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UniProtKB - Q4R0W3 (DOIS_STRRI)
Protein
2-deoxy-scyllo-inosose synthase
Gene
rbmA
Organism
Streptomyces ribosidificus
Status
Functioni
Catalyzes the intramolecular carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose (DOI).
1 PublicationCatalytic activityi
- EC:4.2.3.124
Cofactori
Protein has several cofactor binding sites:: 2-deoxystreptamine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes 2-deoxystreptamine from D-glucose 6-phosphate. This subpathway is part of the pathway 2-deoxystreptamine biosynthesis, which is itself part of Metabolic intermediate biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-deoxystreptamine from D-glucose 6-phosphate, the pathway 2-deoxystreptamine biosynthesis and in Metabolic intermediate biosynthesis.
Pathwayi: ribostamycin biosynthesis
This protein is involved in the pathway ribostamycin biosynthesis, which is part of Antibiotic biosynthesis.View all proteins of this organism that are known to be involved in the pathway ribostamycin biosynthesis and in Antibiotic biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 42 | NADBy similarity | 1 | |
Active sitei | 142 | By similarity | 1 | |
Metal bindingi | 184 | CobaltBy similarity | 1 | |
Active sitei | 244 | By similarity | 1 | |
Metal bindingi | 247 | CobaltBy similarity | 1 | |
Metal bindingi | 263 | CobaltBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 73 – 76 | NADBy similarity | 4 | |
Nucleotide bindingi | 105 – 109 | NADBy similarity | 5 | |
Nucleotide bindingi | 129 – 130 | NADBy similarity | 2 | |
Nucleotide bindingi | 140 – 142 | NADBy similarity | 3 | |
Nucleotide bindingi | 151 – 152 | NADBy similarity | 2 |
GO - Molecular functioni
- carbon-oxygen lyase activity, acting on phosphates Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- antibiotic biosynthetic process Source: UniProtKB-KW
- aromatic amino acid family biosynthetic process Source: InterPro
Keywordsi
Molecular function | Lyase |
Biological process | Antibiotic biosynthesis |
Ligand | Cobalt, Metal-binding, NAD |
Enzyme and pathway databases
UniPathwayi | UPA00907;UER00921 UPA00972 |
Names & Taxonomyi
Protein namesi | Recommended name: 2-deoxy-scyllo-inosose synthase (EC:4.2.3.124)Short name: DOI synthase Short name: DOIS |
Gene namesi | Name:rbmA Synonyms:ribC |
Organismi | Streptomyces ribosidificus |
Taxonomic identifieri | 80859 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000234039 | 1 – 391 | 2-deoxy-scyllo-inosose synthaseAdd BLAST | 391 |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR030963, DHQ_synth_fam IPR030960, DHQS/DOIS |
Pfami | View protein in Pfam PF01761, DHQ_synthase, 1 hit |
PIRSFi | PIRSF001455, DHQ_synth, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4R0W3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVTPIAMED ASFAYRLGTE CTEDVVARLA TLGASSYLVV ADTTVAGLYG
60 70 80 90 100
HDLTARIDKE AGPAHLLTHE SGEVHKDLTT VSVLAEQALE RGADRRSVVV
110 120 130 140 150
ALGGGVTGNI TGLMASLLFR GIRLVHVPTT VVAMLDSVLS LKQAVNATFG
160 170 180 190 200
KNLVGTFYQP VEVLADTAFL RTLPPREIRS GLGEVVKNAL AIRPAMLDRL
210 220 230 240 250
GDALRADARY DDETLRWIIA ESLTAKADVT RDDKHERRTG LVLEYGHTAG
260 270 280 290 300
HAIEHASRGE VAHGAGVAVG MTIAAEVSRR LGHAGPDFVA LHRELVAAAG
310 320 330 340 350
VEPAVPAHVD PALVKNWLAY DNKRGYLDSP PGHTPMVLLS APGEVLHTGP
360 370 380 390
MPLVPVPLAL LEEAVDEAAR RGRDAAPAAA YVGPPAAGPL P
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ748131 Genomic DNA Translation: CAG34718.1 AJ744850 Genomic DNA Translation: CAG34037.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ748131 Genomic DNA Translation: CAG34718.1 AJ744850 Genomic DNA Translation: CAG34037.1 |
3D structure databases
SMRi | Q4R0W3 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00907;UER00921 UPA00972 |
Family and domain databases
InterProi | View protein in InterPro IPR030963, DHQ_synth_fam IPR030960, DHQS/DOIS |
Pfami | View protein in Pfam PF01761, DHQ_synthase, 1 hit |
PIRSFi | PIRSF001455, DHQ_synth, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DOIS_STRRI | |
Accessioni | Q4R0W3Primary (citable) accession number: Q4R0W3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | July 19, 2005 | |
Last modified: | December 11, 2019 | |
This is version 39 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families