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Entry version 99 (26 Feb 2020)
Sequence version 1 (05 Jul 2005)
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Protein

Seizure 6-like protein 2

Gene

Sez6l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May contribute to specialized endoplasmic reticulum functions in neurons.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-977606 Regulation of Complement cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Seizure 6-like protein 2
Alternative name(s):
Brain-specific receptor-like protein A
Short name:
BSRP-A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sez6l2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385295 Sez6l2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 844ExtracellularSequence analysisAdd BLAST817
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei845 – 865HelicalSequence analysisAdd BLAST21
Topological domaini866 – 910CytoplasmicSequence analysisAdd BLAST45

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice lacking Sez6, Sez6l1, Sez6l2 exhibit motor discordination, and PCs are ofen innervated by multiple climbing fibers with different neuronal origins in the cerebellum.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27By similarityAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033388928 – 910Seizure 6-like protein 2Add BLAST883

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi173 ↔ 202By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi290 ↔ 330By similarity
Disulfide bondi316 ↔ 345By similarity
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi349 ↔ 376By similarity
Glycosylationi373N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi464 ↔ 508By similarity
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi491 ↔ 523By similarity
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi527 ↔ 553By similarity
Disulfide bondi644 ↔ 686By similarity
Disulfide bondi672 ↔ 699By similarity
Disulfide bondi705 ↔ 747By similarity
Disulfide bondi733 ↔ 764By similarity
Disulfide bondi771 ↔ 813By similarity
Disulfide bondi799 ↔ 828By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4V9Z5

PeptideAtlas

More...
PeptideAtlasi
Q4V9Z5

PRoteomics IDEntifications database

More...
PRIDEi
Q4V9Z5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4V9Z5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4V9Z5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed exclusively in the brain, predominantly in the neurons. Wide expression in the gray matter of the brain with high levels in the olfactory bulb, anterior olfactory nuclei, hippocampal formation and cerebellar cortex. Detected diffusely and weakly in the white matter, such as the corpus callosum and cerebellar medulla. In the cerebellar cortex, intensely expressed in Purkinje cells (PC) and granule cells. Detected also in interneurons in the molecular layer. Up-regulated at two weeks after birth.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030683 Expressed in pituitary gland and 168 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4V9Z5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4V9Z5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q4V9Z5, 2 interactors

Molecular INTeraction database

More...
MINTi
Q4V9Z5

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101940

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4V9Z5 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini173 – 286CUB 1PROSITE-ProRule annotationAdd BLAST114
Domaini288 – 347Sushi 1PROSITE-ProRule annotationAdd BLAST60
Domaini349 – 459CUB 2PROSITE-ProRule annotationAdd BLAST111
Domaini462 – 525Sushi 2PROSITE-ProRule annotationAdd BLAST64
Domaini527 – 638CUB 3PROSITE-ProRule annotationAdd BLAST112
Domaini642 – 701Sushi 3PROSITE-ProRule annotationAdd BLAST60
Domaini703 – 766Sushi 4PROSITE-ProRule annotationAdd BLAST64
Domaini769 – 830Sushi 5PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi70 – 146Pro-richAdd BLAST77
Compositional biasi153 – 168Thr-richAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEZ6 family.Curated

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJTP Eukaryota
ENOG410ZD9C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160492

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011474_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4V9Z5

Identification of Orthologs from Complete Genome Data

More...
OMAi
WDLSWSN

Database of Orthologous Groups

More...
OrthoDBi
126806at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4V9Z5

TreeFam database of animal gene trees

More...
TreeFami
TF330037

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033 CCP, 5 hits
cd00041 CUB, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 1 hit
PF00084 Sushi, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032 CCP, 5 hits
SM00042 CUB, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854 SSF49854, 3 hits
SSF57535 SSF57535, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180 CUB, 3 hits
PS50923 SUSHI, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Named isoforms=3.

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4V9Z5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTPKAQHPP PSQLLLLILL SCAWIEGLPL KEDEMMPEPG SETPTVASED
60 70 80 90 100
LAELLHGALL RKGPEIGFLP GSDPDPTLAT PPAGQTLAAP SLPRATEPGT
110 120 130 140 150
GPLTTAVTPK GVRGAGPTAP ELLTPPPGTT APPPPGPASP VPPLRPEGGE
160 170 180 190 200
EETTTTIITT TTVTTTVTSP VLCNNNISEG EGFVESPDLG STASRSVELL
210 220 230 240 250
DCTYSIHVYP GYGIEIQVQT LNLSQEEELL VLAGGGSPGL APRLLANSSM
260 270 280 290 300
LGEGQVLRSP TNRLLLHFQS PRVPRGNGFR IHYQAYLLSC GFPPRPAHGD
310 320 330 340 350
VSVTDLHPGG TATFHCDSGY QLQGEETLIC LNGTRPAWTG EPPSCTASCG
360 370 380 390 400
GTIHNATLGR IVSPEPGGAA GPNLTCRWVI EAAEGRRLHL HFERVSLDED
410 420 430 440 450
NDRLMVRSGG SPLSPVIYDS DMDDVPERGL ISDAQSLYVE LLSETPANPL
460 470 480 490 500
LLSLRFEAFE EDRCFPPFLA HGNVTTTDPE FHPGALATFS CLPGYALEPP
510 520 530 540 550
GPPNAIECVD PTEPHWNDTE PACKAMCGGE LSEPAGVVLS PDWPQSYSPG
560 570 580 590 600
QDCVWGLHVQ EEKRILLQVE ILNVREGDML TLFDGDGPSA RVLAQLRGPQ
610 620 630 640 650
PRRRLLSSGP DLTLQFQAPP GPPNPGLGQG FVLHFKEVPR NDTCPELPPP
660 670 680 690 700
EWGWRTASHG DLIRGTVLTY QCEPGYELLG SDILTCQWDL SWSAAPPACQ
710 720 730 740 750
KIMTCADPGE ITNGHRTASD AGFPVGSHVQ YRCLPGYSLE GAAVLTCYSR
760 770 780 790 800
DTGTPKWSDR VPKCALKYEP CLNPGVPENG YQTLYKHHYQ AGESLRFFCY
810 820 830 840 850
EGFELIGEVT ITCVPGHPSQ WTSQPPLCKV TQTTDPSRQL EGGNLALAIL
860 870 880 890 900
LPLGLVIVLG IGVYIYYTKL QGKSLFGFSG SHSYSPITVE SDFSNPLYEA
910
GDTREYEVSI
Length:910
Mass (Da):97,504
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F58777166A6AA1F
GO
Isoform 2 (identifier: Q4V9Z5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     830-830: V → VAYEELLDNRKLEV

Show »
Length:923
Mass (Da):99,078
Checksum:iDD15A1DF50848889
GO
Isoform 3 (identifier: Q4V9Z5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-130: Missing.
     830-830: V → VAYEELLDNRKLEV

Show »
Length:863
Mass (Da):93,371
Checksum:i82AC231639C0EB75
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YY14D3YY14_MOUSE
Seizure 6-like protein 2
Sez6l2
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RNQ8A0A0U1RNQ8_MOUSE
Seizure 6-like protein 2
Sez6l2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPR3A0A0U1RPR3_MOUSE
Seizure 6-like protein 2
Sez6l2
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03359871 – 130Missing in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_033599830V → VAYEELLDNRKLEV in isoform 2 and isoform 3. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK034088 mRNA Translation: BAC28579.1
AB206789 mRNA Translation: BAE44442.1
BC011475 mRNA Translation: AAH11475.1
BC079573 mRNA Translation: AAH79573.1
BC096615 mRNA Translation: AAH96615.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40135.1 [Q4V9Z5-2]
CCDS57585.1 [Q4V9Z5-1]
CCDS57586.1 [Q4V9Z5-3]

NCBI Reference Sequences

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RefSeqi
NP_001239495.1, NM_001252566.1 [Q4V9Z5-1]
NP_001239496.1, NM_001252567.1 [Q4V9Z5-3]
NP_659175.1, NM_144926.5 [Q4V9Z5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000106333; ENSMUSP00000101940; ENSMUSG00000030683 [Q4V9Z5-2]
ENSMUST00000106335; ENSMUSP00000101942; ENSMUSG00000030683 [Q4V9Z5-1]
ENSMUST00000106332; ENSMUSP00000101939; ENSMUSG00000030683 [Q4V9Z5-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
233878

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:233878

UCSC genome browser

More...
UCSCi
uc009jtq.2 mouse [Q4V9Z5-2]
uc009jtr.2 mouse [Q4V9Z5-1]
uc012ftx.2 mouse [Q4V9Z5-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034088 mRNA Translation: BAC28579.1
AB206789 mRNA Translation: BAE44442.1
BC011475 mRNA Translation: AAH11475.1
BC079573 mRNA Translation: AAH79573.1
BC096615 mRNA Translation: AAH96615.1
CCDSiCCDS40135.1 [Q4V9Z5-2]
CCDS57585.1 [Q4V9Z5-1]
CCDS57586.1 [Q4V9Z5-3]
RefSeqiNP_001239495.1, NM_001252566.1 [Q4V9Z5-1]
NP_001239496.1, NM_001252567.1 [Q4V9Z5-3]
NP_659175.1, NM_144926.5 [Q4V9Z5-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ4V9Z5, 2 interactors
MINTiQ4V9Z5
STRINGi10090.ENSMUSP00000101940

PTM databases

iPTMnetiQ4V9Z5
PhosphoSitePlusiQ4V9Z5

Proteomic databases

PaxDbiQ4V9Z5
PeptideAtlasiQ4V9Z5
PRIDEiQ4V9Z5

Genome annotation databases

EnsembliENSMUST00000106333; ENSMUSP00000101940; ENSMUSG00000030683 [Q4V9Z5-2]
ENSMUST00000106335; ENSMUSP00000101942; ENSMUSG00000030683 [Q4V9Z5-1]
ENSMUST00000106332; ENSMUSP00000101939; ENSMUSG00000030683 [Q4V9Z5-3]
GeneIDi233878
KEGGimmu:233878
UCSCiuc009jtq.2 mouse [Q4V9Z5-2]
uc009jtr.2 mouse [Q4V9Z5-1]
uc012ftx.2 mouse [Q4V9Z5-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26470
MGIiMGI:2385295 Sez6l2

Phylogenomic databases

eggNOGiENOG410IJTP Eukaryota
ENOG410ZD9C LUCA
GeneTreeiENSGT00940000160492
HOGENOMiCLU_011474_3_0_1
InParanoidiQ4V9Z5
OMAiWDLSWSN
OrthoDBi126806at2759
PhylomeDBiQ4V9Z5
TreeFamiTF330037

Enzyme and pathway databases

ReactomeiR-MMU-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Sez6l2 mouse

Protein Ontology

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PROi
PR:Q4V9Z5
RNActiQ4V9Z5 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000030683 Expressed in pituitary gland and 168 other tissues
ExpressionAtlasiQ4V9Z5 baseline and differential
GenevisibleiQ4V9Z5 MM

Family and domain databases

CDDicd00033 CCP, 5 hits
cd00041 CUB, 3 hits
Gene3Di2.60.120.290, 3 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431 CUB, 1 hit
PF00084 Sushi, 5 hits
SMARTiView protein in SMART
SM00032 CCP, 5 hits
SM00042 CUB, 3 hits
SUPFAMiSSF49854 SSF49854, 3 hits
SSF57535 SSF57535, 5 hits
PROSITEiView protein in PROSITE
PS01180 CUB, 3 hits
PS50923 SUSHI, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSE6L2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4V9Z5
Secondary accession number(s): Q6AXF9, Q91X64
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2005
Last modified: February 26, 2020
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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