UniProtKB - Q4VAA2 (CDV3_MOUSE)
Protein
Protein CDV3
Gene
Cdv3
Organism
Mus musculus (Mouse)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein CDV3Alternative name(s): Carnitine deficiency-associated protein 3 Tyrosine-phosphorylated protein 36 Short name: TPP36 |
Gene namesi | Name:Cdv3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2448759, Cdv3 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000299561 | 2 – 281 | Protein CDV3Add BLAST | 280 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Modified residuei | 4 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 8 | PhosphoserineBy similarity | 1 | |
Modified residuei | 120 | Phosphotyrosine; by ABL1 Publication | 1 | |
Modified residuei | 131 | PhosphoserineBy similarity | 1 | |
Modified residuei | 155 | PhosphoserineBy similarity | 1 | |
Modified residuei | 205 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 213 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 267 | PhosphotyrosineBy similarity | 1 |
Post-translational modificationi
Isoform 1 and isoform 2 are phosphorylated on tyrosines by ABL1 in B-cells.1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-4022 |
EPDi | Q4VAA2 |
jPOSTi | Q4VAA2 |
PaxDbi | Q4VAA2 |
PeptideAtlasi | Q4VAA2 |
PRIDEi | Q4VAA2 |
PTM databases
iPTMneti | Q4VAA2 |
PhosphoSitePlusi | Q4VAA2 |
Expressioni
Tissue specificityi
Ubiquitously expressed (at protein level). Up-regulated in ventricles of juvenile visceral steatosis mice.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000032803, Expressed in primary oocyte and 309 other tissues |
ExpressionAtlasi | Q4VAA2, baseline and differential |
Genevisiblei | Q4VAA2, MM |
Interactioni
Protein-protein interaction databases
IntActi | Q4VAA2, 1 interactor |
STRINGi | 10090.ENSMUSP00000044420 |
Miscellaneous databases
RNActi | Q4VAA2, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 18 – 22 | Poly-Lys | 5 | |
Compositional biasi | 34 – 100 | Gly-richAdd BLAST | 67 | |
Compositional biasi | 151 – 156 | Poly-Gly | 6 |
Sequence similaritiesi
Belongs to the CDV3 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QRFT, Eukaryota |
GeneTreei | ENSGT00390000000805 |
HOGENOMi | CLU_089760_1_0_1 |
InParanoidi | Q4VAA2 |
OMAi | YREEDEW |
OrthoDBi | 1568537at2759 |
PhylomeDBi | Q4VAA2 |
TreeFami | TF315891 |
Family and domain databases
InterProi | View protein in InterPro IPR026806, CDV3 |
PANTHERi | PTHR16284, PTHR16284, 1 hit |
Pfami | View protein in Pfam PF15359, CDV3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q4VAA2-1) [UniParc]FASTAAdd to basket
Also known as: B
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAETEERSLD NFFAKRDKKK KKERSSRAAN AASGAGGSSA AAGSRPGDGG
60 70 80 90 100
SLGSGARSGD GGSLGSGSRS GDGGSSGSGA RSGDGGSSRS GDGGSAGPAG
110 120 130 140 150
KAITKDENEW KEFEQREVDY SGLRVQAMQI SEKEDDDNEK REDPGDNWEE
160 170 180 190 200
GGGGSGAEKS SGPWNKTAPV QAPPAPVTVT ETPEPAMPSG VYRPPGARLT
210 220 230 240 250
TTRKTPQGPP EIYSDTQFPS LQSTAKHVES RKDKEMEKSF EVVRHKNRDR
260 270 280
EEVSKNQALK LQLDNQYAVL ENQKYSHTQY S
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8WGL9 | F8WGL9_MOUSE | Protein CDV3 | Cdv3 | 109 | Annotation score: | ||
A0A087WNP6 | A0A087WNP6_MOUSE | Protein CDV3 | Cdv3 | 235 | Annotation score: | ||
A0A087WRM0 | A0A087WRM0_MOUSE | Protein CDV3 | Cdv3 | 154 | Annotation score: | ||
A0A087WS49 | A0A087WS49_MOUSE | Protein CDV3 | Cdv3 | 154 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 81 – 88 | Missing in AAH62156 (PubMed:15489334).Curated | 8 | |
Sequence conflicti | 216 | T → M in AAH96479 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 259 | L → F in AAH96479 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027762 | 232 – 236 | KDKEM → NRYLK in isoform 2. 1 Publication | 5 | |
Alternative sequenceiVSP_027763 | 237 – 281 | Missing in isoform 2. 1 PublicationAdd BLAST | 45 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF215660 mRNA Translation: AAL27860.1 AF320340 mRNA Translation: AAL30162.1 AF414107 , AF414103, AF414104, AF414105, AF414106 Genomic DNA Translation: AAL65134.1 AF414107 , AF414103, AF414104, AF414105, AF414106 Genomic DNA Translation: AAL65135.1 AB046372 mRNA Translation: BAB82988.1 BC052770 mRNA Translation: AAH52770.1 BC062156 mRNA Translation: AAH62156.1 BC096479 mRNA Translation: AAH96479.1 |
CCDSi | CCDS23454.1 [Q4VAA2-1] CCDS40748.1 [Q4VAA2-2] |
RefSeqi | NP_780774.1, NM_175565.3 [Q4VAA2-2] NP_787027.1, NM_175833.2 [Q4VAA2-1] |
Genome annotation databases
Ensembli | ENSMUST00000035484; ENSMUSP00000044420; ENSMUSG00000032803 [Q4VAA2-1] ENSMUST00000072249; ENSMUSP00000072101; ENSMUSG00000032803 [Q4VAA2-2] |
GeneIDi | 321022 |
KEGGi | mmu:321022 |
UCSCi | uc009rgo.1, mouse [Q4VAA2-1] uc009rgq.1, mouse [Q4VAA2-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF215660 mRNA Translation: AAL27860.1 AF320340 mRNA Translation: AAL30162.1 AF414107 , AF414103, AF414104, AF414105, AF414106 Genomic DNA Translation: AAL65134.1 AF414107 , AF414103, AF414104, AF414105, AF414106 Genomic DNA Translation: AAL65135.1 AB046372 mRNA Translation: BAB82988.1 BC052770 mRNA Translation: AAH52770.1 BC062156 mRNA Translation: AAH62156.1 BC096479 mRNA Translation: AAH96479.1 |
CCDSi | CCDS23454.1 [Q4VAA2-1] CCDS40748.1 [Q4VAA2-2] |
RefSeqi | NP_780774.1, NM_175565.3 [Q4VAA2-2] NP_787027.1, NM_175833.2 [Q4VAA2-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q4VAA2, 1 interactor |
STRINGi | 10090.ENSMUSP00000044420 |
PTM databases
iPTMneti | Q4VAA2 |
PhosphoSitePlusi | Q4VAA2 |
Proteomic databases
CPTACi | non-CPTAC-4022 |
EPDi | Q4VAA2 |
jPOSTi | Q4VAA2 |
PaxDbi | Q4VAA2 |
PeptideAtlasi | Q4VAA2 |
PRIDEi | Q4VAA2 |
Protocols and materials databases
Antibodypediai | 33371, 84 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000035484; ENSMUSP00000044420; ENSMUSG00000032803 [Q4VAA2-1] ENSMUST00000072249; ENSMUSP00000072101; ENSMUSG00000032803 [Q4VAA2-2] |
GeneIDi | 321022 |
KEGGi | mmu:321022 |
UCSCi | uc009rgo.1, mouse [Q4VAA2-1] uc009rgq.1, mouse [Q4VAA2-2] |
Organism-specific databases
CTDi | 55573 |
MGIi | MGI:2448759, Cdv3 |
Phylogenomic databases
eggNOGi | ENOG502QRFT, Eukaryota |
GeneTreei | ENSGT00390000000805 |
HOGENOMi | CLU_089760_1_0_1 |
InParanoidi | Q4VAA2 |
OMAi | YREEDEW |
OrthoDBi | 1568537at2759 |
PhylomeDBi | Q4VAA2 |
TreeFami | TF315891 |
Miscellaneous databases
BioGRID-ORCSi | 321022, 1 hit in 15 CRISPR screens |
ChiTaRSi | Cdv3, mouse |
PROi | PR:Q4VAA2 |
RNActi | Q4VAA2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032803, Expressed in primary oocyte and 309 other tissues |
ExpressionAtlasi | Q4VAA2, baseline and differential |
Genevisiblei | Q4VAA2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR026806, CDV3 |
PANTHERi | PTHR16284, PTHR16284, 1 hit |
Pfami | View protein in Pfam PF15359, CDV3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDV3_MOUSE | |
Accessioni | Q4VAA2Primary (citable) accession number: Q4VAA2 Secondary accession number(s): Q6P6L7, Q920C7, Q920I4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | September 11, 2007 | |
Last modified: | February 10, 2021 | |
This is version 107 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families