MYHGVPPKDT VTMALILLTV TVPPVLPAAL
460 470 480 490 500
TIGNVYAQKR LKKKKIFCIS PQRINMCGQI NLVCFDKTGT LTEDGLDLWG
510 520 530 540 550
TVPTADNCFQ EAHSFASGQA VPWSPLCAAM ASCHSLILLN GTIQGDPLDL
560 570 580 590 600
KMFEGTAWKM EDCIVDSCKF GTSVSNIIKP GPKASKSPVE AIITLCQFPF
610 620 630 640 650
SSSLQRMSVI AQLAGENHFH VYMKGAPEMV ARFCRSETVP KNFPQELRSY
660 670 680 690 700
TVQGFRVIAL AHKTLKMGNL SEVEHLAREK VESELTFLGL LIMENRLKKE
710 720 730 740 750
TKLVLKELSE ARIRTVMITG DNLQTAITVA KNSEMIPPGS QVIIVEADEP
760 770 780 790 800
EEFVPASVTW QLVENQETGP GKKEIYMHTG NSSTPRGEGG SCYHFAMSGK
810 820 830 840 850
SYQVIFQHFN SLLPKILVNG TVFARMSPGQ KSSLIEEFQK LNYYVGMCGD
860 870 880 890 900
GANDCGALKA AHAGISLSEQ EASVASPFTS KTTNIQCVPH LIREGRAALV
910 920 930 940 950
SSFGVFKYLT MYGIIQFISA LLLYWQLQLF GNYQYLMQDV AITLMVCLTM
960 970 980 990 1000
SSTHAYPKLA PYRPAGQLLS PPLLLSIFLN SCFSCIVQIS AFLYVKQQPW
1010 1020 1030 1040 1050
YCEVYQYSEC FLANQSNFST NVSLERNWTG NATLIPGSIL SFETTTLWPI
1060 1070 1080 1090 1100
TTINYITVAF IFSKGKPFRK PIYTNYIFSF LLLAALGLTI FILFSDFQVI
1110 1120 1130 1140 1150
YRGMELIPTI TSWRVLILVV ALTQFCVAFF VEDSILQNHE LWLLIKREFG
1160 1170 1180 1190 1200
FYSKSQYRTW QKKLAEDSTW PPINRTDYSG DGKNGFYING GYESHEQIPK
1210
RKLKLGGQPT EQHFWARL
Length:1,218
Mass (Da):137,327
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70A58A83549DEE31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JPQ4C9JPQ4_HUMAN
Cation-transporting ATPase
ATP13A5
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X108A0A087X108_HUMAN
Probable cation-transporting ATPase...
ATP13A5
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ89030 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ89030 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC85490 differs from that shown. Unlikely isoform. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti357K → E in BAC85490 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06103996S → Y1 PublicationCorresponds to variant dbSNP:rs12637558Ensembl.1
Natural variantiVAR_043614133E → Q. Corresponds to variant dbSNP:rs6797429Ensembl.1
Natural variantiVAR_043615739G → S. Corresponds to variant dbSNP:rs2280268Ensembl.1
Natural variantiVAR_0436161053I → V. Corresponds to variant dbSNP:rs6787746Ensembl.1
Natural variantiVAR_0436171131V → A1 PublicationCorresponds to variant dbSNP:rs2271791Ensembl.1
Natural variantiVAR_0436181204K → Q. Corresponds to variant dbSNP:rs7428010Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY823163 mRNA Translation: AAX24103.1
AK122613 mRNA Translation: BAC85490.1 Sequence problems.
AY358667 mRNA Translation: AAQ89030.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33914.1

NCBI Reference Sequences

More...
RefSeqi
NP_940907.2, NM_198505.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342358; ENSP00000341942; ENSG00000187527

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
344905

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:344905

UCSC genome browser

More...
UCSCi
uc011bsq.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823163 mRNA Translation: AAX24103.1
AK122613 mRNA Translation: BAC85490.1 Sequence problems.
AY358667 mRNA Translation: AAQ89030.1 Sequence problems.
CCDSiCCDS33914.1
RefSeqiNP_940907.2, NM_198505.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000341942

PTM databases

GlyGeniQ4VNC0, 3 sites
iPTMnetiQ4VNC0
PhosphoSitePlusiQ4VNC0

Genetic variation databases

BioMutaiATP13A5
DMDMi74753861

Proteomic databases

MassIVEiQ4VNC0
PaxDbiQ4VNC0
PeptideAtlasiQ4VNC0
PRIDEiQ4VNC0
ProteomicsDBi62310

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
65947, 10 antibodies

The DNASU plasmid repository

More...
DNASUi
344905

Genome annotation databases

EnsembliENST00000342358; ENSP00000341942; ENSG00000187527
GeneIDi344905
KEGGihsa:344905
UCSCiuc011bsq.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
344905
DisGeNETi344905

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ATP13A5
HGNCiHGNC:31789, ATP13A5
HPAiENSG00000187527, Group enriched (brain, breast, salivary gland)
MIMi619119, gene
neXtProtiNX_Q4VNC0
OpenTargetsiENSG00000187527
PharmGKBiPA134952038
VEuPathDBiHostDB:ENSG00000187527.10

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0208, Eukaryota
GeneTreeiENSGT00940000160327
HOGENOMiCLU_001828_0_0_1
InParanoidiQ4VNC0
OMAiKMEDCNV
OrthoDBi172453at2759
PhylomeDBiQ4VNC0
TreeFamiTF300331

Enzyme and pathway databases

PathwayCommonsiQ4VNC0
ReactomeiR-HSA-936837, Ion transport by P-type ATPases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
344905, 4 hits in 978 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
344905
PharosiQ4VNC0, Tdark

Protein Ontology

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PROi
PR:Q4VNC0
RNActiQ4VNC0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000187527, Expressed in epithelium of mammary gland and 103 other tissues
ExpressionAtlasiQ4VNC0, baseline and differential
GenevisibleiQ4VNC0, HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom
PfamiView protein in Pfam
PF00690, Cation_ATPase_N, 1 hit
PF12409, P5-ATPase, 1 hit
SFLDiSFLDF00027, p-type_atpase, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01494, ATPase_P-type, 1 hit
TIGR01657, P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT135_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4VNC0
Secondary accession number(s): Q6UWS4, Q6ZWL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2005
Last modified: April 7, 2021
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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