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Entry version 99 (11 Dec 2019)
Sequence version 1 (19 Jul 2005)
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Protein

C-type mannose receptor 2

Gene

Mrc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices (By similarity). May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs) secreted by hepatic stellate cells. May mediate endocytosis of partially degraded collagens and glycoproteins produced in the extracellular matrix by MMPs.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandCalcium, Lectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-type mannose receptor 2
Alternative name(s):
Endocytic receptor 180
Macrophage mannose receptor 2
CD_antigen: CD280
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mrc2
Synonyms:Endo180
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
1559436 Mrc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini31 – 1413ExtracellularSequence analysisAdd BLAST1383
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1414 – 1434HelicalSequence analysisAdd BLAST21
Topological domaini1435 – 1480CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004608031 – 1480C-type mannose receptor 2Add BLAST1450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi53 ↔ 67By similarity
Disulfide bondi92 ↔ 111By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi186 ↔ 212By similarity
Disulfide bondi200 ↔ 227By similarity
Disulfide bondi265 ↔ 358By similarity
Disulfide bondi334 ↔ 350By similarity
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi409 ↔ 503By similarity
Disulfide bondi480 ↔ 495By similarity
Disulfide bondi617 ↔ 634By similarity
Disulfide bondi703 ↔ 807By similarity
Disulfide bondi784 ↔ 799By similarity
Disulfide bondi852 ↔ 949By similarity
Disulfide bondi926 ↔ 941By similarity
Glycosylationi1028N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1077 ↔ 1097By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Disulfide bondi1219 ↔ 1233By similarity
Glycosylationi1348N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1367 ↔ 1382By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication
Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4TU93

PRoteomics IDEntifications database

More...
PRIDEi
Q4TU93

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4TU93

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4TU93

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex.

Interacts with collagen V (By similarity).

Interacts with C-terminal region of type I collagen/COL1A1.

By similarity1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000052010

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4TU93

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 166Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST127
Domaini181 – 229Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST49
Domaini243 – 359C-type lectin 1PROSITE-ProRule annotationAdd BLAST117
Domaini388 – 504C-type lectin 2PROSITE-ProRule annotationAdd BLAST117
Domaini527 – 643C-type lectin 3PROSITE-ProRule annotationAdd BLAST117
Domaini677 – 808C-type lectin 4PROSITE-ProRule annotationAdd BLAST132
Domaini831 – 950C-type lectin 5PROSITE-ProRule annotationAdd BLAST120
Domaini978 – 1106C-type lectin 6PROSITE-ProRule annotationAdd BLAST129
Domaini1131 – 1242C-type lectin 7PROSITE-ProRule annotationAdd BLAST112
Domaini1271 – 1391C-type lectin 8PROSITE-ProRule annotationAdd BLAST121

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner (By similarity).By similarity
Fibronectin type-II domain mediates collagen-binding.By similarity
Ricin B-type lectin domain contacts with the second C-type lectin domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IS43 Eukaryota
ENOG410XQ89 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231191

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4TU93

KEGG Orthology (KO)

More...
KOi
K06560

Database of Orthologous Groups

More...
OrthoDBi
29241at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4TU93

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03590 CLECT_DC-SIGN_like, 1 hit
cd00062 FN2, 1 hit
cd00161 RICIN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
3.10.100.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits
SSF57440 SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 3 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q4TU93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPIRPALAP WPRHLLRCVL LLGGLRLGHP ADSAAALLEP DVFLIFSQGM
60 70 80 90 100
QGCLEAQGVQ VRVIPVCNAS LPAQRWKWVS RNRLFNLGAM QCLGTGWPAT
110 120 130 140 150
NTTVSLGMYE CDREALSLRW QCRTLGDQLS LLLGARANNA SKPGTLERGD
160 170 180 190 200
QTRSGHWNIY GSEEDLCARP YYEVYTIQGN SHGKPCTIPF KYDNQWFHGC
210 220 230 240 250
TSTGREDGHL WCATTQDYGK DERWGFCPIK SNDCETFWDK DQLTDSCYQF
260 270 280 290 300
NFQSTLSWRE AWASCEQQGA DLLSITEIHE QTYINGLLTG YSSTLWIGLN
310 320 330 340 350
DLDTSGGWQW SDNSPLKYLN WESDQPDNPG EENCGVIRTE SSGGWQNHDC
360 370 380 390 400
SIALPYVCKK KPNATAEPIQ PDRWANVKVE CDPSWQPFQG HCYRLQAEKR
410 420 430 440 450
SWQESKRACL RGGGDLLSIH SMTELEFITK QIKQEVEELW IGLNDLKLQM
460 470 480 490 500
NFEWSDGSLV SFTHWHPFEP NNFRDSLEDC VTIWGPEGRW NDSPCNQSLP
510 520 530 540 550
SICKKAGRLS QGTAEEDHGC RKGWTWHSPS CYWLGEDQVI YSDARRLCTD
560 570 580 590 600
HGSQLVTITN RFEQAFVSSL IYNWEGEYFW TALQDLNSTG SFRWLSGDEV
610 620 630 640 650
MYTHWNRDQP GYRRGGCVAL ATGSAMGLWE VKNCTSFRAR YICRQSLGTP
660 670 680 690 700
VTPELPGPDP TPSLTGSCPQ GWVSDPKLRH CYKVFSSERL QEKKSWIEAL
710 720 730 740 750
GVCRELGAQL LSLASYEEEH FVANMLNKIF GESEPENHEQ HWFWIGLNRR
760 770 780 790 800
DPREGHSWRW SDGLGFSYHN FARSQHDDDN IRGCAVLDLA SLQWVAMQCQ
810 820 830 840 850
TQLDWICKIP RGVDVREPDI GRQGRLEWVR FQEAEYKFFE HHSSWAQAQR
860 870 880 890 900
ICTWFQAELT SVHSQAELDF LGQNMQKLSS DQEQHWWIGL HTSESDGRFR
910 920 930 940 950
WSDGSVINFV SWAPGKPRPI GKDKKCVYMT ARQEDWGDQR CHTALPYICK
960 970 980 990 1000
RSNSSGETRP HDLPPSTLGG CPSGWNQFLN KCFRIQGQDP QDRVKWSEAQ
1010 1020 1030 1040 1050
FSCEQQEAQL VTIANPLEQA YITASLPNVT FDLWIGLHGS QRDFQWIEQE
1060 1070 1080 1090 1100
PLLYTNWAPG EPSGPSPAPS GTKPTSCAVI LHSPSAHFTG RWDDRSCTEE
1110 1120 1130 1140 1150
THGFICQKGT DPSLSPSPAA ALPAPGTELS YLNRTFRLLQ KPLRWKDALL
1160 1170 1180 1190 1200
LCESRNASLA HVPDPYTQAF LTQAARGLQA PLWIGLASEE GSRRYSWLSE
1210 1220 1230 1240 1250
EPLNYASWQD GEPQHTGGCA YVDVDGTWRT TSCDTKLQGA VCGVSRGPPP
1260 1270 1280 1290 1300
PRISYRGSCP QGLADSSWIP FREHCYSFHT ELLLGHKEAL QRCQRAGGTV
1310 1320 1330 1340 1350
LSILDEMENV FVWEHLQTAE TQSRGAWLGM NFNPKGGMLV WQDNTAVNYS
1360 1370 1380 1390 1400
NWGPPGLGPS MLSHNSCYWI QSSSGLWRPG ACTNVTMGVV CKLPRVEENG
1410 1420 1430 1440 1450
FLPSAALPEN PVALVVVLTA AVLLLLALLT GALILYRRRQ SAERGSFEGA
1460 1470 1480
RYSRSSRSGP AEATEKNILV SDMEMNEQQE
Length:1,480
Mass (Da):167,022
Last modified:July 19, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E0E5C9542C95072
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1LMA7F1LMA7_RAT
C-type mannose receptor 2
Mrc2
1,514Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ058624 mRNA Translation: AAY53886.1

NCBI Reference Sequences

More...
RefSeqi
NP_001019858.1, NM_001024687.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
498011

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:498011

UCSC genome browser

More...
UCSCi
RGD:1559436 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ058624 mRNA Translation: AAY53886.1
RefSeqiNP_001019858.1, NM_001024687.1

3D structure databases

SMRiQ4TU93
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052010

PTM databases

iPTMnetiQ4TU93
PhosphoSitePlusiQ4TU93

Proteomic databases

PaxDbiQ4TU93
PRIDEiQ4TU93

Genome annotation databases

GeneIDi498011
KEGGirno:498011
UCSCiRGD:1559436 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9902
RGDi1559436 Mrc2

Phylogenomic databases

eggNOGiENOG410IS43 Eukaryota
ENOG410XQ89 LUCA
HOGENOMiHOG000231191
InParanoidiQ4TU93
KOiK06560
OrthoDBi29241at2759
PhylomeDBiQ4TU93

Enzyme and pathway databases

ReactomeiR-RNO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q4TU93

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
cd00062 FN2, 1 hit
cd00161 RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 8 hits
SMARTiView protein in SMART
SM00034 CLECT, 8 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 8 hits
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 3 hits
PS50041 C_TYPE_LECTIN_2, 8 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRC2_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4TU93
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: July 19, 2005
Last modified: December 11, 2019
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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