UniProtKB - Q4U2R1 (HERC2_MOUSE)
E3 ubiquitin-protein ligase HERC2
Herc2
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.26
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 4764 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 2703 – 2750 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 48 |
GO - Molecular functioni
- SUMO binding Source: UniProtKB
- ubiquitin protein ligase activity Source: UniProtKB
- ubiquitin protein ligase binding Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- DNA repair Source: UniProtKB-KW
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein ubiquitination Source: UniProtKB
- spermatogenesis Source: MGI
Keywordsi
Molecular function | Transferase |
Biological process | DNA damage, DNA repair, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-3108214, SUMOylation of DNA damage response and repair proteins R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-MMU-5693571, Nonhomologous End-Joining (NHEJ) R-MMU-5693607, Processing of DNA double-strand break ends R-MMU-69473, G2/M DNA damage checkpoint R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase HERC2 (EC:2.3.2.26By similarity)Alternative name(s): HECT domain and RCC1-like domain-containing protein 2 HECT-type E3 ubiquitin transferase HERC2 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103234, Herc2 |
Subcellular locationi
Cytoskeleton
- centriole Source: UniProtKB-SubCell
Cytosol
- cytosol Source: MGI
Mitochondrion
- mitochondrial inner membrane Source: MGI
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Involvement in diseasei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000229740 | 1 – 4836 | E3 ubiquitin-protein ligase HERC2Add BLAST | 4836 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 273 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 648 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1578 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1943 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1945 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 2455 | PhosphoserineBy similarity | 1 | |
Modified residuei | 2929 | PhosphoserineCombined sources | 1 | |
Modified residuei | 4812 | PhosphoserineBy similarity | 1 | |
Modified residuei | 4813 | PhosphoserineBy similarity | 1 | |
Modified residuei | 4816 | PhosphoserineBy similarity | 1 | |
Modified residuei | 4829 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | Q4U2R1 |
PaxDbi | Q4U2R1 |
PeptideAtlasi | Q4U2R1 |
PRIDEi | Q4U2R1 |
PTM databases
iPTMneti | Q4U2R1 |
PhosphoSitePlusi | Q4U2R1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000030451, Expressed in skeletal muscle tissue and 312 other tissues |
Genevisiblei | Q4U2R1, MM |
Interactioni
Subunit structurei
Interacts (when phosphorylated at Thr-4829 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment.
Interacts with XPA.
Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97.
By similarityGO - Molecular functioni
- SUMO binding Source: UniProtKB
- ubiquitin protein ligase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200274, 70 interactors |
IntActi | Q4U2R1, 59 interactors |
STRINGi | 10090.ENSMUSP00000075579 |
Miscellaneous databases
RNActi | Q4U2R1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 416 – 462 | RCC1 1-1Add BLAST | 47 | |
Repeati | 463 – 513 | RCC1 1-2Add BLAST | 51 | |
Repeati | 514 – 569 | RCC1 1-3Add BLAST | 56 | |
Repeati | 570 – 621 | RCC1 1-4Add BLAST | 52 | |
Repeati | 624 – 675 | RCC1 1-5Add BLAST | 52 | |
Repeati | 676 – 727 | RCC1 1-6Add BLAST | 52 | |
Repeati | 729 – 779 | RCC1 1-7Add BLAST | 51 | |
Domaini | 1208 – 1284 | Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST | 77 | |
Domaini | 1860 – 1933 | MIB/HERC2PROSITE-ProRule annotationAdd BLAST | 74 | |
Domaini | 2760 – 2937 | DOCPROSITE-ProRule annotationAdd BLAST | 178 | |
Repeati | 2959 – 3010 | RCC1 2-1Add BLAST | 52 | |
Repeati | 3011 – 3065 | RCC1 2-2Add BLAST | 55 | |
Repeati | 3066 – 3117 | RCC1 2-3Add BLAST | 52 | |
Repeati | 3119 – 3169 | RCC1 2-4Add BLAST | 51 | |
Repeati | 3172 – 3223 | RCC1 2-5Add BLAST | 52 | |
Repeati | 3225 – 3275 | RCC1 2-6Add BLAST | 51 | |
Repeati | 3276 – 3327 | RCC1 2-7Add BLAST | 52 | |
Repeati | 3953 – 4004 | RCC1 3-1Add BLAST | 52 | |
Repeati | 4006 – 4058 | RCC1 3-2Add BLAST | 53 | |
Repeati | 4060 – 4110 | RCC1 3-3Add BLAST | 51 | |
Repeati | 4112 – 4164 | RCC1 3-4Add BLAST | 53 | |
Repeati | 4166 – 4216 | RCC1 3-5Add BLAST | 51 | |
Repeati | 4218 – 4268 | RCC1 3-6Add BLAST | 51 | |
Repeati | 4270 – 4320 | RCC1 3-7Add BLAST | 51 | |
Domaini | 4459 – 4796 | HECTPROSITE-ProRule annotationAdd BLAST | 338 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 948 – 981 | Sequence analysisAdd BLAST | 34 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 2703 – 2750 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 48 |
Keywords - Domaini
Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1426, Eukaryota |
GeneTreei | ENSGT00940000154975 |
HOGENOMi | CLU_000101_0_0_1 |
InParanoidi | Q4U2R1 |
OMAi | MQAFCVG |
OrthoDBi | 1062377at2759 |
TreeFami | TF320636 |
Family and domain databases
CDDi | cd08664, APC10-HERC2, 1 hit cd00078, HECTc, 1 hit cd02344, ZZ_HERC2, 1 hit |
Gene3Di | 2.130.10.30, 3 hits 2.30.30.30, 1 hit 2.30.30.920, 1 hit 2.60.120.260, 1 hit 3.10.120.10, 1 hit 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR004939, APC_su10/DOC_dom IPR006624, Beta-propeller_rpt_TECPR IPR021097, CPH_domain IPR001199, Cyt_B5-like_heme/steroid-bd IPR036400, Cyt_B5-like_heme/steroid_sf IPR008979, Galactose-bd-like_sf IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR037976, HERC2_APC10 IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR009091, RCC1/BLIP-II IPR000408, Reg_chr_condens IPR014722, Rib_L2_dom2 IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf IPR041987, ZZ_HERC2 |
Pfami | View protein in Pfam PF03256, ANAPC10, 1 hit PF11515, Cul7, 1 hit PF00173, Cyt-b5, 1 hit PF00632, HECT, 1 hit PF06701, MIB_HERC2, 1 hit PF00415, RCC1, 16 hits PF00569, ZZ, 1 hit |
PRINTSi | PR00633, RCCNDNSATION |
SMARTi | View protein in SMART SM01337, APC10, 1 hit SM01117, Cyt-b5, 1 hit SM00119, HECTc, 1 hit SM00706, TECPR, 4 hits SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF159034, SSF159034, 1 hit SSF49785, SSF49785, 1 hit SSF50985, SSF50985, 3 hits SSF55856, SSF55856, 1 hit SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50255, CYTOCHROME_B5_2, 1 hit PS51284, DOC, 1 hit PS50237, HECT, 1 hit PS51416, MIB_HERC2, 1 hit PS00626, RCC1_2, 1 hit PS50012, RCC1_3, 19 hits PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPSESFCLAA QSRLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT
60 70 80 90 100
ELAQNRELPL RKDDGVDAQS GTKKEDLNDK EKKEEEETPA PVYRAKSILE
110 120 130 140 150
SWVWGRQPDV NELKECLSVL VKEQQALAVQ SATTTLSALR LKQRLVILER
160 170 180 190 200
YFIALNRTVF QENVKVKWKS SSISVPPTEK KSARPTGRGV EGLARVGSRA
210 220 230 240 250
ALSFAFAFLR RAWRSGEDAD LCSELLQESL DALRALPEAS LFDESTVSSV
260 270 280 290 300
WLEVVERATR FLRSVVTGDV HGTPGTKGPG GVPLQDQHLA LAILLELAVQ
310 320 330 340 350
RGTLSQMLSA ILLLLQLWDS GAQETDNERS AQGTSAPLLP LLQRFQSIIC
360 370 380 390 400
SKDVPHTESD MHLLSGPLSP NESFLRYLTL PQDNELAIDL RQTAVVVMAH
410 420 430 440 450
LDRLATPCMP PLCSSPTSHK GSLQEVIGWG LIGWKYYANV IGPIQCEGLA
460 470 480 490 500
SLGVMQVACA EKRFLILSRN GRVYTQAYNS DMLAPQLVQG LASRNIVKIA
510 520 530 540 550
AHSDGHHYLA LAATGEVYSW GCGDGGRLGH GDTVPLEEPK VISAFSGKQA
560 570 580 590 600
GKHVVHIACG STYSAAITAE GELYTWGRGN YGRLGHGSSE DEAIPMLVAG
610 620 630 640 650
LKGLKVIDVA CGSGDAQTLA VTENGQVWSW GDGDYGKLGR GGSDGCKTPK
660 670 680 690 700
LIEKLQDLDV IKVRCGSQFS IALTKDGQVY SWGKGDNQRL GHGTEEHVRY
710 720 730 740 750
PKLLEGLQGK KVIDVAAGST HCLALTEDSE VHSWGSNDQC QHFDTLRVTK
760 770 780 790 800
PEPTALPGLD SKHIVGIACG PAQSFAWSSC SEWSIGLRVP FVVDICSMTF
810 820 830 840 850
EQLDLLLRQV SEGMDGTADW PPPQEKECMA VATLNLLRLQ LHAAISHQVD
860 870 880 890 900
PEFLGLGLGS VLLNSLKQTV VTLASSAGVL STVQSAAQAV LQSGWSVLLP
910 920 930 940 950
TAEERARALS ALLPCTVSGN EVNISPGRRF MIDLLVGSLM ADGGLESALN
960 970 980 990 1000
AAITAEIQDI EAKKEAQKEK EIDEQEASAS TFHRSRTPLD KDLINTGIYE
1010 1020 1030 1040 1050
SSGKQCLPLV QLIQQLLRNI ASQTVARLKD VARRISSCLD FEQQSCERSA
1060 1070 1080 1090 1100
SLDLLLRFQR LLISKLYPGE KIGPISDTSS PELMGVGSLL KKYTALVCTH
1110 1120 1130 1140 1150
IGDILPVAAS IASSSWQHFA EVACVMEGDF TGVLLPELVV SIVLLLSKNA
1160 1170 1180 1190 1200
SLMQEAGAIP LLGGLLEHLD RFNHLAPGKE RDDHEELAWP GIMESFFTGQ
1210 1220 1230 1240 1250
NCRNNEEVTL IRKADLENHN KDGGFWTVID GKVYGIKDFQ TQSLTGNSIL
1260 1270 1280 1290 1300
AQFAGEDPVV ALEAALQFED TQESMHAFCV GQYLEPDQEV VTIPDLGSLS
1310 1320 1330 1340 1350
SPLIDTERNL GLLLGLHASY LAMSTPLSPV EVECAKWLQS SIFSGGLQTS
1360 1370 1380 1390 1400
QIHYSYNEEK DEDHCSSPGG TPISKSRLCS HRWALGDHSQ AFLQAIADNN
1410 1420 1430 1440 1450
IQDYNVKDFL CQIERYCRQC HLTTPITFPP EHPVEEVGRL LLCCLLKHED
1460 1470 1480 1490 1500
LGHVALSLVH VGTLGIEQVK HRTLPKSVVD VCRVVYQAKC SLIKTHQEQG
1510 1520 1530 1540 1550
RSYKEVCAPV IERLRFLFNE LRPAVCSDLS IMSKFKLLGS LPRWRRIAQK
1560 1570 1580 1590 1600
IIRERRKKRV PKKPESIDSE EKIGNEESDL EEACVLPHSP INVDKRPISM
1610 1620 1630 1640 1650
KSPKDKWQPL LNTVTGVHKY KWLKQNVQGL YPQSALLNTI VEFALKEEPV
1660 1670 1680 1690 1700
DVEKMRKCLL KQLERAEVRL EGIDTILKLA AKSFLLPSVQ YAMFCGWQRL
1710 1720 1730 1740 1750
IPEGIDIGEP LTDCLRDVDL IPPFNRMLLE VTFGKLYAWA VQNIRSVLMD
1760 1770 1780 1790 1800
ASARFKELGI QPVPLQTITN ENPAGPSLGT IPQARFLLVM LSMLTLQHGA
1810 1820 1830 1840 1850
NNLDLLLNSG TLALTQTALR LIGPTCDSVE DDMNASARGA SATVLEETRK
1860 1870 1880 1890 1900
ETAPVQLPVS GPELAAMMKI GTRVMRGVDW KWGDQDGPPP GLGRVIGELG
1910 1920 1930 1940 1950
EDGWIRVQWD TGSTNSYRMG KEGKYDLKLV ELPVSSQPSA EDSDTEDDSE
1960 1970 1980 1990 2000
AEQGERNIHP TAMMLTSVIN LLQTLCLSVG VHADIMQSEA TKTLCGLLRM
2010 2020 2030 2040 2050
LVESGTTDKP APPDRLVARE QHRSWCTLGF VRSIALTPQA CGALSSPRWI
2060 2070 2080 2090 2100
TLLMKVVEGH APFTAASLQR QILAVHLLQA VLPSWDKTER ARDMKCLVEK
2110 2120 2130 2140 2150
LFGFLGSLLT TCSSDVPLLR ESTLRKRRAR PQASLTATHS STLAEEVVGL
2160 2170 2180 2190 2200
LRTLHSLTQW NGLINKYINS QLCSVTQSYA GKTSERAQLE DYFPDSENLE
2210 2220 2230 2240 2250
VGGLMAVLAV IGGIDGRLRL GGQVMHDEFG EGTVTRITPK GRITVQFCDM
2260 2270 2280 2290 2300
RMCRVCPLNQ LKPLPAVAFS VNNLPFTEPM LSVWAELVNL AGSKLEKHKT
2310 2320 2330 2340 2350
KKSAKPAFAG QVDLDLLRSQ QLKLYILKAG RALLSHQDKL RQILSQPAVQ
2360 2370 2380 2390 2400
GTGTLQTDDG AAASPDLGDM SPEGPQPPMI LLQQLLSSAT QPSPVKAIFD
2410 2420 2430 2440 2450
KQELEAAALA LCQCLAVEST HPSSPGCEDC SSSEATTPVS VQHIHLARAK
2460 2470 2480 2490 2500
KRRQSPAPAL PIVVQLMEMG FPRKNIEFAL KSLTGTSGNA SGLPGVEALV
2510 2520 2530 2540 2550
GWLLDHSDVQ VTEFSDAETL SDEYSDEEVV EDVDDTPYPV AAGAVVTESQ
2560 2570 2580 2590 2600
TYKKRADFLS NDDYAVYVRE NVQVGMMVRC CRTYEEVCEG DVGKVIKLDR
2610 2620 2630 2640 2650
DGLHDLNVQC DWQQKGGTYW VRYIHVELIG YPPPSSSSHI KIGDKVRVKA
2660 2670 2680 2690 2700
SVTTPKYKWG SVTHQSVGLV KAFSANGKDI IVDFPQQSHW TGLLSEMELV
2710 2720 2730 2740 2750
PSIHPGVTCD GCQTFPINGS RFKCRNCDDF DFCETCFKTK KHNTRHTFGR
2760 2770 2780 2790 2800
INEPGQSAVF CGRSGKQLKR CHSSQPGMLL DSWSRMVKSL NVSSSVNQAS
2810 2820 2830 2840 2850
RLIDGSEPCW QSSGSQGKHW IRLEIFPDVL VHRLKMIVDP ADSSYMPSLV
2860 2870 2880 2890 2900
VVSGGNSLNN LIELKTININ QTDTTVPLLS DCAEYHRYIE IAIKQCRSSG
2910 2920 2930 2940 2950
IDCKIHGLIL LGRIRAEEED LAAVPFLASD NEEEEDDKGS TGSLIRKKTP
2960 2970 2980 2990 3000
GLESTATIRT KVFVWGLNDK DQLGGLKGSK IKVPSFSETL SALNVVQVAG
3010 3020 3030 3040 3050
GSKSLFAVTV EGKVYSCGEA TNGRLGLGMS SGTVPIPRQI TALSSYVVKK
3060 3070 3080 3090 3100
VAVHSGGRHA TALTVDGKVF SWGEGDDGKL GHFSRMNCDK PRLIEALKTK
3110 3120 3130 3140 3150
RIRDIACGSS HSAALTSSGE LYTWGLGEYG RLGHGDNTTQ LKPKMVKVLL
3160 3170 3180 3190 3200
GHRVIQVACG SRDAQTLALT DEGLVFSWGD GDFGKLGRGG SEGCNIPQNI
3210 3220 3230 3240 3250
ERLNGQGVCQ IECGAQFSLA LTKSGVVWTW GKGDYFRLGH GSDVHVRKPQ
3260 3270 3280 3290 3300
VVEGLRGKKI VHVAVGALHC LAVTDSGQVY AWGDNDHGQQ GNGTTTVNRK
3310 3320 3330 3340 3350
PTLVQGLEGQ KITRVACGSS HSVAWTTVDV ATPSVHEPVL FQTARDPLGA
3360 3370 3380 3390 3400
SYLGVPSDAD SSSSSNKISG ANNCKPNRPS LAKILLSLEG NLAKQQALSH
3410 3420 3430 3440 3450
ILTALQIMYA RDAVVGALMP AGMLAPVECP SFSSSAPASD VSAMASPMHM
3460 3470 3480 3490 3500
EDSTLAADLE DRLSPNLWQE KREIVSSEDA VTPSAVTPSA PSASSRPFIP
3510 3520 3530 3540 3550
VTDDPGAASI IAETMTKTKE DVESQNKTSG PEPQSLDEFT SLLIPDDTRV
3560 3570 3580 3590 3600
VVELLKLSVC SRAGDKGREV LSAVLSGMGT AYPQVADMLL ELCVTELEDV
3610 3620 3630 3640 3650
ATDSQSGRLS SQPVVVESSH PYTDDTSTSG TVKIPGAEGL RVEFDRQCST
3660 3670 3680 3690 3700
ERRHDPLTVM DGVNRIVSVR SGREWSDWSS ELRIPGDELK WKFISDGSVN
3710 3720 3730 3740 3750
GWGWRFTVYP IMPAAGPKDL LSDRCVLSCP SMDLVTCLLD FRLNLTSNRS
3760 3770 3780 3790 3800
IVPRLAASLA ACAQLSALAA SHRMWALQRL RRLLTTEFGQ SININRLLGE
3810 3820 3830 3840 3850
NDGESRALSF TGSALAALVK GLPEALQRQF EYEDPIVRGG KQLLHSPFFK
3860 3870 3880 3890 3900
VLVALACDLE LDTLPCCAET HKWAWFRRYC MASRVAVALD KRTPLPRLFL
3910 3920 3930 3940 3950
DEVAKKIREL MADSESMDVL HESHSIFKRE QDEQLVQWMN RRPDDWTLSA
3960 3970 3980 3990 4000
GGSGTIYGWG HNHRGQLGGI EGAKVKVPTP CEALATLRPV QLIGGEQTLF
4010 4020 4030 4040 4050
AVTADGKLYA TGYGAGGRLG IGGTESVSTP TLLESIQHVF IKKVAVNSGG
4060 4070 4080 4090 4100
KHCLALSSEG EVYSWGEAED GKLGHGNRSP CDRPRVIESL RGIEVVDVAA
4110 4120 4130 4140 4150
GGAHSACVTA AGDLYTWGKG RYGRLGHSDS EDQLKPKLVE ALQGHRVIDI
4160 4170 4180 4190 4200
ACGSGDAQTL CLTDDDTVWS WGDGDYGKLG RGGSDGCKVP MKIDSLTGLG
4210 4220 4230 4240 4250
VVKVECGSQF SVALTKSGAV YTWGKGDYHR LGHGSDDHVR RPRQVQGLQG
4260 4270 4280 4290 4300
KKVIAIATGS LHCVCCTEDG EVYTWGDNDE GQLGDGTTNA IQRPRLVAAL
4310 4320 4330 4340 4350
QGKKVNRVAC GSAHTLAWST SKPASAGKLP AQVPMEYNHL QEIPIIALRN
4360 4370 4380 4390 4400
RLLLLHHISE LFCPCIPMFD LEGSLDETGL GPSVGFDTLR GILISQGKEA
4410 4420 4430 4440 4450
AFRKVVQATM VRDRQHGPVV ELNRIQVKRS RSKGGLAGPD GTKSVFGQMC
4460 4470 4480 4490 4500
AKMSSFSPDS LLLPHRVWKV KFVGESVDDC GGGYSESIAE ICEELQNGLT
4510 4520 4530 4540 4550
PLLIVTPNGR DESGANRDCY LLNPATRAPV HCSMFRFLGV LLGIAIRTGS
4560 4570 4580 4590 4600
PLSLNLAEPV WKQLAGMSLT IADLSEVDKD FIPGLMYIRD NEATSEEFEA
4610 4620 4630 4640 4650
MSLPFTVPSA SGQDIQLSSK HTHITLDNRA EYVRLAINYR LHEFDEQVAA
4660 4670 4680 4690 4700
VREGMARVVP VPLLSLFTGY ELETMVCGSP DIPLHLLKSV ATYKGIEPSA
4710 4720 4730 4740 4750
SLVQWFWEVM ESFSNTERSL FLRFVWGRTR LPRTIADFRG RDFVIQVLDK
4760 4770 4780 4790 4800
YNPPDHFLPE SYTCFFLLKL PRYSCKQVLE EKLKYAIHFC KSIDTDDYAR
4810 4820 4830
IALTGEPAAD DSSEDSDNED ADSFASDSTQ DYLTGH
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RNG9 | A0A0U1RNG9_MOUSE | E3 ubiquitin-protein ligase HERC2 | Herc2 | 167 | Annotation score: | ||
A0A0U1RPZ3 | A0A0U1RPZ3_MOUSE | E3 ubiquitin-protein ligase HERC2 | Herc2 | 965 | Annotation score: | ||
A0A0U1RP01 | A0A0U1RP01_MOUSE | E3 ubiquitin-protein ligase HERC2 | Herc2 | 40 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 692 | H → L in AAC31431 (PubMed:9689098).Curated | 1 | |
Sequence conflicti | 724 | A → V in AAD08658 (PubMed:9949213).Curated | 1 | |
Sequence conflicti | 747 | R → G in AAD08658 (PubMed:9949213).Curated | 1 | |
Sequence conflicti | 756 | L → F in AAD08658 (PubMed:9949213).Curated | 1 | |
Sequence conflicti | 929 | R → P in AAD08658 (PubMed:9949213).Curated | 1 | |
Sequence conflicti | 1114 | S → N in AAD08658 (PubMed:9949213).Curated | 1 | |
Sequence conflicti | 1235 | G → D in AAD08658 (PubMed:9949213).Curated | 1 | |
Sequence conflicti | 2348 | A → P in AAC31431 (PubMed:9689098).Curated | 1 | |
Sequence conflicti | 2470 | G → S in BAE36828 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 2523 | E → D in AAC31431 (PubMed:9689098).Curated | 1 | |
Sequence conflicti | 2567 | Y → F in AAC31431 (PubMed:9689098).Curated | 1 | |
Sequence conflicti | 2572 | V → L in AAC31431 (PubMed:9689098).Curated | 1 | |
Sequence conflicti | 3095 | E → Q in AAD08658 (PubMed:9949213).Curated | 1 | |
Sequence conflicti | 3107 | C → Y in AAD08658 (PubMed:9949213).Curated | 1 | |
Sequence conflicti | 3114 | A → P in AAD08658 (PubMed:9949213).Curated | 1 | |
Sequence conflicti | 3161 | S → T in AAC31431 (PubMed:9689098).Curated | 1 | |
Sequence conflicti | 3385 – 3386 | LL → VV in AAD08658 (PubMed:9949213).Curated | 2 | |
Sequence conflicti | 3508 | A → V in AAD08658 (PubMed:9949213).Curated | 1 | |
Sequence conflicti | 4069 | E → K in BAD90404 (Ref. 5) Curated | 1 | |
Sequence conflicti | 4187 | C → S in AAC31431 (PubMed:9689098).Curated | 1 | |
Sequence conflicti | 4604 | P → S in BAE36593 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 4716 | T → A in AAC31431 (PubMed:9689098).Curated | 1 | |
Sequence conflicti | 4723 | R → C in AAD08658 (PubMed:9949213).Curated | 1 | |
Sequence conflicti | 4730 | R → S in AAC31431 (PubMed:9689098).Curated | 1 | |
Sequence conflicti | 4752 | N → Y in AAC31431 (PubMed:9689098).Curated | 1 | |
Sequence conflicti | 4790 | C → S in AAC31431 (PubMed:9689098).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_051975 | 3637 – 3672 | Missing in isoform 2. 1 PublicationAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF061529 mRNA Translation: AAC31431.1 AF071173 mRNA Translation: AAD08658.1 AC102121 Genomic DNA No translation available. AC102150 Genomic DNA No translation available. AK141515 mRNA Translation: BAE24711.1 AK148361 mRNA Translation: BAE28504.1 AK161826 mRNA Translation: BAE36593.1 AK162270 mRNA Translation: BAE36828.1 AK162708 mRNA Translation: BAE37031.1 AK220338 mRNA Translation: BAD90404.1 BC044667 mRNA Translation: AAH44667.1 BC054829 mRNA Translation: AAH54829.1 |
CCDSi | CCDS21318.1 [Q4U2R1-1] |
RefSeqi | NP_034548.2, NM_010418.2 [Q4U2R1-1] XP_006540700.1, XM_006540637.3 [Q4U2R1-1] XP_006540701.1, XM_006540638.2 XP_006540702.1, XM_006540639.1 [Q4U2R1-2] |
Genome annotation databases
Ensembli | ENSMUST00000076226; ENSMUSP00000075579; ENSMUSG00000030451 [Q4U2R1-1] ENSMUST00000164095; ENSMUSP00000131573; ENSMUSG00000030451 [Q4U2R1-1] ENSMUST00000205303; ENSMUSP00000145997; ENSMUSG00000030451 [Q4U2R1-2] |
GeneIDi | 15204 |
KEGGi | mmu:15204 |
UCSCi | uc009hdv.1, mouse [Q4U2R1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF061529 mRNA Translation: AAC31431.1 AF071173 mRNA Translation: AAD08658.1 AC102121 Genomic DNA No translation available. AC102150 Genomic DNA No translation available. AK141515 mRNA Translation: BAE24711.1 AK148361 mRNA Translation: BAE28504.1 AK161826 mRNA Translation: BAE36593.1 AK162270 mRNA Translation: BAE36828.1 AK162708 mRNA Translation: BAE37031.1 AK220338 mRNA Translation: BAD90404.1 BC044667 mRNA Translation: AAH44667.1 BC054829 mRNA Translation: AAH54829.1 |
CCDSi | CCDS21318.1 [Q4U2R1-1] |
RefSeqi | NP_034548.2, NM_010418.2 [Q4U2R1-1] XP_006540700.1, XM_006540637.3 [Q4U2R1-1] XP_006540701.1, XM_006540638.2 XP_006540702.1, XM_006540639.1 [Q4U2R1-2] |
3D structure databases
SMRi | Q4U2R1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200274, 70 interactors |
IntActi | Q4U2R1, 59 interactors |
STRINGi | 10090.ENSMUSP00000075579 |
PTM databases
iPTMneti | Q4U2R1 |
PhosphoSitePlusi | Q4U2R1 |
Proteomic databases
jPOSTi | Q4U2R1 |
PaxDbi | Q4U2R1 |
PeptideAtlasi | Q4U2R1 |
PRIDEi | Q4U2R1 |
Protocols and materials databases
Antibodypediai | 22335, 51 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000076226; ENSMUSP00000075579; ENSMUSG00000030451 [Q4U2R1-1] ENSMUST00000164095; ENSMUSP00000131573; ENSMUSG00000030451 [Q4U2R1-1] ENSMUST00000205303; ENSMUSP00000145997; ENSMUSG00000030451 [Q4U2R1-2] |
GeneIDi | 15204 |
KEGGi | mmu:15204 |
UCSCi | uc009hdv.1, mouse [Q4U2R1-1] |
Organism-specific databases
CTDi | 8924 |
MGIi | MGI:103234, Herc2 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1426, Eukaryota |
GeneTreei | ENSGT00940000154975 |
HOGENOMi | CLU_000101_0_0_1 |
InParanoidi | Q4U2R1 |
OMAi | MQAFCVG |
OrthoDBi | 1062377at2759 |
TreeFami | TF320636 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-MMU-3108214, SUMOylation of DNA damage response and repair proteins R-MMU-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-MMU-5693571, Nonhomologous End-Joining (NHEJ) R-MMU-5693607, Processing of DNA double-strand break ends R-MMU-69473, G2/M DNA damage checkpoint R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 15204, 0 hits in 17 CRISPR screens |
ChiTaRSi | Herc2, mouse |
PROi | PR:Q4U2R1 |
RNActi | Q4U2R1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030451, Expressed in skeletal muscle tissue and 312 other tissues |
Genevisiblei | Q4U2R1, MM |
Family and domain databases
CDDi | cd08664, APC10-HERC2, 1 hit cd00078, HECTc, 1 hit cd02344, ZZ_HERC2, 1 hit |
Gene3Di | 2.130.10.30, 3 hits 2.30.30.30, 1 hit 2.30.30.920, 1 hit 2.60.120.260, 1 hit 3.10.120.10, 1 hit 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR004939, APC_su10/DOC_dom IPR006624, Beta-propeller_rpt_TECPR IPR021097, CPH_domain IPR001199, Cyt_B5-like_heme/steroid-bd IPR036400, Cyt_B5-like_heme/steroid_sf IPR008979, Galactose-bd-like_sf IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR037976, HERC2_APC10 IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR009091, RCC1/BLIP-II IPR000408, Reg_chr_condens IPR014722, Rib_L2_dom2 IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf IPR041987, ZZ_HERC2 |
Pfami | View protein in Pfam PF03256, ANAPC10, 1 hit PF11515, Cul7, 1 hit PF00173, Cyt-b5, 1 hit PF00632, HECT, 1 hit PF06701, MIB_HERC2, 1 hit PF00415, RCC1, 16 hits PF00569, ZZ, 1 hit |
PRINTSi | PR00633, RCCNDNSATION |
SMARTi | View protein in SMART SM01337, APC10, 1 hit SM01117, Cyt-b5, 1 hit SM00119, HECTc, 1 hit SM00706, TECPR, 4 hits SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF159034, SSF159034, 1 hit SSF49785, SSF49785, 1 hit SSF50985, SSF50985, 3 hits SSF55856, SSF55856, 1 hit SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50255, CYTOCHROME_B5_2, 1 hit PS51284, DOC, 1 hit PS50237, HECT, 1 hit PS51416, MIB_HERC2, 1 hit PS00626, RCC1_2, 1 hit PS50012, RCC1_3, 19 hits PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HERC2_MOUSE | |
Accessioni | Q4U2R1Primary (citable) accession number: Q4U2R1 Secondary accession number(s): E9PZT6 Q9Z171 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | July 27, 2011 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways