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Entry version 135 (08 May 2019)
Sequence version 3 (27 Jul 2011)
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Protein

E3 ubiquitin-protein ligase HERC2

Gene

Herc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4764Glycyl thioester intermediatePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2703 – 2750ZZ-typePROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA repair, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-5693571 Nonhomologous End-Joining (NHEJ)
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-69473 G2/M DNA damage checkpoint
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase HERC2 (EC:2.3.2.26By similarity)
Alternative name(s):
HECT domain and RCC1-like domain-containing protein 2
HECT-type E3 ubiquitin transferase HERC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Herc2Imported
Synonyms:Jdf2, Kiaa0393Imported, Rjs
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:103234 Herc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Herc2 are the cause of the runty, jerky, sterile phenotype (rjs), also known as the juvenile development and fertility phenotype (jfd2), which is characterized by reduced size, jerky gait, fertility problems including spermatocyte and oocyte abnormalities, defective maternal behavior and reduced lifespan with juvenile lethality.3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002297401 – 4836E3 ubiquitin-protein ligase HERC2Add BLAST4836

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei273PhosphothreonineBy similarity1
Modified residuei648PhosphothreonineBy similarity1
Modified residuei1578PhosphoserineCombined sources1
Modified residuei1943PhosphoserineCombined sources1
Modified residuei1945PhosphothreonineCombined sources1
Modified residuei2455PhosphoserineBy similarity1
Modified residuei2929PhosphoserineCombined sources1
Modified residuei4812PhosphoserineBy similarity1
Modified residuei4813PhosphoserineBy similarity1
Modified residuei4816PhosphoserineBy similarity1
Modified residuei4829PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Thr-4829 is required for interaction with RNF8.
Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs), promoting the interaction with RNF8.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q4U2R1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4U2R1

PeptideAtlas

More...
PeptideAtlasi
Q4U2R1

PRoteomics IDEntifications database

More...
PRIDEi
Q4U2R1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4U2R1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4U2R1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels are found in brain and testis with lower levels in heart, lung, liver, skeletal muscle and kidney. Little expression detected in spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030451 Expressed in 299 organ(s), highest expression level in skeletal muscle tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4U2R1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4U2R1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (when phosphorylated at Thr-4829 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment.

Interacts with XPA.

Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
200274, 64 interactors

Protein interaction database and analysis system

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IntActi
Q4U2R1, 59 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000075579

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4U2R1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati416 – 462RCC1 1-1Add BLAST47
Repeati463 – 513RCC1 1-2Add BLAST51
Repeati514 – 569RCC1 1-3Add BLAST56
Repeati570 – 621RCC1 1-4Add BLAST52
Repeati624 – 675RCC1 1-5Add BLAST52
Repeati676 – 727RCC1 1-6Add BLAST52
Repeati729 – 779RCC1 1-7Add BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1208 – 1284Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST77
Domaini1860 – 1933MIB/HERC2PROSITE-ProRule annotationAdd BLAST74
Domaini2760 – 2937DOCPROSITE-ProRule annotationAdd BLAST178
Repeati2959 – 3010RCC1 2-1Add BLAST52
Repeati3011 – 3065RCC1 2-2Add BLAST55
Repeati3066 – 3117RCC1 2-3Add BLAST52
Repeati3119 – 3169RCC1 2-4Add BLAST51
Repeati3172 – 3223RCC1 2-5Add BLAST52
Repeati3225 – 3275RCC1 2-6Add BLAST51
Repeati3276 – 3327RCC1 2-7Add BLAST52
Repeati3953 – 4004RCC1 3-1Add BLAST52
Repeati4006 – 4058RCC1 3-2Add BLAST53
Repeati4060 – 4110RCC1 3-3Add BLAST51
Repeati4112 – 4164RCC1 3-4Add BLAST53
Repeati4166 – 4216RCC1 3-5Add BLAST51
Repeati4218 – 4268RCC1 3-6Add BLAST51
Repeati4270 – 4320RCC1 3-7Add BLAST51
Domaini4459 – 4796HECTPROSITE-ProRule annotationAdd BLAST338

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili948 – 981Sequence analysisAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ZZ-type zinc finger mediates binding to SUMO1, and at low level SUMO2.By similarity
The RCC1 repeats are grouped into three seven-bladed beta-propeller regions.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2703 – 2750ZZ-typePROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1426 Eukaryota
COG5021 LUCA
COG5184 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154975

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4U2R1

KEGG Orthology (KO)

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KOi
K10595

Identification of Orthologs from Complete Genome Data

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OMAi
IMEMGFT

Database of Orthologous Groups

More...
OrthoDBi
1062377at2759

TreeFam database of animal gene trees

More...
TreeFami
TF320636

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08664 APC10-HERC2, 1 hit
cd00078 HECTc, 1 hit
cd02344 ZZ_HERC2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.30, 3 hits
2.30.30.30, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit
3.10.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR006624 Beta-propeller_rpt_TECPR
IPR021097 CPH_domain
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR008979 Galactose-bd-like_sf
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR037976 HERC2_APC10
IPR010606 Mib_Herc2
IPR037252 Mib_Herc2_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR014722 Rib_L2_dom2
IPR000433 Znf_ZZ
IPR041987 ZZ_HERC2

Pfam protein domain database

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Pfami
View protein in Pfam
PF03256 ANAPC10, 1 hit
PF11515 Cul7, 1 hit
PF00173 Cyt-b5, 1 hit
PF00632 HECT, 1 hit
PF06701 MIB_HERC2, 1 hit
PF00415 RCC1, 16 hits
PF00569 ZZ, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00633 RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01337 APC10, 1 hit
SM01117 Cyt-b5, 1 hit
SM00119 HECTc, 1 hit
SM00706 TECPR, 4 hits
SM00291 ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF159034 SSF159034, 1 hit
SSF49785 SSF49785, 1 hit
SSF50985 SSF50985, 3 hits
SSF55856 SSF55856, 1 hit
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50255 CYTOCHROME_B5_2, 1 hit
PS51284 DOC, 1 hit
PS50237 HECT, 1 hit
PS51416 MIB_HERC2, 1 hit
PS00626 RCC1_2, 1 hit
PS50012 RCC1_3, 19 hits
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 12 Publications (identifier: Q4U2R1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSESFCLAA QSRLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT
60 70 80 90 100
ELAQNRELPL RKDDGVDAQS GTKKEDLNDK EKKEEEETPA PVYRAKSILE
110 120 130 140 150
SWVWGRQPDV NELKECLSVL VKEQQALAVQ SATTTLSALR LKQRLVILER
160 170 180 190 200
YFIALNRTVF QENVKVKWKS SSISVPPTEK KSARPTGRGV EGLARVGSRA
210 220 230 240 250
ALSFAFAFLR RAWRSGEDAD LCSELLQESL DALRALPEAS LFDESTVSSV
260 270 280 290 300
WLEVVERATR FLRSVVTGDV HGTPGTKGPG GVPLQDQHLA LAILLELAVQ
310 320 330 340 350
RGTLSQMLSA ILLLLQLWDS GAQETDNERS AQGTSAPLLP LLQRFQSIIC
360 370 380 390 400
SKDVPHTESD MHLLSGPLSP NESFLRYLTL PQDNELAIDL RQTAVVVMAH
410 420 430 440 450
LDRLATPCMP PLCSSPTSHK GSLQEVIGWG LIGWKYYANV IGPIQCEGLA
460 470 480 490 500
SLGVMQVACA EKRFLILSRN GRVYTQAYNS DMLAPQLVQG LASRNIVKIA
510 520 530 540 550
AHSDGHHYLA LAATGEVYSW GCGDGGRLGH GDTVPLEEPK VISAFSGKQA
560 570 580 590 600
GKHVVHIACG STYSAAITAE GELYTWGRGN YGRLGHGSSE DEAIPMLVAG
610 620 630 640 650
LKGLKVIDVA CGSGDAQTLA VTENGQVWSW GDGDYGKLGR GGSDGCKTPK
660 670 680 690 700
LIEKLQDLDV IKVRCGSQFS IALTKDGQVY SWGKGDNQRL GHGTEEHVRY
710 720 730 740 750
PKLLEGLQGK KVIDVAAGST HCLALTEDSE VHSWGSNDQC QHFDTLRVTK
760 770 780 790 800
PEPTALPGLD SKHIVGIACG PAQSFAWSSC SEWSIGLRVP FVVDICSMTF
810 820 830 840 850
EQLDLLLRQV SEGMDGTADW PPPQEKECMA VATLNLLRLQ LHAAISHQVD
860 870 880 890 900
PEFLGLGLGS VLLNSLKQTV VTLASSAGVL STVQSAAQAV LQSGWSVLLP
910 920 930 940 950
TAEERARALS ALLPCTVSGN EVNISPGRRF MIDLLVGSLM ADGGLESALN
960 970 980 990 1000
AAITAEIQDI EAKKEAQKEK EIDEQEASAS TFHRSRTPLD KDLINTGIYE
1010 1020 1030 1040 1050
SSGKQCLPLV QLIQQLLRNI ASQTVARLKD VARRISSCLD FEQQSCERSA
1060 1070 1080 1090 1100
SLDLLLRFQR LLISKLYPGE KIGPISDTSS PELMGVGSLL KKYTALVCTH
1110 1120 1130 1140 1150
IGDILPVAAS IASSSWQHFA EVACVMEGDF TGVLLPELVV SIVLLLSKNA
1160 1170 1180 1190 1200
SLMQEAGAIP LLGGLLEHLD RFNHLAPGKE RDDHEELAWP GIMESFFTGQ
1210 1220 1230 1240 1250
NCRNNEEVTL IRKADLENHN KDGGFWTVID GKVYGIKDFQ TQSLTGNSIL
1260 1270 1280 1290 1300
AQFAGEDPVV ALEAALQFED TQESMHAFCV GQYLEPDQEV VTIPDLGSLS
1310 1320 1330 1340 1350
SPLIDTERNL GLLLGLHASY LAMSTPLSPV EVECAKWLQS SIFSGGLQTS
1360 1370 1380 1390 1400
QIHYSYNEEK DEDHCSSPGG TPISKSRLCS HRWALGDHSQ AFLQAIADNN
1410 1420 1430 1440 1450
IQDYNVKDFL CQIERYCRQC HLTTPITFPP EHPVEEVGRL LLCCLLKHED
1460 1470 1480 1490 1500
LGHVALSLVH VGTLGIEQVK HRTLPKSVVD VCRVVYQAKC SLIKTHQEQG
1510 1520 1530 1540 1550
RSYKEVCAPV IERLRFLFNE LRPAVCSDLS IMSKFKLLGS LPRWRRIAQK
1560 1570 1580 1590 1600
IIRERRKKRV PKKPESIDSE EKIGNEESDL EEACVLPHSP INVDKRPISM
1610 1620 1630 1640 1650
KSPKDKWQPL LNTVTGVHKY KWLKQNVQGL YPQSALLNTI VEFALKEEPV
1660 1670 1680 1690 1700
DVEKMRKCLL KQLERAEVRL EGIDTILKLA AKSFLLPSVQ YAMFCGWQRL
1710 1720 1730 1740 1750
IPEGIDIGEP LTDCLRDVDL IPPFNRMLLE VTFGKLYAWA VQNIRSVLMD
1760 1770 1780 1790 1800
ASARFKELGI QPVPLQTITN ENPAGPSLGT IPQARFLLVM LSMLTLQHGA
1810 1820 1830 1840 1850
NNLDLLLNSG TLALTQTALR LIGPTCDSVE DDMNASARGA SATVLEETRK
1860 1870 1880 1890 1900
ETAPVQLPVS GPELAAMMKI GTRVMRGVDW KWGDQDGPPP GLGRVIGELG
1910 1920 1930 1940 1950
EDGWIRVQWD TGSTNSYRMG KEGKYDLKLV ELPVSSQPSA EDSDTEDDSE
1960 1970 1980 1990 2000
AEQGERNIHP TAMMLTSVIN LLQTLCLSVG VHADIMQSEA TKTLCGLLRM
2010 2020 2030 2040 2050
LVESGTTDKP APPDRLVARE QHRSWCTLGF VRSIALTPQA CGALSSPRWI
2060 2070 2080 2090 2100
TLLMKVVEGH APFTAASLQR QILAVHLLQA VLPSWDKTER ARDMKCLVEK
2110 2120 2130 2140 2150
LFGFLGSLLT TCSSDVPLLR ESTLRKRRAR PQASLTATHS STLAEEVVGL
2160 2170 2180 2190 2200
LRTLHSLTQW NGLINKYINS QLCSVTQSYA GKTSERAQLE DYFPDSENLE
2210 2220 2230 2240 2250
VGGLMAVLAV IGGIDGRLRL GGQVMHDEFG EGTVTRITPK GRITVQFCDM
2260 2270 2280 2290 2300
RMCRVCPLNQ LKPLPAVAFS VNNLPFTEPM LSVWAELVNL AGSKLEKHKT
2310 2320 2330 2340 2350
KKSAKPAFAG QVDLDLLRSQ QLKLYILKAG RALLSHQDKL RQILSQPAVQ
2360 2370 2380 2390 2400
GTGTLQTDDG AAASPDLGDM SPEGPQPPMI LLQQLLSSAT QPSPVKAIFD
2410 2420 2430 2440 2450
KQELEAAALA LCQCLAVEST HPSSPGCEDC SSSEATTPVS VQHIHLARAK
2460 2470 2480 2490 2500
KRRQSPAPAL PIVVQLMEMG FPRKNIEFAL KSLTGTSGNA SGLPGVEALV
2510 2520 2530 2540 2550
GWLLDHSDVQ VTEFSDAETL SDEYSDEEVV EDVDDTPYPV AAGAVVTESQ
2560 2570 2580 2590 2600
TYKKRADFLS NDDYAVYVRE NVQVGMMVRC CRTYEEVCEG DVGKVIKLDR
2610 2620 2630 2640 2650
DGLHDLNVQC DWQQKGGTYW VRYIHVELIG YPPPSSSSHI KIGDKVRVKA
2660 2670 2680 2690 2700
SVTTPKYKWG SVTHQSVGLV KAFSANGKDI IVDFPQQSHW TGLLSEMELV
2710 2720 2730 2740 2750
PSIHPGVTCD GCQTFPINGS RFKCRNCDDF DFCETCFKTK KHNTRHTFGR
2760 2770 2780 2790 2800
INEPGQSAVF CGRSGKQLKR CHSSQPGMLL DSWSRMVKSL NVSSSVNQAS
2810 2820 2830 2840 2850
RLIDGSEPCW QSSGSQGKHW IRLEIFPDVL VHRLKMIVDP ADSSYMPSLV
2860 2870 2880 2890 2900
VVSGGNSLNN LIELKTININ QTDTTVPLLS DCAEYHRYIE IAIKQCRSSG
2910 2920 2930 2940 2950
IDCKIHGLIL LGRIRAEEED LAAVPFLASD NEEEEDDKGS TGSLIRKKTP
2960 2970 2980 2990 3000
GLESTATIRT KVFVWGLNDK DQLGGLKGSK IKVPSFSETL SALNVVQVAG
3010 3020 3030 3040 3050
GSKSLFAVTV EGKVYSCGEA TNGRLGLGMS SGTVPIPRQI TALSSYVVKK
3060 3070 3080 3090 3100
VAVHSGGRHA TALTVDGKVF SWGEGDDGKL GHFSRMNCDK PRLIEALKTK
3110 3120 3130 3140 3150
RIRDIACGSS HSAALTSSGE LYTWGLGEYG RLGHGDNTTQ LKPKMVKVLL
3160 3170 3180 3190 3200
GHRVIQVACG SRDAQTLALT DEGLVFSWGD GDFGKLGRGG SEGCNIPQNI
3210 3220 3230 3240 3250
ERLNGQGVCQ IECGAQFSLA LTKSGVVWTW GKGDYFRLGH GSDVHVRKPQ
3260 3270 3280 3290 3300
VVEGLRGKKI VHVAVGALHC LAVTDSGQVY AWGDNDHGQQ GNGTTTVNRK
3310 3320 3330 3340 3350
PTLVQGLEGQ KITRVACGSS HSVAWTTVDV ATPSVHEPVL FQTARDPLGA
3360 3370 3380 3390 3400
SYLGVPSDAD SSSSSNKISG ANNCKPNRPS LAKILLSLEG NLAKQQALSH
3410 3420 3430 3440 3450
ILTALQIMYA RDAVVGALMP AGMLAPVECP SFSSSAPASD VSAMASPMHM
3460 3470 3480 3490 3500
EDSTLAADLE DRLSPNLWQE KREIVSSEDA VTPSAVTPSA PSASSRPFIP
3510 3520 3530 3540 3550
VTDDPGAASI IAETMTKTKE DVESQNKTSG PEPQSLDEFT SLLIPDDTRV
3560 3570 3580 3590 3600
VVELLKLSVC SRAGDKGREV LSAVLSGMGT AYPQVADMLL ELCVTELEDV
3610 3620 3630 3640 3650
ATDSQSGRLS SQPVVVESSH PYTDDTSTSG TVKIPGAEGL RVEFDRQCST
3660 3670 3680 3690 3700
ERRHDPLTVM DGVNRIVSVR SGREWSDWSS ELRIPGDELK WKFISDGSVN
3710 3720 3730 3740 3750
GWGWRFTVYP IMPAAGPKDL LSDRCVLSCP SMDLVTCLLD FRLNLTSNRS
3760 3770 3780 3790 3800
IVPRLAASLA ACAQLSALAA SHRMWALQRL RRLLTTEFGQ SININRLLGE
3810 3820 3830 3840 3850
NDGESRALSF TGSALAALVK GLPEALQRQF EYEDPIVRGG KQLLHSPFFK
3860 3870 3880 3890 3900
VLVALACDLE LDTLPCCAET HKWAWFRRYC MASRVAVALD KRTPLPRLFL
3910 3920 3930 3940 3950
DEVAKKIREL MADSESMDVL HESHSIFKRE QDEQLVQWMN RRPDDWTLSA
3960 3970 3980 3990 4000
GGSGTIYGWG HNHRGQLGGI EGAKVKVPTP CEALATLRPV QLIGGEQTLF
4010 4020 4030 4040 4050
AVTADGKLYA TGYGAGGRLG IGGTESVSTP TLLESIQHVF IKKVAVNSGG
4060 4070 4080 4090 4100
KHCLALSSEG EVYSWGEAED GKLGHGNRSP CDRPRVIESL RGIEVVDVAA
4110 4120 4130 4140 4150
GGAHSACVTA AGDLYTWGKG RYGRLGHSDS EDQLKPKLVE ALQGHRVIDI
4160 4170 4180 4190 4200
ACGSGDAQTL CLTDDDTVWS WGDGDYGKLG RGGSDGCKVP MKIDSLTGLG
4210 4220 4230 4240 4250
VVKVECGSQF SVALTKSGAV YTWGKGDYHR LGHGSDDHVR RPRQVQGLQG
4260 4270 4280 4290 4300
KKVIAIATGS LHCVCCTEDG EVYTWGDNDE GQLGDGTTNA IQRPRLVAAL
4310 4320 4330 4340 4350
QGKKVNRVAC GSAHTLAWST SKPASAGKLP AQVPMEYNHL QEIPIIALRN
4360 4370 4380 4390 4400
RLLLLHHISE LFCPCIPMFD LEGSLDETGL GPSVGFDTLR GILISQGKEA
4410 4420 4430 4440 4450
AFRKVVQATM VRDRQHGPVV ELNRIQVKRS RSKGGLAGPD GTKSVFGQMC
4460 4470 4480 4490 4500
AKMSSFSPDS LLLPHRVWKV KFVGESVDDC GGGYSESIAE ICEELQNGLT
4510 4520 4530 4540 4550
PLLIVTPNGR DESGANRDCY LLNPATRAPV HCSMFRFLGV LLGIAIRTGS
4560 4570 4580 4590 4600
PLSLNLAEPV WKQLAGMSLT IADLSEVDKD FIPGLMYIRD NEATSEEFEA
4610 4620 4630 4640 4650
MSLPFTVPSA SGQDIQLSSK HTHITLDNRA EYVRLAINYR LHEFDEQVAA
4660 4670 4680 4690 4700
VREGMARVVP VPLLSLFTGY ELETMVCGSP DIPLHLLKSV ATYKGIEPSA
4710 4720 4730 4740 4750
SLVQWFWEVM ESFSNTERSL FLRFVWGRTR LPRTIADFRG RDFVIQVLDK
4760 4770 4780 4790 4800
YNPPDHFLPE SYTCFFLLKL PRYSCKQVLE EKLKYAIHFC KSIDTDDYAR
4810 4820 4830
IALTGEPAAD DSSEDSDNED ADSFASDSTQ DYLTGH
Length:4,836
Mass (Da):527,456
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i481BC90E231C93D8
GO
Isoform 21 Publication (identifier: Q4U2R1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3637-3672: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:4,800
Mass (Da):523,388
Checksum:i3E3BA1D6DE63BAF7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RNG9A0A0U1RNG9_MOUSE
E3 ubiquitin-protein ligase HERC2
Herc2
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPZ3A0A0U1RPZ3_MOUSE
E3 ubiquitin-protein ligase HERC2
Herc2
965Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RP01A0A0U1RP01_MOUSE
E3 ubiquitin-protein ligase HERC2
Herc2
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti692H → L in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti724A → V in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti747R → G in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti756L → F in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti929R → P in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti1114S → N in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti1235G → D in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti2348A → P in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti2470G → S in BAE36828 (PubMed:16141072).Curated1
Sequence conflicti2523E → D in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti2567Y → F in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti2572V → L in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti3095E → Q in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti3107C → Y in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti3114A → P in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti3161S → T in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti3385 – 3386LL → VV in AAD08658 (PubMed:9949213).Curated2
Sequence conflicti3508A → V in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti4069E → K in BAD90404 (Ref. 5) Curated1
Sequence conflicti4187C → S in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti4604P → S in BAE36593 (PubMed:16141072).Curated1
Sequence conflicti4716T → A in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti4723R → C in AAD08658 (PubMed:9949213).Curated1
Sequence conflicti4730R → S in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti4752N → Y in AAC31431 (PubMed:9689098).Curated1
Sequence conflicti4790C → S in AAC31431 (PubMed:9689098).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0519753637 – 3672Missing in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF061529 mRNA Translation: AAC31431.1
AF071173 mRNA Translation: AAD08658.1
AC102121 Genomic DNA No translation available.
AC102150 Genomic DNA No translation available.
AK141515 mRNA Translation: BAE24711.1
AK148361 mRNA Translation: BAE28504.1
AK161826 mRNA Translation: BAE36593.1
AK162270 mRNA Translation: BAE36828.1
AK162708 mRNA Translation: BAE37031.1
AK220338 mRNA Translation: BAD90404.1
BC044667 mRNA Translation: AAH44667.1
BC054829 mRNA Translation: AAH54829.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS21318.1 [Q4U2R1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_034548.2, NM_010418.2 [Q4U2R1-1]
XP_006540700.1, XM_006540637.3 [Q4U2R1-1]
XP_006540701.1, XM_006540638.2
XP_006540702.1, XM_006540639.1 [Q4U2R1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000076226; ENSMUSP00000075579; ENSMUSG00000030451 [Q4U2R1-1]
ENSMUST00000164095; ENSMUSP00000131573; ENSMUSG00000030451 [Q4U2R1-1]
ENSMUST00000205303; ENSMUSP00000145997; ENSMUSG00000030451 [Q4U2R1-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
15204

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:15204

UCSC genome browser

More...
UCSCi
uc009hdv.1 mouse [Q4U2R1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061529 mRNA Translation: AAC31431.1
AF071173 mRNA Translation: AAD08658.1
AC102121 Genomic DNA No translation available.
AC102150 Genomic DNA No translation available.
AK141515 mRNA Translation: BAE24711.1
AK148361 mRNA Translation: BAE28504.1
AK161826 mRNA Translation: BAE36593.1
AK162270 mRNA Translation: BAE36828.1
AK162708 mRNA Translation: BAE37031.1
AK220338 mRNA Translation: BAD90404.1
BC044667 mRNA Translation: AAH44667.1
BC054829 mRNA Translation: AAH54829.1
CCDSiCCDS21318.1 [Q4U2R1-1]
RefSeqiNP_034548.2, NM_010418.2 [Q4U2R1-1]
XP_006540700.1, XM_006540637.3 [Q4U2R1-1]
XP_006540701.1, XM_006540638.2
XP_006540702.1, XM_006540639.1 [Q4U2R1-2]

3D structure databases

SMRiQ4U2R1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi200274, 64 interactors
IntActiQ4U2R1, 59 interactors
STRINGi10090.ENSMUSP00000075579

PTM databases

iPTMnetiQ4U2R1
PhosphoSitePlusiQ4U2R1

Proteomic databases

jPOSTiQ4U2R1
PaxDbiQ4U2R1
PeptideAtlasiQ4U2R1
PRIDEiQ4U2R1

Genome annotation databases

EnsembliENSMUST00000076226; ENSMUSP00000075579; ENSMUSG00000030451 [Q4U2R1-1]
ENSMUST00000164095; ENSMUSP00000131573; ENSMUSG00000030451 [Q4U2R1-1]
ENSMUST00000205303; ENSMUSP00000145997; ENSMUSG00000030451 [Q4U2R1-2]
GeneIDi15204
KEGGimmu:15204
UCSCiuc009hdv.1 mouse [Q4U2R1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8924
MGIiMGI:103234 Herc2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1426 Eukaryota
COG5021 LUCA
COG5184 LUCA
GeneTreeiENSGT00940000154975
InParanoidiQ4U2R1
KOiK10595
OMAiIMEMGFT
OrthoDBi1062377at2759
TreeFamiTF320636

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-3108214 SUMOylation of DNA damage response and repair proteins
R-MMU-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-MMU-5693571 Nonhomologous End-Joining (NHEJ)
R-MMU-5693607 Processing of DNA double-strand break ends
R-MMU-69473 G2/M DNA damage checkpoint
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Herc2 mouse

Protein Ontology

More...
PROi
PR:Q4U2R1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030451 Expressed in 299 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ4U2R1 baseline and differential
GenevisibleiQ4U2R1 MM

Family and domain databases

CDDicd08664 APC10-HERC2, 1 hit
cd00078 HECTc, 1 hit
cd02344 ZZ_HERC2, 1 hit
Gene3Di2.130.10.30, 3 hits
2.30.30.30, 1 hit
2.30.30.920, 1 hit
2.60.120.260, 1 hit
3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR006624 Beta-propeller_rpt_TECPR
IPR021097 CPH_domain
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR008979 Galactose-bd-like_sf
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR037976 HERC2_APC10
IPR010606 Mib_Herc2
IPR037252 Mib_Herc2_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR014722 Rib_L2_dom2
IPR000433 Znf_ZZ
IPR041987 ZZ_HERC2
PfamiView protein in Pfam
PF03256 ANAPC10, 1 hit
PF11515 Cul7, 1 hit
PF00173 Cyt-b5, 1 hit
PF00632 HECT, 1 hit
PF06701 MIB_HERC2, 1 hit
PF00415 RCC1, 16 hits
PF00569 ZZ, 1 hit
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM01337 APC10, 1 hit
SM01117 Cyt-b5, 1 hit
SM00119 HECTc, 1 hit
SM00706 TECPR, 4 hits
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF159034 SSF159034, 1 hit
SSF49785 SSF49785, 1 hit
SSF50985 SSF50985, 3 hits
SSF55856 SSF55856, 1 hit
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50255 CYTOCHROME_B5_2, 1 hit
PS51284 DOC, 1 hit
PS50237 HECT, 1 hit
PS51416 MIB_HERC2, 1 hit
PS00626 RCC1_2, 1 hit
PS50012 RCC1_3, 19 hits
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHERC2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4U2R1
Secondary accession number(s): E9PZT6
, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 27, 2011
Last modified: May 8, 2019
This is version 135 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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