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Protein

Bardet-Biedl syndrome 5 protein homolog

Gene

BBS5

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 5 protein homolog
Gene namesi
Name:BBS5
ORF Names:QtsA-19140
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232551 – 341Bardet-Biedl syndrome 5 protein homologAdd BLAST341

Proteomic databases

PRIDEiQ4R649

Interactioni

Subunit structurei

Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10 (By similarity). Binds to phosphoinositides (By similarity). Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO (By similarity). Interacts with PKD1 (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ4R649
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BBS5 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000002753
HOVERGENiHBG053449
KOiK16748

Family and domain databases

InterProiView protein in InterPro
IPR006606 BBL5
IPR030804 BBS5/fem-3
IPR014003 DM16_repeat
PANTHERiPTHR21351 PTHR21351, 1 hit
PfamiView protein in Pfam
PF07289 BBL5, 1 hit
PIRSFiPIRSF010072 DUF1448, 1 hit
SMARTiView protein in SMART
SM00683 DM16, 2 hits

Sequencei

Sequence statusi: Complete.

Q4R649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLDALWED RDVRFDLSSQ QMKTRPGEVL IDCLDSIEDT KGNNGDRGRL
60 70 80 90 100
LVTNLRILWH SLALSRVNVS VGYNCILNIT TRTANSKLRG QTEALYILTK
110 120 130 140 150
CNSTRFEFIF TNLVPGSPRL FTSVMAVHRA YETSKMYRDF KLRSALIQNK
160 170 180 190 200
QLRLLPQEHV YDKINGVWNL SSDQGNLGTF FITNVRIVWH ANMNDSFNVS
210 220 230 240 250
IPYLQIRSIK IRDSKFGLAL VIESSQQSGG YVLGFKIDPV EKLQESVKEI
260 270 280 290 300
NSLHKVYSAS PIFGVDYEME EKPQPLEALT VEQIQDDVEI DSDDHTDAFV
310 320 330 340
AYFADGNKQQ DREPVFSEEL GLAIEKLKDG FTLQGLWEVM S
Length:341
Mass (Da):38,829
Last modified:February 7, 2006 - v2
Checksum:i81531C4B1E39BB6D
GO

Sequence cautioni

The sequence BAE01426 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB169341 mRNA Translation: BAE01426.1 Different initiation.
RefSeqiNP_001270514.1, NM_001283585.1
XP_015287559.1, XM_015432073.1
XP_015287560.1, XM_015432074.1
UniGeneiMfa.9074

Genome annotation databases

EnsembliENSMFAT00000024859; ENSMFAP00000006176; ENSMFAG00000040347
GeneIDi101865542
KEGGimcf:101865542

Similar proteinsi

Entry informationi

Entry nameiBBS5_MACFA
AccessioniPrimary (citable) accession number: Q4R649
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: June 20, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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