Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-catenin-like protein 1

Gene

Ctnnbl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-RNO-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-catenin-like protein 1
Alternative name(s):
Nuclear-associated protein
Short name:
NAP
Gene namesi
Name:Ctnnbl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1563558 Ctnnbl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002394501 – 563Beta-catenin-like protein 1Add BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei91N6-acetyllysineBy similarity1
Modified residuei389PhosphoserineBy similarity1
Modified residuei545PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ4V8K2
PRIDEiQ4V8K2

PTM databases

iPTMnetiQ4V8K2
PhosphoSitePlusiQ4V8K2

Expressioni

Gene expression databases

BgeeiENSRNOG00000012021
GenevisibleiQ4V8K2 RN

Interactioni

Subunit structurei

Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060192

Structurei

3D structure databases

SMRiQ4V8K2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati79 – 129HEAT 1Add BLAST51
Repeati134 – 176HEAT 2Add BLAST43
Repeati178 – 228ARM 1Add BLAST51
Repeati229 – 273ARM 2Add BLAST45
Repeati274 – 323ARM 3Add BLAST50
Repeati325 – 363ARM 4Add BLAST39
Repeati364 – 417ARM 5Add BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili476 – 540By similarityAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi16 – 33Nuclear localization signalBy similarityAdd BLAST18
Motifi130 – 140Nuclear export signal (NES)By similarityAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 25Poly-Glu4
Compositional biasi68 – 75Poly-Glu8

Domaini

The surface residues of the concave side of the superhelical ARM repeat region contribute to, but are not essential for NLS binding.By similarity

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2734 Eukaryota
ENOG410XPFW LUCA
GeneTreeiENSGT00390000006931
HOGENOMiHOG000186529
HOVERGENiHBG051212
InParanoidiQ4V8K2
KOiK12864
OMAiASMLRNC
OrthoDBiEOG091G05SE
PhylomeDBiQ4V8K2

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013180 CTNNBL1_N
PfamiView protein in Pfam
PF08216 CTNNBL, 1 hit
SMARTiView protein in SMART
SM01156 DUF1716, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Q4V8K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVGELLSYQ PNRGTKRPRD DEEEELKTRR KQTGPRERGR YREDEATAAE
60 70 80 90 100
DADDDKKRLL QIIDRDGEEE EEEEEPLDES SVKKMILTFE KRSYKNQELR
110 120 130 140 150
IKFPDNPEKF MESELDLNDI IQEMHVVATM PDLYHLLVEL SAVQSLLGLL
160 170 180 190 200
GHDNTDVSIA VVDLLQELTD IDTLHESEEG AEVLIDALVD GQVVALLVQN
210 220 230 240 250
LERLDESVRE EADGVHNTLA IVENMAEFRP EMCTEAAQQG LLQWLLKRLK
260 270 280 290 300
AKMPFDANKL YCSEVLAILL QDNDENRELL GELDGIDVLL QQLSVFKRHN
310 320 330 340 350
PSTAEEQEMM ENLFDALCSC LMLSSNRERF LKGEGLQLMN LMLREKKISR
360 370 380 390 400
SSALKVLDHA MIGPEGADNC HKFVDILGLR TIFPLFMKSP RKIKKVGTTE
410 420 430 440 450
KEHEEHVCSI LASLLRNLRG QQRTRLLNKF TENDSEKVDR LMELHFKYLG
460 470 480 490 500
AMQVADKKIE GEKHDIVRRG EIIDNDMEDE FYLRRLDAGL FILQHICYIM
510 520 530 540 550
AEICNANVPQ IRQRVHQILN MRGSSIKIVR HIIKEYAENI GDGRSPEFRE
560
TEQKRILGLL ENF
Length:563
Mass (Da):64,948
Last modified:July 5, 2005 - v1
Checksum:i7363EFB389CFFD80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097352 mRNA Translation: AAH97352.1
RefSeqiNP_001020041.1, NM_001024870.1
UniGeneiRn.98091

Genome annotation databases

EnsembliENSRNOT00000066808; ENSRNOP00000060192; ENSRNOG00000012021
GeneIDi296320
KEGGirno:296320
UCSCiRGD:1563558 rat

Similar proteinsi

Entry informationi

Entry nameiCTBL1_RAT
AccessioniPrimary (citable) accession number: Q4V8K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2005
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health