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Entry version 121 (12 Aug 2020)
Sequence version 2 (27 Jul 2011)
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Protein

A disintegrin and metalloproteinase with thrombospondin motifs 18

Gene

Adamts18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi436Zinc; catalyticPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei437PROSITE-ProRule annotation1
Metal bindingi440Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi446Zinc; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5173214, O-glycosylation of TSR domain-containing proteins

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.030

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A disintegrin and metalloproteinase with thrombospondin motifs 18 (EC:3.4.24.-)
Short name:
ADAM-TS 18
Short name:
ADAM-TS18
Short name:
ADAMTS-18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442600, Adamts18

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 47Sequence analysisAdd BLAST47
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000043753448 – 284By similarityAdd BLAST237
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000042164285 – 1219A disintegrin and metalloproteinase with thrombospondin motifs 18Add BLAST935

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi369 ↔ 420By similarity
Disulfide bondi395 ↔ 402By similarity
Disulfide bondi414 ↔ 493By similarity
Disulfide bondi453 ↔ 477By similarity
Disulfide bondi521 ↔ 546By similarity
Disulfide bondi532 ↔ 553By similarity
Disulfide bondi541 ↔ 572By similarity
Disulfide bondi566 ↔ 577By similarity
Disulfide bondi601 ↔ 638By similarity
Disulfide bondi605 ↔ 643By similarity
Disulfide bondi616 ↔ 628By similarity
Glycosylationi745N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi838N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi865N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi909N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4VC17

PRoteomics IDEntifications database

More...
PRIDEi
Q4VC17

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q4VC17, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4VC17

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4VC17

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000053399, Expressed in lens of camera-type eye and 97 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4VC17, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4VC17, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
229026, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000090801

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4VC17, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini293 – 498Peptidase M12BPROSITE-ProRule annotationAdd BLAST206
Domaini589 – 644TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini931 – 990TSP type-1 2PROSITE-ProRule annotationAdd BLAST60
Domaini991 – 1049TSP type-1 3PROSITE-ProRule annotationAdd BLAST59
Domaini1052 – 1116TSP type-1 4PROSITE-ProRule annotationAdd BLAST65
Domaini1121 – 1176TSP type-1 5PROSITE-ProRule annotationAdd BLAST56
Domaini1182 – 1219PLACPROSITE-ProRule annotationAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi153 – 156Poly-Ser4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157553

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000660_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4VC17

KEGG Orthology (KO)

More...
KOi
K08632

Identification of Orthologs from Complete Genome Data

More...
OMAi
SQETEYH

Database of Orthologous Groups

More...
OrthoDBi
125522at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313537

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 5 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645, ADAM_CR_2
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF08686, PLAC, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857, ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895, SSF82895, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50900, PLAC, 1 hit
PS50092, TSP1, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q4VC17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MECALLCLCA LRAAGPGPPW GPAGLGRLAK ALQLCCFCCA SVAVALASDS
60 70 80 90 100
GSSGGSGLND DYVFVVPVEV DSGGSYISHD ILHHRKRRSA HGASNSLHYR
110 120 130 140 150
VSAFGQDLHL ELKPSAILSS HFRVQVLGKD GASETREPEV PQCLYQGFIR
160 170 180 190 200
NDSSSSVAVS TCAGLSGLIR TRDNEFLISP LPQLLAQEHN YSSPAGHHPH
210 220 230 240 250
VLYKRTAEKR VRWYQDYPGS QRTYPGHSPS HTPPASQSQE PEYSHRRWQK
260 270 280 290 300
RHFCGRRKKY APKPPAEDAY LRFDEYGGTG RPRRSAGKSQ NGLNVETLVV
310 320 330 340 350
ADAKMVEKHG KDDVTTYILT VMNMVSSLFK DGTIGSDINI VVVSLILLEE
360 370 380 390 400
EPEGLLINHH ADQSLNSFCQ WQSALVGKNG KRHDHAILLT GFDICSWKNE
410 420 430 440 450
PCDTLGFAPI SGMCSKYRSC TINEDTGLGL AFTIAHESGH NFGMVHDGEG
460 470 480 490 500
NPCRKAEGNI MSPTLTGNNG VFSWSSCSRQ YLKKFLSTPQ AGCLVDEPKQ
510 520 530 540 550
TGQYKYPDKL PGQIYDADMQ CKWQFGAKAK LCSLGVMKDI CKSLWCHRVG
560 570 580 590 600
HRCETKFMPA AEGTACGLSM WCRQGQCVKL GELGPRPIHG QWSAWSKWSE
610 620 630 640 650
CSRTCGGGVK FQERHCSNPK PQYGGKYCPG SSRIYKLCNI NPCPENSLDF
660 670 680 690 700
RAQQCAEYNN KPFRGWLYRW KPYTKVEEED RCKLYCKAEN FEFFFAMSGK
710 720 730 740 750
VKDGTPCSPH RNDVCIDGIC ELVGCDHELG SKAVSDACGV CKGDNSTCKF
760 770 780 790 800
YKGLYLSQHK ANEYYPVVTI PAGARSIEIQ ELQLSSSYLA VRSLSQKYYL
810 820 830 840 850
TGGWSIDWPG DFTFAGTTFE YQRSFNRPER LYAPGPTNET LVFEILTQGK
860 870 880 890 900
NPGIAWKYAL PKVMNVTQPA TKRYHHTWRT VQSDCSVTCG GGYISIKAIC
910 920 930 940 950
LRDQHTQVNS SFCSVRTKPA TEPKICNAFS CPAYWLPGEW SACSKSCAGG
960 970 980 990 1000
QQSRKIRCVQ KKPFQKEEAV LHSLCPVSTP TQVQVCNSHA CPPEWSPSPW
1010 1020 1030 1040 1050
SQCSKTCGRG VRRREVLCKS PAAETLPESL CSSSPRPEAQ EGCVLGRCPK
1060 1070 1080 1090 1100
NNRLQWIASA WSECSATCGL GVRKRELKCV EKTLQGKLIT FPERRCRNIK
1110 1120 1130 1140 1150
KPSLELEEAC NQRTCPVYSM AVASWYSSPW QQCTVTCGGG VQTRSVHCMQ
1160 1170 1180 1190 1200
QGRPSSSCLL HQKPPVLRAC NTNFCPAPEK KDDPSCVDFF SWCHLVPQHG
1210
VCNHKFYGKQ CCRSCTRKS
Length:1,219
Mass (Da):135,244
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22D0A535E55553A2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLA5A0A1D5RLA5_MOUSE
A disintegrin and metalloproteinase...
Adamts18
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RLE1A0A1D5RLE1_MOUSE
A disintegrin and metalloproteinase...
Adamts18
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96S → P in AAH94674 (PubMed:15489334).Curated1
Sequence conflicti189H → L in AAH94674 (PubMed:15489334).Curated1
Sequence conflicti487 – 497STPQAGCLVDE → RTPRCIAFLTG in BAC29190 (PubMed:16141072).CuratedAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC108856 Genomic DNA No translation available.
AC125463 Genomic DNA No translation available.
BC094674 mRNA Translation: AAH94674.1
AK035797 mRNA Translation: BAC29190.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40485.1

NCBI Reference Sequences

More...
RefSeqi
NP_766054.2, NM_172466.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093113; ENSMUSP00000090801; ENSMUSG00000053399

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
208936

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:208936

UCSC genome browser

More...
UCSCi
uc009nnr.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108856 Genomic DNA No translation available.
AC125463 Genomic DNA No translation available.
BC094674 mRNA Translation: AAH94674.1
AK035797 mRNA Translation: BAC29190.1
CCDSiCCDS40485.1
RefSeqiNP_766054.2, NM_172466.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi229026, 1 interactor
STRINGi10090.ENSMUSP00000090801

Protein family/group databases

MEROPSiM12.030

PTM databases

GlyGeniQ4VC17, 6 sites
iPTMnetiQ4VC17
PhosphoSitePlusiQ4VC17

Proteomic databases

PaxDbiQ4VC17
PRIDEiQ4VC17

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30389, 145 antibodies

Genome annotation databases

EnsembliENSMUST00000093113; ENSMUSP00000090801; ENSMUSG00000053399
GeneIDi208936
KEGGimmu:208936
UCSCiuc009nnr.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
170692
MGIiMGI:2442600, Adamts18

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
GeneTreeiENSGT00940000157553
HOGENOMiCLU_000660_1_0_1
InParanoidiQ4VC17
KOiK08632
OMAiSQETEYH
OrthoDBi125522at2759
TreeFamiTF313537

Enzyme and pathway databases

ReactomeiR-MMU-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
208936, 1 hit in 18 CRISPR screens

Protein Ontology

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PROi
PR:Q4VC17
RNActiQ4VC17, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000053399, Expressed in lens of camera-type eye and 97 other tissues
ExpressionAtlasiQ4VC17, baseline and differential
GenevisibleiQ4VC17, MM

Family and domain databases

Gene3Di2.20.100.10, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645, ADAM_CR_2
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF08686, PLAC, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 5 hits
PRINTSiPR01857, ADAMTSFAMILY
SMARTiView protein in SMART
SM00209, TSP1, 6 hits
SUPFAMiSSF82895, SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50900, PLAC, 1 hit
PS50092, TSP1, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATS18_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4VC17
Secondary accession number(s): E9QNK0, Q8BZD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 27, 2011
Last modified: August 12, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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