UniProtKB - Q4R518 (MICU1_MACFA)
Calcium uptake protein 1, mitochondrial
MICU1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 231 – 242 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 421 – 432 | 2PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
GO - Biological processi
- calcium import into the mitochondrion Source: UniProtKB
- calcium ion import Source: UniProtKB
- mitochondrial calcium ion homeostasis Source: UniProtKB
- mitochondrial calcium ion transmembrane transport Source: UniProtKB
- positive regulation of mitochondrial calcium ion concentration Source: UniProtKB
- regulation of cellular hyperosmotic salinity response Source: UniProtKB
Keywordsi
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium uptake protein 1, mitochondrialAlternative name(s): Calcium-binding atopy-related autoantigen 1 homolog |
Gene namesi | Name:MICU1 Synonyms:CBARA1 ORF Names:QflA-11816 |
Organismi | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
Taxonomic identifieri | 9541 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Single-pass membrane protein Sequence analysis
- Mitochondrion intermembrane space By similarity
Note: The topology is subject to debate.By similarity
Mitochondrion
- integral component of mitochondrial membrane Source: UniProtKB
- mitochondrial inner membrane Source: UniProtKB
- mitochondrial intermembrane space Source: UniProtKB
- uniplex complex Source: UniProtKB
Other locations
- calcium channel complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 34 – 52 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 53 – 476 | Mitochondrial intermembraneBy similarityAdd BLAST | 424 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 33 | MitochondrionSequence analysisBy similarityAdd BLAST | 33 | |
ChainiPRO_0000322991 | 34 – 476 | Calcium uptake protein 1, mitochondrialAdd BLAST | 443 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 463 | Interchain (with C-413 in MICU2)By similarity |
Keywords - PTMi
Disulfide bondInteractioni
Subunit structurei
Homohexamer; in absence of calcium.
Forms a homohexamer in absence of calcium and rearranges into a heterodimer in presence of calcium. Heterodimer; disulfide-linked; heterodimerizes with MICU2. The heterodimer formed with MICU2 associates with MCU at low calcium concentration and dissociates from MCU at high calcium level.
Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1.
Interacts (via polybasic region) with EMRE/SMDT1; the interaction is direct.
Interacts (via polybasic region) with MCU (via coiled coil domains); the interaction is direct and precedes formation of the heterodimer with MICU2.
Interacts with SLC25A23.
Interacts with CHCHD4/MIA40; which introduces the interchain disulfide bond with MICU2.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 218 – 253 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 408 – 443 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 99 – 110 | Polybasic regionBy similarityAdd BLAST | 12 | |
Regioni | 455 – 465 | C-helix regionBy similarityAdd BLAST | 11 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Transit peptide, Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR039800, MICU1/2/3 |
PANTHERi | PTHR12294, PTHR12294, 1 hit |
Pfami | View protein in Pfam PF13202, EF-hand_5, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MFRLNSLSAL AELAVGSRWY HGGSQPIQIR RRLMMVAFLG ASAVTASTGL
60 70 80 90 100
LWKRAHAESP PCVDNLKSDI GDKGKNKDEG DVCNHEKKTA DLAPHPEEKK
110 120 130 140 150
KKRSGFRDRK VMEYENRIRA YSTPDKIFRY FATLKVINEP GEAEVFMTPE
160 170 180 190 200
DFVRSITPNE KQPEHLGLDQ YIIKRFDGKK ISQEREKFAD EGSIFYTLGE
210 220 230 240 250
CGLISFSDYI FLTTVLSTPQ RNFEIAFKMF DLNGDGEVDM EEFEQVQSII
260 270 280 290 300
RSQTSMGMRH RDRPTTGNTL KSGLCSALTT YFFGADLKGK LTIKNFLEFQ
310 320 330 340 350
RKLQHDVLKL EFERHDPVDG RITERQFGGM LLAYSGVQSK KLTAMQRQLK
360 370 380 390 400
KHFKEGKGLT FQEVENFFTF LKNINDVDTA LSFYHMAGAS LDKVTMQQVA
410 420 430 440 450
RTVAKVELSD HVCDVVFALF DCDGNGELSN KEFVSIMKQR LMRGLEKPKD
460 470
MGFTRLMQAM WKCAQETAWD FALPKQ
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB169726 mRNA Translation: BAE01807.1 Frameshift. |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB169726 mRNA Translation: BAE01807.1 Frameshift. |
3D structure databases
SMRi | Q4R518 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR039800, MICU1/2/3 |
PANTHERi | PTHR12294, PTHR12294, 1 hit |
Pfami | View protein in Pfam PF13202, EF-hand_5, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MICU1_MACFA | |
Accessioni | Q4R518Primary (citable) accession number: Q4R518 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | March 18, 2008 | |
Last modified: | December 2, 2020 | |
This is version 77 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families