ETS-related transcription factor Elf-3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1."
    Kim J.-H., Wilder P.J., Hou J., Nowling T., Rizzino A.
    J. Biol. Chem. 277:17520-17530(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGDInferred from sequence orthologyⁱ
  • "Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1."
    Kim J.-H., Wilder P.J., Hou J., Nowling T., Rizzino A.
    J. Biol. Chem. 277:17520-17530(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1."
    Kim J.-H., Wilder P.J., Hou J., Nowling T., Rizzino A.
    J. Biol. Chem. 277:17520-17530(2002) [PubMed] [Europe PMC] [Abstract]
  • "Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium."
    Ng A.-Y.N., Waring P., Ristevski S., Wang C., Wilson T., Pritchard M., Hertzog P., Kola I.
    Gastroenterology 122:1455-1466(2002) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1."
    Kim J.-H., Wilder P.J., Hou J., Nowling T., Rizzino A.
    J. Biol. Chem. 277:17520-17530(2002) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: RGDInferred from sequence orthologyⁱ
  • "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation."
    Cabral A., Fischer D.F., Vermeij W.P., Backendorf C.
    J. Biol. Chem. 278:17792-17799(2003) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anatomical structure morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium."
    Ng A.-Y.N., Waring P., Ristevski S., Wang C., Wilson T., Pritchard M., Hertzog P., Kola I.
    Gastroenterology 122:1455-1466(2002) [PubMed] [Europe PMC] [Abstract]
• blastocyst development Source: RGDInferred from sequence orthologyⁱ
  • "The role of ETS transcription factors in transcription and development of mouse preimplantation embryos."
    Kageyama S., Liu H., Nagata M., Aoki F.
    Biochem. Biophys. Res. Commun. 344:675-679(2006) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• epithelial cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family."
    Oettgen P., Alani R.M., Barcinski M.A., Brown L., Akbarali Y., Boltax J., Kunsch C., Munger K., Libermann T.A.
    Mol. Cell. Biol. 17:4419-4433(1997) [PubMed] [Europe PMC] [Abstract]
• extracellular matrix organization Source: RGDInferred from sequence orthologyⁱ
  • "Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium."
    Ng A.-Y.N., Waring P., Ristevski S., Wang C., Wilson T., Pritchard M., Hertzog P., Kola I.
    Gastroenterology 122:1455-1466(2002) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: RGDInferred from sequence orthologyⁱ
  • "ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation."
    Brown C., Gaspar J., Pettit A., Lee R., Gu X., Wang H., Manning C., Voland C., Goldring S.R., Goldring M.B., Libermann T.A., Gravallese E.M., Oettgen P.
    J. Biol. Chem. 279:12794-12803(2004) [PubMed] [Europe PMC] [Abstract]
• mammary gland involution Source: RGDInferred from sequence orthologyⁱ
  • "The epithelium-specific ets transcription factor ESX is associated with mammary gland development and involution."
    Neve R., Chang C.-H., Scott G.K., Wong A., Friis R.R., Hynes N.E., Benz C.C.
    FASEB J. 12:1541-1550(1998) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation."
    Brembeck F.H., Opitz O.G., Libermann T.A., Rustgi A.K.
    Oncogene 19:1941-1949(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family."
    Oettgen P., Alani R.M., Barcinski M.A., Brown L., Akbarali Y., Boltax J., Kunsch C., Munger K., Libermann T.A.
    Mol. Cell. Biol. 17:4419-4433(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1."
    Kim J.-H., Wilder P.J., Hou J., Nowling T., Rizzino A.
    J. Biol. Chem. 277:17520-17530(2002) [PubMed] [Europe PMC] [Abstract]
  • "The role of ETS transcription factors in transcription and development of mouse preimplantation embryos."
    Kageyama S., Liu H., Nagata M., Aoki F.
    Biochem. Biophys. Res. Commun. 344:675-679(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: RGDInferred from sequence orthologyⁱ
  • "Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1."
    Kim J.-H., Wilder P.J., Hou J., Nowling T., Rizzino A.
    J. Biol. Chem. 277:17520-17530(2002) [PubMed] [Europe PMC] [Abstract]
  • "Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium."
    Ng A.-Y.N., Waring P., Ristevski S., Wang C., Wilson T., Pritchard M., Hertzog P., Kola I.
    Gastroenterology 122:1455-1466(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription by RNA polymerase II Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAATCEISNV FSNYFNAMYS SEDPTLAPAP LTTFGTEDFV LTLNNQHMSP 
        60         70         80         90        100
EGPVGCVGPQ TRSQRDRTEP PAVLHLAEKA SWTGERPQFW SKTQVLDWIS 
       110        120        130        140        150
YQVEKNKYDA SSIDFSRCDM DGATLCNCAL EELRLVFGPL GDQLHAQLRD 
       160        170        180        190        200
LTSSSSDELS WIIELLEKDG MTFQEGLGDS GPFDQGSPFA QELLDDGRQA 
       210        220        230        240        250
SPYYGSSYGP GAPSPGSSDF STSGTDTPQS SHSSDSGGSD VDLDLTDSKV 
       260        270        280        290        300
FPRDGFPDYK KGEPKHGKRK RGRPRKLSKE YWDCLEGKKS KHAPRGTHLW 
       310        320        330        340        350
EFIRDILIHP ELNEGLMKWE NRHEGVFKFL RSEAVAQLWG QKKKNSNMTY 
       360        370        380        390 
EKLSRAMRYY YKREILERVD GRRLVYKFGK NSSGWKEEEV GESQN      

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families