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Protein

Coiled-coil domain-containing protein 58

Gene

CCDC58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 58
Gene namesi
Name:CCDC58
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000160124.9
HGNCiHGNC:31136 CCDC58
neXtProtiNX_Q4VC31

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160124
PharmGKBiPA143485410

Polymorphism and mutation databases

BioMutaiCCDC58
DMDMi74754617

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002394412 – 144Coiled-coil domain-containing protein 58Add BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei100N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ4VC31
MaxQBiQ4VC31
PaxDbiQ4VC31
PeptideAtlasiQ4VC31
PRIDEiQ4VC31
ProteomicsDBi62300
TopDownProteomicsiQ4VC31

PTM databases

CarbonylDBiQ4VC31
iPTMnetiQ4VC31
PhosphoSitePlusiQ4VC31

Expressioni

Gene expression databases

BgeeiENSG00000160124
CleanExiHS_CCDC58
ExpressionAtlasiQ4VC31 baseline and differential
GenevisibleiQ4VC31 HS

Organism-specific databases

HPAiHPA047777
HPA051965

Interactioni

Protein-protein interaction databases

BioGridi126270, 17 interactors
IntActiQ4VC31, 5 interactors
STRINGi9606.ENSP00000291458

Structurei

3D structure databases

ProteinModelPortaliQ4VC31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili82 – 120Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the CCDC58 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4613 Eukaryota
ENOG4111KXF LUCA
GeneTreeiENSGT00390000011053
HOGENOMiHOG000007601
HOVERGENiHBG061586
InParanoidiQ4VC31
OMAiLNCEDFS
OrthoDBiEOG091G0W2H
PhylomeDBiQ4VC31
TreeFamiTF324875

Family and domain databases

InterProiView protein in InterPro
IPR019171 Caffeine_induced_death_Cid2
PANTHERiPTHR31905 PTHR31905, 1 hit
PfamiView protein in Pfam
PF09774 Cid2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4VC31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSGGVNC EEFAEFQELL KVMRTIDDRI VHELNTTVPT ASFAGKIDAS
60 70 80 90 100
QTCKQLYESL MAAHASRDRV IKNCIAQTSA VVKNLREERE KNLDDLTLLK
110 120 130 140
QLRKEQTKLK WMQSELNVEE VVNDRSWKVF NERCRIHFKP PKNE
Length:144
Mass (Da):16,620
Last modified:July 5, 2005 - v1
Checksum:iA78EE047DDD458C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 5PS → GG in AAI09379 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC062725 mRNA Translation: AAH62725.1
BC109378 mRNA Translation: AAI09379.1
CCDSiCCDS33838.1
RefSeqiNP_001017928.1, NM_001017928.3
NP_001295255.1, NM_001308326.1
UniGeneiHs.220594

Genome annotation databases

EnsembliENST00000291458; ENSP00000291458; ENSG00000160124
GeneIDi131076
KEGGihsa:131076
UCSCiuc003eey.4 human

Similar proteinsi

Entry informationi

Entry nameiCCD58_HUMAN
AccessioniPrimary (citable) accession number: Q4VC31
Secondary accession number(s): Q32LY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2005
Last modified: June 20, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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