UniProtKB - Q4R639 (DHSO_MACFA)
Sorbitol dehydrogenase
SORD
Functioni
Polyol dehydrogenase that catalyzes the reversible NAD+-dependent oxidation of various sugar alcohols. Is active with xylitol, L-iditol and D-sorbitol (D-glucitol) as substrates, leading to the C2-oxidized products D-xylulose, L-sorbose and D-fructose, respectively (By similarity).
Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity).
By similarityCatalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 45 | Zinc; catalyticBy similarity | 1 | |
Binding sitei | 51 | SubstrateBy similarity | 1 | |
Metal bindingi | 70 | Zinc; catalyticBy similarity | 1 | |
Metal bindingi | 71 | Zinc; catalyticBy similarity | 1 | |
Binding sitei | 156 | SubstrateBy similarity | 1 | |
Binding sitei | 184 | NAD; via amide nitrogenBy similarity | 1 | |
Binding sitei | 204 | NADBy similarity | 1 | |
Binding sitei | 209 | NADBy similarity | 1 | |
Binding sitei | 299 | SubstrateBy similarity | 1 | |
Binding sitei | 300 | SubstrateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 273 – 275 | NADBy similarity | 3 | |
Nucleotide bindingi | 297 – 299 | NADBy similarity | 3 |
GO - Molecular functioni
- D-xylulose reductase activity Source: UniProtKB-EC
- L-iditol 2-dehydrogenase activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- flagellated sperm motility Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Metal-binding, NAD, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:SORD ORF Names:QtsA-19202 |
Organismi | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
Taxonomic identifieri | 9541 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSMFAG00000022177 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane By similarity; Peripheral membrane protein By similarity
Other locations
- flagellum By similarity
Note: Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.By similarity
Mitochondrion
- mitochondrial membrane Source: UniProtKB-SubCell
Other locations
- motile cilium Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cilium, Flagellum, Membrane, MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000231004 | 2 – 357 | Sorbitol dehydrogenaseAdd BLAST | 356 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 211 | PhosphoserineBy similarity | 1 | |
Modified residuei | 225 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinInteractioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
STRINGi | 9541.XP_005559475.1 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0024, Eukaryota |
OMAi | ETWYAMS |
OrthoDBi | 1019156at2759 |
Family and domain databases
CDDi | cd05285, sorbitol_DH, 1 hit |
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR045306, SDH-like |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAAAAKPKNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH
60 70 80 90 100
YWEEGRIGNF IVKKPMVLGH EASGTVEKVG SLVKHLKPGD RVAIEPGVPR
110 120 130 140 150
ENDEFCKSGR YNLSPSIFFC ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE
160 170 180 190 200
EGALIEPLSV GIHACRRGGV TLGHRVLVCG AGPIGVVSLL VAKAMGAAQV
210 220 230 240 250
VVTDLSAPRL SKAKEIGADL VLQISKESPQ EIAGKVEGLL GCKPEVTIEC
260 270 280 290 300
TGAEASIQAG IYATRSGGTL VLVGLGSEMT TIPLLHAAVR EVDIKGVFRY
310 320 330 340 350
CNTWPVAISM LASKSVNIKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC
DPNDQNP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB169351 mRNA Translation: BAE01436.1 |
RefSeqi | NP_001270085.1, NM_001283156.1 |
Genome annotation databases
GeneIDi | 101865740 |
KEGGi | mcf:101865740 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB169351 mRNA Translation: BAE01436.1 |
RefSeqi | NP_001270085.1, NM_001283156.1 |
3D structure databases
SMRi | Q4R639 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9541.XP_005559475.1 |
Genome annotation databases
GeneIDi | 101865740 |
KEGGi | mcf:101865740 |
Organism-specific databases
CTDi | 6652 |
VEuPathDBi | HostDB:ENSMFAG00000022177 |
Phylogenomic databases
eggNOGi | KOG0024, Eukaryota |
OMAi | ETWYAMS |
OrthoDBi | 1019156at2759 |
Family and domain databases
CDDi | cd05285, sorbitol_DH, 1 hit |
InterProi | View protein in InterPro IPR013149, ADH_C IPR013154, ADH_N IPR002328, ADH_Zn_CS IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER IPR045306, SDH-like |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00059, ADH_ZINC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DHSO_MACFA | |
Accessioni | Q4R639Primary (citable) accession number: Q4R639 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 91 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families