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Protein

Sodium channel protein

Gene

GSTENG00028138001

Organism
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
ORF Names:GSTENG00028138001Imported
OrganismiTetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)Imported
Taxonomic identifieri99883 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTetraodon

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei199 – 218HelicalUniRule annotationAdd BLAST20
Transmembranei230 – 251HelicalUniRule annotationAdd BLAST22
Transmembranei257 – 277HelicalUniRule annotationAdd BLAST21
Transmembranei351 – 370HelicalUniRule annotationAdd BLAST20
Transmembranei390 – 417HelicalUniRule annotationAdd BLAST28
Transmembranei732 – 756HelicalUniRule annotationAdd BLAST25
Transmembranei768 – 786HelicalUniRule annotationAdd BLAST19
Transmembranei847 – 876HelicalUniRule annotationAdd BLAST30
Transmembranei935 – 961HelicalUniRule annotationAdd BLAST27
Transmembranei1184 – 1202HelicalUniRule annotationAdd BLAST19
Transmembranei1223 – 1242HelicalUniRule annotationAdd BLAST20
Transmembranei1254 – 1274HelicalUniRule annotationAdd BLAST21
Transmembranei1300 – 1326HelicalUniRule annotationAdd BLAST27
Transmembranei1423 – 1449HelicalUniRule annotationAdd BLAST27
Transmembranei1461 – 1479HelicalUniRule annotationAdd BLAST19
Transmembranei1522 – 1540HelicalUniRule annotationAdd BLAST19
Transmembranei1552 – 1574HelicalUniRule annotationAdd BLAST23
Transmembranei1586 – 1605HelicalUniRule annotationAdd BLAST20
Transmembranei1653 – 1674HelicalUniRule annotationAdd BLAST22
Transmembranei1695 – 1714HelicalUniRule annotationAdd BLAST20
Transmembranei1742 – 1765HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ4RVW9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 424Ion_transInterPro annotationAdd BLAST288
Domaini498 – 686Na_trans_cytoplInterPro annotationAdd BLAST189
Domaini738 – 965Ion_transInterPro annotationAdd BLAST228
Domaini975 – 1177Na_trans_assocInterPro annotationAdd BLAST203
Domaini1182 – 1457Ion_transInterPro annotationAdd BLAST276
Domaini1521 – 1775Ion_transInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili15 – 35Sequence analysisAdd BLAST21
Coiled coili414 – 452Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410INF8 Eukaryota
COG1226 LUCA
HOVERGENiHBG053100
KOiK04840

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR008054 Na_channel_a8su
IPR001696 Na_channel_asu
IPR010526 Na_trans_assoc
IPR024583 Na_trans_cytopl
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PF06512 Na_trans_assoc, 1 hit
PF11933 Na_trans_cytopl, 1 hit
PRINTSiPR00170 NACHANNEL
PR01667 NACHANNEL8

Sequencei

Sequence statusi: Fragment.

Q4RVW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPLLAPPG PDSFKKFTRE SLVALEQRIK EEKNKKPPKQ DSSYRDDDDE
60 70 80 90 100
NKPRPNSDLE AGKSLPYIYG DTPQGMVAVP LEDLDPYYLN TQKTFIVLNK
110 120 130 140 150
GKTIFRFSAT SALYFISPFN PVRRVAIKIL IHSYPLTRMI IMCTILTNCI
160 170 180 190 200
FMTFSDPPEW SKQVEYTFTG IYTFESLVKI TARGFCIDDF TFLRDPWNWL
210 220 230 240 250
DFMVISMAYI TEFVNLGNVS ALRTFRVLRA LKTISVIPGL KTIVGALIQS
260 270 280 290 300
VKKLSDVMIL TVFCLSVFAL IGLQLFMGNL RQKCVIWPIN ITDSQLSNKS
310 320 330 340 350
QPFDWDEYIT NDTNFYFLPG QLDALLCGNS SDSGRCPEGY TCMKAGRNPN
360 370 380 390 400
YGYTSFDSFG WAFLALFRLM TQDFWENLYM LTLRAAGKTY MIFFVLVIFV
410 420 430 440 450
GSFYLVNLIL AVVAMAYEEQ NQATMEEAQQ KEEEFKAMLE QLKKQQEDAQ
460 470 480 490 500
AAAMATSAGT VSEDAVEDDG GGHLSCSSSE MSKLSSKSAK ERRNRKKKWR
510 520 530 540 550
QKEQEKEKGD SEKFVKSESD DGSKRSRFRF PDNRLGRKSS IMNQSLLSIP
560 570 580 590 600
GSPFLSRHNS KSSIFSFKGR SKDVGSENEF ADDEHSTVEE CEERRGSLFS
610 620 630 640 650
PYRRSSYSGF HGKRNSTVDC NGVVSLIGPG PGGRLLPEVK IDKAATDDSP
660 670 680 690 700
TTEVEVKKKL SGSLMVSVDQ LNTSFGRKER ANSVMSVITN TLVEELEESQ
710 720 730 740 750
RKCPPCWYKF ANTFLIWECS PKWIKIKEIV NLIVMDPFVD LAITICIVLN
760 770 780 790 800
TLFMAMEHYP MTPDFEHMLS VGNLVFTGIF AGEMLFKLVA MDPYYYFQEA
810 820 830 840 850
WNCFDGFIVT LSLVELALAD VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK
860 870 880 890 900
IIGNSVGALG NLTLVLAIIV FIFAVVGMQL FGKNYKDCVC KIAQDCELPR
910 920 930 940 950
WHMNDFFHSF LIVFRVLCGE WIETMWDCME VAGQAMCLIV FMMVMVIGNL
960 970 980 990 1000
VVLNLFLALL LSSFSADNLA ATDDDGEPNN LQISVMRFKK GIAWTKSKVR
1010 1020 1030 1040 1050
ILMASLLKKP PMEDEQKPLD DMYDKKLNFI ANHTGVDINR DLDYAKNGNG
1060 1070 1080 1090 1100
TTSGIGSSVG KYMIDEDHMS FIHNPNLTVC VPIAVGESDF ENLNTEDFSS
1110 1120 1130 1140 1150
ESDIENSKEL DDTSSSEGST IDIKPDVEEV VVVETVEEYM EPEPCWTDAC
1160 1170 1180 1190 1200
VAKYKCCDVD ITMGWGKSWW FLRKTCYVIV EHNWFETLII FMILLSSGAL
1210 1220 1230 1240 1250
AFEDVYIEQR KTIRIILEYA DRVFTYIFIL EMLLKWVAYG FVKYFTNAWC
1260 1270 1280 1290 1300
WLDFFIVDVS IVSLVANALG YSDLGPIKSL RTLRALRPLR ALSRFEGMRV
1310 1320 1330 1340 1350
VVNALVGAIP SIMNVLLVCL IFWLIFSIMG VNLFAGKYYY CFNETSEEMF
1360 1370 1380 1390 1400
SVDVVNNKTQ CEALIKDNFT EVRWKNVKIN FDNVGAGYLA LLQVATFKGW
1410 1420 1430 1440 1450
MDIMYAAVDS REVEDQPDYE VNIYMYIYFV VFIIFGSFFT LNLFIGVIID
1460 1470 1480 1490 1500
NFNQQKKKIR HFLFFLICMS LYFGGQDIFM TEEQKKYYNA MKKLGSKKPQ
1510 1520 1530 1540 1550
KPIPRPQNKI QGMVFDFVTQ QVFDISIMIL ICLNMVTMMV ETDDQSDETE
1560 1570 1580 1590 1600
TVLYWVNFIF IVVFTTEFLL KLFALRHYYF TNGWNIFDVV VVILSIVGMF
1610 1620 1630 1640 1650
LADIIEKYFV SPTLFRVIRL ARIGRILRLI KGAKGIRTLL FALMMSLPAL
1660 1670 1680 1690 1700
FNIGLLLFLV MFIFSIFGMS NFGYVKHGAG IDDMYNFETF GNSMIILFMI
1710 1720 1730 1740 1750
TTSGGWDGLL LPILNYPPDC DPNSENPGTS VKGNCGNPSV GIFFFVMYII
1760 1770 1780 1790 1800
ISFLIVVNMY IAIILENFSV ATEESADPLS EDDFETFYEI WEKFDPSASQ
1810 1820 1830 1840 1850
FITFAKLSDF ADALEHPLRV PKPNTIELIA MDMPMVSGDR IHCLDILFAF
1860 1870 1880 1890 1900
TKRVLGDSGE LDMLRQQMEE RFVAANPSKV SYEPITTTLR RKQEDVSARI
1910 1920 1930 1940 1950
IQNAYRAHLI RRGIIFKRHT FTNNKLENGG TNQEKKESTP STASLPSYDS
1960 1970 1980
VTKPDKEKQD ENKEEWARKQ KDKNQKDEWE SKC
Length:1,983
Mass (Da):226,097
Last modified:July 19, 2005 - v1
Checksum:iF7D4896A4A433D5C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1983Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAE01014991 Genomic DNA Translation: CAG07463.1

Genome annotation databases

KEGGitng:GSTEN00028138G001

Similar proteinsi

Entry informationi

Entry nameiQ4RVW9_TETNG
AccessioniPrimary (citable) accession number: Q4RVW9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: February 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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