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Entry version 122 (12 Aug 2020)
Sequence version 1 (05 Jul 2005)
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Protein

Sister chromatid cohesion protein PDS5 homolog B

Gene

Pds5b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1247 – 1259A.T hook 1Sequence analysisAdd BLAST13
DNA bindingi1285 – 1297A.T hook 2Sequence analysisAdd BLAST13
DNA bindingi1370 – 1382A.T hook 3Sequence analysisAdd BLAST13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2467813, Separation of Sister Chromatids
R-MMU-2468052, Establishment of Sister Chromatid Cohesion
R-MMU-2470946, Cohesin Loading onto Chromatin
R-MMU-2500257, Resolution of Sister Chromatid Cohesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog B
Alternative name(s):
Androgen-induced proliferation inhibitor
Androgen-induced prostate proliferative shutoff-associated protein AS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pds5b
Synonyms:Aprin, As31 Publication, Kiaa0979Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2140945, Pds5b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002874251 – 1446Sister chromatid cohesion protein PDS5 homolog BAdd BLAST1446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1136N6-acetyllysineCombined sources1
Modified residuei1140PhosphoserineBy similarity1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1166PhosphoserineCombined sources1
Modified residuei1176PhosphoserineCombined sources1
Modified residuei1182PhosphoserineCombined sources1
Modified residuei1191PhosphoserineBy similarity1
Modified residuei1253PhosphothreonineCombined sources1
Modified residuei1255PhosphoserineCombined sources1
Modified residuei1257PhosphoserineCombined sources1
Modified residuei1281PhosphoserineCombined sources1
Modified residuei1356PhosphoserineCombined sources1
Modified residuei1364PhosphoserineCombined sources1
Modified residuei1365PhosphothreonineBy similarity1
Modified residuei1367PhosphoserineCombined sources1
Modified residuei1368PhosphothreonineCombined sources1
Modified residuei1381PhosphoserineBy similarity1
Modified residuei1415PhosphoserineCombined sources1
Modified residuei1418PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q4VA53

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q4VA53

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4VA53

PeptideAtlas

More...
PeptideAtlasi
Q4VA53

PRoteomics IDEntifications database

More...
PRIDEi
Q4VA53

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2716, 3 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q4VA53, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4VA53

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4VA53

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in prostate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034021, Expressed in pes and 288 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4VA53, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the cohesin complex.

Interacts with RAD21; the interaction is direct.

Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
221515, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q4VA53, 2 interactors

Molecular INTeraction database

More...
MINTi
Q4VA53

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000016569

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4VA53, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati383 – 419HEATSequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PDS5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1525, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157257

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004041_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4VA53

KEGG Orthology (KO)

More...
KOi
K11267

Identification of Orthologs from Complete Genome Data

More...
OMAi
VSCRECA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4VA53

TreeFam database of animal gene trees

More...
TreeFami
TF106415

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR039776, Pds5

The PANTHER Classification System

More...
PANTHERi
PTHR12663, PTHR12663, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q4VA53-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE
60 70 80 90 100
EEKELYLNLA LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP
110 120 130 140 150
DKLKDIFMFI TRQLKGLEDT KSPQFNRYFY LLENIAWVKS YNICFELEDS
160 170 180 190 200
NEIFTQLYRT LFSVINNGHN QKVHMHMVDL MSSIICEGDT VSQELLDTVL
210 220 230 240 250
VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV LMLGKTSISD
260 270 280 290 300
LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF
310 320 330 340 350
GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD
360 370 380 390 400
LTEYLKVRSH DPEEAIRHDV IVSIVTAAKK DILLVNDHLL NFVRERTLDK
410 420 430 440 450
RWRVRKEAMM GLAQIYKKYS LQSAAGKDAA KQISWVKDKL LHIYYQNSID
460 470 480 490 500
DRLLVERIFA QYMVPHNLET TERMKCLYYL YATLDLNAVK ALNEMWKCQN
510 520 530 540 550
LLRHQVKDLL DLIKQPKTDA SVKAIFSKVM VITRNLPDPG KAQDFMKKFT
560 570 580 590 600
QVLEDDEKIR KQLEALVSPT CSCKQAEGCV REITKKLGNP KQPTNPFLEM
610 620 630 640 650
IKFLLERIAP VHIDTESISA LIKQVNKSID GTADDEDEGV PTDQAIRAGL
660 670 680 690 700
ELLKVLSFTH PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGSKIE
710 720 730 740 750
EDFPHIRSAL LPVLHHKSKK GPPRQAKYAI HCIHAIFSSK ETQFAQIFEP
760 770 780 790 800
LHKSLDPSNL EHLITPLVTI GHIALLAPDQ FAAPLKSLVA TFIVKDLLMN
810 820 830 840 850
DRLPGKKTTK LWVPDEEVSP ETMVKIQAIK MMVRWLLGMK NNHSKSGTST
860 870 880 890 900
LRLLTTILHS DGDLTEQGKI SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT
910 920 930 940 950
LEQYQLCALA INDECYQVRQ VFAQKLHKGL SRLRLPLEYM AICALCAKDP
960 970 980 990 1000
VKERRAHARQ CLVKNITVRR EYLKQHAAVS EKLLSLLPEY VVPYTIHLLA
1010 1020 1030 1040 1050
HDPDYVKVQD IEQLKDVKEC LWFVLEILMA KNENNSHAFI RKMVENIKQT
1060 1070 1080 1090 1100
KDAQGPDDTK MNEKLYTVCD VAMNIIMSKS TTYSLESPKD PVLPARFFTQ
1110 1120 1130 1140 1150
PDKNFSNTKN YLPPEMKSFF TPGKPKTANV LGAVNKPLSS AGKQSQTKSS
1160 1170 1180 1190 1200
RMETVSNASS SSNPSSPGRI KGRLDSSEMD HSENEDYTMS SPLPGKKSDK
1210 1220 1230 1240 1250
REDPDLSELE KPRSRKKAPV TDPEEKLGMD DLTKLVQEQK PKGSQRGRKR
1260 1270 1280 1290 1300
GRTASDSDEQ QWPEEKRHKE ELLENEDEQN SPPKKGKRGR PPKPLGGGTS
1310 1320 1330 1340 1350
KEEPTMKTSK KGNKKKLVPP VVDDDEEEER QIGNTEHKSK SKQHRTSKRA
1360 1370 1380 1390 1400
QQRAESPETS AVESTQSTPQ KGRGRPSKAP SPSQPPKKIR VGRSKQVATK
1410 1420 1430 1440
ENDSSEEMDV LQASSPVSDD TTQEGAEEED ISVGNVRRRS SKRERR
Length:1,446
Mass (Da):164,419
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3540041DE3C7FCBE
GO
Isoform 21 Publication (identifier: Q4VA53-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-529: Missing.
     1207-1230: SELEKPRSRKKAPVTDPEEKLGMD → VRVRCLVGRVMRLLIVIVLVIFAL
     1231-1446: Missing.

Show »
Length:701
Mass (Da):78,714
Checksum:iFAF6F0351AF7869B
GO
Isoform 31 Publication (identifier: Q4VA53-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1206-1206: L → LVR

Show »
Length:1,448
Mass (Da):164,674
Checksum:i80CFDE441169F45E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHU5F8WHU5_MOUSE
Sister chromatid cohesion protein P...
Pds5b
1,449Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti496W → R in AAM52216 (Ref. 1) Curated1
Sequence conflicti966I → T in AAM52216 (Ref. 1) Curated1
Sequence conflicti978A → S in AAM52216 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0524031 – 529Missing in isoform 2. 1 PublicationAdd BLAST529
Alternative sequenceiVSP_0524041206L → LVR in isoform 3. 1 Publication1
Alternative sequenceiVSP_0524051207 – 1230SELEK…KLGMD → VRVRCLVGRVMRLLIVIVLV IFAL in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0524061231 – 1446Missing in isoform 2. 1 PublicationAdd BLAST216

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY102267 mRNA Translation: AAM52216.1
AK041682 mRNA Translation: BAC31031.1
AK045159 mRNA Translation: BAC32242.1
AK048706 mRNA Translation: BAC33427.1
AK164853 mRNA Translation: BAE37943.1
BC096539 mRNA Translation: AAH96539.1
AK122414 mRNA Translation: BAC65696.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39412.1 [Q4VA53-1]
CCDS85012.1 [Q4VA53-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001333432.1, NM_001346503.1 [Q4VA53-3]
NP_780519.3, NM_175310.6 [Q4VA53-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000016569; ENSMUSP00000016569; ENSMUSG00000034021 [Q4VA53-1]
ENSMUST00000110486; ENSMUSP00000106112; ENSMUSG00000034021 [Q4VA53-2]
ENSMUST00000202170; ENSMUSP00000144572; ENSMUSG00000034021 [Q4VA53-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
100710

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:100710

UCSC genome browser

More...
UCSCi
uc009auh.2, mouse [Q4VA53-1]
uc009aui.1, mouse [Q4VA53-2]
uc009auj.2, mouse [Q4VA53-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY102267 mRNA Translation: AAM52216.1
AK041682 mRNA Translation: BAC31031.1
AK045159 mRNA Translation: BAC32242.1
AK048706 mRNA Translation: BAC33427.1
AK164853 mRNA Translation: BAE37943.1
BC096539 mRNA Translation: AAH96539.1
AK122414 mRNA Translation: BAC65696.1
CCDSiCCDS39412.1 [Q4VA53-1]
CCDS85012.1 [Q4VA53-3]
RefSeqiNP_001333432.1, NM_001346503.1 [Q4VA53-3]
NP_780519.3, NM_175310.6 [Q4VA53-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi221515, 6 interactors
IntActiQ4VA53, 2 interactors
MINTiQ4VA53
STRINGi10090.ENSMUSP00000016569

PTM databases

GlyConnecti2716, 3 N-Linked glycans (1 site)
GlyGeniQ4VA53, 1 site
iPTMnetiQ4VA53
PhosphoSitePlusiQ4VA53

Proteomic databases

EPDiQ4VA53
jPOSTiQ4VA53
PaxDbiQ4VA53
PeptideAtlasiQ4VA53
PRIDEiQ4VA53

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
22916, 154 antibodies

Genome annotation databases

EnsembliENSMUST00000016569; ENSMUSP00000016569; ENSMUSG00000034021 [Q4VA53-1]
ENSMUST00000110486; ENSMUSP00000106112; ENSMUSG00000034021 [Q4VA53-2]
ENSMUST00000202170; ENSMUSP00000144572; ENSMUSG00000034021 [Q4VA53-3]
GeneIDi100710
KEGGimmu:100710
UCSCiuc009auh.2, mouse [Q4VA53-1]
uc009aui.1, mouse [Q4VA53-2]
uc009auj.2, mouse [Q4VA53-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23047
MGIiMGI:2140945, Pds5b

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG1525, Eukaryota
GeneTreeiENSGT00940000157257
HOGENOMiCLU_004041_0_0_1
InParanoidiQ4VA53
KOiK11267
OMAiVSCRECA
PhylomeDBiQ4VA53
TreeFamiTF106415

Enzyme and pathway databases

ReactomeiR-MMU-2467813, Separation of Sister Chromatids
R-MMU-2468052, Establishment of Sister Chromatid Cohesion
R-MMU-2470946, Cohesin Loading onto Chromatin
R-MMU-2500257, Resolution of Sister Chromatid Cohesion

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
100710, 4 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Pds5b, mouse

Protein Ontology

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PROi
PR:Q4VA53
RNActiQ4VA53, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000034021, Expressed in pes and 288 other tissues
GenevisibleiQ4VA53, MM

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR039776, Pds5
PANTHERiPTHR12663, PTHR12663, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDS5B_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4VA53
Secondary accession number(s): Q3TNZ4
, Q7TSS4, Q80TM8, Q8BJ18, Q8BLH6, Q8BX77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2005
Last modified: August 12, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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