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Protein

CLIP-associating protein 1-A

Gene

clasp1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules during anaphase. Plays a crucial role in chromatin-induced microtubule formation. May also act at microtubule minus ends. May be involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
CLIP-associating protein 1-A
Alternative name(s):
Cytoplasmic linker-associated protein 1-A
Short name:
XCLASP1
Gene namesi
Name:clasp1-a
Synonyms:clasp
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6466086 clasp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Kinetochore, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002722751 – 1460CLIP-associating protein 1-AAdd BLAST1460

Proteomic databases

PRIDEiQ4U0G1

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ4U0G1, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ4U0G1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati87 – 124HEAT 1Add BLAST38
Repeati163 – 200HEAT 2Add BLAST38
Repeati407 – 442HEAT 3Add BLAST36
Repeati443 – 479HEAT 4Add BLAST37
Repeati942 – 979HEAT 5Add BLAST38
Repeati1272 – 1309HEAT 6Add BLAST38
Repeati1390 – 1427HEAT 7Add BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi532 – 696Ser-richAdd BLAST165

Sequence similaritiesi

Belongs to the CLASP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG079692
KOiK16578

Family and domain databases

Gene3Di1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR028399 CLASP_1
IPR024395 CLASP_N_dom
IPR021133 HEAT_type_2
IPR034085 TOG
PANTHERiPTHR21567:SF28 PTHR21567:SF28, 1 hit
PfamiView protein in Pfam
PF12348 CLASP_N, 2 hits
SMARTiView protein in SMART
SM01349 TOG, 4 hits
SUPFAMiSSF48371 SSF48371, 5 hits
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q4U0G1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEQGMDYWLG QIQQKDVGKR LQVGPDLIEY LLDRQKSIDL EQDQTLLDRM
60 70 80 90 100
VDGLATSWVN SSNYKVALLG MDILSELVSR LQDRFRTQLG TVLPSLMDRL
110 120 130 140 150
GDAKDSVREQ DQSLLIKIME QASNPQYVWE RMFSGFKHKN FRTREGVCLC
160 170 180 190 200
LIATLNVYGA NSLTLSKIVP HICNLLGDPN SQVRDAAINC LVEIYRHVGE
210 220 230 240 250
RVRADLSKKG LPQSRLNVIF TKFDEVQKSG TMILSASDKN FDDEDSVDGN
260 270 280 290 300
RPSSASSSAS SKAPQTARRG VSLGTARRPG PSSAAAKTGG TAKEGAGALD
310 320 330 340 350
EEDFIRAFED VPNVQIYSSR DLEESLNKIR EILSDDKHDW EQRITALKKI
360 370 380 390 400
RSLLLAGAAE YDNFFQQLRL LDGAFKLSAK DLRSQVVREA CITLGHLSSV
410 420 430 440 450
LGNKFDHGAE AIMPTVFNLV PNSAKIMATS GIVAIRLIIR HTHVPRLIPI
460 470 480 490 500
ITSNCTSKSV AVRRRCYDFL DLLLQEWQTH SLERHVSVLA ETIKKGIHDA
510 520 530 540 550
DSEAKIVARK CYWGFHSHFS KEAEHLFHTL ESSYQKALQS HLKNSDSIVS
560 570 580 590 600
LPQSDRSSSS SQESLNRPLS TKRSPTGSTV SRASSTTSKS TPGSLQRSRS
610 620 630 640 650
DIDVNAAATS KSKAASGAST APFISVAALP PGSYASLGRI RTRRQSSGST
660 670 680 690 700
TSTASTPADT RGRSRAKVVS QSQPGSRSNS PGKLLGSSYG GIATGPQRVP
710 720 730 740 750
QMPSSEKRSR IPRSQGCSRE TSPSRIGLDR FGISQQGRIP SAMRVLSSST
760 770 780 790 800
DLEAAVADAL LLGDSRNKKK PVRRRYEPYG MYSDDDANSD ASSACSERSY
810 820 830 840 850
SSKNGGIPHY LRQTEDVAEV LNHCASSNWS ERKEGLLGLQ NLLKSQRTLS
860 870 880 890 900
RVELKRLCEI FTRMFADPHS KRVFSMFLET LVDFVIIHKD DLQDWLFILL
910 920 930 940 950
TQLLKKMGAD LLGSVQAKVQ KALDVTRDSF PFDQQFNILM RFIVDQTQTP
960 970 980 990 1000
NLKVKVAILK YIESLARQMD PTDFVNSSET RLAVSRIITW TTEPKSSDVR
1010 1020 1030 1040 1050
KAAQIVLISL FELNTPEFTM LLGALPKTFQ DGATKLLHNH LKNSSNSSMG
1060 1070 1080 1090 1100
SPSNTIGRTP SRHSSSRASP LTSPTNCSHG GLSPSMLDYD TENLNSDEIY
1110 1120 1130 1140 1150
SSLRGVTEAI EKFSFRSQVD LNEPVRRDSK KESELGSCDV GIASPASDLR
1160 1170 1180 1190 1200
GGTDMVEGGR MALDNKTSLL NTQPPRAFTG PRGREYNPYA YSDSINSYDK
1210 1220 1230 1240 1250
TALKEAVFDD DMDQLRDVSI DHSDLVADLL KELSNHNERV EERKGALCEL
1260 1270 1280 1290 1300
LKITREDNLA VWEEHFKTIL LLLLETLGDK DHAIRALALR VLREILRNQP
1310 1320 1330 1340 1350
ARFKNYAELT IMKTLEAHKD SHKEVVRAAE EAASTLAGSI HPEQCIKVLC
1360 1370 1380 1390 1400
PIIQTADYPI NLAAIKMQAK VIERISKESL HQILPDIIPG LLQGYDNTES
1410 1420 1430 1440 1450
SVRKASVFCL VAIYSVIGEE LKPYLAQLTG SKMKLLNLYI KRAQTTNSNS
1460
SSSSDVSTHS
Note: No experimental confirmation available.
Length:1,460
Mass (Da):161,499
Last modified:October 5, 2010 - v2
Checksum:iF88E1650288C4EF4
GO
Isoform 2 (identifier: Q4U0G1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     637-637: L → LDGTTSKSD

Show »
Length:1,468
Mass (Da):162,291
Checksum:iD4C8D969E2C70AF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti586T → A in AAY43788 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039722637L → LDGTTSKSD in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ022563 mRNA Translation: AAY43788.1
BC133747 mRNA Translation: AAI33748.1
RefSeqiNP_001088115.1, NM_001094646.1
UniGeneiXl.51958

Genome annotation databases

GeneIDi494817
KEGGixla:494817

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCLA1A_XENLA
AccessioniPrimary (citable) accession number: Q4U0G1
Secondary accession number(s): A3KNB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 5, 2010
Last modified: February 28, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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