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UniProtKB - Q4U2R1 (HERC2_MOUSE)

Entry version 145 (29 Sep 2021)
Sequence version 3 (27 Jul 2011)
Previous versions | rss
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Protein

E3 ubiquitin-protein ligase HERC2

Gene

Herc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2709Zinc 1PROSITE-ProRule annotation1
Metal bindingi2712Zinc 1PROSITE-ProRule annotation1
Metal bindingi2724Zinc 2PROSITE-ProRule annotation1
Metal bindingi2727Zinc 2PROSITE-ProRule annotation1
Metal bindingi2733Zinc 1PROSITE-ProRule annotation1
Metal bindingi2736Zinc 1PROSITE-ProRule annotation1
Metal bindingi2742Zinc 2PROSITE-ProRule annotation1
Metal bindingi2746Zinc 2PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4764Glycyl thioester intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2704 – 2756ZZ-typePROSITE-ProRule annotationAdd BLAST53

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-3108214, SUMOylation of DNA damage response and repair proteins
R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-5693571, Nonhomologous End-Joining (NHEJ)
R-MMU-5693607, Processing of DNA double-strand break ends
R-MMU-69473, G2/M DNA damage checkpoint
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase HERC2 (EC:2.3.2.26By similarity)
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 2
HECT-type E3 ubiquitin transferase HERC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Herc2Imported
Synonyms:Jdf2, Kiaa0393Imported, Rjs
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:103234, Herc2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000030451

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Herc2 are the cause of the runty, jerky, sterile phenotype (rjs), also known as the juvenile development and fertility phenotype (jfd2), which is characterized by reduced size, jerky gait, fertility problems including spermatocyte and oocyte abnormalities, defective maternal behavior and reduced lifespan with juvenile lethality.3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002297401 – 4836E3 ubiquitin-protein ligase HERC2Add BLAST4836

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei273PhosphothreonineBy similarity1
Modified residuei648PhosphothreonineBy similarity1
Modified residuei1578PhosphoserineCombined sources1
Modified residuei1943PhosphoserineCombined sources1
Modified residuei1945PhosphothreonineCombined sources1
Modified residuei2455PhosphoserineBy similarity1
Modified residuei2929PhosphoserineCombined sources1
Modified residuei4812PhosphoserineBy similarity1
Modified residuei4813PhosphoserineBy similarity1
Modified residuei4816PhosphoserineBy similarity1
Modified residuei4829PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Thr-4829 is required for interaction with RNF8.
Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs), promoting the interaction with RNF8.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q4U2R1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q4U2R1

PeptideAtlas

More...PeptideAtlasi		Q4U2R1

PRoteomics IDEntifications database

More...PRIDEi		Q4U2R1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		269656 [Q4U2R1-1]
269657 [Q4U2R1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q4U2R1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q4U2R1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels are found in brain and testis with lower levels in heart, lung, liver, skeletal muscle and kidney. Little expression detected in spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000030451, Expressed in midbrain and 319 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q4U2R1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (when phosphorylated at Thr-4829 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment.

Interacts with XPA.

Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		200274, 72 interactors

Protein interaction database and analysis system

More...IntActi		Q4U2R1, 61 interactors

Molecular INTeraction database

More...MINTi		Q4U2R1

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000075579

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q4U2R1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4U2R1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati416 – 462RCC1 1-1Add BLAST47
Repeati463 – 513RCC1 1-2Add BLAST51
Repeati514 – 569RCC1 1-3Add BLAST56
Repeati570 – 621RCC1 1-4Add BLAST52
Repeati624 – 675RCC1 1-5Add BLAST52
Repeati676 – 727RCC1 1-6Add BLAST52
Repeati729 – 779RCC1 1-7Add BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1208 – 1284Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST77
Domaini1860 – 1933MIB/HERC2PROSITE-ProRule annotationAdd BLAST74
Domaini2760 – 2937DOCPROSITE-ProRule annotationAdd BLAST178
Repeati2959 – 3010RCC1 2-1Add BLAST52
Repeati3011 – 3065RCC1 2-2Add BLAST55
Repeati3066 – 3117RCC1 2-3Add BLAST52
Repeati3119 – 3169RCC1 2-4Add BLAST51
Repeati3172 – 3223RCC1 2-5Add BLAST52
Repeati3225 – 3275RCC1 2-6Add BLAST51
Repeati3276 – 3327RCC1 2-7Add BLAST52
Repeati3953 – 4004RCC1 3-1Add BLAST52
Repeati4006 – 4058RCC1 3-2Add BLAST53
Repeati4060 – 4110RCC1 3-3Add BLAST51
Repeati4112 – 4164RCC1 3-4Add BLAST53
Repeati4166 – 4216RCC1 3-5Add BLAST51
Repeati4218 – 4268RCC1 3-6Add BLAST51
Repeati4270 – 4320RCC1 3-7Add BLAST51
Domaini4459 – 4796HECTPROSITE-ProRule annotationAdd BLAST338

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni58 – 90DisorderedSequence analysisAdd BLAST33
Regioni2351 – 2376DisorderedSequence analysisAdd BLAST26
Regioni2928 – 2947DisorderedSequence analysisAdd BLAST20
Regioni3479 – 3499DisorderedSequence analysisAdd BLAST21
Regioni3517 – 3537DisorderedSequence analysisAdd BLAST21
Regioni3604 – 3632DisorderedSequence analysisAdd BLAST29
Regioni4806 – 4836DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili948 – 981Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3480 – 3496Polar residuesSequence analysisAdd BLAST17
Compositional biasi4810 – 4824Acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ZZ-type zinc finger mediates binding to SUMO1, and at low level SUMO2.By similarity
The RCC1 repeats are grouped into three seven-bladed beta-propeller regions.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2704 – 2756ZZ-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1426, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000101_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4U2R1

Identification of Orthologs from Complete Genome Data

More...OMAi		GPRFKCK

Database of Orthologous Groups

More...OrthoDBi		1062377at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q4U2R1

TreeFam database of animal gene trees

More...TreeFami		TF320636

Family and domain databases

Conserved Domains Database

More...CDDi		cd08664, APC10-HERC2, 1 hit
cd00078, HECTc, 1 hit
cd02344, ZZ_HERC2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.30, 3 hits
2.30.30.30, 1 hit
3.10.120.10, 1 hit
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR006624, Beta-propeller_rpt_TECPR
IPR021097, CPH_domain
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR008979, Galactose-bd-like_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR037976, HERC2_APC10
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR014722, Rib_L2_dom2
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR041987, ZZ_HERC2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03256, ANAPC10, 1 hit
PF11515, Cul7, 1 hit
PF00173, Cyt-b5, 1 hit
PF00632, HECT, 1 hit
PF06701, MIB_HERC2, 1 hit
PF00415, RCC1, 16 hits
PF00569, ZZ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00633, RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01337, APC10, 1 hit
SM01117, Cyt-b5, 1 hit
SM00119, HECTc, 1 hit
SM00706, TECPR, 4 hits
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF159034, SSF159034, 1 hit
SSF49785, SSF49785, 1 hit
SSF50985, SSF50985, 3 hits
SSF55856, SSF55856, 1 hit
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50255, CYTOCHROME_B5_2, 1 hit
PS51284, DOC, 1 hit
PS50237, HECT, 1 hit
PS51416, MIB_HERC2, 1 hit
PS00626, RCC1_2, 1 hit
PS50012, RCC1_3, 19 hits
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 12 Publications (identifier: Q4U2R1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSESFCLAA QSRLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT 
        60         70         80         90        100
ELAQNRELPL RKDDGVDAQS GTKKEDLNDK EKKEEEETPA PVYRAKSILE 
       110        120        130        140        150
SWVWGRQPDV NELKECLSVL VKEQQALAVQ SATTTLSALR LKQRLVILER 
       160        170        180        190        200
YFIALNRTVF QENVKVKWKS SSISVPPTEK KSARPTGRGV EGLARVGSRA 
       210        220        230        240        250
ALSFAFAFLR RAWRSGEDAD LCSELLQESL DALRALPEAS LFDESTVSSV 
       260        270        280        290        300
WLEVVERATR FLRSVVTGDV HGTPGTKGPG GVPLQDQHLA LAILLELAVQ 
       310        320        330        340        350
RGTLSQMLSA ILLLLQLWDS GAQETDNERS AQGTSAPLLP LLQRFQSIIC 
       360        370        380        390        400
SKDVPHTESD MHLLSGPLSP NESFLRYLTL PQDNELAIDL RQTAVVVMAH 
       410        420        430        440        450
LDRLATPCMP PLCSSPTSHK GSLQEVIGWG LIGWKYYANV IGPIQCEGLA 
       460        470        480        490        500
SLGVMQVACA EKRFLILSRN GRVYTQAYNS DMLAPQLVQG LASRNIVKIA 
       510        520        530        540        550
AHSDGHHYLA LAATGEVYSW GCGDGGRLGH GDTVPLEEPK VISAFSGKQA 
       560        570        580        590        600
GKHVVHIACG STYSAAITAE GELYTWGRGN YGRLGHGSSE DEAIPMLVAG 
       610        620        630        640        650
LKGLKVIDVA CGSGDAQTLA VTENGQVWSW GDGDYGKLGR GGSDGCKTPK 
       660        670        680        690        700
LIEKLQDLDV IKVRCGSQFS IALTKDGQVY SWGKGDNQRL GHGTEEHVRY 
       710        720        730        740        750
PKLLEGLQGK KVIDVAAGST HCLALTEDSE VHSWGSNDQC QHFDTLRVTK 
       760        770        780        790        800
PEPTALPGLD SKHIVGIACG PAQSFAWSSC SEWSIGLRVP FVVDICSMTF 
       810        820        830        840        850
EQLDLLLRQV SEGMDGTADW PPPQEKECMA VATLNLLRLQ LHAAISHQVD 
       860        870        880        890        900
PEFLGLGLGS VLLNSLKQTV VTLASSAGVL STVQSAAQAV LQSGWSVLLP 
       910        920        930        940        950
TAEERARALS ALLPCTVSGN EVNISPGRRF MIDLLVGSLM ADGGLESALN 
       960        970        980        990       1000
AAITAEIQDI EAKKEAQKEK EIDEQEASAS TFHRSRTPLD KDLINTGIYE 
      1010       1020       1030       1040       1050
SSGKQCLPLV QLIQQLLRNI ASQTVARLKD VARRISSCLD FEQQSCERSA 
      1060       1070       1080       1090       1100
SLDLLLRFQR LLISKLYPGE KIGPISDTSS PELMGVGSLL KKYTALVCTH 
      1110       1120       1130       1140       1150
IGDILPVAAS IASSSWQHFA EVACVMEGDF TGVLLPELVV SIVLLLSKNA 
      1160       1170       1180       1190       1200
SLMQEAGAIP LLGGLLEHLD RFNHLAPGKE RDDHEELAWP GIMESFFTGQ 
      1210       1220       1230       1240       1250
NCRNNEEVTL IRKADLENHN KDGGFWTVID GKVYGIKDFQ TQSLTGNSIL 
      1260       1270       1280       1290       1300
AQFAGEDPVV ALEAALQFED TQESMHAFCV GQYLEPDQEV VTIPDLGSLS 
      1310       1320       1330       1340       1350
SPLIDTERNL GLLLGLHASY LAMSTPLSPV EVECAKWLQS SIFSGGLQTS 
      1360       1370       1380       1390       1400
QIHYSYNEEK DEDHCSSPGG TPISKSRLCS HRWALGDHSQ AFLQAIADNN 
      1410       1420       1430       1440       1450
IQDYNVKDFL CQIERYCRQC HLTTPITFPP EHPVEEVGRL LLCCLLKHED 
      1460       1470       1480       1490       1500
LGHVALSLVH VGTLGIEQVK HRTLPKSVVD VCRVVYQAKC SLIKTHQEQG 
      1510       1520       1530       1540       1550
RSYKEVCAPV IERLRFLFNE LRPAVCSDLS IMSKFKLLGS LPRWRRIAQK 
      1560       1570       1580       1590       1600
IIRERRKKRV PKKPESIDSE EKIGNEESDL EEACVLPHSP INVDKRPISM 
      1610       1620       1630       1640       1650
KSPKDKWQPL LNTVTGVHKY KWLKQNVQGL YPQSALLNTI VEFALKEEPV 
      1660       1670       1680       1690       1700
DVEKMRKCLL KQLERAEVRL EGIDTILKLA AKSFLLPSVQ YAMFCGWQRL 
      1710       1720       1730       1740       1750
IPEGIDIGEP LTDCLRDVDL IPPFNRMLLE VTFGKLYAWA VQNIRSVLMD 
      1760       1770       1780       1790       1800
ASARFKELGI QPVPLQTITN ENPAGPSLGT IPQARFLLVM LSMLTLQHGA 
      1810       1820       1830       1840       1850
NNLDLLLNSG TLALTQTALR LIGPTCDSVE DDMNASARGA SATVLEETRK 
      1860       1870       1880       1890       1900
ETAPVQLPVS GPELAAMMKI GTRVMRGVDW KWGDQDGPPP GLGRVIGELG 
      1910       1920       1930       1940       1950
EDGWIRVQWD TGSTNSYRMG KEGKYDLKLV ELPVSSQPSA EDSDTEDDSE 
      1960       1970       1980       1990       2000
AEQGERNIHP TAMMLTSVIN LLQTLCLSVG VHADIMQSEA TKTLCGLLRM 
      2010       2020       2030       2040       2050
LVESGTTDKP APPDRLVARE QHRSWCTLGF VRSIALTPQA CGALSSPRWI 
      2060       2070       2080       2090       2100
TLLMKVVEGH APFTAASLQR QILAVHLLQA VLPSWDKTER ARDMKCLVEK 
      2110       2120       2130       2140       2150
LFGFLGSLLT TCSSDVPLLR ESTLRKRRAR PQASLTATHS STLAEEVVGL 
      2160       2170       2180       2190       2200
LRTLHSLTQW NGLINKYINS QLCSVTQSYA GKTSERAQLE DYFPDSENLE 
      2210       2220       2230       2240       2250
VGGLMAVLAV IGGIDGRLRL GGQVMHDEFG EGTVTRITPK GRITVQFCDM 
      2260       2270       2280       2290       2300
RMCRVCPLNQ LKPLPAVAFS VNNLPFTEPM LSVWAELVNL AGSKLEKHKT 
      2310       2320       2330       2340       2350
KKSAKPAFAG QVDLDLLRSQ QLKLYILKAG RALLSHQDKL RQILSQPAVQ 
      2360       2370       2380       2390       2400
GTGTLQTDDG AAASPDLGDM SPEGPQPPMI LLQQLLSSAT QPSPVKAIFD 
      2410       2420       2430       2440       2450
KQELEAAALA LCQCLAVEST HPSSPGCEDC SSSEATTPVS VQHIHLARAK 
      2460       2470       2480       2490       2500
KRRQSPAPAL PIVVQLMEMG FPRKNIEFAL KSLTGTSGNA SGLPGVEALV 
      2510       2520       2530       2540       2550
GWLLDHSDVQ VTEFSDAETL SDEYSDEEVV EDVDDTPYPV AAGAVVTESQ 
      2560       2570       2580       2590       2600
TYKKRADFLS NDDYAVYVRE NVQVGMMVRC CRTYEEVCEG DVGKVIKLDR 
      2610       2620       2630       2640       2650
DGLHDLNVQC DWQQKGGTYW VRYIHVELIG YPPPSSSSHI KIGDKVRVKA 
      2660       2670       2680       2690       2700
SVTTPKYKWG SVTHQSVGLV KAFSANGKDI IVDFPQQSHW TGLLSEMELV 
      2710       2720       2730       2740       2750
PSIHPGVTCD GCQTFPINGS RFKCRNCDDF DFCETCFKTK KHNTRHTFGR 
      2760       2770       2780       2790       2800
INEPGQSAVF CGRSGKQLKR CHSSQPGMLL DSWSRMVKSL NVSSSVNQAS 
      2810       2820       2830       2840       2850
RLIDGSEPCW QSSGSQGKHW IRLEIFPDVL VHRLKMIVDP ADSSYMPSLV 
      2860       2870       2880       2890       2900
VVSGGNSLNN LIELKTININ QTDTTVPLLS DCAEYHRYIE IAIKQCRSSG 
      2910       2920       2930       2940       2950
IDCKIHGLIL LGRIRAEEED LAAVPFLASD NEEEEDDKGS TGSLIRKKTP 
      2960       2970       2980       2990       3000
GLESTATIRT KVFVWGLNDK DQLGGLKGSK IKVPSFSETL SALNVVQVAG 
      3010       3020       3030       3040       3050
GSKSLFAVTV EGKVYSCGEA TNGRLGLGMS SGTVPIPRQI TALSSYVVKK 
      3060       3070       3080       3090       3100
VAVHSGGRHA TALTVDGKVF SWGEGDDGKL GHFSRMNCDK PRLIEALKTK 
      3110       3120       3130       3140       3150
RIRDIACGSS HSAALTSSGE LYTWGLGEYG RLGHGDNTTQ LKPKMVKVLL 
      3160       3170       3180       3190       3200
GHRVIQVACG SRDAQTLALT DEGLVFSWGD GDFGKLGRGG SEGCNIPQNI 
      3210       3220       3230       3240       3250
ERLNGQGVCQ IECGAQFSLA LTKSGVVWTW GKGDYFRLGH GSDVHVRKPQ 
      3260       3270       3280       3290       3300
VVEGLRGKKI VHVAVGALHC LAVTDSGQVY AWGDNDHGQQ GNGTTTVNRK 
      3310       3320       3330       3340       3350
PTLVQGLEGQ KITRVACGSS HSVAWTTVDV ATPSVHEPVL FQTARDPLGA 
      3360       3370       3380       3390       3400
SYLGVPSDAD SSSSSNKISG ANNCKPNRPS LAKILLSLEG NLAKQQALSH 
      3410       3420       3430       3440       3450
ILTALQIMYA RDAVVGALMP AGMLAPVECP SFSSSAPASD VSAMASPMHM 
      3460       3470       3480       3490       3500
EDSTLAADLE DRLSPNLWQE KREIVSSEDA VTPSAVTPSA PSASSRPFIP 
      3510       3520       3530       3540       3550
VTDDPGAASI IAETMTKTKE DVESQNKTSG PEPQSLDEFT SLLIPDDTRV 
      3560       3570       3580       3590       3600
VVELLKLSVC SRAGDKGREV LSAVLSGMGT AYPQVADMLL ELCVTELEDV 
      3610       3620       3630       3640       3650
ATDSQSGRLS SQPVVVESSH PYTDDTSTSG TVKIPGAEGL RVEFDRQCST 
      3660       3670       3680       3690       3700
ERRHDPLTVM DGVNRIVSVR SGREWSDWSS ELRIPGDELK WKFISDGSVN 
      3710       3720       3730       3740       3750
GWGWRFTVYP IMPAAGPKDL LSDRCVLSCP SMDLVTCLLD FRLNLTSNRS 
      3760       3770       3780       3790       3800
IVPRLAASLA ACAQLSALAA SHRMWALQRL RRLLTTEFGQ SININRLLGE 
      3810       3820       3830       3840       3850
NDGESRALSF TGSALAALVK GLPEALQRQF EYEDPIVRGG KQLLHSPFFK 
      3860       3870       3880       3890       3900
VLVALACDLE LDTLPCCAET HKWAWFRRYC MASRVAVALD KRTPLPRLFL 
      3910       3920       3930       3940       3950
DEVAKKIREL MADSESMDVL HESHSIFKRE QDEQLVQWMN RRPDDWTLSA 
      3960       3970       3980       3990       4000
GGSGTIYGWG HNHRGQLGGI EGAKVKVPTP CEALATLRPV QLIGGEQTLF 
      4010       4020       4030       4040       4050
AVTADGKLYA TGYGAGGRLG IGGTESVSTP TLLESIQHVF IKKVAVNSGG 
      4060       4070       4080       4090       4100
KHCLALSSEG EVYSWGEAED GKLGHGNRSP CDRPRVIESL RGIEVVDVAA 
      4110       4120       4130       4140       4150
GGAHSACVTA AGDLYTWGKG RYGRLGHSDS EDQLKPKLVE ALQGHRVIDI 
      4160       4170       4180       4190       4200
ACGSGDAQTL CLTDDDTVWS WGDGDYGKLG RGGSDGCKVP MKIDSLTGLG 
      4210       4220       4230       4240       4250
VVKVECGSQF SVALTKSGAV YTWGKGDYHR LGHGSDDHVR RPRQVQGLQG 
      4260       4270       4280       4290       4300
KKVIAIATGS LHCVCCTEDG EVYTWGDNDE GQLGDGTTNA IQRPRLVAAL 
      4310       4320       4330       4340       4350
QGKKVNRVAC GSAHTLAWST SKPASAGKLP AQVPMEYNHL QEIPIIALRN 
      4360       4370       4380       4390       4400
RLLLLHHISE LFCPCIPMFD LEGSLDETGL GPSVGFDTLR GILISQGKEA 
      4410       4420       4430       4440       4450
AFRKVVQATM VRDRQHGPVV ELNRIQVKRS RSKGGLAGPD GTKSVFGQMC 
      4460       4470       4480       4490       4500
AKMSSFSPDS LLLPHRVWKV KFVGESVDDC GGGYSESIAE ICEELQNGLT 
      4510       4520       4530       4540       4550
PLLIVTPNGR DESGANRDCY LLNPATRAPV HCSMFRFLGV LLGIAIRTGS 
      4560       4570       4580       4590       4600
PLSLNLAEPV WKQLAGMSLT IADLSEVDKD FIPGLMYIRD NEATSEEFEA 
      4610       4620       4630       4640       4650
MSLPFTVPSA SGQDIQLSSK HTHITLDNRA EYVRLAINYR LHEFDEQVAA 
      4660       4670       4680       4690       4700
VREGMARVVP VPLLSLFTGY ELETMVCGSP DIPLHLLKSV ATYKGIEPSA 
      4710       4720       4730       4740       4750
SLVQWFWEVM ESFSNTERSL FLRFVWGRTR LPRTIADFRG RDFVIQVLDK 
      4760       4770       4780       4790       4800
YNPPDHFLPE SYTCFFLLKL PRYSCKQVLE EKLKYAIHFC KSIDTDDYAR 
      4810       4820       4830 
IALTGEPAAD DSSEDSDNED ADSFASDSTQ DYLTGH
Length:4,836
Mass (Da):527,456
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i481BC90E231C93D8
GO
Isoform 21 Publication (identifier: Q4U2R1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3637-3672: Missing.

Show »
Length:4,800
Mass (Da):523,388
Checksum:i3E3BA1D6DE63BAF7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNG9A0A0U1RNG9_MOUSE
E3 ubiquitin-protein ligase HERC2
Herc2
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPZ3A0A0U1RPZ3_MOUSE
E3 ubiquitin-protein ligase HERC2
Herc2
965Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RP01A0A0U1RP01_MOUSE
E3 ubiquitin-protein ligase HERC2
Herc2
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti692H → L in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti724A → V in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti747R → G in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti756L → F in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti929R → P in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti1114S → N in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti1235G → D in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti2348A → P in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti2470G → S in BAE36828 (PubMed:16141072).Curated1
Sequence conflicti2523E → D in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti2567Y → F in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti2572V → L in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti3095E → Q in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti3107C → Y in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti3114A → P in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti3161S → T in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti3385 – 3386LL → VV in AAD08658 (PubMed:9949213).Curated2
Sequence conflicti3508A → V in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti4069E → K in BAD90404 (Ref. 5) Curated1
Sequence conflicti4187C → S in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti4604P → S in BAE36593 (PubMed:16141072).Curated1
Sequence conflicti4716T → A in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti4723R → C in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti4730R → S in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti4752N → Y in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti4790C → S in AAC31431 (PubMed:9689098).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0519753637 – 3672Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF061529 mRNA Translation: AAC31431.1
AF071173 mRNA Translation: AAD08658.1
AC102121 Genomic DNA No translation available.
AC102150 Genomic DNA No translation available.
AK141515 mRNA Translation: BAE24711.1
AK148361 mRNA Translation: BAE28504.1
AK161826 mRNA Translation: BAE36593.1
AK162270 mRNA Translation: BAE36828.1
AK162708 mRNA Translation: BAE37031.1
AK220338 mRNA Translation: BAD90404.1
BC044667 mRNA Translation: AAH44667.1
BC054829 mRNA Translation: AAH54829.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS21318.1 [Q4U2R1-1]

NCBI Reference Sequences

More...RefSeqi		NP_034548.2, NM_010418.2 [Q4U2R1-1]
XP_006540700.1, XM_006540637.3 [Q4U2R1-1]
XP_006540701.1, XM_006540638.2
XP_006540702.1, XM_006540639.1 [Q4U2R1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000076226; ENSMUSP00000075579; ENSMUSG00000030451 [Q4U2R1-1]
ENSMUST00000164095; ENSMUSP00000131573; ENSMUSG00000030451 [Q4U2R1-1]
ENSMUST00000205303; ENSMUSP00000145997; ENSMUSG00000030451 [Q4U2R1-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		15204

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:15204

UCSC genome browser

More...UCSCi		uc009hdv.1, mouse [Q4U2R1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061529 mRNA Translation: AAC31431.1
AF071173 mRNA Translation: AAD08658.1
AC102121 Genomic DNA No translation available.
AC102150 Genomic DNA No translation available.
AK141515 mRNA Translation: BAE24711.1
AK148361 mRNA Translation: BAE28504.1
AK161826 mRNA Translation: BAE36593.1
AK162270 mRNA Translation: BAE36828.1
AK162708 mRNA Translation: BAE37031.1
AK220338 mRNA Translation: BAD90404.1
BC044667 mRNA Translation: AAH44667.1
BC054829 mRNA Translation: AAH54829.1
CCDSiCCDS21318.1 [Q4U2R1-1]
RefSeqiNP_034548.2, NM_010418.2 [Q4U2R1-1]
XP_006540700.1, XM_006540637.3 [Q4U2R1-1]
XP_006540701.1, XM_006540638.2
XP_006540702.1, XM_006540639.1 [Q4U2R1-2]

3D structure databases

SMRiQ4U2R1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi200274, 72 interactors
IntActiQ4U2R1, 61 interactors
MINTiQ4U2R1
STRINGi10090.ENSMUSP00000075579

PTM databases

iPTMnetiQ4U2R1
PhosphoSitePlusiQ4U2R1

Proteomic databases

jPOSTiQ4U2R1
PaxDbiQ4U2R1
PeptideAtlasiQ4U2R1
PRIDEiQ4U2R1
ProteomicsDBi269656 [Q4U2R1-1]
269657 [Q4U2R1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22335, 52 antibodies

The DNASU plasmid repository

More...DNASUi		15204

Genome annotation databases

EnsembliENSMUST00000076226; ENSMUSP00000075579; ENSMUSG00000030451 [Q4U2R1-1]
ENSMUST00000164095; ENSMUSP00000131573; ENSMUSG00000030451 [Q4U2R1-1]
ENSMUST00000205303; ENSMUSP00000145997; ENSMUSG00000030451 [Q4U2R1-2]
GeneIDi15204
KEGGimmu:15204
UCSCiuc009hdv.1, mouse [Q4U2R1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8924
MGIiMGI:103234, Herc2
VEuPathDBiHostDB:ENSMUSG00000030451

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG1426, Eukaryota
GeneTreeiENSGT00940000154975
HOGENOMiCLU_000101_0_0_1
InParanoidiQ4U2R1
OMAiGPRFKCK
OrthoDBi1062377at2759
PhylomeDBiQ4U2R1
TreeFamiTF320636

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-3108214, SUMOylation of DNA damage response and repair proteins
R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-5693571, Nonhomologous End-Joining (NHEJ)
R-MMU-5693607, Processing of DNA double-strand break ends
R-MMU-69473, G2/M DNA damage checkpoint
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		15204, 0 hits in 98 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Herc2, mouse

Protein Ontology

More...PROi		PR:Q4U2R1
RNActiQ4U2R1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000030451, Expressed in midbrain and 319 other tissues
GenevisibleiQ4U2R1, MM

Family and domain databases

CDDicd08664, APC10-HERC2, 1 hit
cd00078, HECTc, 1 hit
cd02344, ZZ_HERC2, 1 hit
Gene3Di2.130.10.30, 3 hits
2.30.30.30, 1 hit
3.10.120.10, 1 hit
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR004939, APC_su10/DOC_dom
IPR006624, Beta-propeller_rpt_TECPR
IPR021097, CPH_domain
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR008979, Galactose-bd-like_sf
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR037976, HERC2_APC10
IPR010606, Mib_Herc2
IPR037252, Mib_Herc2_sf
IPR009091, RCC1/BLIP-II
IPR000408, Reg_chr_condens
IPR014722, Rib_L2_dom2
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
IPR041987, ZZ_HERC2
PfamiView protein in Pfam
PF03256, ANAPC10, 1 hit
PF11515, Cul7, 1 hit
PF00173, Cyt-b5, 1 hit
PF00632, HECT, 1 hit
PF06701, MIB_HERC2, 1 hit
PF00415, RCC1, 16 hits
PF00569, ZZ, 1 hit
PRINTSiPR00633, RCCNDNSATION
SMARTiView protein in SMART
SM01337, APC10, 1 hit
SM01117, Cyt-b5, 1 hit
SM00119, HECTc, 1 hit
SM00706, TECPR, 4 hits
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF159034, SSF159034, 1 hit
SSF49785, SSF49785, 1 hit
SSF50985, SSF50985, 3 hits
SSF55856, SSF55856, 1 hit
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50255, CYTOCHROME_B5_2, 1 hit
PS51284, DOC, 1 hit
PS50237, HECT, 1 hit
PS51416, MIB_HERC2, 1 hit
PS00626, RCC1_2, 1 hit
PS50012, RCC1_3, 19 hits
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHERC2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4U2R1
Secondary accession number(s): E9PZT6
, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: September 29, 2021
This is version 145 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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