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UniProtKB - Q4V328 (GRAP1_HUMAN)

Entry version 142 (23 Feb 2022)
Sequence version 2 (12 Sep 2018)
Previous versions | rss
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Protein

GRIP1-associated protein 1

Gene

GRIPAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity).

By similarity

Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.

1 Publication

Miscellaneous

Antibodies against GRIPAP1 have been found in sera of a patient who developed Raynaud's syndrome and telangiectasias.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q4V328

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q4V328

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q4V328

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRIP1-associated protein 1Curated
Short name:
GRASP-1
Cleaved into the following chain:
GRASP-1 C-terminal chainBy similarity
Alternative name(s):
30kDa C-terminus form
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRIPAP1Imported
Synonyms:KIAA1167
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18706, GRIPAP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300408, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q4V328

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000068400

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell projection, Endosome, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000068400

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38650

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q4V328, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GRIPAP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74753569

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000875812 – 841GRIP1-associated protein 1Add BLAST840
ChainiPRO_0000441811599 – 841GRASP-1 C-terminal chainAdd BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei666PhosphoserineCombined sources1
Modified residuei668PhosphoserineBy similarity1
Modified residuei669PhosphoserineBy similarity1
Modified residuei688PhosphoserineBy similarity1
Modified residuei690PhosphoserineCombined sources1
Modified residuei691PhosphoserineBy similarity1
Modified residuei692PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Proteolytic cleavage is required for JNK signaling activation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei598 – 599Cleavage; by caspase-3By similarity2

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q4V328

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q4V328

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q4V328

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q4V328

PeptideAtlas

More...PeptideAtlasi		Q4V328

PRoteomics IDEntifications database

More...PRIDEi		Q4V328

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62272 [Q4V328-1]
62273 [Q4V328-2]
62274 [Q4V328-3]
62275 [Q4V328-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q4V328, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q4V328

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q4V328

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q4V328

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000068400, Expressed in frontal cortex and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q4V328, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q4V328, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000068400, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GRIP1, GRIP2 and AMPA receptors (By similarity).

Interacts (via C-terminus) with MAPK8/JNK1 and MAP3K1/MEKK1; the interaction promotes MAP3K1-mediated phosphorylation of MAPK8 (PubMed:17761173).

Interacts (via N-terminus) with RAB4A (in GTP-bound form) (PubMed:20098723).

Interacts (via C-terminus) with STX12 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q4V328
With#Exp.IntAct
AARD [Q4LEZ3]3EBI-717919,EBI-5463075
ANKRD11 [X5D778]3EBI-717919,EBI-17183751
ATG5 [Q9H1Y0]3EBI-717919,EBI-1047414
BYSL [Q13895]3EBI-717919,EBI-358049
CBX8 [Q9HC52]3EBI-717919,EBI-712912
CCDC103 [Q8IW40]8EBI-717919,EBI-10261970
CCDC185 [Q8N715]3EBI-717919,EBI-740814
CCNH [P51946]3EBI-717919,EBI-741406
CDC37 [Q16543]3EBI-717919,EBI-295634
CEP57L1 [Q8IYX8]6EBI-717919,EBI-1104570
CFAP53 [Q96M91]3EBI-717919,EBI-742422
CWF19L2 [Q2TBE0]3EBI-717919,EBI-5453285
DAXX [Q9UER7]3EBI-717919,EBI-77321
DISC1 [Q9NRI5]5EBI-717919,EBI-529989
DISC1 - isoform 2 [Q9NRI5-2]3EBI-717919,EBI-11988027
DUSP26 [Q9BV47]3EBI-717919,EBI-2924519
EHHADH [Q08426]3EBI-717919,EBI-2339219
ELOA [Q14241]3EBI-717919,EBI-742350
ENKD1 [Q9H0I2]3EBI-717919,EBI-744099
FAM161A [Q3B820]3EBI-717919,EBI-719941
FAM50B [Q9Y247]3EBI-717919,EBI-742802
FAM90A1 [Q86YD7]3EBI-717919,EBI-6658203
GAS8 [O95995]3EBI-717919,EBI-1052570
itself3EBI-717919,EBI-717919
HDAC4 - isoform 2 [P56524-2]3EBI-717919,EBI-11953488
ING4 [Q9UNL4]3EBI-717919,EBI-2866661
ING5 [Q8WYH8]6EBI-717919,EBI-488533
LNX1 [Q8TBB1]3EBI-717919,EBI-739832
MEOX2 [Q6FHY5]3EBI-717919,EBI-16439278
MFAP1 [P55081]3EBI-717919,EBI-1048159
MGC50722 [Q8IVT4]3EBI-717919,EBI-14086479
MLLT6 [P55198]3EBI-717919,EBI-740216
NUAK2 [Q9H093]3EBI-717919,EBI-1181722
PIBF1 [Q4G0R1]3EBI-717919,EBI-14066006
PKP2 - isoform 1 [Q99959-2]3EBI-717919,EBI-10987518
PPP1R18 [Q6NYC8]4EBI-717919,EBI-2557469
PRPF18 [Q99633]3EBI-717919,EBI-2798416
PSMB1 [P20618]3EBI-717919,EBI-372273
RAB4A [P20338]4EBI-717919,EBI-722284
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-717919,EBI-1504830
SMARCE1 [Q969G3]3EBI-717919,EBI-455078
SNAPC5 - isoform 2 [O75971-2]3EBI-717919,EBI-12004298
SNW1 [Q13573]3EBI-717919,EBI-632715
STAP1 [Q9ULZ2]3EBI-717919,EBI-6083058
TBC1D30 - isoform 2 [Q9Y2I9-2]3EBI-717919,EBI-17455779
TCEA2 [Q15560]3EBI-717919,EBI-710310
TCP10L [Q8TDR4]3EBI-717919,EBI-3923210
TEPSIN [Q96N21]3EBI-717919,EBI-11139477
TRAF2 [Q12933]3EBI-717919,EBI-355744
TSGA10IP [Q3SY00]3EBI-717919,EBI-10241197
TSHZ2 [Q9NRE2]3EBI-717919,EBI-10687282
TTC23 - isoform 3 [Q5W5X9-3]3EBI-717919,EBI-9090990
USP2 [O75604]3EBI-717919,EBI-743272
ZMAT2 [Q96NC0]3EBI-717919,EBI-2682299
ZNF219 [Q9P2Y4]3EBI-717919,EBI-3937106
ZNF250 - isoform 3 [P15622-3]3EBI-717919,EBI-10177272
ZNF35 [P13682]3EBI-717919,EBI-11041653
ZNF835 [Q9Y2P0]3EBI-717919,EBI-5667516

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121210, 150 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q4V328

Database of interacting proteins

More...DIPi		DIP-47299N

Protein interaction database and analysis system

More...IntActi		Q4V328, 77 interactors

Molecular INTeraction database

More...MINTi		Q4V328

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365606

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q4V328, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4V328

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni532 – 551DisorderedSequence analysisAdd BLAST20
Regioni558 – 580DisorderedSequence analysisAdd BLAST23
Regioni681 – 706DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4 – 161Sequence analysisAdd BLAST158
Coiled coili208 – 641Sequence analysisAdd BLAST434
Coiled coili701 – 735Sequence analysisAdd BLAST35
Coiled coili785 – 814Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi684 – 698Polar residuesSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTUD, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00720000108868

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019728_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4V328

Identification of Orthologs from Complete Genome Data

More...OMAi		FLLVQEQ

Database of Orthologous Groups

More...OrthoDBi		1273136at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q4V328

TreeFam database of animal gene trees

More...TreeFami		TF329006

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026204, GRIPAP1

The PANTHER Classification System

More...PANTHERi		PTHR18978, PTHR18978, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4V328-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQALSEEEF QRMQAQLLEL RTNNYQLSDE LRKNGVELTS LRQKVAYLDK 
        60         70         80         90        100
EFSKAQKALS KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF 
       110        120        130        140        150
SKLCSQMEQL EQENQQLKEG AAGAGVAQAG PLVDGELLRL QAENTALQKN 
       160        170        180        190        200
VAALQERYGK EAGKFSAVSE GQGDPPGGLA PTVLAPMPLA EVELKWEMEK 
       210        220        230        240        250
EEKRLLWEQL QGLESSKQAE TSRLQEELAK LSEKLKKKQE SFCRLQTEKE 
       260        270        280        290        300
TLFNDSRNKI EELQQRKEAD HKAQLARTQK LQQELEAANQ SLAELRDQRQ 
       310        320        330        340        350
GERLEHAAAL RALQDQVSIQ SADAQEQVEG LLAENNALRT SLAALEQIQT 
       360        370        380        390        400
AKTQELNMLR EQTTGLAAEL QQQQAEYEDL MGQKDDLNSQ LQESLRANSR 
       410        420        430        440        450
LLEQLQEIGQ EKEQLTQELQ EARKSAEKRK AMLDELAMET LQEKSQHKEE 
       460        470        480        490        500
LGAVRLRHEK EVLGVRARYE RELRELHEDK KRQEEELRGQ IREEKARTRE 
       510        520        530        540        550
LETLQQTVEE LQAQVHSMDG AKGWFERRLK EAEESLQQQQ QEQEEALKQC 
       560        570        580        590        600
REQHAAELKG KEEELQDVRD QLEQAQEERD CHLKTISSLK QEVKDTVDGQ 
       610        620        630        640        650
RILEKKGSAA LKDLKRQLHL ERKRADKLQE RLQDILTNSK SRSGLEELVL 
       660        670        680        690        700
SEMNSPSRTQ TGDSSSISSF SYREILREKE SSAVPARSLS SSPQAQPPRP 
       710        720        730        740        750
AELSDEEVAE LFQRLAETQQ EKWMLEEKVK HLEVSSASMA EDLCRKSAII 
       760        770        780        790        800
ETYVMDSRID VSVAAGHTDR SGLGSVLRDL VKPGDENLRE MNKKLQNMLE 
       810        820        830        840 
EQLTKNMHLH KDMEVLSQEI VRLSKECVGP PDPDLEPGET S
Length:841
Mass (Da):96,006
Last modified:September 12, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10B6A50DAFBBC9D9
GO
Isoform 2 (identifier: Q4V328-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-155: Missing.
     534-559: Missing.
     688-704: SLSSSPQAQPPRPAELS → VRGKEEPTAPASLNPKI
     705-841: Missing.

Show »
Length:625
Mass (Da):71,894
Checksum:iB79355220A0591D5
GO
Isoform 3 (identifier: Q4V328-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
     111-152: EQENQQLKEG...ENTALQKNVA → MWSFGTGTLP...IHHIFLFYSP
     688-704: SLSSSPQAQPPRPAELS → VRGKEEPTAPASLNPKI
     705-841: Missing.

Show »
Length:594
Mass (Da):68,204
Checksum:iD8A9C3CE7EA142BD
GO
Isoform 4 (identifier: Q4V328-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-347: Missing.

Show »
Length:810
Mass (Da):92,754
Checksum:i44175E83ADBCBFEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT45A0A087WT45_HUMAN
GRIP1-associated protein 1
GRIPAP1
796Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXA6A0A087WXA6_HUMAN
GRIP1-associated protein 1
GRIPAP1
302Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZF5A0A087WZF5_HUMAN
GRIP1-associated protein 1
GRIPAP1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW92A0A087WW92_HUMAN
GRIP1-associated protein 1
GRIPAP1
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV84A0A087WV84_HUMAN
GRIP1-associated protein 1
GRIPAP1
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWF2A0A087WWF2_HUMAN
GRIP1-associated protein 1
GRIPAP1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti677R → G in CAB95949 (PubMed:10908365).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080637179L → P3 PublicationsCorresponds to variant dbSNP:rs61735977Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0156991 – 110Missing in isoform 3. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_015700103 – 155Missing in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_015701111 – 152EQENQ…QKNVA → MWSFGTGTLPPEGLKASSPS IRGMARDFRDHLIHHIFLFY SP in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_015702317 – 347Missing in isoform 4. CuratedAdd BLAST31
Alternative sequenceiVSP_015703534 – 559Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_015704688 – 704SLSSS…PAELS → VRGKEEPTAPASLNPKI in isoform 2 and isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_015705705 – 841Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX640704 mRNA Translation: CAE45824.1
BX647804 mRNA Translation: CAI45985.1 Different termination.
AF207550 Genomic DNA No translation available.
BX530088 Genomic DNA No translation available.
BC001522 mRNA Translation: AAH01522.2
BC101544 mRNA Translation: AAI01545.1
BC101546 mRNA Translation: AAI01547.1
AB032993 mRNA Translation: BAA86481.1
AJ297364 mRNA Translation: CAB95949.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35248.1 [Q4V328-1]

NCBI Reference Sequences

More...RefSeqi		NP_064522.3, NM_020137.4 [Q4V328-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376423; ENSP00000365606; ENSG00000068400
ENST00000593475; ENSP00000469842; ENSG00000068400 [Q4V328-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56850

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56850

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000376423.8; ENSP00000365606.5; NM_020137.5; NP_064522.4

UCSC genome browser

More...UCSCi		uc033ecr.2, human [Q4V328-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640704 mRNA Translation: CAE45824.1
BX647804 mRNA Translation: CAI45985.1 Different termination.
AF207550 Genomic DNA No translation available.
BX530088 Genomic DNA No translation available.
BC001522 mRNA Translation: AAH01522.2
BC101544 mRNA Translation: AAI01545.1
BC101546 mRNA Translation: AAI01547.1
AB032993 mRNA Translation: BAA86481.1
AJ297364 mRNA Translation: CAB95949.1
CCDSiCCDS35248.1 [Q4V328-1]
RefSeqiNP_064522.3, NM_020137.4 [Q4V328-1]

3D structure databases

SMRiQ4V328
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121210, 150 interactors
CORUMiQ4V328
DIPiDIP-47299N
IntActiQ4V328, 77 interactors
MINTiQ4V328
STRINGi9606.ENSP00000365606

PTM databases

GlyGeniQ4V328, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ4V328
MetOSiteiQ4V328
PhosphoSitePlusiQ4V328

Genetic variation databases

BioMutaiGRIPAP1
DMDMi74753569

Proteomic databases

EPDiQ4V328
jPOSTiQ4V328
MassIVEiQ4V328
PaxDbiQ4V328
PeptideAtlasiQ4V328
PRIDEiQ4V328
ProteomicsDBi62272 [Q4V328-1]
62273 [Q4V328-2]
62274 [Q4V328-3]
62275 [Q4V328-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		355, 221 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		56850

Genome annotation databases

EnsembliENST00000376423; ENSP00000365606; ENSG00000068400
ENST00000593475; ENSP00000469842; ENSG00000068400 [Q4V328-4]
GeneIDi56850
KEGGihsa:56850
MANE-SelectiENST00000376423.8; ENSP00000365606.5; NM_020137.5; NP_064522.4
UCSCiuc033ecr.2, human [Q4V328-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56850

GeneCards: human genes, protein and diseases

More...GeneCardsi		GRIPAP1
HGNCiHGNC:18706, GRIPAP1
HPAiENSG00000068400, Low tissue specificity
MIMi300408, gene
neXtProtiNX_Q4V328
OpenTargetsiENSG00000068400
PharmGKBiPA38650
VEuPathDBiHostDB:ENSG00000068400

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTUD, Eukaryota
GeneTreeiENSGT00720000108868
HOGENOMiCLU_019728_1_0_1
InParanoidiQ4V328
OMAiFLLVQEQ
OrthoDBi1273136at2759
PhylomeDBiQ4V328
TreeFamiTF329006

Enzyme and pathway databases

PathwayCommonsiQ4V328
SignaLinkiQ4V328
SIGNORiQ4V328

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56850, 9 hits in 680 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GRIPAP1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GRIPAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56850
PharosiQ4V328, Tbio

Protein Ontology

More...PROi		PR:Q4V328
RNActiQ4V328, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000068400, Expressed in frontal cortex and 212 other tissues
ExpressionAtlasiQ4V328, baseline and differential
GenevisibleiQ4V328, HS

Family and domain databases

InterProiView protein in InterPro
IPR026204, GRIPAP1
PANTHERiPTHR18978, PTHR18978, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRAP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4V328
Secondary accession number(s): A6NL78
, Q3MJ75, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 12, 2018
Last modified: February 23, 2022
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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