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Protein

Palmitoyltransferase ZDHHC13

Gene

ZDHHC13

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Palmitoyltransferase for HTT and GAD2. May play a role in Mg2+ transport.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei456S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC13Curated (EC:2.3.1.225By similarity)
Alternative name(s):
Zinc finger DHHC domain-containing protein 13By similarity
Short name:
DHHC-13By similarity
Gene namesi
Name:ZDHHC13By similarity
ORF Names:QtsA-18740
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128881 – 622Palmitoyltransferase ZDHHC13Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Interacts (via ANK repeats) with CLIP3. Interacts (via ANK repeats) with DNAJC5 (via C-terminus). Interacts (via ANK repeats) with HTT. Interacts (via ANK repeats) with MAP6. Interacts (via ANK repeats) with SNAP23. Interacts (via ANK repeats) with SNAP25. May interact (via ANK repeats) with SPRED2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4R690
SMRiQ4R690
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 78ANK 1By similarityAdd BLAST36
Repeati81 – 110ANK 2Sequence analysisAdd BLAST30
Repeati115 – 144ANK 3Sequence analysisAdd BLAST30
Repeati148 – 177ANK 4Sequence analysisAdd BLAST30
Repeati181 – 211ANK 5Sequence analysisAdd BLAST31
Repeati216 – 245ANK 6Sequence analysisAdd BLAST30
Repeati249 – 279ANK 7Sequence analysisAdd BLAST31
Domaini426 – 476DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi328 – 391Phe-richAdd BLAST64

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG051907
KOiK20032

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001594 Palmitoyltrfase_DHHC
IPR030290 ZDHHC13
PANTHERiPTHR24161:SF16 PTHR24161:SF16, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01529 DHHC, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q4R690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPGLGSQC RNHSHGPHPP GFGRYGICAH ENKELANARE ALPLIEDSSN
60 70 80 90 100
CDIVKATQYG IFERCKELVE AGYDVRQPDK ENVSLLHWAA INNRLDLVKF
110 120 130 140 150
YISKGAVVDQ LGGDLNSTPL HWAIRQGHLP MVILLLQHGA DPTLTDGEGF
160 170 180 190 200
SSIHLAVLFQ HMPIIAYLIS KRQSVNMTDV NGQTPLMLSA HKVIGPEPTG
210 220 230 240 250
FLLKFNPSLN VVDKIHQNTP LHWAVAAGNV NAVDKLLEAG SSLDIQNVKG
260 270 280 290 300
ETPLDMALQN KNQLIIHMLK TEAKMRTNQK FRLWRWLQKC ELFLLLMLSV
310 320 330 340 350
ITMWAVGYIL DFNSDSWLLK GCLLVTLFFL TSLFPRFLVG YKNLIYLPTA
360 370 380 390 400
FLLSSIFWIF MTWFILFFPD LAGAPFYFSF IFSIVAFLYF FYKTWATDPG
410 420 430 440 450
FTKASEEEKK VNIITLAETG CLDFRTFCTS CLIRKPLRSL HCHVCNSCVA
460 470 480 490 500
RYDQHCLWTG RCIGFGNHHY YIFFLFFLSM VCGWIIYGSF IYWSNHCATT
510 520 530 540 550
FKEDGLWTYL NQIVACSPWV LYILMLATFH FSWSTFLLLN QLFQIAFLGL
560 570 580 590 600
TSHERISLLK QSKHMKQTLS LRKTPYNLGF MQNLADFFQC GCFGLVKPCV
610 620
VDWTSQYTMV FHPAREKVLR SV
Length:622
Mass (Da):71,077
Last modified:July 19, 2005 - v1
Checksum:iF66B988E45A287B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB169298 mRNA Translation: BAE01385.1
RefSeqiNP_001271600.1, NM_001284671.1
UniGeneiMfa.3249

Genome annotation databases

GeneIDi101865635
KEGGimcf:101865635

Similar proteinsi

Entry informationi

Entry nameiZDH13_MACFA
AccessioniPrimary (citable) accession number: Q4R690
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2005
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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