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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Gene

NDUFS6

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Alternative name(s):
Complex I-13kD-A
Short name:
CI-13kD-A
NADH-ubiquinone oxidoreductase 13 kDa-A subunit
Gene namesi
Name:NDUFS6
ORF Names:QtsA-19927
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionBy similarityAdd BLAST28
ChainiPRO_000004317229 – 124NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialAdd BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4R5X8
SMRiQ4R5X8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFS6 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG006549
KOiK03939

Family and domain databases

InterProiView protein in InterPro
IPR016668 NDUFS6
IPR019401 Znf_CHCC
PfamiView protein in Pfam
PF10276 zf-CHCC, 1 hit
PIRSFiPIRSF016564 CI-13KD-A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4R5X8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASATFYRL LSRCGKAARS RPLGARCFGV RVSPTGEKIT HTGQVYDDKD
60 70 80 90 100
YRRIRFVDRQ KEVNENFAID LIAEQPVSEV QTRVIACDGG GGALGHPKVY
110 120
INLDKETKTG TCGYCGLQFR QHPH
Length:124
Mass (Da):13,774
Last modified:July 19, 2005 - v1
Checksum:iE98DDFC0693C3BC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB169414 mRNA Translation: BAE01497.1
RefSeqiNP_001270954.1, NM_001284025.1
UniGeneiMfa.7141

Genome annotation databases

GeneIDi101865852
KEGGimcf:101865852

Similar proteinsi

Entry informationi

Entry nameiNDUS6_MACFA
AccessioniPrimary (citable) accession number: Q4R5X8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 19, 2005
Last modified: September 27, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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