UniProtKB - Q4R4E0 (NDUB5_MACFA)
Protein
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Gene
NDUFB5
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Functioni
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity
GO - Biological processi
- mitochondrial respiratory chain complex I assembly Source: UniProtKB
- oxidation-reduction process Source: UniProtKB-KW
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialAlternative name(s): Complex I-SGDH Short name: CI-SGDH NADH-ubiquinone oxidoreductase SGDH subunit |
Gene namesi | Name:NDUFB5 ORF Names:QtsA-10659 |
Organismi | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) |
Taxonomic identifieri | 9541 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity; Matrix side By similarity
Mitochondrion
- mitochondrial respiratory chain complex I Source: UniProtKB
Nucleus
- nucleoplasm Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 73 – 93 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 46 | MitochondrionBy similarityAdd BLAST | 46 | |
ChainiPRO_0000233983 | 47 – 189 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialAdd BLAST | 143 |
Interactioni
Subunit structurei
Complex I is composed of 45 different subunits.
By similarityProtein-protein interaction databases
STRINGi | 9541.XP_005546499.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I NDUFB5 subunit family.Curated
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4632, Eukaryota |
GeneTreei | ENSGT00390000009980 |
OMAi | RWGHGKK |
OrthoDBi | 1251699at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR019173, NADH_UbQ_OxRdtase_B5_su |
PANTHERi | PTHR13178, PTHR13178, 1 hit |
Pfami | View protein in Pfam PF09781, NDUF_B5, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q4R4E0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGMSLLRRV SVTAVAALSG RSLGTRLGFG GFLTRGFPKA VAPVRHSGGH
60 70 80 90 100
GKRLFVIKPS RFYDIRFLKL LRFYIALTGI PVVIIITLVN VFIGEAELAE
110 120 130 140 150
IPEGYIPEHW EYYKHPISRW IARNFYDSPE KIYEKSMAVL QIEAEKAELR
160 170 180
LKELEVRRLM RMRGDGPWYY YETIDKELID HSPKATPDN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2K5VYZ1 | A0A2K5VYZ1_MACFA | Complex I-SGDH | 177 | Annotation score: | |||
A0A2K5VYZ5 | A0A2K5VYZ5_MACFA | Complex I-SGDH | 135 | Annotation score: | |||
A0A2K5VZ28 | A0A2K5VZ28_MACFA | Complex I-SGDH | 137 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB178974 mRNA Translation: BAE02025.1 |
RefSeqi | NP_001270530.1, NM_001283601.1 |
Genome annotation databases
Ensembli | ENSMFAT00000004233; ENSMFAP00000030028; ENSMFAG00000042220 |
GeneIDi | 101866824 |
KEGGi | mcf:101866824 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB178974 mRNA Translation: BAE02025.1 |
RefSeqi | NP_001270530.1, NM_001283601.1 |
3D structure databases
SMRi | Q4R4E0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9541.XP_005546499.1 |
Genome annotation databases
Ensembli | ENSMFAT00000004233; ENSMFAP00000030028; ENSMFAG00000042220 |
GeneIDi | 101866824 |
KEGGi | mcf:101866824 |
Organism-specific databases
CTDi | 4711 |
Phylogenomic databases
eggNOGi | KOG4632, Eukaryota |
GeneTreei | ENSGT00390000009980 |
OMAi | RWGHGKK |
OrthoDBi | 1251699at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR019173, NADH_UbQ_OxRdtase_B5_su |
PANTHERi | PTHR13178, PTHR13178, 1 hit |
Pfami | View protein in Pfam PF09781, NDUF_B5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NDUB5_MACFA | |
Accessioni | Q4R4E0Primary (citable) accession number: Q4R4E0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | July 19, 2005 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families