Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Receptor-interacting serine/threonine-protein kinase 2

Gene

ripk2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57ATPUniRule annotation1
Active sitei156Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 42ATPUniRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • CARD domain binding Source: ZFIN
  • protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  • adaptive immune response Source: UniProtKB-UniRule
  • defense response to bacterium Source: ZFIN
  • defense response to virus Source: ZFIN
  • innate immune response Source: UniProtKB-KW
  • positive regulation of apoptotic process Source: InterPro
  • regulation of transcription, DNA-templated Source: ZFIN

Keywordsi

Molecular functionKinase, ReceptorImported, Serine/threonine-protein kinaseUniRule annotation, Transferase
Biological processAdaptive immunityUniRule annotation, Immunity, Innate immunityUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-interacting serine/threonine-protein kinase 2UniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Tyrosine-protein kinase RIPK2UniRule annotation
Gene namesi
Name:ripk2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030902-3 ripk2

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.UniRule annotation

GO - Molecular functioni

  • CARD domain binding Source: ZFIN

Structurei

3D structure databases

ProteinModelPortaliQ4V958
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 304Protein kinaseInterPro annotationAdd BLAST277
Domaini465 – 557CARDInterPro annotationAdd BLAST93

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0192 Eukaryota
COG0515 LUCA
HOGENOMiHOG000136856
HOVERGENiHBG054242
KOiK08846

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017322 Rcpt-int_Ser/Thr_kinase-2
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF00069 Pkinase, 1 hit
PIRSFiPIRSF037921 STPK_RIP2, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q4V958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRNMEHTGC VNICSLTSTL PVIPYRKLTD LHYISKGGFG TVFRAQHSDW
60 70 80 90 100
RTTVAIKCLK LDSPVGERER NCLLKEAEVL HKARFNHIIQ IFGVCNEPEF
110 120 130 140 150
FCIITEYMTN GSLDELLHEK DIYPAVAWPL RLRILYEIAL GVNFLHNMSP
160 170 180 190 200
PLLHHDLKTQ NILMDGEYHV KIADFGLSKW RQLSITKGSG SKPAEMGGTV
210 220 230 240 250
IYMPPEEYEP SKTRRTDVKY DMYSYAIIMW EVLSRRIPFE EATNPMQIMF
260 270 280 290 300
SVLRGARPDT GLDSLPVDIP SRETLINLMT SGWTANPDER PSFLHCLIEL
310 320 330 340 350
EPMLRRFDEI DVLEAVLEVK RIKYRRPSSC CSSTQSNGKK IEEKCVKELN
360 370 380 390 400
VPWPDNSSTS GSGSCSSQEA EISQPGFLTI STPSQGAYAG LPSSLMSLPL
410 420 430 440 450
DPPKPLMDNC SPNNLSPEYQ TAQVVSDLNI PFKAHAPHSE SELALAIQPL
460 470 480 490 500
TLHPHPQDFV TAFDDQGPAA RWIAARREEV VRQMTEACLN QSLDALLSRE
510 520 530 540 550
LLMREDYELV VNQTTRTAKV RKLLDTCERH SEEFCRVVVR KLQDNKQMGL
560 570 580
QPYPDLSTTS SPPSPYVAPS APFLSNSFNN TRNF
Length:584
Mass (Da):65,951
Last modified:July 5, 2005 - v1
Checksum:i147A224AC5535C8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097049 mRNA Translation: AAH97049.1
RefSeqiNP_919392.2, NM_194411.2
UniGeneiDr.150902

Genome annotation databases

GeneIDi373874
KEGGidre:373874

Similar proteinsi

Entry informationi

Entry nameiQ4V958_DANRE
AccessioniPrimary (citable) accession number: Q4V958
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: February 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health