Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

A disintegrin and metalloproteinase with thrombospondin motifs 18

Gene

Adamts18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi436Zinc; catalyticPROSITE-ProRule annotation1
Active sitei437PROSITE-ProRule annotation1
Metal bindingi440Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi446Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • eye development Source: MGI
  • negative regulation of platelet aggregation Source: MGI

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPSiM12.030

Names & Taxonomyi

Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 18 (EC:3.4.24.-)
Short name:
ADAM-TS 18
Short name:
ADAM-TS18
Short name:
ADAMTS-18
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2442600 Adamts18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 47Sequence analysisAdd BLAST47
PropeptideiPRO_000043753448 – 284By similarityAdd BLAST237
ChainiPRO_0000042164285 – 1219A disintegrin and metalloproteinase with thrombospondin motifs 18Add BLAST935

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi369 ↔ 420By similarity
Disulfide bondi395 ↔ 402By similarity
Disulfide bondi414 ↔ 493By similarity
Disulfide bondi453 ↔ 477By similarity
Disulfide bondi521 ↔ 546By similarity
Disulfide bondi532 ↔ 553By similarity
Disulfide bondi541 ↔ 572By similarity
Disulfide bondi566 ↔ 577By similarity
Disulfide bondi601 ↔ 638By similarity
Disulfide bondi605 ↔ 643By similarity
Disulfide bondi616 ↔ 628By similarity
Glycosylationi745N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi838N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi865N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi909N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ4VC17
PRIDEiQ4VC17

PTM databases

iPTMnetiQ4VC17
PhosphoSitePlusiQ4VC17

Expressioni

Gene expression databases

BgeeiENSMUSG00000053399 Expressed in 71 organ(s), highest expression level in epithelium of lens
ExpressionAtlasiQ4VC17 baseline and differential
GenevisibleiQ4VC17 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090801

Structurei

3D structure databases

ProteinModelPortaliQ4VC17
SMRiQ4VC17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini293 – 498Peptidase M12BPROSITE-ProRule annotationAdd BLAST206
Domaini589 – 644TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini931 – 990TSP type-1 2PROSITE-ProRule annotationAdd BLAST60
Domaini991 – 1049TSP type-1 3PROSITE-ProRule annotationAdd BLAST59
Domaini1052 – 1116TSP type-1 4PROSITE-ProRule annotationAdd BLAST65
Domaini1121 – 1176TSP type-1 5PROSITE-ProRule annotationAdd BLAST56
Domaini1182 – 1219PLACPROSITE-ProRule annotationAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi153 – 156Poly-Ser4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00900000140815
HOGENOMiHOG000004800
HOVERGENiHBG004315
InParanoidiQ4VC17
KOiK08632
OMAiYVFVTPV
OrthoDBiEOG091G14M8
TreeFamiTF313537

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF08686 PLAC, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 5 hits
SMARTiView protein in SMART
SM00209 TSP1, 6 hits
SUPFAMiSSF82895 SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q4VC17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MECALLCLCA LRAAGPGPPW GPAGLGRLAK ALQLCCFCCA SVAVALASDS
60 70 80 90 100
GSSGGSGLND DYVFVVPVEV DSGGSYISHD ILHHRKRRSA HGASNSLHYR
110 120 130 140 150
VSAFGQDLHL ELKPSAILSS HFRVQVLGKD GASETREPEV PQCLYQGFIR
160 170 180 190 200
NDSSSSVAVS TCAGLSGLIR TRDNEFLISP LPQLLAQEHN YSSPAGHHPH
210 220 230 240 250
VLYKRTAEKR VRWYQDYPGS QRTYPGHSPS HTPPASQSQE PEYSHRRWQK
260 270 280 290 300
RHFCGRRKKY APKPPAEDAY LRFDEYGGTG RPRRSAGKSQ NGLNVETLVV
310 320 330 340 350
ADAKMVEKHG KDDVTTYILT VMNMVSSLFK DGTIGSDINI VVVSLILLEE
360 370 380 390 400
EPEGLLINHH ADQSLNSFCQ WQSALVGKNG KRHDHAILLT GFDICSWKNE
410 420 430 440 450
PCDTLGFAPI SGMCSKYRSC TINEDTGLGL AFTIAHESGH NFGMVHDGEG
460 470 480 490 500
NPCRKAEGNI MSPTLTGNNG VFSWSSCSRQ YLKKFLSTPQ AGCLVDEPKQ
510 520 530 540 550
TGQYKYPDKL PGQIYDADMQ CKWQFGAKAK LCSLGVMKDI CKSLWCHRVG
560 570 580 590 600
HRCETKFMPA AEGTACGLSM WCRQGQCVKL GELGPRPIHG QWSAWSKWSE
610 620 630 640 650
CSRTCGGGVK FQERHCSNPK PQYGGKYCPG SSRIYKLCNI NPCPENSLDF
660 670 680 690 700
RAQQCAEYNN KPFRGWLYRW KPYTKVEEED RCKLYCKAEN FEFFFAMSGK
710 720 730 740 750
VKDGTPCSPH RNDVCIDGIC ELVGCDHELG SKAVSDACGV CKGDNSTCKF
760 770 780 790 800
YKGLYLSQHK ANEYYPVVTI PAGARSIEIQ ELQLSSSYLA VRSLSQKYYL
810 820 830 840 850
TGGWSIDWPG DFTFAGTTFE YQRSFNRPER LYAPGPTNET LVFEILTQGK
860 870 880 890 900
NPGIAWKYAL PKVMNVTQPA TKRYHHTWRT VQSDCSVTCG GGYISIKAIC
910 920 930 940 950
LRDQHTQVNS SFCSVRTKPA TEPKICNAFS CPAYWLPGEW SACSKSCAGG
960 970 980 990 1000
QQSRKIRCVQ KKPFQKEEAV LHSLCPVSTP TQVQVCNSHA CPPEWSPSPW
1010 1020 1030 1040 1050
SQCSKTCGRG VRRREVLCKS PAAETLPESL CSSSPRPEAQ EGCVLGRCPK
1060 1070 1080 1090 1100
NNRLQWIASA WSECSATCGL GVRKRELKCV EKTLQGKLIT FPERRCRNIK
1110 1120 1130 1140 1150
KPSLELEEAC NQRTCPVYSM AVASWYSSPW QQCTVTCGGG VQTRSVHCMQ
1160 1170 1180 1190 1200
QGRPSSSCLL HQKPPVLRAC NTNFCPAPEK KDDPSCVDFF SWCHLVPQHG
1210
VCNHKFYGKQ CCRSCTRKS
Length:1,219
Mass (Da):135,244
Last modified:July 27, 2011 - v2
Checksum:i22D0A535E55553A2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLA5A0A1D5RLA5_MOUSE
A disintegrin and metalloproteinase...
Adamts18
148Annotation score:
A0A1D5RLE1A0A1D5RLE1_MOUSE
A disintegrin and metalloproteinase...
Adamts18
117Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96S → P in AAH94674 (PubMed:15489334).Curated1
Sequence conflicti189H → L in AAH94674 (PubMed:15489334).Curated1
Sequence conflicti487 – 497STPQAGCLVDE → RTPRCIAFLTG in BAC29190 (PubMed:16141072).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108856 Genomic DNA No translation available.
AC125463 Genomic DNA No translation available.
BC094674 mRNA Translation: AAH94674.1
AK035797 mRNA Translation: BAC29190.1
CCDSiCCDS40485.1
RefSeqiNP_766054.2, NM_172466.3
UniGeneiMm.167471

Genome annotation databases

EnsembliENSMUST00000093113; ENSMUSP00000090801; ENSMUSG00000053399
GeneIDi208936
KEGGimmu:208936
UCSCiuc009nnr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108856 Genomic DNA No translation available.
AC125463 Genomic DNA No translation available.
BC094674 mRNA Translation: AAH94674.1
AK035797 mRNA Translation: BAC29190.1
CCDSiCCDS40485.1
RefSeqiNP_766054.2, NM_172466.3
UniGeneiMm.167471

3D structure databases

ProteinModelPortaliQ4VC17
SMRiQ4VC17
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090801

Protein family/group databases

MEROPSiM12.030

PTM databases

iPTMnetiQ4VC17
PhosphoSitePlusiQ4VC17

Proteomic databases

PaxDbiQ4VC17
PRIDEiQ4VC17

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093113; ENSMUSP00000090801; ENSMUSG00000053399
GeneIDi208936
KEGGimmu:208936
UCSCiuc009nnr.1 mouse

Organism-specific databases

CTDi170692
MGIiMGI:2442600 Adamts18

Phylogenomic databases

eggNOGiKOG3538 Eukaryota
ENOG410XPKZ LUCA
GeneTreeiENSGT00900000140815
HOGENOMiHOG000004800
HOVERGENiHBG004315
InParanoidiQ4VC17
KOiK08632
OMAiYVFVTPV
OrthoDBiEOG091G14M8
TreeFamiTF313537

Enzyme and pathway databases

ReactomeiR-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

PROiPR:Q4VC17
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053399 Expressed in 71 organ(s), highest expression level in epithelium of lens
ExpressionAtlasiQ4VC17 baseline and differential
GenevisibleiQ4VC17 MM

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR010909 PLAC
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF08686 PLAC, 1 hit
PF01421 Reprolysin, 1 hit
PF00090 TSP_1, 5 hits
SMARTiView protein in SMART
SM00209 TSP1, 6 hits
SUPFAMiSSF82895 SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS50900 PLAC, 1 hit
PS50092 TSP1, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiATS18_MOUSE
AccessioniPrimary (citable) accession number: Q4VC17
Secondary accession number(s): E9QNK0, Q8BZD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again