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Protein
Submitted name:

Transcriptional co-activator with PDZ-binding motif (TA)Z, isoform CRA_b

Gene

Wwtr1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-2028269 Signaling by Hippo
R-RNO-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-RNO-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Names & Taxonomyi

Protein namesi
Submitted name:
Transcriptional co-activator with PDZ-binding motif (TA)Z, isoform CRA_bImported
Submitted name:
WW domain-containing transcription regulator 1Imported
Gene namesi
Name:Wwtr1Imported
Synonyms:MGC116096Imported
ORF Names:rCG_50075Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1559609 Wwtr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000016617 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022507

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 157WWInterPro annotationAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili224 – 256Sequence analysisAdd BLAST33

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410KCVW Eukaryota
ENOG4111U1C LUCA
GeneTreeiENSGT00510000046760
HOGENOMiHOG000007854
HOVERGENiHBG002748
KOiK16820
OMAiAMSQPNL
OrthoDBiEOG091G095A
TreeFamiTF326941

Family and domain databases

CDDicd00201 WW, 1 hit
InterProiView protein in InterPro
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q4V7E6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPSSVPHPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE
60 70 80 90 100
SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA
110 120 130 140 150
GAAGGPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT
160 170 180 190 200
TWQDPRKVMN QPLNHVNLHP TITSTSVPQR SMAVSQPNLA MNHQHQQVVA
210 220 230 240 250
TSLSPQNHPA QNPPTGLMSV PNALTTQQQQ QQKLRLQRIQ MERERIRMRQ
260 270 280 290 300
EELMRQEAAL CRQLPMETET MAPVNTPAMN TDMRSVTNSS SDPFLNGGPY
310 320 330 340 350
HSREQSTDSG LGLGCYSVPT TPEDFLSNMD EMDTGENSGQ TPMTVNPQQT
360 370 380 390
RFPDFLDCLP GTNVDLGTLE SEDLIPLFND VESALNKSEP FLTWL
Length:395
Mass (Da):43,600
Last modified:July 5, 2005 - v1
Checksum:i986707E910AC433B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072732 Genomic DNA No translation available.
AC119094 Genomic DNA No translation available.
AC129365 Genomic DNA No translation available.
BC097968 mRNA Translation: AAH97968.1
CH474003 Genomic DNA Translation: EDM14889.1
CH474003 Genomic DNA Translation: EDM14890.1
RefSeqiNP_001020040.1, NM_001024869.1
UniGeneiRn.9622

Genome annotation databases

EnsembliENSRNOT00000022507; ENSRNOP00000022507; ENSRNOG00000016617
GeneIDi295062
KEGGirno:295062
UCSCiRGD:1559609 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07072732 Genomic DNA No translation available.
AC119094 Genomic DNA No translation available.
AC129365 Genomic DNA No translation available.
BC097968 mRNA Translation: AAH97968.1
CH474003 Genomic DNA Translation: EDM14889.1
CH474003 Genomic DNA Translation: EDM14890.1
RefSeqiNP_001020040.1, NM_001024869.1
UniGeneiRn.9622

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022507

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022507; ENSRNOP00000022507; ENSRNOG00000016617
GeneIDi295062
KEGGirno:295062
UCSCiRGD:1559609 rat

Organism-specific databases

CTDi25937
RGDi1559609 Wwtr1

Phylogenomic databases

eggNOGiENOG410KCVW Eukaryota
ENOG4111U1C LUCA
GeneTreeiENSGT00510000046760
HOGENOMiHOG000007854
HOVERGENiHBG002748
KOiK16820
OMAiAMSQPNL
OrthoDBiEOG091G095A
TreeFamiTF326941

Enzyme and pathway databases

ReactomeiR-RNO-2028269 Signaling by Hippo
R-RNO-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression
R-RNO-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Gene expression databases

BgeeiENSRNOG00000016617 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd00201 WW, 1 hit
InterProiView protein in InterPro
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ4V7E6_RAT
AccessioniPrimary (citable) accession number: Q4V7E6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: September 12, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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