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UniProtKB - Q4V8P9 (Q4V8P9_RAT)
Protein
Submitted name:
Transcription factor AP-2, gamma
Gene
Tfap2c
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- anatomical structure development Source: GO_Central
- cell differentiation Source: RGD
- cerebral cortex development Source: RGD
- dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis Source: RGD
- epithelial cell proliferation involved in mammary gland duct elongation Source: RGD
- forebrain neuron fate commitment Source: RGD
- germ-line stem cell population maintenance Source: RGD
- hair follicle development Source: RGD
- keratinocyte development Source: RGD
- male gonad development Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of cell population proliferation Source: GO_Central
- regulation of epidermis development Source: RGD
- regulation of gene expression, epigenetic Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: RGD
- sebaceous gland development Source: RGD
- skin development Source: RGD
- somatic stem cell population maintenance Source: RGD
- stem cell population maintenance Source: RGD
- trophectodermal cell differentiation Source: RGD
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Enzyme and pathway databases
Reactomei | R-RNO-3232118, SUMOylation of transcription factors R-RNO-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-RNO-8866907, Activation of the TFAP2 (AP-2) family of transcription factors R-RNO-8866911, TFAP2 (AP-2) family regulates transcription of cell cycle factors |
Names & Taxonomyi
Protein namesi | Submitted name: Transcription factor AP-2, gammaImported |
Gene namesi | ORF Names:rCG_40857Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Organism-specific databases
RGDi | 1303185, Tfap2c |
Subcellular locationi
Mitochondrion
- mitochondrion Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: RGD
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000005246, Expressed in esophagus and 7 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 224 – 419 | TF_AP-2InterPro annotationAdd BLAST | 196 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 13 – 58 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 90 – 126 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 427 – 450 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 92 – 116 | Polar residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the AP-2 family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_4_1_1 |
OMAi | EANIQGC |
OrthoDBi | 641707at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C IPR008123, TF_AP2_gamma |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01751, AP2CTNSCPFCT PR01748, AP2TNSCPFCT |
i Sequence
Sequence statusi: Complete.
Q4V8P9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLWKITDNVK YEEDCEDRHD ASSNGNPRIP HLSSAGQHLY SPAPPLSHTG
60 70 80 90 100
VAEYQPPPYF PPPYQQLAYS QSADHYSHLG EAYAAAINPL HQPAPTGSQQ
110 120 130 140 150
QAWPGRQSQE GSSLASHHGR SAGLIPHISG LEGSAVSSRR EAYRRSDLLL
160 170 180 190 200
PHAHALEAAG LAENLGLHEM AHPIEEVQNV DDPHLLLHDQ TVIRKGPISM
210 220 230 240 250
TKNPLGLPCQ KDLVGAVMNP SEVFCSVPGR LSLLSSTSKY KVTVAEVQRR
260 270 280 290 300
LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT
310 320 330 340 350
LLTSLVEGEA VHLARDFAYV CEAEFPSKAV ADYLTRPHLG GRNEMAARKS
360 370 380 390 400
VLLAAQQVCK EFTDLLHQDR TPNGNSRPTP VLETNIQNCL SHFSLITHGF
410 420 430 440 450
GSQAICAAVS AVQNYIKEAL ITIDKSYMNP GEQSPADSNK TMEKMEKHRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC097260 mRNA Translation: AAH97260.1 CH474062 Genomic DNA Translation: EDL85139.1 |
RefSeqi | NP_958823.2, NM_201420.2 |
Genome annotation databases
GeneIDi | 362280 |
KEGGi | rno:362280 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC097260 mRNA Translation: AAH97260.1 CH474062 Genomic DNA Translation: EDL85139.1 |
RefSeqi | NP_958823.2, NM_201420.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000006991 |
Genome annotation databases
GeneIDi | 362280 |
KEGGi | rno:362280 |
Organism-specific databases
CTDi | 7022 |
RGDi | 1303185, Tfap2c |
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_4_1_1 |
OMAi | EANIQGC |
OrthoDBi | 641707at2759 |
Enzyme and pathway databases
Reactomei | R-RNO-3232118, SUMOylation of transcription factors R-RNO-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-RNO-8866907, Activation of the TFAP2 (AP-2) family of transcription factors R-RNO-8866911, TFAP2 (AP-2) family regulates transcription of cell cycle factors |
Gene expression databases
Bgeei | ENSRNOG00000005246, Expressed in esophagus and 7 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C IPR008123, TF_AP2_gamma |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01751, AP2CTNSCPFCT PR01748, AP2TNSCPFCT |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4V8P9_RAT | |
Accessioni | Q4V8P9Primary (citable) accession number: Q4V8P9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2005 |
Last sequence update: | July 5, 2005 | |
Last modified: | May 25, 2022 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |