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Protein

Cysteine-rich with EGF-like domain protein 1

Gene

Creld1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich with EGF-like domain protein 1
Gene namesi
Name:Creld1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1309412 Creld1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 362ExtracellularSequence analysisAdd BLAST333
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384CytoplasmicSequence analysis1
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 420ExtracellularSequence analysisAdd BLAST15

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000004278330 – 420Cysteine-rich with EGF-like domain protein 1Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi155 ↔ 169PROSITE-ProRule annotation
Disulfide bondi163 ↔ 181PROSITE-ProRule annotation
Disulfide bondi183 ↔ 192PROSITE-ProRule annotation
Glycosylationi205N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi309 ↔ 321PROSITE-ProRule annotation
Disulfide bondi314 ↔ 330PROSITE-ProRule annotation
Disulfide bondi332 ↔ 343PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ4V7F2
PRIDEiQ4V7F2

Expressioni

Gene expression databases

BgeeiENSRNOG00000009414
GenevisibleiQ4V7F2 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013052

Structurei

3D structure databases

ProteinModelPortaliQ4V7F2
SMRiQ4V7F2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 193EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Repeati208 – 255FU 1Add BLAST48
Repeati268 – 315FU 2Add BLAST48
Domaini305 – 342EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST38

Sequence similaritiesi

Belongs to the CRELD family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4260 Eukaryota
ENOG41107X2 LUCA
GeneTreeiENSGT00680000100014
HOGENOMiHOG000004778
HOVERGENiHBG081344
InParanoidiQ4V7F2
OMAiEPHPCHT
OrthoDBiEOG091G09AA
PhylomeDBiQ4V7F2
TreeFamiTF316507

Family and domain databases

InterProiView protein in InterPro
IPR021852 DUF3456
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR006212 Furin_repeat
IPR009030 Growth_fac_rcpt_cys_sf
IPR002049 Laminin_EGF
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PF07645 EGF_CA, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 4 hits
SM00179 EGF_CA, 2 hits
SM00261 FU, 2 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4V7F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPQPLRGLV PFLLWCLSLF LSLPGPVWLQ PSPPPHSAPR AEPHPCHTCR
60 70 80 90 100
ALVDSFNKGL ERTIRDNFGG GNTAWEEEKL SKYKDSETRL VEVLEGVCSK
110 120 130 140 150
SDFECHRLLE LSEELVEAWW FHRQQEAPDL FQWLCSDSLK LCCPSGTFGP
160 170 180 190 200
SCLPCPGGTE RPCGGYGQCE GEGTRGGSGH CDCQAGYGGE ACGQCGLGYF
210 220 230 240 250
EAERNSSHLV CSACFGPCAR CTGPEESHCL QCRKGWALHH LKCVDIDECG
260 270 280 290 300
TEQATCGAAQ FCVNTEGSYE CRDCAKACLG CMGAGPGRCK KCSRGYQQVG
310 320 330 340 350
SKCLDVDECE TVVCPGENEQ CENTEGSYRC VCAEGFRQED GICVKEQIPE
360 370 380 390 400
SAGFFAEMTE DEMVVLQQMF FGVIICALAT LAAKGDLVFT AIFIGAVAAM
410 420
TGYWLSERSD RVLEGFIKGR
Length:420
Mass (Da):45,697
Last modified:July 5, 2005 - v1
Checksum:i5E424A5C21E7AAB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097951 mRNA Translation: AAH97951.1
RefSeqiNP_001019954.1, NM_001024783.1
UniGeneiRn.6461

Genome annotation databases

EnsembliENSRNOT00000013052; ENSRNOP00000013052; ENSRNOG00000009414
GeneIDi312638
KEGGirno:312638
UCSCiRGD:1309412 rat

Similar proteinsi

Entry informationi

Entry nameiCREL1_RAT
AccessioniPrimary (citable) accession number: Q4V7F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2005
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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