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UniProtKB - Q4V7E0 (TRMO_RAT)

Entry version 69 (16 Oct 2019)
Sequence version 1 (05 Jul 2005)
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Protein

tRNA (adenine(37)-N6)-methyltransferase

Gene

Trmo

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m6t6A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m6t6A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA (adenine(37)-N6)-methyltransferaseCurated (EC:2.1.1.-By similarity)
Alternative name(s):
tRNA methyltransferase OImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TrmoImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Rat genome database

More...RGDi		1305420 Trmo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002888881 – 431tRNA (adenine(37)-N6)-methyltransferaseAdd BLAST431

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q4V7E0

PRoteomics IDEntifications database

More...PRIDEi		Q4V7E0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSRNOG00000009492 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q4V7E0 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000012602

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 168TsaA-likePROSITE-ProRule annotationAdd BLAST139

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2942 Eukaryota
COG1720 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004643

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231645

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4V7E0

KEGG Orthology (KO)

More...KOi		K22900

Identification of Orthologs from Complete Genome Data

More...OMAi		RRKHCQD

Database of Orthologous Groups

More...OrthoDBi		1483097at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q4V7E0

Family and domain databases

Conserved Domains Database

More...CDDi		cd09281 UPF0066, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.30.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023370 TrmO-like_N
IPR023368 UPF0066_cons_site
IPR040372 YaeB-like
IPR036413 YaeB-like_sf
IPR036414 YaeB_N_sf

The PANTHER Classification System

More...PANTHERi		PTHR12818 PTHR12818, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01980 TrmO, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF118196 SSF118196, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00104 tRNA_TsaA, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01318 TSAA_1, 1 hit
PS51668 TSAA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4V7E0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGLEKQGPS ATAAPCGCAQ PALETGNLLT EPIGYLESCF SAKIGTPRQP 
        60         70         80         90        100
SICSQSRACL KIRKSIFNNP EHSLMGLEQF SHVWILFVFH KNGHLNYKAK 
       110        120        130        140        150
VQPPRLNGAK TGVFSTRSPH RPNAIGLTLA KLEKVEGGAV YLSGIDMIHG 
       160        170        180        190        200
TPVLDIKPYI ADYDSPQNLE PQTKHHKLRA AGPSDATANS CDQQLLSGCE 
       210        220        230        240        250
KAQPCHSTKE KPKCREHRTS DENSQKFRDT SEIQHTLPED RERAVDLALE 
       260        270        280        290        300
SSREETMDEP EDQLGPQELK SFLEEGTDRP RKVEGALVLR GSSAETRWDA 
       310        320        330        340        350
SCHARTADRV PCSVVPSWVK EAPVATLQVR FTPHAEMDLR KLSSGGASQT 
       360        370        380        390        400
SFKYFHSAEE AKCAIEAMLS ADPRSVYRRK LCEDRLFFFT VDIAHVTCWF 
       410        420        430 
GDGFAEVLRI KLASEPVEVA DPEESLVALG S
Length:431
Mass (Da):47,595
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i05D283EAAF82F316
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BC097981 mRNA Translation: AAH97981.1

NCBI Reference Sequences

More...RefSeqi		NP_001020823.1, NM_001025652.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSRNOT00000012602; ENSRNOP00000012602; ENSRNOG00000009492

Database of genes from NCBI RefSeq genomes

More...GeneIDi		298072

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:298072

UCSC genome browser

More...UCSCi		RGD:1305420 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097981 mRNA Translation: AAH97981.1
RefSeqiNP_001020823.1, NM_001025652.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012602

Proteomic databases

PaxDbiQ4V7E0
PRIDEiQ4V7E0

Genome annotation databases

EnsembliENSRNOT00000012602; ENSRNOP00000012602; ENSRNOG00000009492
GeneIDi298072
KEGGirno:298072
UCSCiRGD:1305420 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51531
RGDi1305420 Trmo

Phylogenomic databases

eggNOGiKOG2942 Eukaryota
COG1720 LUCA
GeneTreeiENSGT00390000004643
HOGENOMiHOG000231645
InParanoidiQ4V7E0
KOiK22900
OMAiRRKHCQD
OrthoDBi1483097at2759
PhylomeDBiQ4V7E0

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q4V7E0

Gene expression databases

BgeeiENSRNOG00000009492 Expressed in 9 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiQ4V7E0 RN

Family and domain databases

CDDicd09281 UPF0066, 1 hit
Gene3Di2.40.30.70, 1 hit
InterProiView protein in InterPro
IPR023370 TrmO-like_N
IPR023368 UPF0066_cons_site
IPR040372 YaeB-like
IPR036413 YaeB-like_sf
IPR036414 YaeB_N_sf
PANTHERiPTHR12818 PTHR12818, 1 hit
PfamiView protein in Pfam
PF01980 TrmO, 1 hit
SUPFAMiSSF118196 SSF118196, 2 hits
TIGRFAMsiTIGR00104 tRNA_TsaA, 1 hit
PROSITEiView protein in PROSITE
PS01318 TSAA_1, 1 hit
PS51668 TSAA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRMO_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4V7E0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 5, 2005
Last modified: October 16, 2019
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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