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Protein

DPH3 homolog

Gene

DPH3

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).By similarity
Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5 (By similarity).By similarity

Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 60DPH-typePROSITE-ProRule annotationAdd BLAST57

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00559

Names & Taxonomyi

Protein namesi
Recommended name:
DPH3 homolog
Alternative name(s):
CSL-type zinc finger-containing protein 2
Gene namesi
Name:DPH3
Synonyms:ZCSL2
ORF Names:QtsA-20371
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002602211 – 82DPH3 homologAdd BLAST82

Structurei

3D structure databases

ProteinModelPortaliQ4R312
SMRiQ4R312
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DPH3 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 60DPH-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000007225
HOVERGENiHBG056007
KOiK15455

Family and domain databases

Gene3Di3.10.660.10, 1 hit
InterProiView protein in InterPro
IPR007872 Znf_DHP
IPR036671 Znf_DHP_sf
PfamiView protein in Pfam
PF05207 zf-CSL, 1 hit
SUPFAMiSSF144217 SSF144217, 1 hit
PROSITEiView protein in PROSITE
PS51074 ZF_DPH, 1 hit

Sequencei

Sequence statusi: Complete.

Q4R312-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVFHDEVEI EDFQYDEDSE TYFYPCPCGD NFSITKEDLE NGEDVATCPS
60 70 80
CSLIIKVIYD KDQFVCGETV PAPSANKELV KC
Length:82
Mass (Da):9,240
Last modified:July 19, 2005 - v1
Checksum:i7AC8F3FFF8CE766C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB179456 mRNA Translation: BAE02507.1
RefSeqiXP_005545755.1, XM_005545698.2
UniGeneiMfa.9168

Genome annotation databases

EnsembliENSMFAT00000031802; ENSMFAP00000023667; ENSMFAG00000043479
GeneIDi101866524
KEGGimcf:101866524

Similar proteinsi

Entry informationi

Entry nameiDPH3_MACFA
AccessioniPrimary (citable) accession number: Q4R312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 19, 2005
Last modified: September 12, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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