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Protein

S-adenosylmethionine mitochondrial carrier protein

Gene

slc25a26

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-DRE-425393 Transport of inorganic cations/anions and amino acids/oligopeptides

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine mitochondrial carrier protein
Alternative name(s):
Mitochondrial S-adenosylmethionine transporter
Solute carrier family 25 member 26
Gene namesi
Name:slc25a26
Synonyms:samc
ORF Names:zgc:110080
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 11

Organism-specific databases

ZFINiZDB-GENE-050913-126 slc25a26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei49 – 69Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003175891 – 267S-adenosylmethionine mitochondrial carrier proteinAdd BLAST267

Proteomic databases

PaxDbiQ4V9P0

Expressioni

Gene expression databases

BgeeiENSDARG00000058208
ExpressionAtlasiQ4V9P0 baseline

Structurei

3D structure databases

ProteinModelPortaliQ4V9P0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 77Solcar 1Add BLAST74
Repeati86 – 168Solcar 2Add BLAST83
Repeati177 – 265Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0768 Eukaryota
ENOG4110BII LUCA
GeneTreeiENSGT00550000074950
HOGENOMiHOG000038810
HOVERGENiHBG108456
InParanoidiQ4V9P0
KOiK15111
OMAiLKTRVML
OrthoDBiEOG091G0G6Z
PhylomeDBiQ4V9P0
TreeFamiTF313186

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 4 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q4V9P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRREFTASL VAGGCAGMCV DLTLFPLDTI KTRLQSQQGF YKAGGFRGIY
60 70 80 90 100
AGVPSAAIGS FPNAAAFFVT YESTKSVFSG YTTTNLAPIT HMLAASLGEI
110 120 130 140 150
VACLIRVPTE VVKQRTQANP SISTYRVLLN SLQEEGFRGL YRGYGSTVLR
160 170 180 190 200
EIPFSLVQFP LWEYLKAVWW RRQGGRLDSW QAAVCGALAG GVAAFVTTPL
210 220 230 240 250
DVAKTWIMLA KAGTSTASGN IPMVLCEVWR SRGIPGLFAG SIPRVMFISM
260
GGFIFLGAYE KVRRTLL
Length:267
Mass (Da):28,995
Last modified:July 5, 2005 - v1
Checksum:iB7DF20E0D64E0813
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC096793 mRNA Translation: AAH96793.1
BC153538 mRNA Translation: AAI53539.1
RefSeqiNP_001025314.1, NM_001030143.1
UniGeneiDr.80000

Genome annotation databases

EnsembliENSDART00000081035; ENSDARP00000075478; ENSDARG00000058208
GeneIDi560478
KEGGidre:560478

Similar proteinsi

Entry informationi

Entry nameiSAMC_DANRE
AccessioniPrimary (citable) accession number: Q4V9P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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