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Protein

HEPACAM family member 2

Gene

Hepacam2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
HEPACAM family member 2
Alternative name(s):
Mitotic kinetics regulator
Gene namesi
Name:Hepacam2
Synonyms:Miki
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2141520 Hepacam2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 463CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000033222133 – 463HEPACAM family member 2Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi171 ↔ 220PROSITE-ProRule annotation
Disulfide bondi271 ↔ 316PROSITE-ProRule annotation
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Poly-ADP-ribosylated (PARsylated) by tankyrase TNKS during late G2 and prophase, leading to translocation to mitotic centrosomes.By similarity
N-glycosylated.By similarity

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ4VAH7
PRIDEiQ4VAH7

PTM databases

PhosphoSitePlusiQ4VAH7

Expressioni

Gene expression databases

BgeeiENSMUSG00000044156 Expressed in 75 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiQ4VAH7 baseline and differential
GenevisibleiQ4VAH7 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058882

Structurei

3D structure databases

ProteinModelPortaliQ4VAH7
SMRiQ4VAH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 234Ig-like C2-type 1Add BLAST85
Domaini236 – 332Ig-like C2-type 2Add BLAST97

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK28 Eukaryota
ENOG410Z756 LUCA
GeneTreeiENSGT00530000063550
HOGENOMiHOG000263412
HOVERGENiHBG063553
InParanoidiQ4VAH7
OMAiGPYGLRV
OrthoDBiEOG091G05OZ
PhylomeDBiQ4VAH7
TreeFamiTF331199

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q4VAH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQDAFMELL RSMVGLSLCK IHLLLIAGSC LGLKVTVPSY TVHGIRGQAL
60 70 80 90 100
YLPVHYGFHT PASDIQIIWL FERSHTMPKY LLGSVNKSVV PDLEYQHKFT
110 120 130 140 150
MMPPNASLLI NPLQFTDEGN YIVKVNIQGN GTLSASQKIQ VTVDDPVMKP
160 170 180 190 200
MVQFHPASGA VEYVGNITLT CQVEGGTRLV YQWRKSGKPI SINSSHSFSP
210 220 230 240 250
QNNTLWIVPV TKEDIGNYTC LVSNPVSEME SDIIMPTIYY GPYGLQVNSD
260 270 280 290 300
KGLKVGEVFT VDLGEAVLFD CSADSYPPNT YSWIQRSDNT THVIKHGPHL
310 320 330 340 350
EVASEKVAQK TADYVCCAYN NITGRRDETR FTVIITSVGL EKLAQRGKSL
360 370 380 390 400
SPLASITGIS LFLIISMCLL FLWKKYQPYK AIRQKLEGRP ESEYRKAQTF
410 420 430 440 450
SGHEDALSDF GIYEFVTFPD ASGVSRMSSR SSPASDGVTG QDIHGTIYEV
460
IQHIPEQQQE NTE
Length:463
Mass (Da):51,421
Last modified:July 5, 2005 - v1
Checksum:iC55981D167BC680B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GX19V9GX19_MOUSE
HEPACAM family member 2
Hepacam2
153Annotation score:
A0A0J9YTS9A0A0J9YTS9_MOUSE
HEPACAM family member 2
Hepacam2
206Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC096374 mRNA Translation: AAH96374.1
CCDSiCCDS39414.1
RefSeqiNP_849230.1, NM_178899.5
UniGeneiMm.206911

Genome annotation databases

EnsembliENSMUST00000049985; ENSMUSP00000058882; ENSMUSG00000044156
GeneIDi101202
KEGGimmu:101202
UCSCiuc009auz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC096374 mRNA Translation: AAH96374.1
CCDSiCCDS39414.1
RefSeqiNP_849230.1, NM_178899.5
UniGeneiMm.206911

3D structure databases

ProteinModelPortaliQ4VAH7
SMRiQ4VAH7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058882

PTM databases

PhosphoSitePlusiQ4VAH7

Proteomic databases

PaxDbiQ4VAH7
PRIDEiQ4VAH7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049985; ENSMUSP00000058882; ENSMUSG00000044156
GeneIDi101202
KEGGimmu:101202
UCSCiuc009auz.1 mouse

Organism-specific databases

CTDi253012
MGIiMGI:2141520 Hepacam2

Phylogenomic databases

eggNOGiENOG410IK28 Eukaryota
ENOG410Z756 LUCA
GeneTreeiENSGT00530000063550
HOGENOMiHOG000263412
HOVERGENiHBG063553
InParanoidiQ4VAH7
OMAiGPYGLRV
OrthoDBiEOG091G05OZ
PhylomeDBiQ4VAH7
TreeFamiTF331199

Miscellaneous databases

ChiTaRSiHepacam2 mouse
PROiPR:Q4VAH7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044156 Expressed in 75 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiQ4VAH7 baseline and differential
GenevisibleiQ4VAH7 MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHECA2_MOUSE
AccessioniPrimary (citable) accession number: Q4VAH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2005
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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