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Entry version 101 (18 Sep 2019)
Sequence version 2 (05 Feb 2008)
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Protein

Coiled-coil domain-containing protein 88B

Gene

Ccdc88b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells in both the CD4+ and the CD8+ compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation and during the course of infection with the mouse malaria parasite Plasmodium berghei (PubMed:25403443). Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic granule transport along microtubules, and dynein-mediated clustering to MTOC (By similarity). Interacts with HSPA5 and stabilizes the interaction between HSPA5 and ERN1, leading to suppression of ERN1-induced JNK activation and endoplasmic reticulum stress-induced apoptosis (PubMed:21289099).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processStress response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 88B
Alternative name(s):
Gipie1 Publication
Hook-related protein 3
Short name:
HkRP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ccdc88b
Synonyms:Ccdc88
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1925567 Ccdc88b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice show defects in T-cell functions including impaired maturation, significantly reduced activation, reduced cell division as well as impaired cytokine production in response to specific or non-specific stimulation and during the course of infection with the mouse malaria parasite Plasmodium berghei.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003174551 – 1481Coiled-coil domain-containing protein 88BAdd BLAST1481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei441PhosphoserineCombined sources1
Modified residuei649PhosphoserineCombined sources1
Modified residuei1353PhosphoserineCombined sources1
Modified residuei1384PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3967

Encyclopedia of Proteome Dynamics

More...
EPDi
Q4QRL3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q4QRL3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4QRL3

PRoteomics IDEntifications database

More...
PRIDEi
Q4QRL3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4QRL3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4QRL3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundantly expressed in immune cells, including both CD4+ and CD8+ T-cells and in myeloid cells (at protein level) (PubMed:25403443). Expressed in endothelium (at protein level) (PubMed:21289099). Expressed specifically in spleen, bone marrow, lymph nodes and thymus (PubMed:25403443). Expressed in liver and heart (PubMed:21289099).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000047810 Expressed in 54 organ(s), highest expression level in mesenteric lymph node

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4QRL3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with DOCK8 (By similarity).

Interacts (via C-terminus) with intact microtubules (By similarity).

Interacts with dynein-dynactin motor complex (By similarity).

Interacts (via C-terminus) with HSPA5 (PubMed:21289099).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000109067

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4QRL3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili200 – 225Sequence analysisAdd BLAST26
Coiled coili258 – 491Sequence analysisAdd BLAST234
Coiled coili731 – 1308Sequence analysisAdd BLAST578

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi39 – 48Poly-Glu10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC88 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4643 Eukaryota
ENOG410YFRJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162048

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060297

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4QRL3

Identification of Orthologs from Complete Genome Data

More...
OMAi
ACRLATQ

Database of Orthologous Groups

More...
OrthoDBi
59187at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4QRL3

TreeFam database of animal gene trees

More...
TreeFami
TF320231

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036872 CH_dom_sf
IPR008636 Hook-like_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05622 HOOK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4QRL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGAKGPRLR GFLSGSLATW ALGLAGLVGE AEESAGGTEE EEEEEEEEGA
60 70 80 90 100
LCTEKRFLRL IDGALLLRVL GIIAPSSRGG LRMVRGRDGP AACRMWNLCH
110 120 130 140 150
LWGRLRDFYQ EELQLLILSP PPDLQTMGCD PFSEEAVDEL ESILRLLLGA
160 170 180 190 200
SVQCEHRELF IRHIRGLSLD VQSELAGAIQ EVTQPGAGVV LALAGPESGE
210 220 230 240 250
LVAEELEMQL RSLTGMMSRL ARERDLGAQR LAELLLEREP AHLLLPEAPA
260 270 280 290 300
NASAEGVSHH LALQLTNAKA QLRRLRQEVE EKAEQLLDSQ AEVQGLEAEI
310 320 330 340 350
RRLRQETQAL SAQAKRAELY REEAEALRER AGRLPRLQEE LRRCREKLQA
360 370 380 390 400
AEVFKGQLEE ERVLSEALEA SKVLLEEQLE VARERSARLH ETQRENLLLR
410 420 430 440 450
TRLGEAHADL DSLRHQLEQL VEENVELELE LQRSLEPPPG SPGEASLPGA
460 470 480 490 500
APSLQDEVRE AEAGRLRAVE RENRELRGQL QMLQAQLGSQ HPLLEEQREN
510 520 530 540 550
SRQPPVPNRD PATPSALHHS PQSPACQIGG EGSESLDLPS PASYSDITRS
560 570 580 590 600
PKCSQAPDSH PELESPLQMV SQDPQTSDQA LQESDPTVET HQCLEKSGHR
610 620 630 640 650
VPLQSPIVWD PPQGPEVRIE VQELLGETGS REAPQGELVH KAQVLKQESP
660 670 680 690 700
KCRPRSAELT LREPLKDQKA LDRELELSKQ QKETGRHEQR PKGLESKLGP
710 720 730 740 750
QKPQQTSEGV PDAWSREEPT PGETLVSAIP EEQALRDEVA QLRREVAGLE
760 770 780 790 800
VKLQAQAQRL EARSAEALCL SEELAQARRT EAEAHQEAEA QAREQARLRE
810 820 830 840 850
AVDTASLELE AASREREALA EALAAAGRER RQWERDGPRL RAQVEAAEQQ
860 870 880 890 900
VQALESQVRC HLEEAEREHA EKQALREELE KAVLRGQELG DRLEHLQEEL
910 920 930 940 950
EQAALERQKF LQEQENQHQR YRHLEQRLEA ELQAASTSKE EALMELKARA
960 970 980 990 1000
LQLEEELIQL RQYPVDLATG ARAGPRTVET QNGRLIEVER NNATLVAEKA
1010 1020 1030 1040 1050
ALQGQLQHLE GQLGSLQGRA QELLLQSQRA QEHSSRLQAE KSMMEMQGQE
1060 1070 1080 1090 1100
LHRKLGVLEE EVRAARRAQE ETRGQQQALL RDHEALVQLQ RRQETELEGL
1110 1120 1130 1140 1150
LVRHRDLKAN MRALELAHRE LQGRHEQLQA QRANVEAQEV ALLAERERLM
1160 1170 1180 1190 1200
QDGHRQRGLE EELRRLQNEH ERAQMLLAEV SRERGELQGE RGELRSRLAR
1210 1220 1230 1240 1250
LELERAQLEI QSQQLRESNQ QLDLSACRLT TQCELLTQLR SAQEEENRQL
1260 1270 1280 1290 1300
LAEVQALSRE NRELLERSLE SRDHLHREQR EYLDQLNALR REKQKLVEKI
1310 1320 1330 1340 1350
MDQYRVLEPG PLPRTKKGSW LADKVKRLIR PRREGALHGG PRLGADGAGS
1360 1370 1380 1390 1400
TESLGGPLET ELPEGREADG TGSSSPAPMR RVQSSLCLGD ETLAGGQRRR
1410 1420 1430 1440 1450
LSSRFPGGRS SASFSPGDTP RQRFRQRRPG PLGAPSTHSK GSGVEWDGSI
1460 1470 1480
KTLSEHEADD TREAFQEQKP EKQFLTPSLS Q
Note: No experimental confirmation available.
Length:1,481
Mass (Da):166,608
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3229089E792598B8
GO
Isoform 2 (identifier: Q4QRL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     349-359: QAAEVFKGQLE → DSWVKRVKIQQ

Note: No experimental confirmation available.
Show »
Length:1,481
Mass (Da):166,776
Checksum:i98157B55422F4D65
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494BB08A0A494BB08_MOUSE
Coiled-coil domain-containing prote...
Ccdc88b
1,133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494B939A0A494B939_MOUSE
Coiled-coil domain-containing prote...
Ccdc88b
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030966349 – 359QAAEVFKGQLE → DSWVKRVKIQQ in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC120557 Genomic DNA No translation available.
BC076600 mRNA Translation: AAH76600.1
BC151001 mRNA Translation: AAI51002.1
BC151009 mRNA Translation: AAI51010.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37900.1 [Q4QRL3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001074760.1, NM_001081291.1 [Q4QRL3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000113440; ENSMUSP00000109067; ENSMUSG00000047810 [Q4QRL3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
78317

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:78317

UCSC genome browser

More...
UCSCi
uc008gjb.1 mouse [Q4QRL3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120557 Genomic DNA No translation available.
BC076600 mRNA Translation: AAH76600.1
BC151001 mRNA Translation: AAI51002.1
BC151009 mRNA Translation: AAI51010.1
CCDSiCCDS37900.1 [Q4QRL3-1]
RefSeqiNP_001074760.1, NM_001081291.1 [Q4QRL3-1]

3D structure databases

SMRiQ4QRL3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109067

PTM databases

iPTMnetiQ4QRL3
PhosphoSitePlusiQ4QRL3

Proteomic databases

CPTACinon-CPTAC-3967
EPDiQ4QRL3
jPOSTiQ4QRL3
PaxDbiQ4QRL3
PRIDEiQ4QRL3

Genome annotation databases

EnsembliENSMUST00000113440; ENSMUSP00000109067; ENSMUSG00000047810 [Q4QRL3-1]
GeneIDi78317
KEGGimmu:78317
UCSCiuc008gjb.1 mouse [Q4QRL3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
283234
MGIiMGI:1925567 Ccdc88b

Phylogenomic databases

eggNOGiKOG4643 Eukaryota
ENOG410YFRJ LUCA
GeneTreeiENSGT00940000162048
HOGENOMiHOG000060297
InParanoidiQ4QRL3
OMAiACRLATQ
OrthoDBi59187at2759
PhylomeDBiQ4QRL3
TreeFamiTF320231

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q4QRL3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000047810 Expressed in 54 organ(s), highest expression level in mesenteric lymph node
GenevisibleiQ4QRL3 MM

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR036872 CH_dom_sf
IPR008636 Hook-like_fam
PfamiView protein in Pfam
PF05622 HOOK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC88B_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4QRL3
Secondary accession number(s): B2RX63
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 18, 2019
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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