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Protein

39S ribosomal protein L51, mitochondrial

Gene

MRPL51

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L51, mitochondrial
Short name:
L51mt
Short name:
MRP-L51
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL511 Publication
bMRP-64
Short name:
bMRP64
Gene namesi
Name:MRPL51
Synonyms:MRP64
ORF Names:CDA09, HSPC241
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111639.7
HGNCiHGNC:14044 MRPL51
MIMi611855 gene
neXtProtiNX_Q4U2R6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111639
PharmGKBiPA30984

Polymorphism and mutation databases

BioMutaiMRPL51
DMDMi74762954

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionSequence analysisAdd BLAST31
ChainiPRO_000027308232 – 12839S ribosomal protein L51, mitochondrialAdd BLAST97

Proteomic databases

EPDiQ4U2R6
MaxQBiQ4U2R6
PaxDbiQ4U2R6
PeptideAtlasiQ4U2R6
PRIDEiQ4U2R6
ProteomicsDBi62262
TopDownProteomicsiQ4U2R6

Expressioni

Gene expression databases

BgeeiENSG00000111639 Expressed in 198 organ(s), highest expression level in testis
CleanExiHS_MRPL51
ExpressionAtlasiQ4U2R6 baseline and differential
GenevisibleiQ4U2R6 HS

Organism-specific databases

HPAiHPA039923

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with OXA1L (By similarity).By similarity3 Publications

Protein-protein interaction databases

BioGridi119414, 36 interactors
CORUMiQ4U2R6
IntActiQ4U2R6, 6 interactors
MINTiQ4U2R6
STRINGi9606.ENSP00000229238

Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ4U2R6
SMRiQ4U2R6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4045 Eukaryota
ENOG4111M24 LUCA
GeneTreeiENSGT00390000018821
HOGENOMiHOG000154145
HOVERGENiHBG093901
InParanoidiQ4U2R6
KOiK17432
OMAiFNRHGKY
OrthoDBiEOG091G0V79
PhylomeDBiQ4U2R6
TreeFamiTF106130

Family and domain databases

InterProiView protein in InterPro
IPR019373 Ribosomal_L51_mit
PANTHERiPTHR13409 PTHR13409, 1 hit
PfamiView protein in Pfam
PF10244 MRP-L51, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q4U2R6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGNLLSGAG RRLWDWVPLA CRSFSLGVPR LIGIRLTLPP PKVVDRWNEK
60 70 80 90 100
RAMFGVYDNI GILGNFEKHP KELIRGPIWL RGWKGNELQR CIRKRKMVGS
110 120
RMFADDLHNL NKRIRYLYKH FNRHGKFR
Length:128
Mass (Da):15,095
Last modified:July 19, 2005 - v1
Checksum:i9DB4720D5B387A5D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R176M0R176_HUMAN
39S ribosomal protein L51, mitochon...
MRPL51
32Annotation score:
A0A087WU28A0A087WU28_HUMAN
39S ribosomal protein L51, mitochon...
MRPL51
73Annotation score:
A0A0B4J2C1A0A0B4J2C1_HUMAN
39S ribosomal protein L51, mitochon...
MRPL51
76Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79W → R in AAF36161 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030079102M → I. Corresponds to variant dbSNP:rs9526Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049959 mRNA Translation: BAB41012.1
AF212248 mRNA Translation: AAK14931.1
AF151075 mRNA Translation: AAF36161.1
BC000191 mRNA Translation: AAH00191.1
BC014329 mRNA Translation: AAH14329.1
AB051355 Genomic DNA Translation: BAB54944.1
CCDSiCCDS8547.1
RefSeqiNP_057581.2, NM_016497.3
UniGeneiHs.55847

Genome annotation databases

EnsembliENST00000229238; ENSP00000229238; ENSG00000111639
GeneIDi51258
KEGGihsa:51258
UCSCiuc001qom.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049959 mRNA Translation: BAB41012.1
AF212248 mRNA Translation: AAK14931.1
AF151075 mRNA Translation: AAF36161.1
BC000191 mRNA Translation: AAH00191.1
BC014329 mRNA Translation: AAH14329.1
AB051355 Genomic DNA Translation: BAB54944.1
CCDSiCCDS8547.1
RefSeqiNP_057581.2, NM_016497.3
UniGeneiHs.55847

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40i1-128[»]
3J9Melectron microscopy3.50i1-128[»]
5OOLelectron microscopy3.06i1-128[»]
5OOMelectron microscopy3.03i1-128[»]
ProteinModelPortaliQ4U2R6
SMRiQ4U2R6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119414, 36 interactors
CORUMiQ4U2R6
IntActiQ4U2R6, 6 interactors
MINTiQ4U2R6
STRINGi9606.ENSP00000229238

Polymorphism and mutation databases

BioMutaiMRPL51
DMDMi74762954

Proteomic databases

EPDiQ4U2R6
MaxQBiQ4U2R6
PaxDbiQ4U2R6
PeptideAtlasiQ4U2R6
PRIDEiQ4U2R6
ProteomicsDBi62262
TopDownProteomicsiQ4U2R6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229238; ENSP00000229238; ENSG00000111639
GeneIDi51258
KEGGihsa:51258
UCSCiuc001qom.3 human

Organism-specific databases

CTDi51258
EuPathDBiHostDB:ENSG00000111639.7
GeneCardsiMRPL51
HGNCiHGNC:14044 MRPL51
HPAiHPA039923
MIMi611855 gene
neXtProtiNX_Q4U2R6
OpenTargetsiENSG00000111639
PharmGKBiPA30984
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4045 Eukaryota
ENOG4111M24 LUCA
GeneTreeiENSGT00390000018821
HOGENOMiHOG000154145
HOVERGENiHBG093901
InParanoidiQ4U2R6
KOiK17432
OMAiFNRHGKY
OrthoDBiEOG091G0V79
PhylomeDBiQ4U2R6
TreeFamiTF106130

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL51 human
GenomeRNAii51258
PROiPR:Q4U2R6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111639 Expressed in 198 organ(s), highest expression level in testis
CleanExiHS_MRPL51
ExpressionAtlasiQ4U2R6 baseline and differential
GenevisibleiQ4U2R6 HS

Family and domain databases

InterProiView protein in InterPro
IPR019373 Ribosomal_L51_mit
PANTHERiPTHR13409 PTHR13409, 1 hit
PfamiView protein in Pfam
PF10244 MRP-L51, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM51_HUMAN
AccessioniPrimary (citable) accession number: Q4U2R6
Secondary accession number(s): Q96Q57, Q9BQ36, Q9P0N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 19, 2005
Last modified: September 12, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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