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Protein

Alcohol dehydrogenase 2

Gene

ADH2

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Binding sitei69SubstrateBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi177Zinc 1; catalyticBy similarity1
Binding sitei226NADBy similarity1
Binding sitei231NADBy similarity1
Binding sitei272NAD; via carbonyl oxygenBy similarity1
Binding sitei295NAD; via carbonyl oxygenBy similarity1
Binding sitei322NAD; via amide nitrogenBy similarity1
Binding sitei372NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 207NADBy similarity6
Nucleotide bindingi295 – 297NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

ReactomeiR-OSA-2161541 Abacavir metabolism
R-OSA-5365859 RA biosynthesis pathway
R-OSA-71384 Ethanol oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH2
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002914621 – 379Alcohol dehydrogenase 2Add BLAST379

Proteomic databases

PRIDEiQ4R1E8

Expressioni

Gene expression databases

ExpressionAtlasiQ4R1E8 differential

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ4R1E8
SMRiQ4R1E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Q4R1E8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATAGKVIKC KAAVAWEAGK PLSIEEVEVA PPQAMEVRVK ILYTALCHTD
60 70 80 90 100
VYFWEAKGQT PVFPRILGHE AGGIVESVGE GVTELAPGDH VLPVFTGECK
110 120 130 140 150
ECDHCKSEES NMCDLLRINV DRGVMIGDGK SRFTIKGKPI FHFVGTSTFS
160 170 180 190 200
EYTVIHVGCL AKINPEAPLD KVCILSCGFS TGFGATVNVA KPKKGQTVAI
210 220 230 240 250
FGLGAVGLAA MEGARLSGAS RIIGVDLNPA KFEQAKKFGC TDFVNPKDHS
260 270 280 290 300
KPVHEVLIEM TNGGLDRAVE CTGNINAMIS CFECVHDGWG VAVLVGVPTK
310 320 330 340 350
DDVFKTHPMN FLNEKTLKGT FFGNYKPRTD LPNVVELYMK KELELEKFIT
360 370
HSVPFSEINT AFDLMLKGES LRCVMRMDE
Length:379
Mass (Da):41,207
Last modified:July 19, 2005 - v1
Checksum:i2DF98CF6B6BEE8EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4Missing in CAA34364 (PubMed:2562760).Curated1
Sequence conflicti4Missing in AAA33889 (PubMed:2332167).Curated1
Sequence conflicti20 – 21KP → EA in CAA34364 (PubMed:2562760).Curated2
Sequence conflicti20 – 21KP → EA in AAA33889 (PubMed:2332167).Curated2
Sequence conflicti34A → R in CAA34364 (PubMed:2562760).Curated1
Sequence conflicti34A → R in AAA33889 (PubMed:2332167).Curated1
Sequence conflicti87P → A in CAA34364 (PubMed:2562760).Curated1
Sequence conflicti87P → A in AAA33889 (PubMed:2332167).Curated1
Sequence conflicti181 – 182TG → SR in CAA34364 (PubMed:2562760).Curated2
Sequence conflicti181 – 182TG → SR in AAA33889 (PubMed:2332167).Curated2
Sequence conflicti254 – 255HE → Q in CAA34364 (PubMed:2562760).Curated2
Sequence conflicti254 – 255HE → Q in AAA33889 (PubMed:2332167).Curated2
Sequence conflicti298 – 299Missing in CAA34364 (PubMed:2562760).Curated2
Sequence conflicti298 – 299Missing in AAA33889 (PubMed:2332167).Curated2
Sequence conflicti321F → LI in CAA34364 (PubMed:2562760).Curated1
Sequence conflicti321F → LI in AAA33889 (PubMed:2332167).Curated1
Sequence conflicti351Missing in CAA34364 (PubMed:2562760).Curated1
Sequence conflicti351Missing in AAA33889 (PubMed:2332167).Curated1
Sequence conflicti369 – 374ESLRCV → RVSAAS in AAA33889 (PubMed:2332167).Curated6
Sequence conflicti376 – 378RMD → SMY in CAA34364 (PubMed:2562760).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16297 mRNA Translation: CAA34364.1
M36469 Genomic DNA Translation: AAA33889.1
AB208537 Genomic DNA Translation: BAE00045.1
PIRiJH0111 DERZA2

Genome annotation databases

EnsemblPlantsiOs11t0210500-01; Os11t0210500-01; Os11g0210500
GrameneiOs11t0210500-01; Os11t0210500-01; Os11g0210500

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16297 mRNA Translation: CAA34364.1
M36469 Genomic DNA Translation: AAA33889.1
AB208537 Genomic DNA Translation: BAE00045.1
PIRiJH0111 DERZA2

3D structure databases

ProteinModelPortaliQ4R1E8
SMRiQ4R1E8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ4R1E8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOs11t0210500-01; Os11t0210500-01; Os11g0210500
GrameneiOs11t0210500-01; Os11t0210500-01; Os11g0210500

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674

Enzyme and pathway databases

ReactomeiR-OSA-2161541 Abacavir metabolism
R-OSA-5365859 RA biosynthesis pathway
R-OSA-71384 Ethanol oxidation

Gene expression databases

ExpressionAtlasiQ4R1E8 differential

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH2_ORYSI
AccessioniPrimary (citable) accession number: Q4R1E8
Secondary accession number(s): P18332
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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