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Entry version 134 (17 Jun 2020)
Sequence version 2 (12 Sep 2018)
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Protein

GRIP1-associated protein 1

Gene

GRIPAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity).By similarity
Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.1 Publication

Miscellaneous

Antibodies against GRIPAP1 have been found in sera of a patient who developed Raynaud's syndrome and telangiectasias.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GRIP1-associated protein 1Curated
Short name:
GRASP-1
Cleaved into the following chain:
GRASP-1 C-terminal chainBy similarity
Alternative name(s):
30kDa C-terminus form
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRIPAP1Imported
Synonyms:KIAA1167
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000068400.13

Human Gene Nomenclature Database

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HGNCi
HGNC:18706 GRIPAP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300408 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q4V328

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Endosome, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000068400

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38650

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q4V328 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GRIPAP1

Domain mapping of disease mutations (DMDM)

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DMDMi
74753569

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000875812 – 841GRIP1-associated protein 1Add BLAST840
ChainiPRO_0000441811599 – 841GRASP-1 C-terminal chainAdd BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei655PhosphoserineCombined sources1
Modified residuei666PhosphoserineCombined sources1
Modified residuei668PhosphoserineBy similarity1
Modified residuei669PhosphoserineBy similarity1
Modified residuei688PhosphoserineBy similarity1
Modified residuei690PhosphoserineCombined sources1
Modified residuei691PhosphoserineBy similarity1
Modified residuei692PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Proteolytic cleavage is required for JNK signaling activation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei598 – 599Cleavage; by caspase-3By similarity2

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q4V328

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q4V328

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q4V328

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q4V328

PeptideAtlas

More...
PeptideAtlasi
Q4V328

PRoteomics IDEntifications database

More...
PRIDEi
Q4V328

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
62272 [Q4V328-1]
62273 [Q4V328-2]
62274 [Q4V328-3]
62275 [Q4V328-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4V328

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q4V328

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4V328

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000068400 Expressed in frontal cortex and 196 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q4V328 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4V328 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000068400 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GRIP1, GRIP2 and AMPA receptors (By similarity).

Interacts (via C-terminus) with MAPK8/JNK1 and MAP3K1/MEKK1; the interaction promotes MAP3K1-mediated phosphorylation of MAPK8 (PubMed:17761173).

Interacts (via N-terminus) with RAB4A (in GTP-bound form) (PubMed:20098723).

Interacts (via C-terminus) with STX12 (By similarity).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q4V328
With#Exp.IntAct
AARD [Q4LEZ3]3EBI-717919,EBI-5463075
ANKRD11 [X5D778]3EBI-717919,EBI-17183751
ATG5 [Q9H1Y0]3EBI-717919,EBI-1047414
BYSL [Q13895]3EBI-717919,EBI-358049
CBX8 [Q9HC52]3EBI-717919,EBI-712912
CCDC103 [Q8IW40]8EBI-717919,EBI-10261970
CCDC185 [Q8N715]3EBI-717919,EBI-740814
CCNH [P51946]3EBI-717919,EBI-741406
CDC37 [Q16543]3EBI-717919,EBI-295634
CEP57L1 [Q8IYX8]6EBI-717919,EBI-1104570
CFAP53 [Q96M91]3EBI-717919,EBI-742422
CWF19L2 [Q2TBE0]3EBI-717919,EBI-5453285
DAXX [Q9UER7]3EBI-717919,EBI-77321
DISC1 - isoform 2 [Q9NRI5-2]3EBI-717919,EBI-11988027
DUSP26 [Q9BV47]3EBI-717919,EBI-2924519
EHHADH [Q08426]3EBI-717919,EBI-2339219
ELOA [Q14241]3EBI-717919,EBI-742350
ENKD1 [Q9H0I2]3EBI-717919,EBI-744099
FAM161A [Q3B820]3EBI-717919,EBI-719941
FAM50B [Q9Y247]3EBI-717919,EBI-742802
FAM90A1 [Q86YD7]3EBI-717919,EBI-6658203
GAS8 [O95995]3EBI-717919,EBI-1052570
itself3EBI-717919,EBI-717919
HDAC4 - isoform 2 [P56524-2]3EBI-717919,EBI-11953488
ING4 [Q9UNL4]3EBI-717919,EBI-2866661
ING5 [Q8WYH8]6EBI-717919,EBI-488533
LNX1 [Q8TBB1]3EBI-717919,EBI-739832
MEOX2 [Q6FHY5]3EBI-717919,EBI-16439278
MFAP1 [P55081]3EBI-717919,EBI-1048159
MGC50722 [Q8IVT4]3EBI-717919,EBI-14086479
MLLT6 [P55198]3EBI-717919,EBI-740216
NUAK2 [Q9H093]3EBI-717919,EBI-1181722
PIBF1 [Q4G0R1]3EBI-717919,EBI-14066006
PKP2 - isoform 1 [Q99959-2]3EBI-717919,EBI-10987518
PPP1R18 [Q6NYC8]4EBI-717919,EBI-2557469
PRPF18 [Q99633]3EBI-717919,EBI-2798416
PSMB1 [P20618]3EBI-717919,EBI-372273
RAB4A [P20338]4EBI-717919,EBI-722284
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-717919,EBI-1504830
SMARCE1 [Q969G3]3EBI-717919,EBI-455078
SNAPC5 - isoform 2 [O75971-2]3EBI-717919,EBI-12004298
SNW1 [Q13573]3EBI-717919,EBI-632715
STAP1 [Q9ULZ2]3EBI-717919,EBI-6083058
TBC1D30 - isoform 2 [Q9Y2I9-2]3EBI-717919,EBI-17455779
TCEA2 [Q15560]3EBI-717919,EBI-710310
TCP10L [Q8TDR4]3EBI-717919,EBI-3923210
TEPSIN [Q96N21]3EBI-717919,EBI-11139477
TRAF2 [Q12933]3EBI-717919,EBI-355744
TSGA10IP [Q3SY00]3EBI-717919,EBI-10241197
TSHZ2 [Q9NRE2]3EBI-717919,EBI-10687282
TTC23 - isoform 3 [Q5W5X9-3]3EBI-717919,EBI-9090990
USP2 [O75604]3EBI-717919,EBI-743272
ZMAT2 [Q96NC0]3EBI-717919,EBI-2682299
ZNF219 [Q9P2Y4]3EBI-717919,EBI-3937106
ZNF250 - isoform 3 [P15622-3]3EBI-717919,EBI-10177272
ZNF35 [P13682]3EBI-717919,EBI-11041653
ZNF835 [Q9Y2P0]3EBI-717919,EBI-5667516

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121210, 53 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q4V328

Database of interacting proteins

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DIPi
DIP-47299N

Protein interaction database and analysis system

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IntActi
Q4V328, 77 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365606

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q4V328 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4V328

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili4 – 161Sequence analysisAdd BLAST158
Coiled coili208 – 641Sequence analysisAdd BLAST434
Coiled coili701 – 735Sequence analysisAdd BLAST35
Coiled coili785 – 814Sequence analysisAdd BLAST30

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IKP9 Eukaryota
ENOG410YB89 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00720000108868

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_019728_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q4V328

Identification of Orthologs from Complete Genome Data

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OMAi
FLLVQEQ

Database of Orthologous Groups

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OrthoDBi
1273136at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q4V328

TreeFam database of animal gene trees

More...
TreeFami
TF329006

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026204 GRIPAP1

The PANTHER Classification System

More...
PANTHERi
PTHR18978 PTHR18978, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4V328-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQALSEEEF QRMQAQLLEL RTNNYQLSDE LRKNGVELTS LRQKVAYLDK
60 70 80 90 100
EFSKAQKALS KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF
110 120 130 140 150
SKLCSQMEQL EQENQQLKEG AAGAGVAQAG PLVDGELLRL QAENTALQKN
160 170 180 190 200
VAALQERYGK EAGKFSAVSE GQGDPPGGLA PTVLAPMPLA EVELKWEMEK
210 220 230 240 250
EEKRLLWEQL QGLESSKQAE TSRLQEELAK LSEKLKKKQE SFCRLQTEKE
260 270 280 290 300
TLFNDSRNKI EELQQRKEAD HKAQLARTQK LQQELEAANQ SLAELRDQRQ
310 320 330 340 350
GERLEHAAAL RALQDQVSIQ SADAQEQVEG LLAENNALRT SLAALEQIQT
360 370 380 390 400
AKTQELNMLR EQTTGLAAEL QQQQAEYEDL MGQKDDLNSQ LQESLRANSR
410 420 430 440 450
LLEQLQEIGQ EKEQLTQELQ EARKSAEKRK AMLDELAMET LQEKSQHKEE
460 470 480 490 500
LGAVRLRHEK EVLGVRARYE RELRELHEDK KRQEEELRGQ IREEKARTRE
510 520 530 540 550
LETLQQTVEE LQAQVHSMDG AKGWFERRLK EAEESLQQQQ QEQEEALKQC
560 570 580 590 600
REQHAAELKG KEEELQDVRD QLEQAQEERD CHLKTISSLK QEVKDTVDGQ
610 620 630 640 650
RILEKKGSAA LKDLKRQLHL ERKRADKLQE RLQDILTNSK SRSGLEELVL
660 670 680 690 700
SEMNSPSRTQ TGDSSSISSF SYREILREKE SSAVPARSLS SSPQAQPPRP
710 720 730 740 750
AELSDEEVAE LFQRLAETQQ EKWMLEEKVK HLEVSSASMA EDLCRKSAII
760 770 780 790 800
ETYVMDSRID VSVAAGHTDR SGLGSVLRDL VKPGDENLRE MNKKLQNMLE
810 820 830 840
EQLTKNMHLH KDMEVLSQEI VRLSKECVGP PDPDLEPGET S
Length:841
Mass (Da):96,006
Last modified:September 12, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10B6A50DAFBBC9D9
GO
Isoform 2 (identifier: Q4V328-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-155: Missing.
     534-559: Missing.
     688-704: SLSSSPQAQPPRPAELS → VRGKEEPTAPASLNPKI
     705-841: Missing.

Show »
Length:625
Mass (Da):71,894
Checksum:iB79355220A0591D5
GO
Isoform 3 (identifier: Q4V328-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.
     111-152: EQENQQLKEG...ENTALQKNVA → MWSFGTGTLP...IHHIFLFYSP
     688-704: SLSSSPQAQPPRPAELS → VRGKEEPTAPASLNPKI
     705-841: Missing.

Show »
Length:594
Mass (Da):68,204
Checksum:iD8A9C3CE7EA142BD
GO
Isoform 4 (identifier: Q4V328-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-347: Missing.

Show »
Length:810
Mass (Da):92,754
Checksum:i44175E83ADBCBFEB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT45A0A087WT45_HUMAN
GRIP1-associated protein 1
GRIPAP1
796Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXA6A0A087WXA6_HUMAN
GRIP1-associated protein 1
GRIPAP1
302Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZF5A0A087WZF5_HUMAN
GRIP1-associated protein 1
GRIPAP1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW92A0A087WW92_HUMAN
GRIP1-associated protein 1
GRIPAP1
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV84A0A087WV84_HUMAN
GRIP1-associated protein 1
GRIPAP1
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWF2A0A087WWF2_HUMAN
GRIP1-associated protein 1
GRIPAP1
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti677R → G in CAB95949 (PubMed:10908365).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080637179L → P3 PublicationsCorresponds to variant dbSNP:rs61735977Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0156991 – 110Missing in isoform 3. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_015700103 – 155Missing in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_015701111 – 152EQENQ…QKNVA → MWSFGTGTLPPEGLKASSPS IRGMARDFRDHLIHHIFLFY SP in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_015702317 – 347Missing in isoform 4. CuratedAdd BLAST31
Alternative sequenceiVSP_015703534 – 559Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_015704688 – 704SLSSS…PAELS → VRGKEEPTAPASLNPKI in isoform 2 and isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_015705705 – 841Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX640704 mRNA Translation: CAE45824.1
BX647804 mRNA Translation: CAI45985.1 Different termination.
AF207550 Genomic DNA No translation available.
BX530088 Genomic DNA No translation available.
BC001522 mRNA Translation: AAH01522.2
BC101544 mRNA Translation: AAI01545.1
BC101546 mRNA Translation: AAI01547.1
AB032993 mRNA Translation: BAA86481.1
AJ297364 mRNA Translation: CAB95949.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35248.1 [Q4V328-1]

NCBI Reference Sequences

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RefSeqi
NP_064522.3, NM_020137.4 [Q4V328-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000376423; ENSP00000365606; ENSG00000068400 [Q4V328-1]
ENST00000593475; ENSP00000469842; ENSG00000068400 [Q4V328-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56850

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56850

UCSC genome browser

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UCSCi
uc033ecr.2 human [Q4V328-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640704 mRNA Translation: CAE45824.1
BX647804 mRNA Translation: CAI45985.1 Different termination.
AF207550 Genomic DNA No translation available.
BX530088 Genomic DNA No translation available.
BC001522 mRNA Translation: AAH01522.2
BC101544 mRNA Translation: AAI01545.1
BC101546 mRNA Translation: AAI01547.1
AB032993 mRNA Translation: BAA86481.1
AJ297364 mRNA Translation: CAB95949.1
CCDSiCCDS35248.1 [Q4V328-1]
RefSeqiNP_064522.3, NM_020137.4 [Q4V328-1]

3D structure databases

SMRiQ4V328
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121210, 53 interactors
CORUMiQ4V328
DIPiDIP-47299N
IntActiQ4V328, 77 interactors
STRINGi9606.ENSP00000365606

PTM databases

iPTMnetiQ4V328
MetOSiteiQ4V328
PhosphoSitePlusiQ4V328

Polymorphism and mutation databases

BioMutaiGRIPAP1
DMDMi74753569

Proteomic databases

EPDiQ4V328
jPOSTiQ4V328
MassIVEiQ4V328
PaxDbiQ4V328
PeptideAtlasiQ4V328
PRIDEiQ4V328
ProteomicsDBi62272 [Q4V328-1]
62273 [Q4V328-2]
62274 [Q4V328-3]
62275 [Q4V328-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
355 214 antibodies

The DNASU plasmid repository

More...
DNASUi
56850

Genome annotation databases

EnsembliENST00000376423; ENSP00000365606; ENSG00000068400 [Q4V328-1]
ENST00000593475; ENSP00000469842; ENSG00000068400 [Q4V328-4]
GeneIDi56850
KEGGihsa:56850
UCSCiuc033ecr.2 human [Q4V328-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56850
EuPathDBiHostDB:ENSG00000068400.13

GeneCards: human genes, protein and diseases

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GeneCardsi
GRIPAP1
HGNCiHGNC:18706 GRIPAP1
HPAiENSG00000068400 Low tissue specificity
MIMi300408 gene
neXtProtiNX_Q4V328
OpenTargetsiENSG00000068400
PharmGKBiPA38650

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKP9 Eukaryota
ENOG410YB89 LUCA
GeneTreeiENSGT00720000108868
HOGENOMiCLU_019728_1_0_1
InParanoidiQ4V328
OMAiFLLVQEQ
OrthoDBi1273136at2759
PhylomeDBiQ4V328
TreeFamiTF329006

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
56850 2 hits in 414 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GRIPAP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GRIPAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56850
PharosiQ4V328 Tbio

Protein Ontology

More...
PROi
PR:Q4V328
RNActiQ4V328 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000068400 Expressed in frontal cortex and 196 other tissues
ExpressionAtlasiQ4V328 baseline and differential
GenevisibleiQ4V328 HS

Family and domain databases

InterProiView protein in InterPro
IPR026204 GRIPAP1
PANTHERiPTHR18978 PTHR18978, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGRAP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4V328
Secondary accession number(s): A6NL78
, Q3MJ75, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 12, 2018
Last modified: June 17, 2020
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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