UniProtKB - Q4VAR0 (Q4VAR0_HUMAN)
Protein
Submitted name:
CYP11B1 protein
Gene
CYP11B1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Keywordsi
Molecular function | MonooxygenaseUniRule annotation, Oxidoreductase |
Ligand | HemeUniRule annotationARBA annotation, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Submitted name: CYP11B1 proteinImportedSubmitted name: Cytochrome P450 11B1, mitochondrialImported |
Gene namesi | Name:CYP11B1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000160882.11 |
HGNCi | HGNC:2591, CYP11B1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000160882, Expressed in right adrenal gland and 91 other tissues |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000163354 |
OMAi | TIEASHF |
Family and domain databases
Gene3Di | 1.10.630.10, 3 hits |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002403, Cyt_P450_E_grp-IV IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00465, EP450IV PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q4VAR0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALRAKAEVC MAVPWLSLQR AQALGTRAAR VPRTVLPFEA MPRRPGNRWL
60 70 80 90 100
RLLQIWREQG YEDLHLEVHQ TFQELGPIFR SRHSASFGRW GRSAARAGLW
110 120 130 140 150
RCQGRGWCRA NPSSLQRGQD SEALKYDLGG AGMVCVMLPE DVEKLQQVDS
160 170 180 190 200
LHPHRMSLEP WVAYRQHRGH KCGVFLLNVA DRGNSSPPFP GGIHGAPTHS
210 220 230 240 250
GCRNGPEWRF NRLRLNPEVL SPNAVQRFLP MVDAVARDFS QALKKKVLQN
260 270 280 290 300
ARGSLTLDVQ PSIFHYTIEA SNLALFGERL GLVGHSPSSA SLNFLHALEV
310 320 330 340 350
MFKSTVQLMF MPRSLSRWTS PKVWKEHFEA WDCIFQYGDN CIQKIYQELA
360 370 380 390 400
FSRPQQYTSI VAELLLNAEL SPDAIKANSM ELTAGSVDTT VFPLLMTLFE
410 420 430 440 450
LARNPNVQQA LRQESLAAAA SISEHPQKAT TELPLLRAAL KETLRLYPVG
460 470 480 490 500
LFLERVASSD LVLQNYHIPA GTLVRVFLYS LGRNPALFPR PERYNPQRWL
510 520 530 540 550
DIRGSGRNFY HVPFGFGMRQ CLGRRLAEAE MLLLLHHVLK HLQVETLTQE
560 570
DIKMVYSFIL RPSMFPLLTF RAIN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP15538 | C11B1_HUMAN | Cytochrome P450 11B1, mitochondrial | CYP11B1 S11BH | 503 | Annotation score: | ||
H0YBR4 | H0YBR4_HUMAN | Cytochrome P450 11B1, mitochondrial | CYP11B1 | 181 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC083841 Genomic DNA No translation available. BC096285 mRNA Translation: AAH96285.1 |
Genome annotation databases
Ensembli | ENST00000377675; ENSP00000366903; ENSG00000160882 |
UCSCi | uc010mey.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC083841 Genomic DNA No translation available. BC096285 mRNA Translation: AAH96285.1 |
3D structure databases
SMRi | Q4VAR0 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q4VAR0 |
ProteomicsDBi | 62291 |
Protocols and materials databases
Antibodypediai | 27799, 218 antibodies |
Genome annotation databases
Ensembli | ENST00000377675; ENSP00000366903; ENSG00000160882 |
UCSCi | uc010mey.4, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000160882.11 |
HGNCi | HGNC:2591, CYP11B1 |
OpenTargetsi | ENSG00000160882 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000163354 |
OMAi | TIEASHF |
Miscellaneous databases
ChiTaRSi | CYP11B1, human |
Gene expression databases
Bgeei | ENSG00000160882, Expressed in right adrenal gland and 91 other tissues |
Family and domain databases
Gene3Di | 1.10.630.10, 3 hits |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002403, Cyt_P450_E_grp-IV IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00465, EP450IV PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4VAR0_HUMAN | |
Accessioni | Q4VAR0Primary (citable) accession number: Q4VAR0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2005 |
Last sequence update: | July 5, 2005 | |
Last modified: | October 7, 2020 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |