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Protein

Solute carrier family 22 member 6

Gene

SLC22A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p-aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p-chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarity). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate.By similarity6 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=9.3 µM for PAH (isoform 1)4 Publications
  2. KM=4 µM for PAH (isoform 2)4 Publications
  3. KM=11 µM for edaravone4 Publications
  4. KM=46 µM for cidofovir4 Publications
  5. KM=30 µM for adefovir4 Publications
  6. KM=5.77 µM for 2,4-D4 Publications
  7. KM=23.5 µM for HA4 Publications
  8. KM=14 µM for IA4 Publications
  9. KM=20.5 µM for IS4 Publications
  10. KM=141 µM for CMPF4 Publications
  1. Vmax=534 pmol/min/mg enzyme for 2,4-D uptake4 Publications
  2. Vmax=430 pmol/min/mg enzyme for HA uptake4 Publications
  3. Vmax=110 pmol/min/mg enzyme for IA uptake4 Publications
  4. Vmax=216 pmol/min/mg enzyme for IS uptake4 Publications
  5. Vmax=801 pmol/min/mg enzyme for CMPF uptake4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei230Important for interaction with cidofovir1
Sitei438Important for interaction with cidofovir and PAH1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-561048 Organic anion transport

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q4U2R8

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.19.31 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 22 member 6
Alternative name(s):
Organic anion transporter 1
Short name:
hOAT1
PAH transporter
Short name:
hPAHT
Renal organic anion transporter 1
Short name:
hROAT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC22A6
Synonyms:OAT1, PAHT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197901.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10970 SLC22A6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607582 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q4U2R8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 135ExtracellularSequence analysisAdd BLAST105
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 164CytoplasmicSequence analysis8
Transmembranei165 – 187HelicalSequence analysisAdd BLAST23
Topological domaini188 – 190ExtracellularSequence analysis3
Transmembranei191 – 213HelicalSequence analysisAdd BLAST23
Topological domaini214 – 224CytoplasmicSequence analysisAdd BLAST11
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 248ExtracellularSequence analysis3
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 337CytoplasmicSequence analysisAdd BLAST68
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21
Topological domaini359 – 368ExtracellularSequence analysis10
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Topological domaini390 – 395CytoplasmicSequence analysis6
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Topological domaini417 – 425ExtracellularSequence analysis9
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21
Topological domaini447 – 455CytoplasmicSequence analysis9
Transmembranei456 – 475HelicalSequence analysisAdd BLAST20
Topological domaini476 – 484ExtracellularSequence analysis9
Transmembranei485 – 505HelicalSequence analysisAdd BLAST21
Topological domaini506 – 563CytoplasmicSequence analysisAdd BLAST58

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi30L → A: Complete loss of PAH transport activity. 1 Publication1
Mutagenesisi36T → A: Complete loss of PAH transport activity. 1 Publication1
Mutagenesisi39N → Q: Complete loss of PAH transport activity. 1 Publication1
Mutagenesisi230Y → A: Loss of membrane protein expression and little uptake of cidofovir. 1 Publication1
Mutagenesisi431K → A: Decrease in the level of membrane protein expression and 70 % loss of PAH uptake. 1 Publication1
Mutagenesisi438F → A: Decrease in the level of membrane protein expression, 70 % loss of PAH uptake, increased affinity for cidofovir, lower Vmax for PAH, and lower Km and Vmax for cidofovir. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9356

Open Targets

More...
OpenTargetsi
ENSG00000197901

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA388

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1641347

Drug and drug target database

More...
DrugBanki
DB00316 Acetaminophen
DB00819 Acetazolamide
DB06151 Acetylcysteine
DB00945 Acetylsalicylic acid
DB00787 Aciclovir
DB00718 Adefovir Dipivoxil
DB00345 Aminohippuric acid
DB01424 Aminophenazone
DB01060 Amoxicillin
DB01435 Antipyrine
DB00168 Aspartame
DB01053 Benzylpenicillin
DB01237 Bromodiphenhydramine
DB00887 Bumetanide
DB04519 Caprylic acid
DB01197 Captopril
DB00578 Carbenicillin
DB00821 Carprofen
DB00520 Caspofungin
DB01414 Cefacetrile
DB01140 Cefadroxil
DB00456 Cefalotin
DB01326 Cefamandole
DB01327 Cefazolin
DB01329 Cefoperazone
DB00493 Cefotaxime
DB00229 Cefotiam
DB01333 Cefradine
DB00438 Ceftazidime
DB01212 Ceftriaxone
DB00567 Cephalexin
DB00446 Chloramphenicol
DB00880 Chlorothiazide
DB00672 Chlorpropamide
DB00369 Cidofovir
DB01597 Cilastatin
DB00501 Cimetidine
DB00827 Cinoxacin
DB01147 Cloxacillin
DB00286 Conjugated Equine Estrogens
DB02527 Cyclic Adenosine Monophosphate
DB02315 Cyclic Guanosine Monophosphate
DB00091 Cyclosporine
DB00606 Cyclothiazide
DB08912 Dabrafenib
DB04133 Degraded Cephaloridine
DB00586 Diclofenac
DB00900 Didanosine
DB00861 Diflunisal
DB01160 Dinoprost Tromethamine
DB00917 Dinoprostone
DB00254 Doxycycline
DB08846 Ellagic Acid
DB00584 Enalapril
DB00903 Etacrynic acid
DB00311 Ethoxzolamide
DB00749 Etodolac
DB02266 Flufenamic Acid
DB00693 Fluorescein
DB00712 Flurbiprofen
DB00158 Folic Acid
DB00529 Foscarnet
DB00695 Furosemide
DB01004 Ganciclovir
DB00798 Gentamicin
DB03553 Glutaric Acid
DB01016 Glyburide
DB00365 Grepafloxacin
DB00999 Hydrochlorothiazide
DB01050 Ibuprofen
DB00328 Indomethacin
DB01009 Ketoprofen
DB00709 Lamivudine
DB01137 Levofloxacin
DB00678 Losartan
DB00939 Meclofenamic acid
DB00703 Methazolamide
DB00563 Methotrexate
DB01017 Minocycline
DB00607 Nafcillin
DB00779 Nalidixic Acid
DB00788 Naproxen
DB00731 Nateglinide
DB01059 Norfloxacin
DB01051 Novobiocin
DB01165 Ofloxacin
DB03585 Oxyphenbutazone
DB00595 Oxytetracycline
DB03783 Phenacetin
DB00812 Phenylbutazone
DB00319 Piperacillin
DB00554 Piroxicam
DB00175 Pravastatin
DB01032 Probenecid
DB00140 Riboflavin
DB00936 Salicylic acid
DB00649 Stavudine
DB01082 Streptomycin
DB00605 Sulindac
DB04348 Taurocholic Acid
DB00300 Tenofovir
DB00759 Tetracycline
DB01124 Tolbutamide
DB00500 Tolmetin
DB00432 Trifluridine
DB08844 Uric Acid
DB00577 Valaciclovir
DB00313 Valproic Acid
DB00512 Vancomycin
DB00943 Zalcitabine
DB00495 Zidovudine

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1025

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC22A6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762955

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003241661 – 563Solute carrier family 22 member 6Add BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi39N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi56N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi92N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi97N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi113N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated. Glycosylation at Asn-113 may occur at a secondary level. Glycosylation is necessary for proper targeting of the transporter to the plasma membrane.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q4U2R8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4U2R8

PeptideAtlas

More...
PeptideAtlasi
Q4U2R8

PRoteomics IDEntifications database

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PRIDEi
Q4U2R8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62263
62264 [Q4U2R8-2]
62265 [Q4U2R8-3]
62266 [Q4U2R8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4U2R8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4U2R8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197901 Expressed in 48 organ(s), highest expression level in cortex of kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q4U2R8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q4U2R8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB075704
HPA074559

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-749741,EBI-743771

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114759, 24 interactors

Protein interaction database and analysis system

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IntActi
Q4U2R8, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000367102

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q4U2R8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q4U2R8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Multiple cysteine residues are necessary for proper targeting to the plasma membrane.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0255 Eukaryota
COG0477 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157004

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108433

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q4U2R8

KEGG Orthology (KO)

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KOi
K08203

Identification of Orthologs from Complete Genome Data

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OMAi
NGVVPQD

Database of Orthologous Groups

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OrthoDBi
EOG091G07CO

Database for complete collections of gene phylogenies

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PhylomeDBi
Q4U2R8

TreeFam database of animal gene trees

More...
TreeFami
TF315847

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083 Sugar_tr, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00898 2A0119, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4U2R8-1) [UniParc]FASTAAdd to basket
Also known as: OAT1-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFNDLLQQV GGVGRFQQIQ VTLVVLPLLL MASHNTLQNF TAAIPTHHCR
60 70 80 90 100
PPADANLSKN GGLEVWLPRD RQGQPESCLR FTSPQWGLPF LNGTEANGTG
110 120 130 140 150
ATEPCTDGWI YDNSTFPSTI VTEWDLVCSH RALRQLAQSL YMVGVLLGAM
160 170 180 190 200
VFGYLADRLG RRKVLILNYL QTAVSGTCAA FAPNFPIYCA FRLLSGMALA
210 220 230 240 250
GISLNCMTLN VEWMPIHTRA CVGTLIGYVY SLGQFLLAGV AYAVPHWRHL
260 270 280 290 300
QLLVSAPFFA FFIYSWFFIE SARWHSSSGR LDLTLRALQR VARINGKREE
310 320 330 340 350
GAKLSMEVLR ASLQKELTMG KGQASAMELL RCPTLRHLFL CLSMLWFATS
360 370 380 390 400
FAYYGLVMDL QGFGVSIYLI QVIFGAVDLP AKLVGFLVIN SLGRRPAQMA
410 420 430 440 450
ALLLAGICIL LNGVIPQDQS IVRTSLAVLG KGCLAASFNC IFLYTGELYP
460 470 480 490 500
TMIRQTGMGM GSTMARVGSI VSPLVSMTAE LYPSMPLFIY GAVPVAASAV
510 520 530 540 550
TVLLPETLGQ PLPDTVQDLE SRWAPTQKEA GIYPRKGKQT RQQQEHQKYM
560
VPLQASAQEK NGL
Length:563
Mass (Da):61,816
Last modified:July 19, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74AD3EA2678032E4
GO
Isoform 2 (identifier: Q4U2R8-2) [UniParc]FASTAAdd to basket
Also known as: OAT1-2

The sequence of this isoform differs from the canonical sequence as follows:
     523-535: Missing.

Show »
Length:550
Mass (Da):60,318
Checksum:iBC5D6DBDD0072D92
GO
Isoform 3 (identifier: Q4U2R8-3) [UniParc]FASTAAdd to basket
Also known as: OAT1-3

The sequence of this isoform differs from the canonical sequence as follows:
     455-498: Missing.
     523-535: Missing.

Note: No experimental confirmation available.
Show »
Length:506
Mass (Da):55,858
Checksum:iD8EBAE8A113E6C5E
GO
Isoform 4 (identifier: Q4U2R8-4) [UniParc]FASTAAdd to basket
Also known as: OAT1-4

The sequence of this isoform differs from the canonical sequence as follows:
     455-498: Missing.

Note: No experimental confirmation available.
Show »
Length:519
Mass (Da):57,357
Checksum:iE1748C6F9E2002F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H0T7F5H0T7_HUMAN
Solute carrier family 22 member 6
SLC22A6
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14G → S in AAD10052 (PubMed:9950961).Curated1
Sequence conflicti563L → F in AAC70004 (PubMed:9762842).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0396827L → P1 Publication1
Natural variantiVAR_03968350R → H Lower Vmax; increase in substrate affinity and increase in the affinity for the nucleoside phosphonate analogs cidofovir, adefovir and tenofovir. 2 PublicationsCorresponds to variant dbSNP:rs11568626Ensembl.1
Natural variantiVAR_047878104P → L1 PublicationCorresponds to variant dbSNP:rs11568627Ensembl.1
Natural variantiVAR_039684293R → W Increase in substrate affinity. Corresponds to variant dbSNP:rs45607933Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032168455 – 498Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_032169523 – 535Missing in isoform 2 and isoform 3. 7 PublicationsAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF057039 mRNA Translation: AAC70004.1
AB009697 mRNA Translation: BAA75072.1
AB009698 mRNA Translation: BAA75073.1
AF104038 mRNA Translation: AAD10052.1
AF097490 mRNA Translation: AAD19356.1
AF124373 mRNA Translation: AAD55356.1
AJ249369 Genomic DNA Translation: CAB77184.1
AJ251529 mRNA Translation: CAB94830.1
AJ271205 mRNA Translation: CAB97249.1
EU567146 Genomic DNA Translation: ACB21049.1
AP001858 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74129.1
CH471076 Genomic DNA Translation: EAW74130.1
CH471076 Genomic DNA Translation: EAW74131.1
CH471076 Genomic DNA Translation: EAW74132.1
BC033682 mRNA Translation: AAH33682.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31591.1 [Q4U2R8-1]
CCDS44631.1 [Q4U2R8-4]
CCDS44632.1 [Q4U2R8-3]
CCDS8041.1 [Q4U2R8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_004781.2, NM_004790.4 [Q4U2R8-1]
NP_695008.1, NM_153276.2 [Q4U2R8-2]
NP_695009.1, NM_153277.2 [Q4U2R8-3]
NP_695010.1, NM_153278.2 [Q4U2R8-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.369252

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360421; ENSP00000353597; ENSG00000197901 [Q4U2R8-2]
ENST00000377871; ENSP00000367102; ENSG00000197901 [Q4U2R8-1]
ENST00000421062; ENSP00000404441; ENSG00000197901 [Q4U2R8-4]
ENST00000458333; ENSP00000396401; ENSG00000197901 [Q4U2R8-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9356

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9356

UCSC genome browser

More...
UCSCi
uc001nwj.4 human [Q4U2R8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057039 mRNA Translation: AAC70004.1
AB009697 mRNA Translation: BAA75072.1
AB009698 mRNA Translation: BAA75073.1
AF104038 mRNA Translation: AAD10052.1
AF097490 mRNA Translation: AAD19356.1
AF124373 mRNA Translation: AAD55356.1
AJ249369 Genomic DNA Translation: CAB77184.1
AJ251529 mRNA Translation: CAB94830.1
AJ271205 mRNA Translation: CAB97249.1
EU567146 Genomic DNA Translation: ACB21049.1
AP001858 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW74129.1
CH471076 Genomic DNA Translation: EAW74130.1
CH471076 Genomic DNA Translation: EAW74131.1
CH471076 Genomic DNA Translation: EAW74132.1
BC033682 mRNA Translation: AAH33682.1
CCDSiCCDS31591.1 [Q4U2R8-1]
CCDS44631.1 [Q4U2R8-4]
CCDS44632.1 [Q4U2R8-3]
CCDS8041.1 [Q4U2R8-2]
RefSeqiNP_004781.2, NM_004790.4 [Q4U2R8-1]
NP_695008.1, NM_153276.2 [Q4U2R8-2]
NP_695009.1, NM_153277.2 [Q4U2R8-3]
NP_695010.1, NM_153278.2 [Q4U2R8-4]
UniGeneiHs.369252

3D structure databases

ProteinModelPortaliQ4U2R8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114759, 24 interactors
IntActiQ4U2R8, 2 interactors
STRINGi9606.ENSP00000367102

Chemistry databases

BindingDBiQ4U2R8
ChEMBLiCHEMBL1641347
DrugBankiDB00316 Acetaminophen
DB00819 Acetazolamide
DB06151 Acetylcysteine
DB00945 Acetylsalicylic acid
DB00787 Aciclovir
DB00718 Adefovir Dipivoxil
DB00345 Aminohippuric acid
DB01424 Aminophenazone
DB01060 Amoxicillin
DB01435 Antipyrine
DB00168 Aspartame
DB01053 Benzylpenicillin
DB01237 Bromodiphenhydramine
DB00887 Bumetanide
DB04519 Caprylic acid
DB01197 Captopril
DB00578 Carbenicillin
DB00821 Carprofen
DB00520 Caspofungin
DB01414 Cefacetrile
DB01140 Cefadroxil
DB00456 Cefalotin
DB01326 Cefamandole
DB01327 Cefazolin
DB01329 Cefoperazone
DB00493 Cefotaxime
DB00229 Cefotiam
DB01333 Cefradine
DB00438 Ceftazidime
DB01212 Ceftriaxone
DB00567 Cephalexin
DB00446 Chloramphenicol
DB00880 Chlorothiazide
DB00672 Chlorpropamide
DB00369 Cidofovir
DB01597 Cilastatin
DB00501 Cimetidine
DB00827 Cinoxacin
DB01147 Cloxacillin
DB00286 Conjugated Equine Estrogens
DB02527 Cyclic Adenosine Monophosphate
DB02315 Cyclic Guanosine Monophosphate
DB00091 Cyclosporine
DB00606 Cyclothiazide
DB08912 Dabrafenib
DB04133 Degraded Cephaloridine
DB00586 Diclofenac
DB00900 Didanosine
DB00861 Diflunisal
DB01160 Dinoprost Tromethamine
DB00917 Dinoprostone
DB00254 Doxycycline
DB08846 Ellagic Acid
DB00584 Enalapril
DB00903 Etacrynic acid
DB00311 Ethoxzolamide
DB00749 Etodolac
DB02266 Flufenamic Acid
DB00693 Fluorescein
DB00712 Flurbiprofen
DB00158 Folic Acid
DB00529 Foscarnet
DB00695 Furosemide
DB01004 Ganciclovir
DB00798 Gentamicin
DB03553 Glutaric Acid
DB01016 Glyburide
DB00365 Grepafloxacin
DB00999 Hydrochlorothiazide
DB01050 Ibuprofen
DB00328 Indomethacin
DB01009 Ketoprofen
DB00709 Lamivudine
DB01137 Levofloxacin
DB00678 Losartan
DB00939 Meclofenamic acid
DB00703 Methazolamide
DB00563 Methotrexate
DB01017 Minocycline
DB00607 Nafcillin
DB00779 Nalidixic Acid
DB00788 Naproxen
DB00731 Nateglinide
DB01059 Norfloxacin
DB01051 Novobiocin
DB01165 Ofloxacin
DB03585 Oxyphenbutazone
DB00595 Oxytetracycline
DB03783 Phenacetin
DB00812 Phenylbutazone
DB00319 Piperacillin
DB00554 Piroxicam
DB00175 Pravastatin
DB01032 Probenecid
DB00140 Riboflavin
DB00936 Salicylic acid
DB00649 Stavudine
DB01082 Streptomycin
DB00605 Sulindac
DB04348 Taurocholic Acid
DB00300 Tenofovir
DB00759 Tetracycline
DB01124 Tolbutamide
DB00500 Tolmetin
DB00432 Trifluridine
DB08844 Uric Acid
DB00577 Valaciclovir
DB00313 Valproic Acid
DB00512 Vancomycin
DB00943 Zalcitabine
DB00495 Zidovudine
GuidetoPHARMACOLOGYi1025

Protein family/group databases

TCDBi2.A.1.19.31 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ4U2R8
PhosphoSitePlusiQ4U2R8

Polymorphism and mutation databases

BioMutaiSLC22A6
DMDMi74762955

Proteomic databases

EPDiQ4U2R8
PaxDbiQ4U2R8
PeptideAtlasiQ4U2R8
PRIDEiQ4U2R8
ProteomicsDBi62263
62264 [Q4U2R8-2]
62265 [Q4U2R8-3]
62266 [Q4U2R8-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9356
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360421; ENSP00000353597; ENSG00000197901 [Q4U2R8-2]
ENST00000377871; ENSP00000367102; ENSG00000197901 [Q4U2R8-1]
ENST00000421062; ENSP00000404441; ENSG00000197901 [Q4U2R8-4]
ENST00000458333; ENSP00000396401; ENSG00000197901 [Q4U2R8-3]
GeneIDi9356
KEGGihsa:9356
UCSCiuc001nwj.4 human [Q4U2R8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9356
DisGeNETi9356
EuPathDBiHostDB:ENSG00000197901.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC22A6
HGNCiHGNC:10970 SLC22A6
HPAiCAB075704
HPA074559
MIMi607582 gene
neXtProtiNX_Q4U2R8
OpenTargetsiENSG00000197901
PharmGKBiPA388

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00940000157004
HOVERGENiHBG108433
InParanoidiQ4U2R8
KOiK08203
OMAiNGVVPQD
OrthoDBiEOG091G07CO
PhylomeDBiQ4U2R8
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-HSA-561048 Organic anion transport
SABIO-RKiQ4U2R8

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Organic_anion_transporter_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9356

Protein Ontology

More...
PROi
PR:Q4U2R8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197901 Expressed in 48 organ(s), highest expression level in cortex of kidney
ExpressionAtlasiQ4U2R8 baseline and differential
GenevisibleiQ4U2R8 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS22A6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4U2R8
Secondary accession number(s): A8MY93
, B2D0R6, O95187, O95742, Q7LDA0, Q8N192, Q9NQA6, Q9NQC2, Q9UBG6, Q9UEQ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 19, 2005
Last modified: December 5, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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