Transcription factor AP-2, gamma

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGD
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription factor activity Source: RGD
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
• sequence-specific double-stranded DNA binding Source: RGD

GO - Biological processⁱ

• anatomical structure development Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: RGD
• cerebral cortex development Source: RGD
• dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis Source: RGD
• epithelial cell proliferation involved in mammary gland duct elongation Source: RGD
• forebrain neuron fate commitment Source: RGD
• germ-line stem cell population maintenance Source: RGD
• hair follicle development Source: RGD
• keratinocyte development Source: RGD
• male gonad development Source: RGD
• positive regulation of transcription by RNA polymerase II Source: RGD
• regulation of cell population proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of epidermis development Source: RGD
• regulation of gene expression, epigenetic Source: RGD
• regulation of transcription, DNA-templated Source: RGD
• regulation of transcription by RNA polymerase II Source: RGD
• sebaceous gland development Source: RGD
• skin development Source: RGD
• somatic stem cell population maintenance Source: RGD
• stem cell population maintenance Source: RGD
• trophectodermal cell differentiation Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MLWKITDNVK YEEDCEDRHD ASSNGNPRIP HLSSAGQHLY SPAPPLSHTG 
        60         70         80         90        100
VAEYQPPPYF PPPYQQLAYS QSADHYSHLG EAYAAAINPL HQPAPTGSQQ 
       110        120        130        140        150
QAWPGRQSQE GSSLASHHGR SAGLIPHISG LEGSAVSSRR EAYRRSDLLL 
       160        170        180        190        200
PHAHALEAAG LAENLGLHEM AHPIEEVQNV DDPHLLLHDQ TVIRKGPISM 
       210        220        230        240        250
TKNPLGLPCQ KDLVGAVMNP SEVFCSVPGR LSLLSSTSKY KVTVAEVQRR 
       260        270        280        290        300
LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT 
       310        320        330        340        350
LLTSLVEGEA VHLARDFAYV CEAEFPSKAV ADYLTRPHLG GRNEMAARKS 
       360        370        380        390        400
VLLAAQQVCK EFTDLLHQDR TPNGNSRPTP VLETNIQNCL SHFSLITHGF 
       410        420        430        440        450
GSQAICAAVS AVQNYIKEAL ITIDKSYMNP GEQSPADSNK TMEKMEKHRK 

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ