UniProtKB - Q4V7E1 (ELF3_RAT)
Protein
ETS-related transcription factor Elf-3
Gene
Elf3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 297 – 379 | ETSPROSITE-ProRule annotationAdd BLAST | 83 |
GO - Molecular functioni
- DNA binding Source: RGD
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- anatomical structure morphogenesis Source: RGD
- blastocyst development Source: RGD
- cell differentiation Source: GO_Central
- epithelial cell differentiation Source: InterPro
- extracellular matrix organization Source: RGD
- inflammatory response Source: RGD
- mammary gland involution Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- transcription by RNA polymerase II Source: InterPro
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding, Repressor |
Biological process | Differentiation, Inflammatory response, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-RNO-1912408, Pre-NOTCH Transcription and Translation |
Names & Taxonomyi
Protein namesi | Recommended name: ETS-related transcription factor Elf-3Alternative name(s): E74-like factor 3 |
Gene namesi | Name:Elf3Imported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1310687, Elf3 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287683 | 1 – 395 | ETS-related transcription factor Elf-3Add BLAST | 395 |
Proteomic databases
PaxDbi | Q4V7E1 |
PRIDEi | Q4V7E1 |
PTM databases
iPTMneti | Q4V7E1 |
PhosphoSitePlusi | Q4V7E1 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000006330, Expressed in stomach and 17 other tissues |
Genevisiblei | Q4V7E1, RN |
Interactioni
Subunit structurei
Interacts with TBP.
Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function.
Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008753 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 69 – 155 | PNTPROSITE-ProRule annotationAdd BLAST | 87 |
Sequence similaritiesi
Belongs to the ETS family.Sequence analysis
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000158955 |
HOGENOMi | CLU_048172_0_0_1 |
InParanoidi | Q4V7E1 |
OMAi | ASWSGKQ |
OrthoDBi | 837296at2759 |
PhylomeDBi | Q4V7E1 |
TreeFami | TF318679 |
Family and domain databases
CDDi | cd08537, SAM_PNT-ESE-1-like, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR042693, Elf-3_PNT IPR033074, Elf3 IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849:SF13, PTHR11849:SF13, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4V7E1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAATCEISNV FSNYFNAMYS SEDPTLAPAP LTTFGTEDFV LTLNNQHMSP
60 70 80 90 100
EGPVGCVGPQ TRSQRDRTEP PAVLHLAEKA SWTGERPQFW SKTQVLDWIS
110 120 130 140 150
YQVEKNKYDA SSIDFSRCDM DGATLCNCAL EELRLVFGPL GDQLHAQLRD
160 170 180 190 200
LTSSSSDELS WIIELLEKDG MTFQEGLGDS GPFDQGSPFA QELLDDGRQA
210 220 230 240 250
SPYYGSSYGP GAPSPGSSDF STSGTDTPQS SHSSDSGGSD VDLDLTDSKV
260 270 280 290 300
FPRDGFPDYK KGEPKHGKRK RGRPRKLSKE YWDCLEGKKS KHAPRGTHLW
310 320 330 340 350
EFIRDILIHP ELNEGLMKWE NRHEGVFKFL RSEAVAQLWG QKKKNSNMTY
360 370 380 390
EKLSRAMRYY YKREILERVD GRRLVYKFGK NSSGWKEEEV GESQN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC097980 mRNA Translation: AAH97980.1 |
RefSeqi | NP_001019939.1, NM_001024768.1 |
Genome annotation databases
Ensembli | ENSRNOT00000008754; ENSRNOP00000008753; ENSRNOG00000006330 |
GeneIDi | 304815 |
KEGGi | rno:304815 |
UCSCi | RGD:1310687, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC097980 mRNA Translation: AAH97980.1 |
RefSeqi | NP_001019939.1, NM_001024768.1 |
3D structure databases
SMRi | Q4V7E1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000008753 |
PTM databases
iPTMneti | Q4V7E1 |
PhosphoSitePlusi | Q4V7E1 |
Proteomic databases
PaxDbi | Q4V7E1 |
PRIDEi | Q4V7E1 |
Genome annotation databases
Ensembli | ENSRNOT00000008754; ENSRNOP00000008753; ENSRNOG00000006330 |
GeneIDi | 304815 |
KEGGi | rno:304815 |
UCSCi | RGD:1310687, rat |
Organism-specific databases
CTDi | 1999 |
RGDi | 1310687, Elf3 |
Phylogenomic databases
eggNOGi | KOG3804, Eukaryota |
GeneTreei | ENSGT00940000158955 |
HOGENOMi | CLU_048172_0_0_1 |
InParanoidi | Q4V7E1 |
OMAi | ASWSGKQ |
OrthoDBi | 837296at2759 |
PhylomeDBi | Q4V7E1 |
TreeFami | TF318679 |
Enzyme and pathway databases
Reactomei | R-RNO-1912408, Pre-NOTCH Transcription and Translation |
Miscellaneous databases
PROi | PR:Q4V7E1 |
Gene expression databases
Bgeei | ENSRNOG00000006330, Expressed in stomach and 17 other tissues |
Genevisiblei | Q4V7E1, RN |
Family and domain databases
CDDi | cd08537, SAM_PNT-ESE-1-like, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR042693, Elf-3_PNT IPR033074, Elf3 IPR000418, Ets_dom IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849:SF13, PTHR11849:SF13, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ELF3_RAT | |
Accessioni | Q4V7E1Primary (citable) accession number: Q4V7E1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | July 5, 2005 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families