UniProtKB - Q4UK22 (NUOG_RICFE)
Protein
NADH-quinone oxidoreductase subunit G
Gene
nuoG
Organism
Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
Status
Functioni
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity
Catalytic activityi
Cofactori
Protein has several cofactor binding sites:- [2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
- [4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 34 | Iron-sulfur 1 (2Fe-2S)By similarity | 1 | |
Metal bindingi | 45 | Iron-sulfur 1 (2Fe-2S)By similarity | 1 | |
Metal bindingi | 48 | Iron-sulfur 1 (2Fe-2S)By similarity | 1 | |
Metal bindingi | 62 | Iron-sulfur 1 (2Fe-2S)By similarity | 1 | |
Metal bindingi | 94 | Iron-sulfur 2 (4Fe-4S); via tele nitrogenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 98 | Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 101 | Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 107 | Iron-sulfur 2 (4Fe-4S)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 146 | Iron-sulfur 3 (4Fe-4S)By similarity | 1 | |
Metal bindingi | 149 | Iron-sulfur 3 (4Fe-4S)By similarity | 1 | |
Metal bindingi | 152 | Iron-sulfur 3 (4Fe-4S)By similarity | 1 | |
Metal bindingi | 196 | Iron-sulfur 3 (4Fe-4S)By similarity | 1 |
GO - Molecular functioni
- 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- NADH dehydrogenase (ubiquinone) activity Source: InterPro
- quinone binding Source: UniProtKB-KW
GO - Biological processi
- ATP synthesis coupled electron transport Source: InterPro
Keywordsi
Molecular function | Translocase |
Ligand | 2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD |
Enzyme and pathway databases
BioCyci | RFEL315456:G1G4G-2113-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: NADH-quinone oxidoreductase subunit G (EC:7.1.1.-)Alternative name(s): NADH dehydrogenase I subunit G NDH-1 subunit G |
Gene namesi | Name:nuoG Ordered Locus Names:RF_1262 |
Organismi | Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi) |
Taxonomic identifieri | 315456 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287843 | 1 – 671 | NADH-quinone oxidoreductase subunit GAdd BLAST | 671 |
Keywords - PTMi
QuinoneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 78 | 2Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 78 – 117 | 4Fe-4S His(Cys)3-ligated-typePROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 215 – 271 | 4Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd BLAST | 57 |
Sequence similaritiesi
Belongs to the complex I 75 kDa subunit family.Curated
Phylogenomic databases
eggNOGi | COG1034, Bacteria |
HOGENOMi | CLU_000422_11_6_5 |
OMAi | QDQAMAY |
OrthoDBi | 323168at2 |
Family and domain databases
CDDi | cd00207, fer2, 1 hit |
InterProi | View protein in InterPro IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR006656, Mopterin_OxRdtase IPR006963, Mopterin_OxRdtase_4Fe-4S_dom IPR000283, NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228, NADH_UbQ_OxRdtase_Gsu IPR019574, NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd IPR015405, NuoG_C |
Pfami | View protein in Pfam PF00384, Molybdopterin, 1 hit PF10588, NADH-G_4Fe-4S_3, 1 hit PF09326, NADH_dhqG_C, 1 hit |
SMARTi | View protein in SMART SM00929, NADH-G_4Fe-4S_3, 1 hit |
SUPFAMi | SSF54292, SSF54292, 1 hit |
TIGRFAMsi | TIGR01973, NuoG, 1 hit |
PROSITEi | View protein in PROSITE PS51085, 2FE2S_FER_2, 1 hit PS51839, 4FE4S_HC3, 1 hit PS51669, 4FE4S_MOW_BIS_MGD, 1 hit PS00641, COMPLEX1_75K_1, 1 hit PS00642, COMPLEX1_75K_2, 1 hit PS00643, COMPLEX1_75K_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4UK22-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIKLNIDGSE IEVSEGSTVY QACTQAGKEI PHFCYHERLK IAGNCRMCLV
60 70 80 90 100
EMEKSPKPIA SCAMPVSNGM VIHTDTPMVK KAREGVMEFL LINHPLDCPI
110 120 130 140 150
CDQGGECDLQ DQAFRYGKGT NRFHENKRSI KDKYMGPLIK TAMTRCIQCT
160 170 180 190 200
RCIRFANDIA GIEEMGAIHR GEHMEVTSYL EQTLDSEMSG NMIDICPVGA
210 220 230 240 250
LNSKPYAFKA RKWELKHTAS IGVHDAEGSN IRIDSRGDEV MRILPRVNEE
260 270 280 290 300
INEEWLSDKN RFSYDGLKYQ RLDLPYIRKN GKLVEASWSE ALKTIADKIK
310 320 330 340 350
SVKPEKIAAI AGSLVSVEAM FMLKTLLQKL GSNNYSVNQF DYKFDTTQRG
360 370 380 390 400
NYLFNTTIAG VEKADLCLLI GANLRQIAPV LNSRIGQRVR AGSLKVARIG
410 420 430 440 450
EGHNQTYRIQ DLGSDIKIIE ELAIGTHEFT KALKAAKYPM IIVGDGVYAR
460 470 480 490 500
DDGYAILSLI HKIVAEYNIM RDDFQGFNML HNHASIVGGL DIGFNTPIKL
510 520 530 540 550
EELELTYLLG ADELPFDKLK SAFIIYQGHH GDSGAANADV ILPAAAYTEQ
560 570 580 590 600
SGIYVNLEGR PQIAEKAVAP VGVAKEDIEI IKELAGSLKI DIGMDNLQEV
610 620 630 640 650
RVRLAKEYKI FANIDKIVES KFAKFSFKDK LSKEPITMGP INYYMTDVIS
660 670
KNSVTMAKCV EAKEKRNERA A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000053 Genomic DNA Translation: AAY62113.1 |
RefSeqi | WP_011271562.1, NC_007109.1 |
Genome annotation databases
EnsemblBacteriai | AAY62113; AAY62113; RF_1262 |
KEGGi | rfe:RF_1262 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000053 Genomic DNA Translation: AAY62113.1 |
RefSeqi | WP_011271562.1, NC_007109.1 |
3D structure databases
SMRi | Q4UK22 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 315456.RF_1262 |
Genome annotation databases
EnsemblBacteriai | AAY62113; AAY62113; RF_1262 |
KEGGi | rfe:RF_1262 |
Phylogenomic databases
eggNOGi | COG1034, Bacteria |
HOGENOMi | CLU_000422_11_6_5 |
OMAi | QDQAMAY |
OrthoDBi | 323168at2 |
Enzyme and pathway databases
BioCyci | RFEL315456:G1G4G-2113-MONOMER |
Family and domain databases
CDDi | cd00207, fer2, 1 hit |
InterProi | View protein in InterPro IPR036010, 2Fe-2S_ferredoxin-like_sf IPR001041, 2Fe-2S_ferredoxin-type IPR006656, Mopterin_OxRdtase IPR006963, Mopterin_OxRdtase_4Fe-4S_dom IPR000283, NADH_UbQ_OxRdtase_75kDa_su_CS IPR010228, NADH_UbQ_OxRdtase_Gsu IPR019574, NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd IPR015405, NuoG_C |
Pfami | View protein in Pfam PF00384, Molybdopterin, 1 hit PF10588, NADH-G_4Fe-4S_3, 1 hit PF09326, NADH_dhqG_C, 1 hit |
SMARTi | View protein in SMART SM00929, NADH-G_4Fe-4S_3, 1 hit |
SUPFAMi | SSF54292, SSF54292, 1 hit |
TIGRFAMsi | TIGR01973, NuoG, 1 hit |
PROSITEi | View protein in PROSITE PS51085, 2FE2S_FER_2, 1 hit PS51839, 4FE4S_HC3, 1 hit PS51669, 4FE4S_MOW_BIS_MGD, 1 hit PS00641, COMPLEX1_75K_1, 1 hit PS00642, COMPLEX1_75K_2, 1 hit PS00643, COMPLEX1_75K_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NUOG_RICFE | |
Accessioni | Q4UK22Primary (citable) accession number: Q4UK22 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | July 5, 2005 | |
Last modified: | April 7, 2021 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |