UniProtKB - Q4V8B0 (OXR1_RAT)
Protein
Oxidation resistance protein 1
Gene
Oxr1
Organism
Rattus norvegicus (Rat)
Status
Functioni
May be involved in protection from oxidative damage.By similarity
GO - Molecular functioni
- oxidoreductase activity Source: RGD
GO - Biological processi
- adult walking behavior Source: RGD
- cellular response to hydroperoxide Source: RGD
- negative regulation of cellular response to oxidative stress Source: RGD
- negative regulation of neuron apoptotic process Source: RGD
- negative regulation of oxidative stress-induced neuron death Source: RGD
- negative regulation of peptidyl-cysteine S-nitrosylation Source: RGD
- neuron apoptotic process Source: RGD
- response to oxidative stress Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Oxidation resistance protein 1Alternative name(s): Protein C7 |
Gene namesi | Name:Oxr1 Synonyms:C7 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621857, Oxr1 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000231647 | 1 – 839 | Oxidation resistance protein 1Add BLAST | 839 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 83 | PhosphoserineBy similarity | 1 | |
Modified residuei | 111 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 194 | PhosphoserineCombined sources | 1 | |
Modified residuei | 195 | PhosphoserineCombined sources | 1 | |
Modified residuei | 197 | PhosphoserineCombined sources | 1 | |
Modified residuei | 287 | PhosphoserineBy similarity | 1 | |
Modified residuei | 327 | PhosphoserineCombined sources | 1 | |
Modified residuei | 329 | PhosphoserineCombined sources | 1 | |
Modified residuei | 334 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 339 | PhosphoserineCombined sources | 1 | |
Modified residuei | 488 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q4V8B0 |
PRIDEi | Q4V8B0 |
PTM databases
iPTMneti | Q4V8B0 |
PhosphoSitePlusi | Q4V8B0 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000056487, Expressed in frontal cortex and 20 other tissues |
ExpressionAtlasi | Q4V8B0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 91 – 134 | LysMPROSITE-ProRule annotationAdd BLAST | 44 | |
Domaini | 206 – 261 | GRAMAdd BLAST | 56 | |
Domaini | 678 – 839 | TLDcPROSITE-ProRule annotationAdd BLAST | 162 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 543 – 570 | Mediates oxidative antimutator activityBy similarityAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 24 – 29 | Poly-Gly | 6 | |
Compositional biasi | 198 – 201 | Poly-Glu | 4 |
Sequence similaritiesi
Belongs to the OXR1 family.Curated
Phylogenomic databases
eggNOGi | KOG2372, Eukaryota |
GeneTreei | ENSGT00940000155187 |
InParanoidi | Q4V8B0 |
OrthoDBi | 767847at2759 |
PhylomeDBi | Q4V8B0 |
Family and domain databases
CDDi | cd00118, LysM, 1 hit |
Gene3Di | 3.10.350.10, 1 hit |
InterProi | View protein in InterPro IPR018392, LysM_dom IPR036779, LysM_dom_sf IPR006571, TLDc_dom |
Pfami | View protein in Pfam PF01476, LysM, 1 hit PF07534, TLD, 1 hit |
SMARTi | View protein in SMART SM00257, LysM, 1 hit SM00584, TLDc, 1 hit |
PROSITEi | View protein in PROSITE PS51782, LYSM, 1 hit PS51886, TLDC, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q4V8B0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDYLTTFTGK SGRLLRGTAS RLWGLGGGGE ARQVRFEDYL REPAPGDPGC
60 70 80 90 100
GPGELRPPSP TSPEGPDTGQ KKTLDKKDGR RMSFQKPKGT IEYTVESRDS
110 120 130 140 150
LNSIALKFDT TPNELVQLNK LFSRAVVTGQ VLYVPDPEYV SSVESSPSLS
160 170 180 190 200
PVSPLSPTSS EAEFDKTTTP DVVHPKEAPP SSTESSIRPA RVVSSTSEEE
210 220 230 240 250
EAFTEKFLKI NCKYITNGKG TVSGVLLVTP NNIMFDPHKT DPLVQENGCE
260 270 280 290 300
EYGIMCPMEE VMSAAMYKEI LDSKLKESLP IEVDQLSGRG FCHSKKMTGV
310 320 330 340 350
PAEETDSRSR DQGNDSVSTA PRSTEESLSE DVFTESELSP IREELPSSEL
360 370 380 390 400
RQEKSSDASS ESVQTVSQIE VESLTAASES ADVPDHTNAN SGRSSSEVGA
410 420 430 440 450
LSHETGLSSL EIATKEGDKA TGNLQEVSGP KEQSTDIKGQ DNQDSFHHEN
460 470 480 490 500
SLQQEAGEDS LSSGETVELT EKPTVLKDQQ GKELKRDSET EVEELRKLWK
510 520 530 540 550
THSMQQAKQQ RDTIQQVAQR ESKHRGAPAD AHGEGSSLLK EKRRHRLHKF
560 570 580 590 600
LCLRVGKPMR KTFVSQASAT MQQYAQRDKK HEYWFAVPQE RTDHLYAFFI
610 620 630 640 650
QWSPEIYAED TGEYTREPGF IVVKKMAESG PDEAPAGEAA AREWEITTRE
660 670 680 690 700
DINSKQAAPA KADLEPESFR PNLSDPSELL LPDQIEKLTK HLPPRTIGYP
710 720 730 740 750
WTLVYGTGKH GTSLKTLYRT MTGLDTPVLM VIKDSDGQVF GALASEPFKV
760 770 780 790 800
SDGFYGTGET FVFTFCPEFE VFKWTGDNMF FIKGDMDSLA FGGGGGEFAL
810 820 830
WLDGDLYHGR SHSCKTFGNH TLSKKEDFFI QDIEIWAFE
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K7Y2 | A0A0G2K7Y2_RAT | Oxidation resistance protein 1 | Oxr1 | 873 | Annotation score: | ||
A0A0G2KAL4 | A0A0G2KAL4_RAT | Oxidation resistance protein 1 | Oxr1 | 758 | Annotation score: | ||
A0A0G2JYS1 | A0A0G2JYS1_RAT | Oxidation resistance protein 1 | Oxr1 | 804 | Annotation score: | ||
A0A0G2JZ50 | A0A0G2JZ50_RAT | Oxidation resistance protein 1 | Oxr1 | 837 | Annotation score: |
Sequence cautioni
The sequence AAI66763 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017869 | 1 – 623 | Missing in isoform 3. 2 PublicationsAdd BLAST | 623 | |
Alternative sequenceiVSP_017870 | 1 – 510 | Missing in isoform 2. 1 PublicationAdd BLAST | 510 | |
Alternative sequenceiVSP_017871 | 511 – 645 | RDTIQ…AREWE → MEKAYTLIVFFLLLRLSFIL CGFPEATCFWRINHNEHLES NMRKDCGFILFTIPVHLVED HFRVLLDFPFPLRCAVCLAI LVSRNRILKEKQTAVLIVSD VLPMRFPTPQVVSVAEYHRR IDALNTEELRTLCRRLQ in isoform 2. 1 PublicationAdd BLAST | 135 | |
Alternative sequenceiVSP_017872 | 624 – 645 | KKMAE…AREWE → MSRLWYGKKGRRHQQVNHKY TL in isoform 3. 2 PublicationsAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF333986 mRNA Translation: AAK29401.1 AABR03055922 Genomic DNA No translation available. AABR03056092 Genomic DNA No translation available. AABR03059133 Genomic DNA No translation available. AABR03060217 Genomic DNA No translation available. BC081744 mRNA Translation: AAH81744.1 BC097465 mRNA Translation: AAH97465.1 BC166763 mRNA Translation: AAI66763.1 Different initiation. |
RefSeqi | NP_001184261.1, NM_001197332.1 [Q4V8B0-3] NP_476494.2, NM_057153.3 XP_017450109.1, XM_017594620.1 |
Genome annotation databases
Ensembli | ENSRNOT00000079962; ENSRNOP00000074353; ENSRNOG00000056487 [Q4V8B0-3] |
GeneIDi | 117520 |
KEGGi | rno:117520 |
UCSCi | RGD:621857, rat [Q4V8B0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF333986 mRNA Translation: AAK29401.1 AABR03055922 Genomic DNA No translation available. AABR03056092 Genomic DNA No translation available. AABR03059133 Genomic DNA No translation available. AABR03060217 Genomic DNA No translation available. BC081744 mRNA Translation: AAH81744.1 BC097465 mRNA Translation: AAH97465.1 BC166763 mRNA Translation: AAI66763.1 Different initiation. |
RefSeqi | NP_001184261.1, NM_001197332.1 [Q4V8B0-3] NP_476494.2, NM_057153.3 XP_017450109.1, XM_017594620.1 |
3D structure databases
SMRi | Q4V8B0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000010856 |
PTM databases
iPTMneti | Q4V8B0 |
PhosphoSitePlusi | Q4V8B0 |
Proteomic databases
PaxDbi | Q4V8B0 |
PRIDEi | Q4V8B0 |
Genome annotation databases
Ensembli | ENSRNOT00000079962; ENSRNOP00000074353; ENSRNOG00000056487 [Q4V8B0-3] |
GeneIDi | 117520 |
KEGGi | rno:117520 |
UCSCi | RGD:621857, rat [Q4V8B0-1] |
Organism-specific databases
CTDi | 55074 |
RGDi | 621857, Oxr1 |
Phylogenomic databases
eggNOGi | KOG2372, Eukaryota |
GeneTreei | ENSGT00940000155187 |
InParanoidi | Q4V8B0 |
OrthoDBi | 767847at2759 |
PhylomeDBi | Q4V8B0 |
Miscellaneous databases
PROi | PR:Q4V8B0 |
Gene expression databases
Bgeei | ENSRNOG00000056487, Expressed in frontal cortex and 20 other tissues |
ExpressionAtlasi | Q4V8B0, baseline and differential |
Family and domain databases
CDDi | cd00118, LysM, 1 hit |
Gene3Di | 3.10.350.10, 1 hit |
InterProi | View protein in InterPro IPR018392, LysM_dom IPR036779, LysM_dom_sf IPR006571, TLDc_dom |
Pfami | View protein in Pfam PF01476, LysM, 1 hit PF07534, TLD, 1 hit |
SMARTi | View protein in SMART SM00257, LysM, 1 hit SM00584, TLDc, 1 hit |
PROSITEi | View protein in PROSITE PS51782, LYSM, 1 hit PS51886, TLDC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OXR1_RAT | |
Accessioni | Q4V8B0Primary (citable) accession number: Q4V8B0 Secondary accession number(s): B2RYF9, Q99MK0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | April 20, 2010 | |
Last modified: | August 12, 2020 | |
This is version 101 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families