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Entry version 127 (07 Oct 2020)
Sequence version 1 (05 Jul 2005)
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Protein
Submitted name:

Serine peptidase inhibitor, Kunitz type 1

Gene

Spint1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: RGD

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-6806942, MET Receptor Activation
R-RNO-8852405, Signaling by MST1

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I02.007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Serine peptidase inhibitor, Kunitz type 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Spint1Imported
ORF Names:rCG_26836Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
1303138, Spint1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei444 – 466HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501430945030 – 507Sequence analysisAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi313 ↔ 325PROSITE-ProRule annotation
Disulfide bondi320 ↔ 338PROSITE-ProRule annotation
Disulfide bondi332 ↔ 347PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q4V8Q2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000012811, Expressed in jejunum and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000017223

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 134MANSCInterPro annotationAdd BLAST84
Domaini244 – 294BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51
Domaini369 – 419BPTI/Kunitz inhibitorInterPro annotationAdd BLAST51

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4295, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161683

KEGG Orthology (KO)

More...
KOi
K15619

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRKGFHR

Database of Orthologous Groups

More...
OrthoDBi
687721at2759

TreeFam database of animal gene trees

More...
TreeFami
TF325867

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00109, KU, 2 hits
cd00112, LDLa, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
4.10.400.10, 1 hit
4.10.410.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR013980, MANSC_dom
IPR011106, MANSC_N
IPR020901, Prtase_inh_Kunz-CS
IPR042482, Spint1

The PANTHER Classification System

More...
PANTHERi
PTHR46750, PTHR46750, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00014, Kunitz_BPTI, 2 hits
PF00057, Ldl_recept_a, 1 hit
PF07502, MANEC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00759, BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00131, KU, 2 hits
SM00192, LDLa, 1 hit
SM00765, MANEC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57362, SSF57362, 2 hits
SSF57424, SSF57424, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280, BPTI_KUNITZ_1, 2 hits
PS50279, BPTI_KUNITZ_2, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS50986, MANSC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4V8Q2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARRLAQAS ISTVCVWLLC ALGLQGTETE LPSAPPEFSG GAACLNRFTS
60 70 80 90 100
GVPAFVLDTE ASVSNGATFL GSPTVHRGWD CVRACCTTQN CNLALVELQP
110 120 130 140 150
DGGEDAISAC FLMNCLYEQN FVCKFAPKDG FINYLTQDLY NSYRELRTRG
160 170 180 190 200
FGGSRIPRIW MGIDLKVQLQ KPLVLRDADN TDWHLLQGDQ DVSVKRNHPE
210 220 230 240 250
EVELWGLKEG TYLFQLTRTD SDQLEETVNL TITVLTAEQT EDYCLASYKV
260 270 280 290 300
GRCRGSFPRW YYDPKEQICK SFTFGGCLGN KNNYLREEEC MLACKDVKGI
310 320 330 340 350
SPKRHHPVCT GSCHSTQFQC SNGCCIDGFL ECDDTPDCPD GSDEATCEKY
360 370 380 390 400
SSGFDELQSI HFLSDKGYCA ELPDTGFCKE NIPRWYYNPF SERCARFTYG
410 420 430 440 450
GCYGNKNNFE KEQQCLESCR GISKKDVFGL RRESSVPSAG SVEVAIAVLL
460 470 480 490 500
AVCIIVVLTI LGYCFFKNQK KNFHSPLHQP PPTPASSTVS TTEDTEHLVY

NHTTQPL
Length:507
Mass (Da):56,498
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3824D1E70C513D7E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC132987 Genomic DNA No translation available.
BC097253 mRNA Translation: AAH97253.1
CH473949 Genomic DNA Translation: EDL79898.1

NCBI Reference Sequences

More...
RefSeqi
NP_001004265.2, NM_001004265.2
XP_006234825.1, XM_006234763.2
XP_006234826.1, XM_006234764.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000017223; ENSRNOP00000017223; ENSRNOG00000012811
ENSRNOT00000088870; ENSRNOP00000069737; ENSRNOG00000012811

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
311331

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:311331

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132987 Genomic DNA No translation available.
BC097253 mRNA Translation: AAH97253.1
CH473949 Genomic DNA Translation: EDL79898.1
RefSeqiNP_001004265.2, NM_001004265.2
XP_006234825.1, XM_006234763.2
XP_006234826.1, XM_006234764.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017223

Protein family/group databases

MEROPSiI02.007

Proteomic databases

PRIDEiQ4V8Q2

Genome annotation databases

EnsembliENSRNOT00000017223; ENSRNOP00000017223; ENSRNOG00000012811
ENSRNOT00000088870; ENSRNOP00000069737; ENSRNOG00000012811
GeneIDi311331
KEGGirno:311331

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6692
RGDi1303138, Spint1

Phylogenomic databases

eggNOGiKOG4295, Eukaryota
GeneTreeiENSGT00940000161683
KOiK15619
OMAiQRKGFHR
OrthoDBi687721at2759
TreeFamiTF325867

Enzyme and pathway databases

ReactomeiR-RNO-6806942, MET Receptor Activation
R-RNO-8852405, Signaling by MST1

Gene expression databases

BgeeiENSRNOG00000012811, Expressed in jejunum and 21 other tissues

Family and domain databases

CDDicd00109, KU, 2 hits
cd00112, LDLa, 1 hit
Gene3Di2.60.40.10, 1 hit
4.10.400.10, 1 hit
4.10.410.10, 2 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR002223, Kunitz_BPTI
IPR036880, Kunitz_BPTI_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR013980, MANSC_dom
IPR011106, MANSC_N
IPR020901, Prtase_inh_Kunz-CS
IPR042482, Spint1
PANTHERiPTHR46750, PTHR46750, 1 hit
PfamiView protein in Pfam
PF00014, Kunitz_BPTI, 2 hits
PF00057, Ldl_recept_a, 1 hit
PF07502, MANEC, 1 hit
PRINTSiPR00759, BASICPTASE
SMARTiView protein in SMART
SM00131, KU, 2 hits
SM00192, LDLa, 1 hit
SM00765, MANEC, 1 hit
SUPFAMiSSF57362, SSF57362, 2 hits
SSF57424, SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS00280, BPTI_KUNITZ_1, 2 hits
PS50279, BPTI_KUNITZ_2, 2 hits
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 1 hit
PS50986, MANSC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4V8Q2_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4V8Q2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: October 7, 2020
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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