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Protein

G antigen 13

Gene

GAGE13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

This gene belongs to a multigene family expressed in a large variety of tumors whereas in normal tissues, expression is restricted to germ cells. These genes organized in clustered repeats, have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution. Their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells.

Caution

The first GAGE nomenclature was based on identified mRNA sequences, but the high identity of the GAGE members made impossible to separate products of paralogous genes from polymorph products. PubMed:18179644 presented a new GAGE gene nomenclature based on the identified genes and their products.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
G antigen 13Curated
Short name:
GAGE-13
Alternative name(s):
G antigen 12A
Short name:
GAGE-12A
Gene namesi
Name:GAGE13Imported
Synonyms:GAGE12A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000274274.1
HGNCiHGNC:29081 GAGE13
MIMi300734 gene
neXtProtiNX_Q4V321

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000274274

Polymorphism and mutation databases

BioMutaiGAGE13
DMDMi74753563

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524761 – 117G antigen 13Add BLAST117

Proteomic databases

PaxDbiQ4V321
PeptideAtlasiQ4V321
PRIDEiQ4V321
ProteomicsDBi62270

Expressioni

Gene expression databases

BgeeiENSG00000274274
CleanExiHS_GAGE13

Organism-specific databases

HPAiHPA043232

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371170

Structurei

3D structure databases

ProteinModelPortaliQ4V321
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiENOG410KIHC Eukaryota
ENOG4110Q8D LUCA
GeneTreeiENSGT00900000141202
HOGENOMiHOG000237345
HOVERGENiHBG056227
InParanoidiQ4V321
OMAiYLQPPEM
OrthoDBiEOG091G0UGV
PhylomeDBiQ4V321
TreeFamiTF340669

Family and domain databases

InterProiView protein in InterPro
IPR031320 GAGE
IPR008625 GAGE_fam
PANTHERiPTHR14047 PTHR14047, 1 hit
PfamiView protein in Pfam
PF05831 GAGE, 1 hit
SMARTiView protein in SMART
SM01379 GAGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q4V321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWRGRSTYY WPRPRRYVEP PEMIGPMRPE QFSDEVEPAT PEEGEPATQR
60 70 80 90 100
QDPAAAQEGE DEGASAGQGP KPEADSQEQG HPQTGCECED GPDGQEMDPP
110
NPEEVKTPEE GEKQSQC
Length:117
Mass (Da):12,957
Last modified:March 28, 2018 - v2
Checksum:i375ACB1AF3800671
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11W → R in CAI95426 (PubMed:15772651).Curated1
Sequence conflicti50R → C in CAI95426 (PubMed:15772651).Curated1
Sequence conflicti112E → K in CAI95426 (PubMed:15772651).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC233302 Genomic DNA No translation available.
BX649339, AF235097 Genomic DNA Translation: CAI95426.1
CCDSiCCDS48110.1
RefSeqiNP_001091882.2, NM_001098412.2

Genome annotation databases

EnsembliENST00000612958; ENSP00000483811; ENSG00000274274
GeneIDi645051
KEGGihsa:645051

Similar proteinsi

Entry informationi

Entry nameiGAG13_HUMAN
AccessioniPrimary (citable) accession number: Q4V321
Secondary accession number(s): A0A087X111
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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