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Protein

Protein MEMO1

Gene

MEMO1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MEMO1
Alternative name(s):
Mediator of ErbB2-driven cell motility 1
Short name:
Memo-1
Gene namesi
Name:MEMO1
ORF Names:QtsA-18196
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002605091 – 297Protein MEMO1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with ERBB2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4R6D9
SMRiQ4R6D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MEMO1 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000006408
HOVERGENiHBG050811
KOiK06990

Family and domain databases

CDDicd07361 MEMO_like, 1 hit
HAMAPiMF_00055 MEMO1, 1 hit
InterProiView protein in InterPro
IPR002737 MEMO1_fam
PANTHERiPTHR11060 PTHR11060, 1 hit
PfamiView protein in Pfam
PF01875 Memo, 1 hit

Sequencei

Sequence statusi: Complete.

Q4R6D9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA
60 70 80 90 100
GYTYCGSCAA HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL
110 120 130 140 150
YDLRIDQKIY GELWKTGMFE RMSLQTDEDE HSIEMHLPYT AKAMESHKDE
160 170 180 190 200
FTIIPVLVGA LSESKEQEFG KLFSKYLADP SNLFVVSSDF CHWGQRFRYS
210 220 230 240 250
YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH NTICGRHPIG
260 270 280 290
VLLNAITELQ KNGMNMSFSF LNYAQSSQCR NWQDSSVSYA AGALTVH
Length:297
Mass (Da):33,733
Last modified:July 19, 2005 - v1
Checksum:iE315FD5587776211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB169245 mRNA Translation: BAE01336.1
RefSeqiNP_001271481.1, NM_001284552.1
UniGeneiMfa.8370

Genome annotation databases

EnsembliENSMFAT00000014788; ENSMFAP00000040520; ENSMFAG00000046335
GeneIDi102146322
KEGGimcf:102146322

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB169245 mRNA Translation: BAE01336.1
RefSeqiNP_001271481.1, NM_001284552.1
UniGeneiMfa.8370

3D structure databases

ProteinModelPortaliQ4R6D9
SMRiQ4R6D9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMFAT00000014788; ENSMFAP00000040520; ENSMFAG00000046335
GeneIDi102146322
KEGGimcf:102146322

Organism-specific databases

CTDi7795

Phylogenomic databases

GeneTreeiENSGT00390000006408
HOVERGENiHBG050811
KOiK06990

Family and domain databases

CDDicd07361 MEMO_like, 1 hit
HAMAPiMF_00055 MEMO1, 1 hit
InterProiView protein in InterPro
IPR002737 MEMO1_fam
PANTHERiPTHR11060 PTHR11060, 1 hit
PfamiView protein in Pfam
PF01875 Memo, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMEMO1_MACFA
AccessioniPrimary (citable) accession number: Q4R6D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 19, 2005
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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