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UniProtKB - Q4VNC0 (AT135_HUMAN)

Protein

Probable cation-transporting ATPase 13A5

Gene

ATP13A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4864-aspartylphosphate intermediateBy similarity1
Metal bindingi850MagnesiumBy similarity1
Metal bindingi854MagnesiumBy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A5 (EC:3.6.3.-)
Alternative name(s):
P5-ATPase isoform 5
Gene namesi
Name:ATP13A5
ORF Names:UNQ488/PRO1004
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000187527.10
HGNCiHGNC:31789 ATP13A5
neXtProtiNX_Q4VNC0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Transmembranei433 – 453HelicalSequence analysisAdd BLAST21
Transmembranei903 – 923HelicalSequence analysisAdd BLAST21
Transmembranei940 – 956HelicalSequence analysisAdd BLAST17
Transmembranei973 – 993HelicalSequence analysisAdd BLAST21
Transmembranei1042 – 1062HelicalSequence analysisAdd BLAST21
Transmembranei1077 – 1097HelicalSequence analysisAdd BLAST21
Transmembranei1115 – 1135HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187527
PharmGKBiPA134952038

Polymorphism and mutation databases

BioMutaiATP13A5
DMDMi74753861

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371221 – 1218Probable cation-transporting ATPase 13A5Add BLAST1218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi540N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi669N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi819N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4VNC0
PeptideAtlasiQ4VNC0
PRIDEiQ4VNC0
ProteomicsDBi62310

PTM databases

iPTMnetiQ4VNC0
PhosphoSitePlusiQ4VNC0

Expressioni

Gene expression databases

BgeeiENSG00000187527 Expressed in 72 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_ATP13A5
ExpressionAtlasiQ4VNC0 baseline and differential
GenevisibleiQ4VNC0 HS

Organism-specific databases

HPAiHPA031771
HPA031774

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341942

Structurei

3D structure databases

ProteinModelPortaliQ4VNC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi462 – 465Poly-Lys4

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208 Eukaryota
ENOG410XRCA LUCA
GeneTreeiENSGT00530000063001
HOGENOMiHOG000171813
HOVERGENiHBG065757
InParanoidiQ4VNC0
KOiK14951
OMAiPWYCEVY
OrthoDBiEOG091G01IL
PhylomeDBiQ4VNC0
TreeFamiTF300331

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006544 P-type_TPase_V
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PF12409 P5-ATPase, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01494 ATPase_P-type, 1 hit
TIGR01657 P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q4VNC0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEENSKKDHR ALLNQGEEDE LEVFGYRDHN VRKAFCLVAS VLTCGGLLLV 
        60         70         80         90        100
FYWRPQWRVW ANCIPCPLQE ADTVLLRTTD EFQRYMRKKV FCLYLSTLKF 
       110        120        130        140        150
PVSKKWEESL VADRHSVINQ ALIKPELKLR CMEVQKIRYV WNDLEKRFQK 
       160        170        180        190        200
VGLLEDSNSC SDIHQTFGLG LTSEEQEVRR LVCGPNAIEV EIQPIWKLLV 
       210        220        230        240        250
KQVLNPFYVF QAFTLTLWLS QGYIEYSVAI IILTVISIVL SVYDLRQQSV 
       260        270        280        290        300
KLHNLVEDHN KVQVTIIVKD KGLEELESRL LVPGDILILP GKFSLPCDAV 
       310        320        330        340        350
LIDGSCVVNE GMLTGESIPV TKTPLPQMEN TMPWKCHSLE DYRKHVLFCG 
       360        370        380        390        400
TEVIQVKPSG QGPVRAVVLQ TGYNTAKGDL VRSILYPRPL NFKLYSDAFK 
       410        420        430        440        450
FIVFLACLGV MGFFYALGVY MYHGVPPKDT VTMALILLTV TVPPVLPAAL 
       460        470        480        490        500
TIGNVYAQKR LKKKKIFCIS PQRINMCGQI NLVCFDKTGT LTEDGLDLWG 
       510        520        530        540        550
TVPTADNCFQ EAHSFASGQA VPWSPLCAAM ASCHSLILLN GTIQGDPLDL 
       560        570        580        590        600
KMFEGTAWKM EDCIVDSCKF GTSVSNIIKP GPKASKSPVE AIITLCQFPF 
       610        620        630        640        650
SSSLQRMSVI AQLAGENHFH VYMKGAPEMV ARFCRSETVP KNFPQELRSY 
       660        670        680        690        700
TVQGFRVIAL AHKTLKMGNL SEVEHLAREK VESELTFLGL LIMENRLKKE 
       710        720        730        740        750
TKLVLKELSE ARIRTVMITG DNLQTAITVA KNSEMIPPGS QVIIVEADEP 
       760        770        780        790        800
EEFVPASVTW QLVENQETGP GKKEIYMHTG NSSTPRGEGG SCYHFAMSGK 
       810        820        830        840        850
SYQVIFQHFN SLLPKILVNG TVFARMSPGQ KSSLIEEFQK LNYYVGMCGD 
       860        870        880        890        900
GANDCGALKA AHAGISLSEQ EASVASPFTS KTTNIQCVPH LIREGRAALV 
       910        920        930        940        950
SSFGVFKYLT MYGIIQFISA LLLYWQLQLF GNYQYLMQDV AITLMVCLTM 
       960        970        980        990       1000
SSTHAYPKLA PYRPAGQLLS PPLLLSIFLN SCFSCIVQIS AFLYVKQQPW 
      1010       1020       1030       1040       1050
YCEVYQYSEC FLANQSNFST NVSLERNWTG NATLIPGSIL SFETTTLWPI 
      1060       1070       1080       1090       1100
TTINYITVAF IFSKGKPFRK PIYTNYIFSF LLLAALGLTI FILFSDFQVI 
      1110       1120       1130       1140       1150
YRGMELIPTI TSWRVLILVV ALTQFCVAFF VEDSILQNHE LWLLIKREFG 
      1160       1170       1180       1190       1200
FYSKSQYRTW QKKLAEDSTW PPINRTDYSG DGKNGFYING GYESHEQIPK 
      1210 
RKLKLGGQPT EQHFWARL
Length:1,218
Mass (Da):137,327
Last modified:July 5, 2005 - v1
Checksum:i70A58A83549DEE31
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JPQ4C9JPQ4_HUMAN
Probable cation-transporting ATPase...
ATP13A5
158Annotation score:
A0A087X108A0A087X108_HUMAN
Probable cation-transporting ATPase...
ATP13A5
114Annotation score:

Sequence cautioni

The sequence AAQ89030 differs from that shown. Reason: Frameshift at positions 1126 and 1135.Curated
The sequence AAQ89030 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC85490 differs from that shown. Unlikely isoform. Cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti357K → E in BAC85490 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06103996S → Y1 PublicationCorresponds to variant dbSNP:rs12637558Ensembl.1
Natural variantiVAR_043614133E → Q. Corresponds to variant dbSNP:rs6797429Ensembl.1
Natural variantiVAR_043615739G → S. Corresponds to variant dbSNP:rs2280268Ensembl.1
Natural variantiVAR_0436161053I → V. Corresponds to variant dbSNP:rs6787746Ensembl.1
Natural variantiVAR_0436171131V → A1 PublicationCorresponds to variant dbSNP:rs2271791Ensembl.1
Natural variantiVAR_0436181204K → Q. Corresponds to variant dbSNP:rs7428010Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823163 mRNA Translation: AAX24103.1
AK122613 mRNA Translation: BAC85490.1 Sequence problems.
AY358667 mRNA Translation: AAQ89030.1 Sequence problems.
CCDSiCCDS33914.1
RefSeqiNP_940907.2, NM_198505.2
UniGeneiHs.658032

Genome annotation databases

EnsembliENST00000342358; ENSP00000341942; ENSG00000187527
GeneIDi344905
KEGGihsa:344905
UCSCiuc011bsq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823163 mRNA Translation: AAX24103.1
AK122613 mRNA Translation: BAC85490.1 Sequence problems.
AY358667 mRNA Translation: AAQ89030.1 Sequence problems.
CCDSiCCDS33914.1
RefSeqiNP_940907.2, NM_198505.2
UniGeneiHs.658032

3D structure databases

ProteinModelPortaliQ4VNC0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341942

PTM databases

iPTMnetiQ4VNC0
PhosphoSitePlusiQ4VNC0

Polymorphism and mutation databases

BioMutaiATP13A5
DMDMi74753861

Proteomic databases

PaxDbiQ4VNC0
PeptideAtlasiQ4VNC0
PRIDEiQ4VNC0
ProteomicsDBi62310

Protocols and materials databases

DNASUi344905
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342358; ENSP00000341942; ENSG00000187527
GeneIDi344905
KEGGihsa:344905
UCSCiuc011bsq.3 human

Organism-specific databases

CTDi344905
EuPathDBiHostDB:ENSG00000187527.10
GeneCardsiATP13A5
HGNCiHGNC:31789 ATP13A5
HPAiHPA031771
HPA031774
neXtProtiNX_Q4VNC0
OpenTargetsiENSG00000187527
PharmGKBiPA134952038
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0208 Eukaryota
ENOG410XRCA LUCA
GeneTreeiENSGT00530000063001
HOGENOMiHOG000171813
HOVERGENiHBG065757
InParanoidiQ4VNC0
KOiK14951
OMAiPWYCEVY
OrthoDBiEOG091G01IL
PhylomeDBiQ4VNC0
TreeFamiTF300331

Enzyme and pathway databases

ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRSiATP13A5 human
GenomeRNAii344905
PROiPR:Q4VNC0

Gene expression databases

BgeeiENSG00000187527 Expressed in 72 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_ATP13A5
ExpressionAtlasiQ4VNC0 baseline and differential
GenevisibleiQ4VNC0 HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006544 P-type_TPase_V
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00690 Cation_ATPase_N, 1 hit
PF12409 P5-ATPase, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01494 ATPase_P-type, 1 hit
TIGR01657 P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAT135_HUMAN
AccessioniPrimary (citable) accession number: Q4VNC0
Secondary accession number(s): Q6UWS4, Q6ZWL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2005
Last modified: September 12, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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