LIM homeobox transcription factor 1, beta 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• closure of optic fissure Source: ZFIN <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish."
    McMahon C., Gestri G., Wilson S.W., Link B.A.
    Dev Biol 332:287-298(2009) [PubMed] [Europe PMC] [Abstract]
• fourth ventricle development Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis."
    Elsen G.E., Choi L.Y., Millen K.J., Grinblat Y., Prince V.E.
    Dev Biol 314:376-392(2008) [PubMed] [Europe PMC] [Abstract]
• glutamatergic neuron differentiation Source: ZFINInferred from mutant phenotypeⁱ
  • "Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons."
    Hilinski W.C., Bostrom J.R., England S.J., Juarez-Morales J.L., de Jager S., Armant O., Legradi J., Strahle U., Link B.A., Lewis K.E.
    Neural Dev 11:16-16(2016) [PubMed] [Europe PMC] [Abstract]
• hindbrain development Source: ZFINInferred from mutant phenotypeⁱ
  • "Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis."
    Elsen G.E., Choi L.Y., Millen K.J., Grinblat Y., Prince V.E.
    Dev Biol 314:376-392(2008) [PubMed] [Europe PMC] [Abstract]
• midbrain-hindbrain boundary development Source: ZFINInferred from genetic interactionⁱ
  • Ref.1

    "Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer."
    O'Hara F.P., Beck E., Barr L.K., Wong L.L., Kessler D.S., Riddle R.D.
    Development 132:3163-3173(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• optic cup morphogenesis involved in camera-type eye development Source: ZFINInferred from genetic interactionⁱ
  • "Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish."
    McMahon C., Gestri G., Wilson S.W., Link B.A.
    Dev Biol 332:287-298(2009) [PubMed] [Europe PMC] [Abstract]
• pronephric glomerulus morphogenesis Source: ZFINInferred from genetic interactionⁱ
  • "LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys."
    Burghardt T., Kastner J., Suleiman H., Rivera-Milla E., Stepanova N., Lottaz C., Kubitza M., Boger C.A., Schmidt S., Gorski M., de Vries U., Schmidt H., Hertting I., Kopp J., Rascle A., Moser M., Heid I.M., Warth R.

    , Spang R., Wegener J., Mierke C.T., Englert C., Witzgall R.
    J Am Soc Nephrol 24:1830-1848(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• retina development in camera-type eye Source: ZFINInferred from genetic interactionⁱ
  • "Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish."
    McMahon C., Gestri G., Wilson S.W., Link B.A.
    Dev Biol 332:287-298(2009) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MLDGIKIEDQ FRTGAETLGV MLDCAHHQSV CEGCHRPISD RFLLRMNDSS 
        60         70         80         90        100
WHEECLQCSV CQQLLTMSCY SRDHKLYCKH DYQQLFATKC SGCLEKISPT 
       110        120        130        140        150
ELVMRALESV YHLSCFCCCV CERRLCKGDE FVLKEGQLLC KTDYEREKDL 
       160        170        180        190        200
ASPDLSDSDK SEDEDLDVKP EKGAGGQGKG SDDSKDPRRP KRPRTILTTQ 
       210        220        230        240        250
QRRAFKASFE VSSKPCRKVR ETLAAETGLS VRVVQVWFQN QRAKMKKLAR 
       260        270        280        290        300
RQQQQQEQQN SQRLGQDVMS SRMENLMSSY TPLAPPPPHA LVSMESSGYS 
       310        320        330        340        350
TDPFQQGLTP PQMPGDHMNP YGNDSIFHDI DSDTSLTSLS DCFMSASDAA 
       360        370 
ALQSRVGNPI DRLYSMQSSY FTS                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ