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Entry version 121 (02 Jun 2021)
Sequence version 1 (05 Jul 2005)
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Protein

Phosphoenolpyruvate synthase

Gene

ppsA

Organism
Xanthomonas campestris pv. campestris (strain 8004)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

UniRule annotationARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotationARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotationARBA annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationARBA annotation, Transferase
LigandATP-bindingUniRule annotationARBA annotation, MagnesiumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00138

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoenolpyruvate synthaseUniRule annotationARBA annotation (EC:2.7.9.2UniRule annotationARBA annotation)
Short name:
PEP synthaseUniRule annotation
Alternative name(s):
Pyruvate, water dikinaseUniRule annotationARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ppsAImported
Ordered Locus Names:XC_1952Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXanthomonas campestris pv. campestris (strain 8004)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri314565 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000420 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 344PPDK_NInterPro annotationAdd BLAST327
Domaini384 – 455PEP-utilizersInterPro annotationAdd BLAST72
Domaini482 – 788PEP-utilizers_CInterPro annotationAdd BLAST307

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PEP-utilizing enzyme family.UniRule annotationARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007308_6_2_6

Identification of Orthologs from Complete Genome Data

More...
OMAi
LETWFFL

Database of Orthologous Groups

More...
OrthoDBi
997616at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.60, 1 hit
3.30.1490.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR008279, PEP-util_enz_mobile_dom
IPR006319, PEP_synth
IPR018274, PEP_util_AS
IPR000121, PEP_util_C
IPR023151, PEP_util_CS
IPR036637, Phosphohistidine_dom_sf
IPR002192, PPDK_AMP/ATP-bd
IPR015813, Pyrv/PenolPyrv_Kinase-like_dom
IPR040442, Pyrv_Kinase-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR43030, PTHR43030, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00391, PEP-utilizers, 1 hit
PF02896, PEP-utilizers_C, 1 hit
PF01326, PPDK_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000854, PEP_synthase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51621, SSF51621, 1 hit
SSF52009, SSF52009, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01418, PEP_synth, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00742, PEP_ENZYMES_2, 1 hit
PS00370, PEP_ENZYMES_PHOS_SITE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4UVA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNENILWLHE LRLVDLARVG GKNSSLGEMI GNLAGLGVSV PGGYATTAEA
60 70 80 90 100
FKDFIAHNDL SKRIFDKLET LDVEDVTALT VAGKEIRGWV IDAPLQPELD
110 120 130 140 150
RDIRSAYEKL CAENGGGEVA VAVRSSATAE DLPDASFAGQ QETFLNVTGA
160 170 180 190 200
DDVVHKVKEV FASLYNDRAI AYRVHHGFKH EDVFLSAGVQ LMVRSGVGSS
210 220 230 240 250
GVLFTLDTES GFRDVVFVTS SFGLGEMVVQ GAVNPDEFYV YKPTLTAGKP
260 270 280 290 300
AILRRSLGSK AIRMVYSDVP GERVRIEDTP VELRNTFSIS DEDVQELSKQ
310 320 330 340 350
ALVIEKHYGR PMDIEWAKDG VSGKLFIVQA RPETVKSRSH ATQIERFSLE
360 370 380 390 400
AKDAKILVEG RAVGAKIGSG VARVVRSLED MNRVQAGDVL IADMTDPDWE
410 420 430 440 450
PVMKRASAIV TNRGGRTCHA AIIARELGVP AVVGSGNATD VISDGQEVTV
460 470 480 490 500
SCAEGDTGFI YEGLLPFERT TTDLGNMPPA PLKIMMNVAN PERAFDFGQL
510 520 530 540 550
PNAGIGLARL EMIIAAHIGI HPNALLEYDK QDADVRKKID AKIAGYGDPV
560 570 580 590 600
SFYINRLAEG IATLTASVAP NTVIVRLSDF KSNEYANLIG GSRYEPHEEN
610 620 630 640 650
PMIGFRGASR YVDPSFTKAF SLECKAVLKV RNEMGLDNLW VMIPFVRTLE
660 670 680 690 700
EGRKVIEVLE QNGLKQGENG LKIIMMCELP SNALLADEFL EIFDGFSIGS
710 720 730 740 750
NDLTQLTLGL DRDSSIVAHL FDERNPAVKK LLSMAIKSAR AKGKYVGICG
760 770 780 790
QGPSDHPELA EWLMQEGIES VSLNPDTVVD TWLRLAKLKS EG
Length:792
Mass (Da):86,227
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF7E8612AD4F8BDC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY618213 Genomic DNA Translation: AAT88065.1
CP000050 Genomic DNA Translation: AAY49015.1

NCBI Reference Sequences

More...
RefSeqi
WP_011037312.1, NC_007086.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAY49015; AAY49015; XC_1952

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xcb:XC_1952

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY618213 Genomic DNA Translation: AAT88065.1
CP000050 Genomic DNA Translation: AAY49015.1
RefSeqiWP_011037312.1, NC_007086.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAAY49015; AAY49015; XC_1952
KEGGixcb:XC_1952

Phylogenomic databases

HOGENOMiCLU_007308_6_2_6
OMAiLETWFFL
OrthoDBi997616at2

Enzyme and pathway databases

UniPathwayiUPA00138

Family and domain databases

Gene3Di3.20.20.60, 1 hit
3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815, ATP_grasp_subdomain_1
IPR008279, PEP-util_enz_mobile_dom
IPR006319, PEP_synth
IPR018274, PEP_util_AS
IPR000121, PEP_util_C
IPR023151, PEP_util_CS
IPR036637, Phosphohistidine_dom_sf
IPR002192, PPDK_AMP/ATP-bd
IPR015813, Pyrv/PenolPyrv_Kinase-like_dom
IPR040442, Pyrv_Kinase-like_dom_sf
PANTHERiPTHR43030, PTHR43030, 1 hit
PfamiView protein in Pfam
PF00391, PEP-utilizers, 1 hit
PF02896, PEP-utilizers_C, 1 hit
PF01326, PPDK_N, 1 hit
PIRSFiPIRSF000854, PEP_synthase, 1 hit
SUPFAMiSSF51621, SSF51621, 1 hit
SSF52009, SSF52009, 1 hit
TIGRFAMsiTIGR01418, PEP_synth, 1 hit
PROSITEiView protein in PROSITE
PS00742, PEP_ENZYMES_2, 1 hit
PS00370, PEP_ENZYMES_PHOS_SITE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4UVA8_XANC8
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4UVA8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: June 2, 2021
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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