Tfap2c

Functionⁱ

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein dimerization activity Source: Ensembl
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

male gonad development Source: Ensembl
regulation of gene expression, epigenetic Source: Ensembl
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-RNO-3232118 SUMOylation of transcription factors R-RNO-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-RNO-8866907 Activation of the TFAP2 (AP-2) family of transcription factors R-RNO-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors

Reactomeⁱ

R-RNO-3232118 SUMOylation of transcription factors
R-RNO-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-RNO-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
R-RNO-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Transcription factor AP-2 gammaImported Submitted name: Transcription factor AP-2, gammaImported
Gene namesⁱ	Name:Tfap2cImported Synonyms:Tcfap2cImported ORF Names:rCG_40857Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 3

Organism-specific databases

Rat genome database More...RGDⁱ	1303185 Tfap2c

RGDⁱ

1303185 Tfap2c

Subcellular locationⁱ

GO - Cellular component

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000005246 Expressed in 3 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000005246 Expressed in 3 organ(s), highest expression level in brain

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000006991

STRINGⁱ

10116.ENSRNOP00000006991

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	224 – 418	TF_AP-2InterPro annotationAdd BLAST		195

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074577
HOGENOMⁱ	HOG000231737
HOVERGENⁱ	HBG002455
KEGG Orthology (KO) More...KOⁱ	K09177
OMAⁱ	RPHVERN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PR6

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR013854 TF_AP2_C IPR008123 TF_AP2_gamma
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01751 AP2CTNSCPFCT PR01748 AP2TNSCPFCT

Sequenceⁱ

Sequence statusⁱ: Complete.

Q4V8P9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLWKITDNVK YEEDCEDRHD ASSNGNPRIP HLSSAGQHLY SPAPPLSHTG 
        60         70         80         90        100
VAEYQPPPYF PPPYQQLAYS QSADHYSHLG EAYAAAINPL HQPAPTGSQQ 
       110        120        130        140        150
QAWPGRQSQE GSSLASHHGR SAGLIPHISG LEGSAVSSRR EAYRRSDLLL 
       160        170        180        190        200
PHAHALEAAG LAENLGLHEM AHPIEEVQNV DDPHLLLHDQ TVIRKGPISM 
       210        220        230        240        250
TKNPLGLPCQ KDLVGAVMNP SEVFCSVPGR LSLLSSTSKY KVTVAEVQRR 
       260        270        280        290        300
LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT 
       310        320        330        340        350
LLTSLVEGEA VHLARDFAYV CEAEFPSKAV ADYLTRPHLG GRNEMAARKS 
       360        370        380        390        400
VLLAAQQVCK EFTDLLHQDR TPNGNSRPTP VLETNIQNCL SHFSLITHGF 
       410        420        430        440        450
GSQAICAAVS AVQNYIKEAL ITIDKSYMNP GEQSPADSNK TMEKMEKHRK

Length:450

Mass (Da):49,098

Last modified:July 5, 2005 - v1

Checksum:ⁱB05330591EBBA16A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07054819 Genomic DNA No translation available. BC097260 mRNA Translation: AAH97260.1 CH474062 Genomic DNA Translation: EDL85139.1
NCBI Reference Sequences More...RefSeqⁱ	NP_958823.2, NM_201420.2
UniGeneⁱ	Rn.16142

Genome annotation databases

Ensemblⁱ	ENSRNOT00000006991; ENSRNOP00000006991; ENSRNOG00000005246
GeneIDⁱ	362280
KEGGⁱ	rno:362280

Protein	Similar proteins		Species	Score	Length	Source
Q4V8P9	Transcription factor AP-2 gamma		HUMAN		450	UniRef90_Q92754
Transcription factor AP-2 gamma		PANTR		450
Uncharacterized protein		PANPA		450
Transcription factor AP-2 gamma		GORGO		450
Transcription factor AP-2 gamma		CALJA		548
+103

Protein	Similar proteins		Species	Score	Length	Source
Q4V8P9	Transcription factor AP-2 gamma		HUMAN		450	UniRef50_Q92754
Transcription factor AP-2 gamma		PANTR		450
Uncharacterized protein		PANPA		450
Transcription factor AP-2 gamma		GORGO		450
Transcription factor AP-2 gamma		CALJA		548
+112

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR07054819 Genomic DNA No translation available. BC097260 mRNA Translation: AAH97260.1 CH474062 Genomic DNA Translation: EDL85139.1
RefSeqⁱ	NP_958823.2, NM_201420.2
UniGeneⁱ	Rn.16142

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000006991

STRINGⁱ

10116.ENSRNOP00000006991

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000006991; ENSRNOP00000006991; ENSRNOG00000005246
GeneIDⁱ	362280
KEGGⁱ	rno:362280

Organism-specific databases

CTDⁱ	7022
RGDⁱ	1303185 Tfap2c

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
GeneTreeⁱ	ENSGT00550000074577
HOGENOMⁱ	HOG000231737
HOVERGENⁱ	HBG002455
KOⁱ	K09177
OMAⁱ	RPHVERN
OrthoDBⁱ	EOG091G0PR6

Enzyme and pathway databases

Reactomeⁱ	R-RNO-3232118 SUMOylation of transcription factors R-RNO-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-RNO-8866907 Activation of the TFAP2 (AP-2) family of transcription factors R-RNO-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors

Reactomeⁱ

R-RNO-3232118 SUMOylation of transcription factors
R-RNO-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-RNO-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
R-RNO-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors

Gene expression databases

Bgeeⁱ	ENSRNOG00000005246 Expressed in 3 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000005246 Expressed in 3 organ(s), highest expression level in brain

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR013854 TF_AP2_C IPR008123 TF_AP2_gamma
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit
Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01751 AP2CTNSCPFCT PR01748 AP2TNSCPFCT
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q4V8P9_RAT
Accessionⁱ	Q4V8P9Primary (citable) accession number: Q4V8P9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 5, 2005
	Last sequence update:	July 5, 2005
	Last modified:	November 7, 2018
	This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q4V8P9 (Q4V8P9_RAT)

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Transcription factor AP-2 gamma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Nucleus

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ