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UniProtKB - Q4V7Q6 (ULK3_XENLA)
Protein
Serine/threonine-protein kinase ULK3
Gene
ulk3
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy.
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 136 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 19 – 27 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
GO - Biological processi
- autophagy Source: UniProtKB-KW
- negative regulation of smoothened signaling pathway Source: UniProtKB
- positive regulation of smoothened signaling pathway Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Autophagy |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase ULK3 (EC:2.7.11.1)Alternative name(s): Unc-51-like kinase 3 |
Gene namesi | Name:ulk3 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-5958954, ulk3.L |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000250153 | 1 – 468 | Serine/threonine-protein kinase ULK3Add BLAST | 468 |
Proteomic databases
MaxQBi | Q4V7Q6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 269 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 257 | |
Domaini | 279 – 347 | MIT 1Add BLAST | 69 | |
Domaini | 374 – 442 | MIT 2Add BLAST | 69 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.PROSITE-ProRule annotation
Keywords - Domaini
RepeatPhylogenomic databases
OrthoDBi | 1084750at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR045269, Atg1-like IPR011009, Kinase-like_dom_sf IPR007330, MIT_dom IPR036181, MIT_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24348, PTHR24348, 1 hit |
Pfami | View protein in Pfam PF04212, MIT, 2 hits PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00745, MIT, 2 hits SM00220, S_TKc, 1 hit |
SUPFAMi | SSF116846, SSF116846, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4V7Q6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAGWAPPRL EDFILTEKLG SGSYATVYKA YRKRNAREVV AIKCVSKKSL
60 70 80 90 100
NKAAVENLLT EIEILKTVHH PHILELKDFQ WDQDYIFLIT EYCAGGDLSR
110 120 130 140 150
FIRTRRILPE RIVQVFLQQL ASALKFLHEK NISHLDLKPQ NILLSRLDRP
160 170 180 190 200
HLKLADFGFA QHMSSEDAPQ ALRGSPLYMA PEMVCSKHYD ARVDLWSVGV
210 220 230 240 250
ILYEALFGKA PFASKSFSEL EEKILSHKTI ELPTRPRLSP ECRDLLQQLL
260 270 280 290 300
QRDPDKRISF IEFFAHLFVD LEHMPSAETL EKATRLVVEA VEKDSAGEHS
310 320 330 340 350
AALTLYCKAL EYFIPALHYE SDAKRKEAMR SKVCQYISRA EELKVLVSSS
360 370 380 390 400
NKTLLMQGIS GRELLKEMAQ DKPRLFSALE VASAAVAKDE EGCACDALDL
410 420 430 440 450
YQQSLGELLL MLSAESPGRR RELLHAEIQT LMGRAEFLKE QMKTSQWKSE
460
SLGQEVLSES VRNSCSLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC097772 mRNA Translation: AAH97772.1 |
RefSeqi | NP_001089515.1, NM_001096046.1 |
Genome annotation databases
GeneIDi | 734568 |
KEGGi | xla:734568 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC097772 mRNA Translation: AAH97772.1 |
RefSeqi | NP_001089515.1, NM_001096046.1 |
3D structure databases
AlphaFoldDBi | Q4V7Q6 |
SMRi | Q4V7Q6 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q4V7Q6 |
Protocols and materials databases
DNASUi | 734568 |
Genome annotation databases
GeneIDi | 734568 |
KEGGi | xla:734568 |
Organism-specific databases
CTDi | 734568 |
Xenbasei | XB-GENE-5958954, ulk3.L |
Phylogenomic databases
OrthoDBi | 1084750at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR045269, Atg1-like IPR011009, Kinase-like_dom_sf IPR007330, MIT_dom IPR036181, MIT_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24348, PTHR24348, 1 hit |
Pfami | View protein in Pfam PF04212, MIT, 2 hits PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00745, MIT, 2 hits SM00220, S_TKc, 1 hit |
SUPFAMi | SSF116846, SSF116846, 2 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ULK3_XENLA | |
Accessioni | Q4V7Q6Primary (citable) accession number: Q4V7Q6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2006 |
Last sequence update: | July 5, 2005 | |
Last modified: | May 25, 2022 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families