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Protein

Sister chromatid cohesion protein PDS5 homolog B

Gene

Pds5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1247 – 1259A.T hook 1Sequence analysisAdd BLAST13
DNA bindingi1285 – 1297A.T hook 2Sequence analysisAdd BLAST13
DNA bindingi1370 – 1382A.T hook 3Sequence analysisAdd BLAST13

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • DNA repair Source: GO_Central
  • enteric nervous system development Source: MGI
  • lens development in camera-type eye Source: MGI
  • mitotic sister chromatid cohesion Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • neuroblast migration Source: MGI
  • regulation of cell proliferation Source: MGI

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2467813 Separation of Sister Chromatids
R-MMU-2468052 Establishment of Sister Chromatid Cohesion
R-MMU-2470946 Cohesin Loading onto Chromatin
R-MMU-2500257 Resolution of Sister Chromatid Cohesion

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog B
Alternative name(s):
Androgen-induced proliferation inhibitor
Androgen-induced prostate proliferative shutoff-associated protein AS3
Gene namesi
Name:Pds5b
Synonyms:Aprin, As31 Publication, Kiaa0979Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2140945 Pds5b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874251 – 1446Sister chromatid cohesion protein PDS5 homolog BAdd BLAST1446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1136N6-acetyllysineCombined sources1
Modified residuei1140PhosphoserineBy similarity1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1166PhosphoserineCombined sources1
Modified residuei1176PhosphoserineCombined sources1
Modified residuei1182PhosphoserineCombined sources1
Modified residuei1191PhosphoserineBy similarity1
Modified residuei1253PhosphothreonineCombined sources1
Modified residuei1255PhosphoserineCombined sources1
Modified residuei1257PhosphoserineCombined sources1
Modified residuei1281PhosphoserineCombined sources1
Modified residuei1356PhosphoserineCombined sources1
Modified residuei1364PhosphoserineCombined sources1
Modified residuei1365PhosphothreonineBy similarity1
Modified residuei1367PhosphoserineCombined sources1
Modified residuei1368PhosphothreonineCombined sources1
Modified residuei1381PhosphoserineBy similarity1
Modified residuei1415PhosphoserineCombined sources1
Modified residuei1418PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ4VA53
PaxDbiQ4VA53
PeptideAtlasiQ4VA53
PRIDEiQ4VA53

PTM databases

iPTMnetiQ4VA53
PhosphoSitePlusiQ4VA53

Expressioni

Tissue specificityi

Expressed in prostate.1 Publication

Gene expression databases

BgeeiENSMUSG00000034021 Expressed in 275 organ(s), highest expression level in pes
ExpressionAtlasiQ4VA53 baseline and differential
GenevisibleiQ4VA53 MM

Interactioni

Subunit structurei

Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (By similarity).By similarity

Protein-protein interaction databases

BioGridi221515, 2 interactors
IntActiQ4VA53, 1 interactor
MINTiQ4VA53
STRINGi10090.ENSMUSP00000016569

Structurei

3D structure databases

ProteinModelPortaliQ4VA53
SMRiQ4VA53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati383 – 419HEATSequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the PDS5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1525 Eukaryota
ENOG410XQW7 LUCA
GeneTreeiENSGT00390000012488
HOVERGENiHBG108241
InParanoidiQ4VA53
KOiK11267
PhylomeDBiQ4VA53
TreeFamiTF106415

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039776 Pds5
PANTHERiPTHR12663 PTHR12663, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q4VA53-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE
60 70 80 90 100
EEKELYLNLA LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP
110 120 130 140 150
DKLKDIFMFI TRQLKGLEDT KSPQFNRYFY LLENIAWVKS YNICFELEDS
160 170 180 190 200
NEIFTQLYRT LFSVINNGHN QKVHMHMVDL MSSIICEGDT VSQELLDTVL
210 220 230 240 250
VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV LMLGKTSISD
260 270 280 290 300
LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF
310 320 330 340 350
GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD
360 370 380 390 400
LTEYLKVRSH DPEEAIRHDV IVSIVTAAKK DILLVNDHLL NFVRERTLDK
410 420 430 440 450
RWRVRKEAMM GLAQIYKKYS LQSAAGKDAA KQISWVKDKL LHIYYQNSID
460 470 480 490 500
DRLLVERIFA QYMVPHNLET TERMKCLYYL YATLDLNAVK ALNEMWKCQN
510 520 530 540 550
LLRHQVKDLL DLIKQPKTDA SVKAIFSKVM VITRNLPDPG KAQDFMKKFT
560 570 580 590 600
QVLEDDEKIR KQLEALVSPT CSCKQAEGCV REITKKLGNP KQPTNPFLEM
610 620 630 640 650
IKFLLERIAP VHIDTESISA LIKQVNKSID GTADDEDEGV PTDQAIRAGL
660 670 680 690 700
ELLKVLSFTH PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGSKIE
710 720 730 740 750
EDFPHIRSAL LPVLHHKSKK GPPRQAKYAI HCIHAIFSSK ETQFAQIFEP
760 770 780 790 800
LHKSLDPSNL EHLITPLVTI GHIALLAPDQ FAAPLKSLVA TFIVKDLLMN
810 820 830 840 850
DRLPGKKTTK LWVPDEEVSP ETMVKIQAIK MMVRWLLGMK NNHSKSGTST
860 870 880 890 900
LRLLTTILHS DGDLTEQGKI SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT
910 920 930 940 950
LEQYQLCALA INDECYQVRQ VFAQKLHKGL SRLRLPLEYM AICALCAKDP
960 970 980 990 1000
VKERRAHARQ CLVKNITVRR EYLKQHAAVS EKLLSLLPEY VVPYTIHLLA
1010 1020 1030 1040 1050
HDPDYVKVQD IEQLKDVKEC LWFVLEILMA KNENNSHAFI RKMVENIKQT
1060 1070 1080 1090 1100
KDAQGPDDTK MNEKLYTVCD VAMNIIMSKS TTYSLESPKD PVLPARFFTQ
1110 1120 1130 1140 1150
PDKNFSNTKN YLPPEMKSFF TPGKPKTANV LGAVNKPLSS AGKQSQTKSS
1160 1170 1180 1190 1200
RMETVSNASS SSNPSSPGRI KGRLDSSEMD HSENEDYTMS SPLPGKKSDK
1210 1220 1230 1240 1250
REDPDLSELE KPRSRKKAPV TDPEEKLGMD DLTKLVQEQK PKGSQRGRKR
1260 1270 1280 1290 1300
GRTASDSDEQ QWPEEKRHKE ELLENEDEQN SPPKKGKRGR PPKPLGGGTS
1310 1320 1330 1340 1350
KEEPTMKTSK KGNKKKLVPP VVDDDEEEER QIGNTEHKSK SKQHRTSKRA
1360 1370 1380 1390 1400
QQRAESPETS AVESTQSTPQ KGRGRPSKAP SPSQPPKKIR VGRSKQVATK
1410 1420 1430 1440
ENDSSEEMDV LQASSPVSDD TTQEGAEEED ISVGNVRRRS SKRERR
Length:1,446
Mass (Da):164,419
Last modified:July 5, 2005 - v1
Checksum:i3540041DE3C7FCBE
GO
Isoform 21 Publication (identifier: Q4VA53-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-529: Missing.
     1207-1230: SELEKPRSRKKAPVTDPEEKLGMD → VRVRCLVGRVMRLLIVIVLVIFAL
     1231-1446: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:701
Mass (Da):78,714
Checksum:iFAF6F0351AF7869B
GO
Isoform 31 Publication (identifier: Q4VA53-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1206-1206: L → LVR

Note: No experimental confirmation available.Curated
Show »
Length:1,448
Mass (Da):164,674
Checksum:i80CFDE441169F45E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHU5F8WHU5_MOUSE
Sister chromatid cohesion protein P...
Pds5b
1,449Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti496W → R in AAM52216 (Ref. 1) Curated1
Sequence conflicti966I → T in AAM52216 (Ref. 1) Curated1
Sequence conflicti978A → S in AAM52216 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0524031 – 529Missing in isoform 2. 1 PublicationAdd BLAST529
Alternative sequenceiVSP_0524041206L → LVR in isoform 3. 1 Publication1
Alternative sequenceiVSP_0524051207 – 1230SELEK…KLGMD → VRVRCLVGRVMRLLIVIVLV IFAL in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0524061231 – 1446Missing in isoform 2. 1 PublicationAdd BLAST216

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY102267 mRNA Translation: AAM52216.1
AK041682 mRNA Translation: BAC31031.1
AK045159 mRNA Translation: BAC32242.1
AK048706 mRNA Translation: BAC33427.1
AK164853 mRNA Translation: BAE37943.1
BC096539 mRNA Translation: AAH96539.1
AK122414 mRNA Translation: BAC65696.1
CCDSiCCDS39412.1 [Q4VA53-1]
CCDS85012.1 [Q4VA53-3]
RefSeqiNP_001333432.1, NM_001346503.1 [Q4VA53-3]
NP_780519.3, NM_175310.6 [Q4VA53-1]
UniGeneiMm.32959

Genome annotation databases

EnsembliENSMUST00000016569; ENSMUSP00000016569; ENSMUSG00000034021 [Q4VA53-1]
ENSMUST00000110486; ENSMUSP00000106112; ENSMUSG00000034021 [Q4VA53-2]
ENSMUST00000202170; ENSMUSP00000144572; ENSMUSG00000034021 [Q4VA53-3]
GeneIDi100710
KEGGimmu:100710
UCSCiuc009auh.2 mouse [Q4VA53-1]
uc009aui.1 mouse [Q4VA53-2]
uc009auj.2 mouse [Q4VA53-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY102267 mRNA Translation: AAM52216.1
AK041682 mRNA Translation: BAC31031.1
AK045159 mRNA Translation: BAC32242.1
AK048706 mRNA Translation: BAC33427.1
AK164853 mRNA Translation: BAE37943.1
BC096539 mRNA Translation: AAH96539.1
AK122414 mRNA Translation: BAC65696.1
CCDSiCCDS39412.1 [Q4VA53-1]
CCDS85012.1 [Q4VA53-3]
RefSeqiNP_001333432.1, NM_001346503.1 [Q4VA53-3]
NP_780519.3, NM_175310.6 [Q4VA53-1]
UniGeneiMm.32959

3D structure databases

ProteinModelPortaliQ4VA53
SMRiQ4VA53
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221515, 2 interactors
IntActiQ4VA53, 1 interactor
MINTiQ4VA53
STRINGi10090.ENSMUSP00000016569

PTM databases

iPTMnetiQ4VA53
PhosphoSitePlusiQ4VA53

Proteomic databases

EPDiQ4VA53
PaxDbiQ4VA53
PeptideAtlasiQ4VA53
PRIDEiQ4VA53

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016569; ENSMUSP00000016569; ENSMUSG00000034021 [Q4VA53-1]
ENSMUST00000110486; ENSMUSP00000106112; ENSMUSG00000034021 [Q4VA53-2]
ENSMUST00000202170; ENSMUSP00000144572; ENSMUSG00000034021 [Q4VA53-3]
GeneIDi100710
KEGGimmu:100710
UCSCiuc009auh.2 mouse [Q4VA53-1]
uc009aui.1 mouse [Q4VA53-2]
uc009auj.2 mouse [Q4VA53-3]

Organism-specific databases

CTDi23047
MGIiMGI:2140945 Pds5b
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1525 Eukaryota
ENOG410XQW7 LUCA
GeneTreeiENSGT00390000012488
HOVERGENiHBG108241
InParanoidiQ4VA53
KOiK11267
PhylomeDBiQ4VA53
TreeFamiTF106415

Enzyme and pathway databases

ReactomeiR-MMU-2467813 Separation of Sister Chromatids
R-MMU-2468052 Establishment of Sister Chromatid Cohesion
R-MMU-2470946 Cohesin Loading onto Chromatin
R-MMU-2500257 Resolution of Sister Chromatid Cohesion

Miscellaneous databases

PROiPR:Q4VA53
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034021 Expressed in 275 organ(s), highest expression level in pes
ExpressionAtlasiQ4VA53 baseline and differential
GenevisibleiQ4VA53 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039776 Pds5
PANTHERiPTHR12663 PTHR12663, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDS5B_MOUSE
AccessioniPrimary (citable) accession number: Q4VA53
Secondary accession number(s): Q3TNZ4
, Q7TSS4, Q80TM8, Q8BJ18, Q8BLH6, Q8BX77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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